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All Journal Indonesian Journal of Tropical and Infectious Disease REKAYASA ODONTO Dental Journal Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) MDJ (Makassar Dental Journal) Indonesian Journal of Dental Medicine Indian Journal of Forensic Medicine & Toxicology Odonto dental journal
Ernie Maduratna Setiawatie
Department Of Periodontics, Faculty Of Dentistry, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Computer Science & IT Dentistry Earth & Planetary Sciences Electrical & Electronics Engineering Engineering Health Professions Medicine & Pharmacology Physics Public Health

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Number of Osteoblasts and Osteoclasts in Combination Carbonate Hydroxyapatite, Platelet Rich Fibrin (PRF) and Antioxidant in Socket Rats Wistar After Tooth Extraction Widarena, Rachma; Marlie, Hengky; Rubianto, M.; Setiawatie, Ernie Maduratna
Indonesian Journal of Dental Medicine Vol. 4 No. 1 (2021): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v4i1.2021.15-18

Abstract

Background: Bone graft materials have been used extensively to support bone healing after tooth extraction. Bone healing could be increased reactive oxygen species (ROS) that prolong the phase of the inflammatory and delay reparative phase. Antioxidants are substances that can improve and reduce the number and the damage produced by ROS. Hence, the utilization of antioxidant which is utilized in conjunction to Carbonate hydroxyapatite is expected to increase the success of bone healing. Purpose: The aim of this study is to compare the number of osteoblasts and osteoclast in the process of bone healing after employing Carbonate Hydroxyapatite and antioxidant in the Wistar rats' incisor tooth extraction socket. Methods: Twenty-seven male Rattus norvegicus strain Wistar rats were divided into 3 treatment groups. This study uses a post-test only control design. Sample of 27 rats were divided into 3 groups. Mandibular incisive is extraction. Group 1, socket is lefted to fill with blood (control). Group 2, socket is filled bonegraft and antioxidants and group III, socket is filled antioxidants, bonegraft and platelet rich fibrin (PRF). After that, the wound is sutured. On day 14, the mice are terminated then viewed in microscopy of osteoblasts. The preparation of the bone tissues was given the staining by hematoxylin-eosin and then the numbers of the osteoblasts and osteoclast were calculated. Results: Statistical testing by using one-way ANOVA has proved that there are significant differences in the number of osteoblasts in all 3 groups (p = 0.000). The highest numbers of osteoblasts were found in the group that was given Carbonate Hydroxyapatite combined with antioxidant and PRF and the lowest numbers of osteoblasts were found in the control group. Conclusion: Combination bonegraft, antioxidants and PRF could be increased the highest number of osteoblasts and could be decreased the lowest number of osteoclasts compared with control group and the group bonegraft and antioxidants.
Examining the Impact of Porphyromonas gingivalis Infection on Ovarian Health: A Reduction in Primordial Follicles in a Female Periodontitis Model Meilawaty, Zahara; Galau, Argha Sirna; Permatasari, Sabania Dinar; Setyaningsih, Sari; Astuti, Pudji; Setiawatie, Ernie Maduratna; Hendarto, Hendy; Suci Dharmayanti, Agustin Wulan
Jurnal Kesehatan Gigi Vol 12, No 1 (2025): Juni 2025
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v12i1.12547

Abstract

Periodontitis is a chronic inflammation of the periodontal tissues caused by periodontal pathogens, such as Porphyromonas gingivalis (P. gingivalis). P. gingivalis possesses several virulence factors that enable it to invade and spread through the bloodstream to other organs, including the ovaries. It triggers inflammation, which may impact the number of primordial follicles. The aim of this study was to assess the effects of P. gingivalis infection on the number of primordial follicles in the ovaries. This study was a laboratory experiment with a post-test control group design. The rats were divided into control and periodontitis groups. The periodontitis group consisted of rats induced with P. gingivalis in their sulcus gingiva of the first mandible molar every three days for 19 days. Therefore, control groups were without P. gingivalis induction. Seven days after the last induction of P. gingivalis, the rats were euthanized, and their ovarian tissues were collected for histological preparation. The primordial follicles were counted under 400x magnification. The results indicated that the treatment group had a significantly lower number of primordial follicles (2.2 ± 2.61) compared to the control group (12.4 ± 2.41). The study concludes that P. gingivalis infection led to a reduction in the number of ovarian primordial follicles in periodontitis models.
Examining the Impact of Porphyromonas gingivalis Infection on Ovarian Health: A Reduction in Primordial Follicles in a Female Periodontitis Model Meilawaty, Zahara; Galau, Argha Sirna; Permatasari, Sabania Dinar; Setyaningsih, Sari; Astuti, Pudji; Setiawatie, Ernie Maduratna; Hendarto, Hendy; Suci Dharmayanti, Agustin Wulan
Jurnal Kesehatan Gigi Vol. 12 No. 1 (2025): Juni 2025
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v12i1.12547

