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Bestari Jaka Budiman
Fakultas Kedokteran Universitas Andalas
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Biofilm Bakteri pada Penderita Rinosinusitis Kronis Dolly Irfandy; Yolazenia Yolazenia; Bestari Jaka Budiman; Dolly Irfandy
Jurnal Kesehatan Melayu Vol 1, No 2 (2018): April 2018
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (575.208 KB) | DOI: 10.26891/jkm.v1i2.2018.106-113

Abstract

Banyak dilaporkan kegagalan pengobatan pada rinosinusitis kronis (RSK) disebabkan resistensi terhadap antibiotik. Beberapa penelitian menunjukkan bahwa biofilm bakteri berperan penting pada etiologi dan persistensi dari RSK. Penulisan tinjauan pustaka ini adalah untuk mengetahui implikasi biofilm bakteri pada penderita RSK. Rinosinusitis kronis adalah penyakit inflamasi mukosa hidung dan sinus paranasal yang berlangsung dalam waktu lebih dari 12 minggu. Biofilm adalah suatu struktur komunitas sel-sel bakteri yang ditutupi oleh matriks polimer yang dihasilkan sendiri dan menempel pada permukaan. Berbagai penelitian menunjukkan terdapatnya biofilm bakteri pada mukosa sinonasal penderita RSK dan berhubungan dengan resistensi terhadap pengobatan dengan antibiotika. Berbagai pemeriksaan untuk mendeteksi biofilm yaitu Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Confocal Scanning Laser Microscopy (CSLM), modifikasi Calgary Biofilm Device Assay, Tube Method dan Congo Red Agar Method. Beberapa terapi potensial untuk mengatasi biofilm pada RSK sedang berkembang.
Diagnosis dan Penatalaksanaan Angiofibroma Septum Nasi Suci Riskiah; Bestari Jaka Budiman
Jurnal Kesehatan Andalas Vol 7 (2018): Supplement 3
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v7i0.860

Abstract

Pendahuluan: Angiofibroma merupakan tumor yang bersifat jinak secara histopatologis tetapi secara klinis bersifat ganas. Kasus Angiofibroma di septum nasi merupakan kasus yang jarang. Diagnosis pasti ditegakkan dengan pemeriksaan histopatologi.  Sebagian besar dokter mempertimbangkan operasi sebagai pilihan penatalaksanaan. Laporan kasus: Dilaporkan pasien laki-laki    14 tahun dengan diagnosis angiofibroma septum nasi. Pada pasien dilakukan Rinoplasti eksterna untuk ekstirpasi tumor dalam bius umum. Ekstirpasi diawali dengan insisi traskolumela inverted V dan pasien dievaluasi selama 1 bulan. Kesimpulan: Angiofibroma septum salah satu tumor angiofibroma ekstranasofaring yang sangat jarang terjadi. Tumor ini memiliki histopatologi yang sama dengan angiofibroma nasofaring. Diagnosis pasti ditegakkan dengan pemeriksaan histopatologi dan penatalaksanaan dengan cara ekstirpasi massa secara keseluruhan.
Sakit Kepala pada Variasi Anatomi Hidung dan Sinus Paranasal Dolly Irfandy; Tika Hakikah; Dolly Irfandy; Bestari Jaka Budiman
Jurnal Kesehatan Andalas Vol 10, No 3 (2021): Online November 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1919

Abstract

The anatomical variations of the nasal and sinus paranasal can cause headaches. The most common variants have deviated septum, concha bullosa, and agger nasi cells. These variations can cause narrowing of the osteomeatal complex. Computed tomography was the primary modality for evaluating anatomical variations of the nasal and paranasal sinuses in diagnosis and management. Functional endoscopic sinus surgery was generally performed to restore the sinuses' drainage and ventilation in anatomical variations. It has been reported a 45-year-old woman with a congested left nostril and headache that has gotten worse since 2 months ago and computed tomography of the paranasal sinuses show thickening of the bilateral maxillary sinus mucosa, bilateral anterior ethmoid, left septum deviation, concha bullous, and right inferior turbinate hypertrophy. Functional Endoscopy Sinus Surgery was performed, found anatomical variations namely, deviation septum, concha bullosa, agger nasi cells and supra agger cells. The operation gave satisfactory results. Correct evaluation of anatomical variations based on history, physical examination and investigations can assist in patient management and avoid errors during surgery. The operation gave a satisfactory result for managing symptoms on patient with anatomical variation of nasal and paranasal sinuses when compared with medicamentosa.Keywords: anatomical variations,  agger nasi cells , concha bullosa,  deviated septum, headache, supra agger cell
Trombosis Sinus Kavernosus Akibat Komplikasi Furunkulosis Hidung Dolly Irfandy; Bestari Jaka Budiman; Dolly Irfandy; Effy Huriyati; Dewi Yuri Lestari
Jurnal Kesehatan Andalas Vol 6, No 1 (2017)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v6i1.675

