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All Journal International Journal of Public Health Science (IJPHS) Proceedings of KNASTIK Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Science and Technology Indonesia Communications in Science and Technology Jurnal Kebidanan JFL : Jurnal Farmasi Lampung KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Indonesia Berdaya Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sehat Indonesia (JUSINDO)
Arif Budi Setianto
Universitas Ahmad Dahlan
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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PREDIKSI TOKSISITAS, ANALISIS ADME DAN DOCKING MOLEKULER ASIATICOSIDE TERHADAP PENGHAMBATAN ANGIOTENSIN CONVERTING ENZYME: TOXICITY PREDICTION, ADME ANALYSIS AND MOLECULAR DOCKING OF ASIATICOSIDE AGAINST ANGIOTENSIN CONVERTING ENZYME INHIBITION Capritasari, Rafiastiana; Akrom, Akrom; Setianto, Arif Budi; Putri, Meilisa; Hasna, Elly Rosita; Astuti, Febriana
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2411

Abstract

The presence of risk factors related to the severity of cardiovascular disease is a key consideration in adjunct therapy as an immunostimulant.One of the plants with potential as a cardioprotective immunostimulant is pegagan.Asiaticoside in pegagan leaves can inhibit AT1R and reduce NF-κβ activity.This study aims to predict the interaction of ligands with the receptor of cardioprotective immunostimulant agents.This study uses Molecular Docking simulations with molecular docking using Autodock Tools 1.5.6 and visualization using BIOVIA Discovery Studio Visualizer 24.1.The target macromolecule used is AT1R (PDB 4ZUD) which was downloaded from the PDB.The molecular docking parameters were analyzed based on binding energy.Pharmacokinetic characteristics were evaluated using the SwissADME tool.The binding result of the test ligand molecule to AT1R is -4.50 ±0.595 kcal/mol. The reference ligand has an AT1R binding value of -7.74±0.036 kcal/mol. Validation of the molecular docking method has an RMSD value of 1.857±0.356 Å. The toxicity prediction of the compound Asiatikoside at LD50 4000mg/kg and pharmacokinetic analysis were conducted using the boiled-egg method, which indicates that  Asiatikoside is predicted cannot cross the blood-brain barrier. The ADME prediction results show that the Asiatikoside has 3 parameters that do not meet the bioavailability parameters, namely a molecular weight of 959.12g/mol, TPSA polarity of 315.21A, and flexibility of 10. Conclusion Asiaticosides is predicted to have limitations in terms of oral bioavailability, so special formulations such as nanoencapsulation techniques are needed to help improve its bioavailability Keywords:  Asiaticosides; ACE Inhibition; Molecular Docking
Formulasi dan Optimasi Variasi Basis Carbopol dan Emulgator Terhadap Karakteristik Sediaan Emulgel Husain, Dewi Putri; Kintoko; Setianto, Arif Budi
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 2 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/.v7i2.360

Abstract

Emulgel memiliki beberapa kelebihan seperti waktu kontak yang lebih lama, kosistensi yang baik, dapat melembabkan, transparan, mudah penyebaranya, mudah penyerapanya, mudah dihilangkan, dapat bercampur dengan eksipien lain dan larut dalam air. Pembuatan emulgel memerlukan emulgator agar dapat menyatukan dua fase yang berbeda, sediaan dengan emulgator campuran seringkali lebih efektif daripada emulgator tunggal. Penelitian ini bertujuan mengetahui proporsi optimum dari campuran carbopol 940 dan perbandingan konsentrasi tween80 banding span60 sehingga dapat menghasilkan sediaan yang stabil secara fisikokimia. Metode dilakukan dengan memformulasikan sediaan emulgel terlebih dahulu dan diuji fisikokimia meliputi stabilitas, viskositas, daya sebar, daya lekat, nilai pH dan homogenitas. Hasil pengujian didapatkan nilai stabilitas yang baik pada F2 nilai pH sebesar 5.1, viskositas 13.1972 Pa.s, daya sebar 6.05 cm, dan daya lekat 8.80 detik. Analisis data menggunakan One-Way ANOVA dan Kruskal Wallis Test (p<0,05). Berdasarkan nilai rata-rata uji fisikokimia dari setiap pengujian F1, F2, F3, dan F4, dapat disimpulkan bahwa formula optimal yang didapatkan yaitu F2. Hal ini dikarenakan hanya F2 yang memenuhi setiap standar fisikokimia yang telah ditetapkan.
Co-Authors Abdul Fadlil Akrom, Akrom Ari Wahyudi Astuti, Febriana Capritasari, Rafiastiana Faikah Dyah Utami Hasan, Nuradnin Hasna, Elly Rosita Husain, Dewi Putri Iis Wahyuningsih Kintoko Mohamad Reski Manno Muhammad Ma'ruf Muhammad Yusron Maulana El-Yunusi Mustofa Mustofa Nuradnin Hasan Putri Purnamasari Putri, Meilisa Rindi Ibrahim Lasanudin Sapto Yuliani Sri Mulyaningsih Sri Mulyaningsih Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Yunda Maymanah Rahmadewi