Abstract

Periodontitis is a chronic inflammation of the periodontal tissues caused by periodontal pathogens, such as Porphyromonas gingivalis (P. gingivalis). P. gingivalis possesses several virulence factors that enable it to invade and spread through the bloodstream to other organs, including the ovaries. It triggers inflammation, which may impact the number of primordial follicles. The aim of this study was to assess the effects of P. gingivalis infection on the number of primordial follicles in the ovaries. This study was a laboratory experiment with a post-test control group design. The rats were divided into control and periodontitis groups. The periodontitis group consisted of rats induced with P. gingivalis in their sulcus gingiva of the first mandible molar every three days for 19 days. Therefore, control groups were without P. gingivalis induction. Seven days after the last induction of P. gingivalis, the rats were euthanized, and their ovarian tissues were collected for histological preparation. The primordial follicles were counted under 400x magnification. The results indicated that the treatment group had a significantly lower number of primordial follicles (2.2 ± 2.61) compared to the control group (12.4 ± 2.41). The study concludes that P. gingivalis infection led to a reduction in the number of ovarian primordial follicles in periodontitis models.
Analysis of antioxidant and antibacterial activity of cocoa pod husk extract (Theobroma cacao L.) Rahayu, Yani Corvianindya; Setiawatie, Ernie Maduratna; Rahayu, Retno Pudji; Ramadan, Doaa Elsayed
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 4 (2023): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i4.p220-225

Abstract

Background: Theobroma cacao bean manufacturing worldwide includes undesired byproducts such as cocoa pod husks. Cocoa pods contain a variety of beneficial chemicals, including polyphenols. Polyphenols have a vital function in the treatment of many illnesses and infections of the oral cavity. This is due to their vital qualities in the oral cavity, including anti-inflammatory, antibacterial, and antioxidant actions. Purpose: The goal of this study was to look at the antioxidant content and antibacterial activity of cocoa pod husk extract (Theobroma cacao L.) against Phorphyromonas gingivalis (P. gingivalis) and Streptococcus mutans (S. mutans). Methods: Cocoa pod husk extract was produced using an ultrasonic homogenizer and 70% ethanol. Thin layer chromatography and the Folin–Ciocalteu test were used to determine the phytochemical content and total phenolic content of the extract. The 2,2-diphenyl-1-picryl-hydrazyl-hydrate technique was used to measure antioxidant activity. Minimum inhibitory concentration (MIC) tests were used to measure the antibacterial activity of ethanolic extract at concentrations of 1, 4, 8, 16, 32, and 64 mg/ml using a deep-well broth microdilution technique. Results: The presence of alkaloids, flavonoids, tannins, saponins, and triterpenoids was discovered in the cocoa pod husk extract. Conclusion: The antioxidant activity of the extract was significant (IC50 = 62 ppm), and the MIC of P. gingivalis and S. mutans was 16 mg/ml and 8 mg/ml, respectively.
Co-Authors Agustin Wulan Suci Dharmayanti Bambang Hadi Sugito Desi Sandrasari Eprilina, Alifiani Galau, Argha Sirna Hadinoto, Maria Elisea Kiswantoro Hendy Hendarto Lambang Bargowo Lusi Zafriana Marlie, Hengky Masya, Resgita Nadila Mohamad Rubianto Muhammad Naufal Ilmi Roswand Noer Ulfah Permatasari, Sabania Dinar Prihartini Widiyanti PUDJI ASTUTI Ramadan, Doaa Elsayed Retno Pudji Rahayu Retno puji Rahayu Rihandhita Shinta Meiliana Rikko Hudyono Rosa Pratiwi, Rosa Rubianto, M. Sari Setyaningsih Savitri, Irma Yosephina Setyaningsih, Sari Wahyudadi, Badai Septa Westy Agrawanty Widarena, Rachma Yani Corvianindya Rahayu Zahara Meilawaty