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All Journal Jurnal Kedokteran Brawijaya Medical Journal of Indonesia Indonesian Journal of Urology Jurnal EECCIS MNJ (Malang Neurology Journal) Molecular and Cellular Biomedical Sciences (MCBS) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Brawijaya Journal of Urology
Taufiq Nur Budaya
Department Of Urology, Faculty Of Medicine Universitas Brawijaya, Saiful Anwar General Hospital
Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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PROGNOSTIC FACTORS FOR ORCHIDECTOMY IN TESTICULAR TORSION PATIENTS AT TERTIARY HOSPITAL Budaya, Taufiq Nur; Daryanto, Besut; Mahandita, I Made
Indonesian Journal of Urology Vol 31 No 3 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i3.993

Abstract

Objective: This study was conducted to analyze the prognostic factors for orchidectomy in testicular torsion patients. Material & Methods: From January 2001 to December 2021, 100 cases of testicular torsion cases were retrospectively collected. Data were described and analyzed based on clinical factors (age, duration of symptoms, scrotal swelling, high-riding testis, Prehn test, cremasteric reflex, leukocytosis, degree of twisting) and non-clinical factors (distance from hospital, duration of travel to hospital, education level and employment status) for each surgical procedure. Then logistic regression analysis was performed. Results: There were 88 testicular torsion patients (88%) underwent orchidectomy and 12 patients (12%) underwent orchidopexy. There was no significant relationship between age, duration of symptoms, scrotal swelling, Prehn test, cremasteric reflex, leukocytosis, distance from hospital, duration of travel to hospital, education level and employment status with orchidectomy (p>0.05). Significant prognostic factors for orchidectomy in testicular torsion patients were high-riding testis (OR = 0.06; 95% CI = 0.01-0.37; p = 0.002) and degree of twisting (OR = 0.04; 95% CI = 0.006-0.24; p = 0.000). Conclusion: High-riding testis and degree of twisting are prognostic factors for orchidectomy in testicular torsion patients. Keywords: Orchidectomy, prognostic factors, testicular torsion.
The Association Between Urinary Tract Stones and The Incidence of Urinary Tract Infections Budaya, Taufiq Nur; Rohman, Mohammad Saifur; Ardhino, Ardhino; Dhani, Fauzan Kurniawan
Brawijaya Journal of Urology Vol. 5 No. 01 (2024): Brawijaya Journal of Urology
Publisher : Department of Urology, Faculty of Medicine, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/bjurology.2024.005.01.1

Abstract

Introduction. This research was conducted to investigate the association between urinary tract stones and the occurrence of urinary tract infections in patients receiving treatment at Saiful Anwar General Hospital in Malang.Methods. This research constitutes an analytical observational study employing a case-control research design conducted at Saiful Anwar General Hospital in Malang from 2015 to 2020.Results. This study comprised a sample size of 104 patients. In the group of patients with urinary tract stones, the highest occurrence was among men (77.3%), particularly those aged between 30-60 years (59.1%). In the group of patients with UTIs, males had the highest prevalence (67.3%), with a significant portion at the age of 50 (55.8%). The Chi-Square analysis investigating the association between urinary tract stones and the presence of urinary tract infections resulted in a p-value of 0.008, accompanied by an Odd Ratio of 4.566.Conclusions. A notable association has been identified between urinary tract stones and the presence of urinary tract infections.
Hubungan Antara Volume Prostat dan Risiko Chronic Kidney Disease (CKD) pada Pasien Benign Prostate Hyperplasia (BPH) Pasca Transurethral Resection of the Prostate (TURP): Sebuah Studi Observasional Daryanto, Besut; Afifah, Maghfirah Nur; Budaya, Taufiq Nur
Majalah Kedokteran Indonesia Vol 74 No 3 (2024): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.74.3-2024-1420