Abstract

Trombosis sinus kavernosus merupakan kasus yang jarang, tetapi dapat mengancam kehidupan. Penyebab trombosis dapat berasal dari infeksi daerah sinonasal, midface atau orbita. Gejala klinis meliputi gejala yang melibatkan mata dan beberapa nervus kranial. Penatalaksanaan pada trombosis sinus kavernosus terdiri dari pemberian antibiotik, pembedahan terhadap sumber infeksi, kortikosteroid dan pemberian antikoagulan yang masih kontroversial. Dilaporkan satu kasus trombosis sinus kavernosus akibat komplikasi furunkulosis hidung pada pasien laki-laki 13 tahun dengan penurunan penglihatan pada kedua mata. Pasien diberi terapi antibiotik empirik dan kortikosteroid, memperlihatkan perbaikan. Simpulan studi ini ialah trombosis sinus kavernosus merupakan kondisi yang fatal. Terapi yang segera dan tepat dapat memberikan prognosis yang lebih baik. Penatalaksanaan medikamentosa merupakan pengobatan dasar trombosis sinus kavernosus.
Peran biofilm bakteri terhadap derajat keparahan rinosinusitis kronis berdasarkan skor Lund-Mackay Dolly Irfandy; Y Yolazenia; Bestari Jaka Budiman; Effy Huriyati; Aziz Djamal; Rizanda Machmud; Dolly Irfandy
Oto Rhino Laryngologica Indonesiana Vol 47, No 2 (2017): Volume 47, No. 2 July - December 2017
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.193 KB) | DOI: 10.32637/orli.v47i2.220

Abstract

Latar belakang: Rinosinusitis kronis (RSK) adalah penyakit inflamasi mukosa hidung dan sinus paranasal yang berlangsung lebih dari 12 minggu. Berbagai kondisi telah dikaitkan dengan patogenesis penyakit ini, seperti infeksi bakteri, jamur, superantigen, dan biofilm. Banyak penelitian telah menunjukkan terdapatnya biofilm bakteri pada pasien dengan RSK. Biofilm bakteri dapat memfasilitasi terjadinya resistensi pada antibiotik. CT Scan sinus paranasal (SPN) merupakan pemeriksaan penunjang pilihan untuk diagnosis radiologik RSK. Lund dan Mackay telah mengembangkan suatu sistem berdasarkan skor dari CT Scan SPN untuk menilai kuantifikasi proses peradangan pada sinus paranasal. Beberapa penelitian menunjukkan bahwa pasien dengan biofilm bakteri memiliki skor Lund-Mackay CT Scan SPN yang lebih tinggi pada saat pra operatif. Tujuan: Penelitian ini bertujuan untuk mengetahui peran biofilm bakteri terhadap derajat keparahan RSK berdasarkan skor Lund-Mackay. Metode: Penelitian ini adalah penelitian cross-sectional dengan jumlah total sampel adalah 48 orang pasien RSK. Sekret hidung diambil menggunakan kapas lidi steril dengan swab pada meatus medius lalu dilakukan identifikasi bakteri dan pemeriksaan biofilm dengan tube method. Skor Lund-Mackay dihitung dari CT Scan SPN potongan koronal. Data dianalisis dengan uji Fisher. Hasil: Proporsi pasien RSK dengan skor Lund-Mackay yang tinggi lebih banyak pada pasien dengan biofilm (46,2%), dibandingkan tanpa biofilm (44,4%). Secara statistik tidak terdapat perbedaan bermakna pada skor Lund-Mackay antara pasien dengan biofilm dan tanpa biofilm (p=1,000). Kesimpulan: Tidak terdapat hubungan antara biofilm bakteri dengan derajat keparahan RSK berdasarkan skor Lund-Mackay. Kata Kunci: Rinosinusitis kronis, biofilm bakteri, tube method, skor Lund-Mackay ABSTRACT Background: Chronic rhinosinusitis (CRS) is inflammation of the nose and paranasal sinuses with the symptoms duration more than 12 weeks. Many conditions have been linked to its pathogenesis such as bacterial and fungal infection, superantigens and biofilm. Many studies showed the presence of bacterial biofilms in patients with CRS. Bacterial biofilms can facilitate the resistance to antibiotics. Paranasal sinuses (PNS) CT scan is the method of choice for radiological diagnosis of CRS. Lund and Mackay has developed a scoring system based on the CT finding to assess the quantification of inflammatory process in PNS. Some research suggested that patients with bacterial biofilms have higher Lund-Mackay score pre-operatively. Purpose: To determine the role of bacterial biofilms to the severity of CRS according to Lund-Mackay score. Methods: This was a cross-sectional study with 48 CRS patient’s sample. Nasal discharges were taken by swab in middle meatal using sterile cotton buds, followed by identification of bacteria and detection of bacterial biofilms using tube method. Lund-Mackay score was counted from coronal section of PNS CT Scan. Data was analyzed by Fisher’s exact test. Results: Proportion of patients CRS with high Lund-Mackay score was more common in patient with biofilm (46.2%) compared to patients without biofilm (44.4%). Statistically, there was no significant difference of Lund-Mackay score between patient with biofilm and without biofilm (p=1.00). Conclusion: There was no relationship between the bacterial biofilm with the severity of CRS according to Lund-Mackay score. Keywords: Chronic rhinosinusitis, bacterial biofilm, tube method, Lund-Mackay scores
Endoscopic transsphenoidal resection of craniopharyngioma Dolly Irfandy; Esmaralda Nurul Amany; Bestari Jaka Budiman; Dolly Irfandy; Hesty Lidya Ningsih
Oto Rhino Laryngologica Indonesiana Vol 50, No 2 (2020): Volume 50, No. 2 July - December 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i2.338

