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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology JFIOnline Pharmaceutical Sciences and Research (PSR) Jurnal Kefarmasian Indonesia Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Anton Bahtiar
Departemen Farmasi, FMIPA Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Journal : JFIOnline

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Pengaruh pemberian fraksi air kulit buah delima (Punica granatum L) terhadap jumlah duktus payudara tikus yang diovariektomi Sunarmi, Sunarmi; Bahtiar, Anton; Wuyung, Puspita Eka
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 2 (2016)
Publisher : Indonesian Research Gateway

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Abstract

Pomegranate (Punica granatum L.) is known to have estrogenic activity. Pomegranate peel proven to increase the number of osteoblasts and increases bone density. This study aims to determine the potential of the water fraction of the pomegranate peel as natural Selective Estrogen Receptor Modulators (SERMs) through histological mammary in ovariectomized rats. Ovariectomy method used as a model representing menopause, conducted on 42 rats female Sprague Dawley strain aged 50 days were divided into 7 groups: Sham, OVX, and a group of OVX, each getting estradiol, tamoxifen and fractions water pomegranate peel dose of 50, 100, and 200 mg/kg BW. The results obtained showed water fraction of pomegranate peel did not show any increase in volume and number of mammary ducts.
Pengaruh Pemberian Sari Kacang Hijau (Vigna radiata (L.) R. Wilczek) Terhadap Densitas Tulang dan Jumlah Osteoklas pada Tikus(Rattus norvegicus) yang Diovariektomi Yeyen, Arnita; Bahtiar, Anton; Soetanto, Sriangky
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 2 (2016)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Greenbean (Vigna radiata (L.) R. Wilczek) contained phytoestrogen suspected has a potential effect as an preventive and alternative treatment of osteoporosis. This study is proposed to determine the effect of extracts of greenbean juice (Vigna radiata (L.) R. Wilczek) on bone density by measuring calcium levels using Atomic Absorption Spectrofotometry (AAS) from femur and the number of osteoclasts collected from histological object which made from ovariectomized rat tibia. Ovariectomy method conducted to represent the osteoporosis condition on 36 female Sprague Dawley rats were divided into 7 groups. Group 1 noticed as Sham was the rat control with surgery without ovariectomy and distilled water, group 2 as negative control is given distilled water and ovariectomized rat control, group 3 as positive control was given estradiol and ovariectomized rat control, group 4 as positive control was given vitamin E and ovariectomized rat control. Group 5, 6, and 7 were given 50 g/100 ml the greenbean juice with volume variation 5 ml/200 gBW, 2.5 ml/200 gBW, and 1.25 ml /200 gBW. Six groups had ovariectomized except sham group and rested for 20 days. Greenbean juice was given orally once daily started from day 21 until day 50. Calcium concentration and osteoclast measurement process taken on day 51. The results of bone calcium levels and osteoclast number showed that greenbean juice did not give significant differences among ovariectomized rats.
Pengaruh pemberian fraksi air kulit buah delima (Punica granatum L) terhadap jumlah duktus payudara tikus yang diovariektomi Sunarmi, Sunarmi; Bahtiar, Anton; Wuyung, Puspita Eka
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (619.422 KB) | DOI: 10.35617/jfi.v8i2.512

Abstract

Pomegranate (Punica granatum L.) is known to have estrogenic activity. Pomegranate peel proven to increase the number of osteoblasts and increases bone density. This study aims to determine the potential of the water fraction of the pomegranate peel as natural Selective Estrogen Receptor Modulators (SERMs) through histological mammary in ovariectomized rats. Ovariectomy method used as a model representing menopause, conducted on 42 rats female Sprague Dawley strain aged 50 days were divided into 7 groups: Sham, OVX, and a group of OVX, each getting estradiol, tamoxifen and fractions water pomegranate peel dose of 50, 100, and 200 mg/kg BW. The results obtained showed water fraction of pomegranate peel did not show any increase in volume and number of mammary ducts.
Pengaruh Pemberian Sari Kacang Hijau (Vigna radiata (L.) R. Wilczek) Terhadap Densitas Tulang dan Jumlah Osteoklas pada Tikus(Rattus norvegicus) yang Diovariektomi Yeyen, Arnita; Bahtiar, Anton; Soetanto, Sriangky
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (506.262 KB) | DOI: 10.35617/jfi.v8i2.513

Abstract

Greenbean (Vigna radiata (L.) R. Wilczek) contained phytoestrogen suspected has a potential effect as an preventive and alternative treatment of osteoporosis. This study is proposed to determine the effect of extracts of greenbean juice (Vigna radiata (L.) R. Wilczek) on bone density by measuring calcium levels using Atomic Absorption Spectrofotometry (AAS) from femur and the number of osteoclasts collected from histological object which made from ovariectomized rat tibia. Ovariectomy method conducted to represent the osteoporosis condition on 36 female Sprague Dawley rats were divided into 7 groups. Group 1 noticed as Sham was the rat control with surgery without ovariectomy and distilled water, group 2 as negative control is given distilled water and ovariectomized rat control, group 3 as positive control was given estradiol and ovariectomized rat control, group 4 as positive control was given vitamin E and ovariectomized rat control. Group 5, 6, and 7 were given 50 g/100 ml the greenbean juice with volume variation 5 ml/200 gBW, 2.5 ml/200 gBW, and 1.25 ml /200 gBW. Six groups had ovariectomized except sham group and rested for 20 days. Greenbean juice was given orally once daily started from day 21 until day 50. Calcium concentration and osteoclast measurement process taken on day 51. The results of bone calcium levels and osteoclast number showed that greenbean juice did not give significant differences among ovariectomized rats.
Co-Authors . Azizahwati Aprilita Rina Yanti Arry Yanuar Dina Rahmawanty Effionora Anwar Fitri Nurhayati Handayani, Nur Hayati Dwi Harahap, Armansyah Maulana Herman Suryadi Ika Puspitasari Indriani, Lusi Joshita Djajadisastra, Joshita kurnia agustini Maksum Radji Melva Louisa Puspita Eka Wuyung Putri, Risani Andalusia Putri, Sartika Harka Rahmawanty, Dina Rahmi Hutabarat Retnosari Andrajati Silvia Surini Sitompul, Fransiska Soetanto, Sriangky Soetanto, Sriangky Sri Ningsih Sumali Wiryowidagdo Sunarmi Sunarmi tri wahyuni Yeyen, Arnita Yeyen, Arnita