Abstract

Introduction: Benign Prostate Hyperplasia (BPH) is an enlarged prostate gland that causes problems in micturition and results in disruption of urine flow. Factors that cause prostate enlargement from a combination of chronic and progressive urine retention, high bladder pressure and ureterohydronephrosis can cause progressive kidney injury. The obstructive process changes the cells and physiological conditions in the bladder muscle and collagen contributes to increasing bladder pressure and the inability to empty the bladder and ends up causing kidney failure. This study was to determine the prevalence of chronic kidney disease (CKD) in BPH patients undergoing transurethral resection of the prostate (TURP) surgery.Method: Using non-probability sampling method with consecutive sampling technique. Data were analyzed by univariate analysis using data frequency tables and bivariate analysis using the chi-square test.Result: Of the total 178 BPH patients, 15 of them suffered from CKD (8.4%). BPH prevalence was highest in the age category 61-70 (39.3%), the majority had prostate volume greater than 50 ml (59%), the most common symptoms were severe lower urinary tract symptoms (LUTS) (83.1%) and urine retention (74.7%), some of them were accompanied by comorbidities such as hypertension (33.7%). The most common indication for surgery in patients who underwent TURP was recurrent retention (79.2%). The chi-square test showed an association between BPH and the incidence of CKD.Conclusion: The prevalence of CKD at all stages in BPH patients who underwent TURP surgery was 8.4%. The most influential factors for the occurrence of CKD in BPH patients are prostate volume 30-40 ml, prostate volume 41-50 ml, and men aged 71-80 years.
The Early Detection Tool for Bladder Cancer Based on Quantum Dots Fluorescence Integrated with Fuzzy Logic Classification Application Programming Interface Ekiawan, Krisna Seiya; Tan, Evan Manuel; Faustin, Levina Nasywa; Ahmad, Verousson; Suroso, Ajeng Lintang Kinasih; Budaya, Taufiq Nur; Nurussa’adah, Nurussa’adah
Jurnal EECCIS (Electrics, Electronics, Communications, Controls, Informatics, Systems) Vol. 19 No. 1 (2025)
Publisher : Faculty of Engineering, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/jeeccis.v19i1.1727

Abstract

Cancer is a disease caused by genetic changes that cause abnormal and uncontrolled cell growth. One of the cancers with an enormous growth in the number of cases is bladder cancer, with the number of new cases in 2020 amounting to 573,000 cases in the world. This number is supported by inadequate early detection modalities that cannot reach the wider community. The Detection On The Spot Bladder Cancer (DOTS Bca) innovation aims to reduce the prevalence of bladder cancer and becomes an affordable early bladder cancer detection tool that can be used repeatedly and has high sensitivity. DOTS BCa detects the 47 kiloDalton epitope protein biomarker in the patient's urine. This tool uses Carbon Quantum Dots (CDs) as a semiconductor material, which will be analyzed for the level of fluorescence when it binds to a 47 kiloDalton epitope. The innovation design method includes literature study, design, tool making and testing. The early detection system test was carried out by comparing the CDs fluorescence results with the bladder cancer diagnostic test and obtained an accuracy of 85% with sensitivity 90% and specificity 80%. This tool is analyzed using fluorescence resonance energy transfer, integrated application programming interface, and fuzzy logic classification, which can work non-invasively.
SARM Rad140 Increases Osteoblasts, Muscle Fiber Size, Myonuclei, and Reduces Osteoclasts in Orchidectomized Wistar Rats Budaya, Taufiq Nur; Daryanto, Besut; Seputra, Kurnia Penta; Fabrianta, Dio Mafazi; Ekaputra, Aditya Airlangga; Dewi, RA Rose Khasana; Anita, Kenty Wantri; Dhani, Fauzan Kurniawan; Rofifa, Amira Fithri
Molecular and Cellular Biomedical Sciences Vol 9, No 1 (2025)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v9i1.536