Abstract

ABSTRACTBackground: Endoscopic surgery techniques had been advancing in this last two decades. Transsphenoidal approach endoscopic surgery to the skull base provides better visualization of the operation field compared to microscopic surgery, and also brought lower morbidity than other techniques. Purpose: To report a transsphenoidal endoscopic skull base surgery for craniopharyngioma resection. Case Report: A case of craniopharyngioma in a 47-year-old man. The tumor resection was performed with transsphenoidal endoscopic approach, in collaboration with a neurosurgeon. Clinical Question: Is transsphenoidal endoscopic skull base surgery approach, the appropriate surgical procedure for craniopharyngioma management? Review Method: Evidence based literature study of skull base surgery with transsphenoidal endoscopic approach in craniopharyngioma through database Cochrane library, Pubmed Medline, and hand searching. Result: Skull base surgery with transsphenoidal endoscopic approach was minimally invasive with maximally invasion compared to transcranial surgery, and  also provided better view, and could reduce complication rate. Conclusion: Skull base surgery with transsphenoidal endoscopic approach offers more advantage in skull base lesion management compared to other techniques. Collaboration between neurosurgeon and otorhinolaryngologist using this technique could reduce complication and morbidity rate.  ABSTRAKLatar belakang: Teknik operasi endoskopi mengalami perkembangan pesat dalam dua dekade terakhir. Bedah basis kranii dengan pendekatan endoskopi transfenoid memberikan kualitas visualisasi lapang pandang operasi lebih baik dibanding menggunakan mikroskop, dan juga mengakibatkan morbiditas lebih rendah dibanding teknik lainnya. Tujuan: Melaporkan keberhasilan bedah basis kranii dengan pendekatan endoskopi transfenoid pada kraniofaringioma. Laporan kasus: Seorang laki-laki 47 tahun dengan diagnosis kraniofaringioma yang dilakukan tindakan reseksi tumor dengan pendekatan endoskopi transfenoid berkolaborasi dengan ahli bedah saraf. Pertanyaan Klinis: Apakah bedah basis kranii dengan pendekatan endoskopi transfenoid merupakan teknik operasi yang tepat untuk tatalaksana kraniofaringioma? Telaah literatur: Telaah literatur berbasis bukti mengenai bedah basis kranii dengan pendekatan endoskopi transfenoid pada kraniofaringioma melalui database Cochrane library, Pubmed Medline, dan pencarian manual. Hasil: Bedah basis kranii dengan pendekatan endoskopi transfenoid memberikan akses minimal dengan invasi maksimal, visualisasi lebih baik, dan dapat menurunkan angka komplikasi. Kesimpulan: Bedah basis kranii dengan pendekatan endoskopi transfenoid merupakan teknik operasi lesi basis kranii yang lebih unggul dibandingkan teknik lainnya. Kolaborasi antara ahli bedah saraf dan THT dapat mengurangi angka komplikasi dan morbiditas tindakan ini.
EPIDERMAL GROWTH FACTOR RECEPTOR EXPRESSION IN NON-KERATINIZED NASOPHARYNGEAL CARCINOMA SUBTYPE AT PADANG Histawara Subroto; Sukri Rahman; Bestari J Budiman; Aswiyanti Asri; Hafni Bachtiar
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 02 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (561.682 KB) | DOI: 10.32734/ijnpc.v1i2.1140

