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All Journal International Journal of Public Health Science (IJPHS) Jurnal Kesehatan Gigi Sehat Rakyat: Jurnal Kesehatan Masyarakat Promotor: Jurnal Mahasiswa Kesehatan Masyarakat
Risya Cilmiaty
Universitas Sebelas Maret
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary Other

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Stress, Nutritional Status and Blood Glucose Levels among Patients with Diabetes Mellitus Type 2 Dyah Ayu Kusuma Wardani; Sugiarto Sugiarto; Risya Cilmiaty
International Journal of Public Health Science (IJPHS) Vol 7, No 4: December 2018
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.155 KB) | DOI: 10.11591/ijphs.v7i4.14914

Abstract

Prevalence of diabetes mellitus (DM) was increased significantly. Stress increased cortisol could increase blood glucose levels while obesity could increase insulin resistance. Objective of this study was to examine correlation of stress and nutritional status with blood glucose levels in patients with DM type 2. Design study was cross sectional using 120 samples from patients with DM type 2 at Polyclinic of Internal Disease Dr. Moewardi Hospital Surakarta during April-May 2018. Variables in this study were stress with perceived stress scale 10 items (PSS-10), nutritional status with body mass index (BMI) and blood glucose levels with fasting blood glucose (FBG) and post-prandial blood glucose (PPBG) examination. The results showed that mean of FBG was 152.9±63.66 mg/dL and PPBG was 213.96±70.17 mg/dL. There was no significant correlation between stress and blood glucose levels, by FBG (p=0.389) and PPBG (p=0.202). However, there was significant correlation between nutritional status and PPBG (p=0.016), but FBG was not significant (p=0.209). In conclusion, there was significant correlation between nutritional status and PPBG in patients with DM type 2, but FBG was not significant. However, there was no significant correlation between stress and blood glucose levels in patients with DM type 2.
Keunggulan L-PRF Dibandingkan P-PRF, PRFM, A-PRF, & I-PRF sebagai Cangkok pada Operasi Miringoplasti: Studi Penyembuhan Luka pada Perforasi Membran Timpani Antonius Christanto; Risya Cilmiaty; Made Setiamika; Ratih Dewi Yudhani; Paramasari Dirgahayu
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v5i1.6020

Abstract

This study aims to analyze the advantages of Leukocyte-Platelet Rich Fibrin (L-PRF) application in myringoplasty surgery compared to other platelet concentrates such as Platelet-Rich Fibrin Membrane (PFRM), Advanced Platelet-Rich Fibrin (A-PRF), and Injectable Platelet-Rich Fibrin (I-PRF). The research method used is a qualitative literature review, collecting and analyzing data from recent scientific journals and clinical studies related to the use of L-PRF in tympanic membrane repair. The study finds that L-PRF, with its dense fibrin network and high content of leukocytes and growth factors, enhances tissue regeneration, angiogenesis, and epithelialization, which are critical for successful graft integration and faster healing after myringoplasty. Compared to other platelet concentrates, L-PRF offers better mechanical strength and a more sustained release of growth factors. Additionally, L-PRF reduces postoperative complications and improves hearing outcomes. Being an autologous biomaterial, it also reduces the risk of immune rejection. The findings suggest that L-PRF is a promising graft material in otologic surgery, though further clinical trials are needed to optimize its application protocols.
Systematic Review: Peran Sel, Jaringan, dan Kolagen dalam Penyembuhan Perforasi Membran Timpani Antonius Christanto; Risya Cilmiaty; Made Setiamika; Ratih Dewi Yudhani; Paramasari Dirgahayu
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 4 No. 4 (2025): November 2025
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v4i4.5771