Abstract

Background: Orchidectomy is a surgical androgen deprivation therapy (ADT) for prostate cancer patients to achieve castrate testosterone levels. Selective androgen receptor modulators (SARMs) are used to mitigate the adverse effects of ADT, including elevated risk of osteoporosis, and reduced skeletal muscle mass. Rad140 is a novel SARMs that has high affinity for the androgen receptors. This study was conducted to determine the effects of SARM Rad140 on the number of osteoblasts, osteoclasts, muscle fiber cross-sectional area (CSA), muscle size, and number of myonuclei in rats underwent orchidectomy.Materials and Methods: An experimental study was conducted using a randomized post-test only control group design. Following orchidectomy, SARM Rad140 was administered orally for six weeks at various doses. Osteoblasts, osteoclasts, muscle fiber CSA, muscle size, and number of myonuclei were measured. Quantitative analysis was performed using one-way ANOVA.Results: There were significant differences in the effects of SARM Rad140 at different doses on osteoblast and osteoclast cells. At higher doses, the osteoblast cell counts in rats tended to increase, while the osteoclast counts tended to decline. The treatment group also showed significant results in the CSA of the gastrocnemius muscle fibers, as well as in the number of myonuclei of the gastrocnemius muscle.Conclusion: SARM Rad140 significantly increased the number of osteoblasts, muscle fiber CSA, and gastrocnemius muscle myonuclei, while decreasing osteoclasts. SARM Rad140 is a promising therapy for osteoporosis and muscle weakening due to ADT.Keywords: SARM Rad140, orchidectomy, osteoblasts, osteoclasts, muscle fiber cross sectional area, myonuclei
A COMPLETE DUPLICATED SYSTEM WITH INTRAVESICAL URETEROCELE IN A 60-YEARS-OLD WOMAN: A CASE REPORT Hady Prabowo, Satria Adji; Budaya, Taufiq Nur; Kustono, Andri
Indonesian Journal of Urology Vol 32 No 2 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i2.942

Abstract

Objective: This case report presents a 60-year-old woman with intravesical ureterocele complicated by severe right upper-moiety hydronephrosis. Case(s) Presentation: A 60-year-old woman came with the chief complaint of right flank pain radiating to the umbilicus and groin accompanied by nausea, vomiting and decreased appetite. Ultrasound examination showed severe hydronephrosis of the right kidney. Abdominal CT revealed a double collecting system with severe hydroureteronephrosis at the upper pelvicalyceal system and the presence of an intravesical ureterocele. Cystoscopy and right RPG of upper and lower moiety procedures were performed and showed right severe hydroureteronephrosis with stenosis of right upper moiety ureteral orifice and ureterocele, followed by uroterocele incision and upper moiety ureteral re-implantation. No further complaints or complications were found after discharge from the hospital. Discussion: Adult ureterocele is a rare congenital anomaly often detected incidentally or due to complications like obstruction and infection. Diagnosis relies on imaging modalities such as ultrasonography, intravenous urography, and CT urography, while treatment options range from minimally invasive endoscopic decompression to surgical excision, depending on severity and associated complications. Conclusion: Ureterocele is a rare congenital urological abnormality found in non-Caucasians. Due to the rarity of the case, a thorough examination is required to establish this dia\gnosis and the choice of the appropriate treatment procedure. The managements include incision of ureterocele and ureteroneocystostomy. Keywords: Adult ureterocele, intravesical ureterocele, hydronephrosis, complete double collecting system, vesicoureteral reflux
Incidence of urethral stricture in patients with urethral trauma: a 10-year experience in an Indonesian tertiary hospital Satyagraha, Paksi; Lazuardi, Muhammad Adi Satrio; Budaya, Taufiq Nur
Medical Journal of Indonesia Vol. 33 No. 1 (2024): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247152