Abstract

Introduction: Patients with nasopharyngeal carcinoma have a poor prognosis, there are several factors that cause it to happen, one of the existing therapeutic response has been inadequate. Expression of Epidermal Growth Factor Receptor (EGFR) has been used as a biological marker targeted therapy in nasopharyngeal carcinoma. Histopathologic subtype tumors also determine the prognosis of patients with nasopharyngeal carcinoma. Objective: The aim of the study to determine between the expression of epidermal growth factor receptor between non-keratinized differentiated and undifferentiated subtypes in nasopharyngeal carcinoma and correlation with their clinical stage. Study design, Cross-sectional comparative study. Place and duration study, Department of Otorhinolaryngology, Department of Pathology Anatomy in Dr. M. Djamil Hospital, Padang and Department of Pathology Anatomy in Gajah Mada University, between May 2015 until October 2015 Material and methods: We included 36 samples paraffin blocks of nasopharyngeal carcinoma biopsy, respectively 18 paraffin blocks are non-keratinized differentiated and 18 non-keratinized undifferentiated nasopharyngeal carcinoma subtypes. Each sample examined EGFR expression by immunohistochemical staining methods. Results: There were positive EGFR expression results in all sample as 69.4%. Expression of EGFR positive non-keratinized differentiated subtypes in nasopharyngeal carcinoma as 77.8% and undifferentiated subtype as 61.6%. There are no significant differences of EGFR expression between non keratinized differentiated and undifferentiated subtypes nasopharyngeal carcinoma (P>0.05). There are no significant differences of EGFR expression between new and advanced stage nasopharyngeal carcinoma (P>0.05). Conclusion: There were no significant differences of EGFR expression between non-keratinized differentiated and non-keratinized undifferentiated subtypes in nasopharyngeal carcinoma. Analysis of the study also showed no significant differences of EGFR expression based on the clinical stage nasopharyngeal carcinoma.
Epistaksis pada Polip Nasal Dolly Irfandy; Dolly Irfandy; Yunita Wulandari; Bestari Jaka Budiman; Pamelia Mayorita
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 1 (2022): Maret 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i1.436