Abstract

Tympanic membrane perforation is a significant clinical concern that can lead to hearing impairment and recurrent ear infections. This study aims to review the roles of Interleukin-1 beta (IL-1β), Fibroblast Growth Factor (FGF), fibroblasts, keratinocytes, granulation tissue, and collagen density during the wound-healing phases of the tympanic membrane.A Systematic Journal Review was conducted by analyzing studies retrieved from PubMed, Scopus, ScienceDirect, and Google Scholar databases published between 2020 and 2025. Of the 400 records screened,, 10 studies met the inclusion criteria. The findings revealed that IL-1β plays a key role in the inflammatory phase by modulating immune responses and recruiting healing cells. FGF stimulates fibroblast and keratinocyte proliferation, which are essential for extracellular matrix (ECM) remodeling and re-epithelialization. Moreover, granulation tissue formation and collagen deposition are critical determinants of structural integrity and healing quality. Overall, tympanic membrane repair requires synergistic interactions among molecular mediators, cellular components, and biomaterial support to optimize tissue regeneration. These findings provide a scientific basis for developing more effective regenerative and tissue-engineering strategies for middle ear therapy.
Systematic Journal Review: Mechanical Durability Of L-PRF Organic Material At Body Temperature During The Wound Healing Phase (14 Days) Of Tympanic Membrane Perforation And Myringoplasty Surgery Antonius Christanto; Risya Cilmiaty; Made Setiamika; Ratih Dewi Yudhani; Paramasari Dirgahayu; Eti Poncorini Pamungkasari; Ida Nurwati
PROMOTOR Vol. 9 No. 1 (2026): FEBRUARI
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/pro.v9i1.1741

Abstract

The purpose of this study is to evaluate the viability and structural stability of L-PRF at 37°C over 14 days. It aims to determine its sustained growth factor release and potential effectiveness in regenerative clinical applications. This research employed a Systematic Journal Review (SJR) approach, surveying articles from databases such as PubMed, Scopus, and Google Scholar using specific keywords related to L-PRF. A total of 25 articles meeting the inclusion criteria were filtered for analysis. Furthermore, common experimental methods described in the literature include the preparation of L-PRF via blood centrifugation and viability testing over 14 days at 37°C, encompassing analysis of microscopic structure, mechanical properties, and biochemical and biological activities. Literature analysis indicates that L-PRF is an effective autologous biomaterial for regenerative applications, capable of continuously releasing growth factors such as PDGF, TGF-β, VEGF, and IGF for up to 14 days at body temperature. Cell viability within the fibrin matrix is maintained, positioning L-PRF as a promising active biological scaffold for accelerating tissue healing. Although challenges such as matrix degradation persist, modification strategies and optimized centrifugation protocols can enhance the effectiveness and durability of L-PRF in clinical applications.
Gingival Index as a Marker of Oral Inflammation in Systemic Lupus Erythematosus Risya Cilmiaty; Widia Susanti; Betty Saptiwi; Adi Prayitno; Alfiyah Pujiyati; Damiana Tribhuwaneswari Mahendra Wardhani
Jurnal Kesehatan Gigi Vol. 13 No. 1 (2026): June 2026
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v13i1.14342

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with multisystem involvement that can affect periodontal tissues, leading to gingival inflammation. While global studies have employed various clinical parameters to assess this association, specific research comparing gingival inflammation between SLE patients and healthy controls in the Indonesian population remains limited. This study aimed to investigate this association by using the Gingival Index (GI) in a cohort from Surakarta, Indonesia. This comparative analytical study involved 100 participants (50 SLE patients and 50 healthy controls). SLE diagnosis was confirmed using the 2019 EULAR/ACR criteria. Gingival inflammation was assessed with the Löe and Silness Gingival Index. The Mann-Whitney U test was used to compare GI scores between groups, and Spearman's correlation was used to analyze the relationship between GI and group status, with statistical significance set at p < 0.05. The SLE group exhibited a significantly higher median GI of 0.5 (IQR: 0.0–1.0) compared to 0.1 (IQR: 0.0–0.2) in the healthy control group (p < 0.05). Spearman's correlation confirmed a moderate association between group status and GI scores (r = -0.379, p < 0.05), indicating that the SLE group had higher gingival inflammation compared to healthy controls. These findings indicate that SLE is significantly associated with increased gingival inflammation, highlighting the interplay between systemic autoimmunity and periodontal health. The Gingival Index may serve as a useful clinical marker for systemic inflammation in SLE, which underscores the need for collaborative care between rheumatologists and dental professionals. Keyword: systemic lupus erythematosus (SLE); gingival index (GI); periodontal health; gingival inflammation; autoimmune disease
Co-Authors Adi Prayitno Alfiyah Pujiyati Antonius Christanto Betty Saptiwi Damiana Tribhuwaneswari Mahendra Wardhani Dyah Ayu Kusuma Wardani Eti Poncorini Pamungkasari Ida Nurwati Made Setiamika Paramasari Dirgahayu Ratih Dewi Yudhani Sugiarto Sugiarto Widia Susanti