Abstract

BACKGROUND Urethral injuries are rarely life-threatening but can cause significant morbidity if left untreated. Until now, data on urethral trauma incidence are still limited in Indonesia. This study aimed to report the incidence of traumatic urethral stricture within 10 years of experience in treating urethral trauma. METHODS This retrospective study used a total sampling method for all patients with urethral trauma who came to the emergency department and agreed to undergo radiological evaluation. Patient data were collected from January 2012 to December 2021. All patients were followed up for 3 months after trauma, and the incidence of urethral stricture was analyzed using the chi-square or Fisher's exact tests as an alternative. RESULTS The overall incidence of urethral stricture was 48.4%. Of 122 patients, 82.0% had anterior urethral trauma. Grade III American Association for the Surgery of Trauma (43.4%) was the most common urethral trauma. The cause of urethral trauma was iatrogenic, pelvic fracture urethral injury (PFUI), straddle injury, and penile fracture, contributing in 64.8%, 18.0%, 16.4%, and 0.8% of the cases, respectively. Most patients (70.5%) underwent a cystostomy catheterization procedure as initial treatment. Straddle injury, PFUI, and a higher degree of urethral trauma were significantly associated with urethral stricture formation (p<0.05). CONCLUSIONS Straddle injury, PFUI, and a higher degree of urethral trauma were significantly related to a higher incidence of urethral stricture. Most low-grade and anterior urethral traumas can resolve spontaneously.
Effect of selective androgen receptor modulator RAD140 on prostate and testosterone levels in Wistar strain rats with bilateral orchidectomy Budaya, Taufiq Nur; Nurhadi, Pradana; Anita, Kenty Wantri; Nugroho, Prasetyo; Dhani, Fauzan Kurniawan
Medical Journal of Indonesia Vol. 33 No. 2 (2024): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247289

Abstract

BACKGROUND Selective androgen receptor modulators (SARMs) have been investigated as a potential treatment for hypogonadism, a condition characterized by low testosterone levels in men. The idea is to provide therapeutic benefits similar to traditional testosterone replacement therapy. However, research in this area is still in its early stages, and more extensive studies are needed to establish the efficacy of SARM. This study aimed to determine the impact of SARM RAD140 on testosterone levels, fibromuscular stroma, and prostate mass in rats undergoing bilateral orchidectomy. METHODS This was an in vivo study using posttest-only control group design in rats (Rattus norvegicus). The positive and negative control groups consisted of rats with and without bilateral orchidectomy, respectively. The treatment groups were rats given SARM RAD140 with and without orchidectomy. Testosterone levels, histopathology, and prostate mass were examined at the end of week 6, and the quantitative data were analyzed using one-way ANOVA. RESULTS This study found no difference in prostate mass (0.598 [0.05] g versus 0.590 [0.07] g, p = 0.984), fibromuscular stroma ratio (0.483 [0.094] versus 0.463 [0.057], p = 0.984), and testosterone level (0.006 [0.005] ng/dl versus 0.014 [0.004] ng/dl, p = 0.098) compared to positive control with orchidectomy and SARM RAD140 administration 6 weeks after treatment. CONCLUSIONS There were no differences in testosterone levels, prostate mass, or the ratio of fibromuscular stroma to epithelium area in rats undergoing bilateral orchidectomy and placebo surgery with the administration of SARM RAD140.
Co-Authors Afifah, Maghfirah Nur Ahmad, Verousson Ardhino, Ardhino Ardian Rizal Athaya Febriantyo Purnomo Basuki B. Purnomo Dewi, Rose Khasana Dhani, Fauzan Kurniawan Ekaputra, Aditya Airlangga Ekiawan, Krisna Seiya Fabrianta, Dio Mafazi Faustin, Levina Nasywa Fauzan Kurniawan Dhani Hady Prabowo, Satria Adji Hafizh Ananda Wibowo Kenty Wantri Anita, Kenty Wantri Kurnia Penta Seputra Kurnia Penta Seputra Kustono, Andri Lazuardi, Muhammad Adi Satrio Mahandita, I Made Mangkubumi Putra Wijaya Meiyanto, Johanes Dwi Mohammad Saifur Rohman Muhammad Baihaqy Ibnu Hakim Nadia Artha Dewi Nurhadi, Pradana Nurussa’adah, Nurussa’adah Nyoman Gede Prayudi Paksi Satyagraha Prasetyo Nugroho Rofifa, Amira Fithri Seskoati Prayitnaningsih Suroso, Ajeng Lintang Kinasih Tan, Evan Manuel Utama, Yohanes Dona Christi Zen Ary Prasetyo Zen Ary Prasetyo