Abstract

Pendahuluan: Polip nasal merupakan kondisi multifaktorial yang sering dikaitkan dengan berbagai penyakit dan gangguan patogen, seperti alergi, infeksi, sinusitis jamur alergi, fibrosis kistik, asma, dan intoleransi aspirin. Polip nasal dapat berperilaku agresif dan menirukan patologi lain di rongga hidung dan paranasal. Polip nasal inflammatory type merupakan tipe polip nasal terbanyak kedua dari kasus polip. Bedah sinus endoskopi (BSE) biasanya diperuntukkan bagi pasien yang tidak mendapatkan perbaikan gejala dari tatalaksana medikamentosa, pasien yang memiliki kontraindikasi atau yang mengalami efek samping dari terapi tersebut. Maksilektomi medial menjadi salah satu teknik operasi untuk tatalaksana pada polip nasal. Dilaporkan satu kasus pasien perempuan, 33 tahun dengan keluhan utama riwayat hidung berdarah berulang dan didiagnosis dengan polip nasal inflammatory type yang dilakukan terapi maksilektomi medial. Maksilektomi medial merupakan salah satu teknik pembedahan pada tatalakasana polip nasal.
Caldwell-Luc approach for odontogenic maxillary sinusitis Dolly Irfandy; Bestari Jaka Budiman; Putri Sari Ivanny
Oto Rhino Laryngologica Indonesiana Vol 52, No 2 (2022): VOLUME 52, NO. 2 JULY - DECEMBER 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTBackground: Maxillary odontogenic sinusitis is a maxillary sinusitis of dental origin. Odontogenic origin of infection must be suspected in those sinusitis patients who have symptoms of unilateral maxillary sinusitis, sinonasal symptoms such as nasal obstruction, rhinorrhea, and/or foul odour, a history of dental pain or dental/oral surgical treatment, and in those who are resistant to conventional treatment of sinusitis. Purpose: To report and analyze the result of Caldwell-Luc approach for odontogenic maxillary sinusitis. Case report: One case of odontogenic maxillary dextra sinusitis treated by Caldwell-Luc approach. After 2 months of follow-up, there was no thick and smelly discharge coming out of the nose, no complaints of pain in the nose, nor swelling and numbness of the cheeks and gums. Clinical question: “Does Caldwell-Luc approach provide good result for odontogenic maxillary sinusitis?” Review method: Literature searching was performed through Cochrane database, PubMed, ClinicalKey, and Google Scholar using keywords “Caldwell-Luc” and “odontogenic sinusitis.” Result: The search obtained 76 literatures which were related to clinical question. Afterwards filtered with eligible criteria, had resulted 21 relevant literatures. Conclusion: The choice of Caldwell-Luc approach for treating odontogenic maxillary sinusitis is a less invasive procedure and gave a satisfying result. Overlooking to identify a dental cause of maxillary sinusitis could lead to persistent symptoms, and failure of medical, as well as surgical intervention. ABSTRAKLatar belakang: Sinusitis maksilaris odontogenik adalah sinusitis maksilaris yang bersumber dari infeksi gigi. Sumber infeksi odontogenik harus dipikirkan ketika ditemukan gejala sinusitis maksila unilateral, gejala sinonasal seperti obstruksi hidung, rinorea dan bau busuk, riwayat infeksi gigi sebelumnya, trauma atau karena prosedur bedah pada tatalaksana gigi, dan pada pasien yang resisten terhadap pengobatan konvensional sinusitis. Tujuan: Melaporkan dan menganalisis hasil pendekatan Caldwell-Luc pada kasus sinusitis maksilaris odontogenik. Laporan Kasus: Satu kasus sinusitis maksilaris odontogenik dekstra yang ditatalaksana dengan pendekatan Caldwell-Luc. Setelah 2 bulan follow-up, tidak ada ingus kental dan berbau busuk yang keluar dari hidung, tidak ada keluhan nyeri di hidung, bengkak dan mati rasa pada pipi dan gusi. Pertanyaan klinis: “Apakah prosedur Caldwell-Luc memberikan hasil terbaik untuk kasus sinusitis maksilaris odontogenik?” Telaah literatur: Dilakukan pencarian melalui database Cochrane, PubMed, CinicalKey dan Google Scholar, menggunakan kata kunci “Caldwell-Luc” dan “sinusitis odontogenic”. Hasil: Diperoleh 76 literatur yang terkait dengan pertanyaan klinis. Setelah disaring dengan kriteria riset, terdapat 21 literatur yang relevan. Kesimpulan: Pemilihan tatalaksana sinusitis maksilaris odontogenik dengan pendekatan Caldwell-Luc merupakan prosedur invasif minimal, dan memberikan hasil yang memuaskan. Bila sumber infeksi dari gigi pada sinusitis maksilaris tidak terdeteksi, hal itu akan menyebabkan gejala persisten, dan kegagalan dalam tatalaksana medikamentosa maupun intervensi bedah.
Rinosinusitis Kronis dengan Polip Nasal Inflamatori Bilateral serta Elongated Unsinatus Bestari Jaka Budiman; Dolly Irfandy; Mohd Redza Qurniawan
Jurnal Kesehatan Andalas Vol 12, No 1 (2023): Online March 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2162

Abstract

Chronic rhinosinusitis (CRS) is defined as chronic inflammation of the nose and paranasal sinuses with two or more symptoms, one of which can be nasal congestion/obstruction/congestion or rhinorrhea (anterior/postnasal drip), and/or with facial pain, reduced or loss of smell. Elongated uncinate is one of the anatomical variants of the uncinate process where the uncinate process is curved or bent, which causes sinus problems and is one of the risk factors for CRS. It has been reported a 19-year-old man with the diagnosis of chronic rhinosinusitis with third-grade bilateral nasal polyp from computed tomography of the paranasal sinusitis. There was an impression of the sinonasal polyp with inverted papilloma as a differential diagnosis. The patient was treated through microdebrider-assisted functional endoscopic sinus surgery. This was chronic rhinosinusitis with grade III bilateral nasal polyps, and microdebrider-assisted fungsional endoscopic sinus surgery was performed with great results.Keywords: chronic rhinosinusitis, elongated unsinatus,  functional endoscopic sinus surgery, nasal polyp
Co-Authors Ade Asyari Al Hafiz Aswiyanti Asri Aziz Djamal Dewi Yuri Lestari Dolly Irfandy Effy Huriyati Efrida Esmaralda Nurul Amany Fachzi Fitri Hafni Bachtiar Hesty Lidya Ningsih Histawara Subroto Jacky Munilson Mohd Redza Qurniawan Nirza Warto Novialdi . Pamelia Mayorita Putri Sari Ivanny Rizanda Machmud Rossy Rosalinda Suci Riskiah Sukri Rahman Tika Hakikah Yan Edward Yolazenia Yolazenia Yunita Wulandari