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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Damianus Journal of Medicine Indonesian Journal of Tropical and Infectious Disease Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of General Procedural Dermatology and Venereology Indonesia Cermin Dunia Kedokteran
Alius Cahyadi
Faculty Of Medicine UNIKA Atma Jaya/Atma Jaya Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Drug-induced hypersensitivity syndrome with liver injury due to phenytoin: A case report Wijaya, Lorettha; Adevita, Stella; Alvianto, Steven; Christiani, Yoseveline; Cahyadi, Alius; Yolanda, Raesa
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Drug-induced hypersensitivity syndrome (DIHS) is a rare and severe systemic drug reaction characterized by skin involvement, internal organ complications, and hematologic disorders. Management of this condition is challenging due to its wide range of cutaneous manifestations and 10% mortality rate. Case Illustration: A 52-year-old male presented with widespread redness throughout his body with a prior history of regular phenytoin consumption. The rash continued to spread despite the patient’s abrupt discontinuation of the suspected medication. He was diagnosed with atypical DIHS according to J-SCAR criteria and was given high-dose corticosteroid. Drastic clinical improvement was observed after nine days of therapy, and complete resolution of the rash was achieved after 14 days. The steroid was stopped after four weeks, and no relapse was observed after four months of follow-up. Discussion: Discontinuing the suspected medication is the first crucial step in DIHS management. No specific pharmaceutical strategy has been established for this syndrome; however, systemic corticosteroids have been frequently prescribed as a first-line therapy. Steroids need to be tapered off slowly over 6–8 weeks, even upon clinical resolution, to prevent relapse. In the current case, the steroid was tapered off slowly over four weeks. The lack of relapse observed after steroid discontinuation could be due to the fact that the patient stopped consuming the suspected medication immediately. Conclusion: Education on the consequences of prescribing high-risk medications is important. Early detection and prompt cessation of offending medications are needed for better DIHS outcomes.
Effect of Asana Pranayama Yoga on Sleep Quality: Implications for Stress Management and Healthy Lifestyle in Young Adults Adella, Abigail Sherolyn; Lilis, Lilis; Sudiyono, Nelson; Cahyadi, Alius; Gracia, Isadora
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.3799

Abstract

Background: Sleep is a fundamental human need. Young adults, such as medical students, are particularly vulnerable to poor sleep quality due to the academic pressures.  Yoga has a relaxing effect that may help improve sleep quality. This study aimed to evaluate the effects of Asana Pranayama yoga on sleep quality among female medical students.Methods: This quasi-experimental and case-control study was conducted in September 2023, including preclinical female medical students from the Atma Jaya Catholic University of Indonesia. Sleep quality was assessed using the Indonesian version of the Pittsburgh Sleep Quality Index (PSQI-I). The intervention group (n=24) had performed yoga Asana Pranayama six times per week for four weeks, with each session lasting 45 minutes, whereasthe control group had received no intervention. Data were analyzed using the Wilcoxon signed-rank test to compare pre- and post-intervention PSQI scores, and Spearman’s correlation to examine the relationship between yoga frequency and PSQI scores (p<0.05).Results: The intervention group showed a significant improvement in sleep quality (p=0.002). A significant negative correlation was found between yoga practice frequency and post-test PSQI scores (r=-0.607), indicating that higher consistency in yoga practice was associated with better sleep quality.Conclusion: Regular practice of asana pranayama yoga can improve sleep quality among female medical students. Incorporating yoga into daily routines may serve as a practical, non-pharmacological approach to promote wellness in young adults.
Menjelajahi Efektivitas Minyak Zaitun dalam Mencegah Luka Tekanan: Sebuah Ulasan Sistematis: Tinjauan Sistematik Wijaya, Lorettha; Isabella, Maria Victoria; Yolanda, Rennie; Soeselo, Daniel Ardian; -, William; Cahyadi, Alius
Cermin Dunia Kedokteran Vol 53 No 02 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i02.1755

Abstract

Introduction: Pressure ulcers frequently occur in bedridden patients as a result of immobility and friction, causing delays in recovery and leading to complications. Natural skin care, including olive oil, have shown promising results in preventing ulcers. This paper aims to assessthe efficacy of olive oil in reducing the risk factors associated with pressure ulcers and preventing their occurrence in bedridden patients. Methods: A systematic review using PRISMA guidelines, examining studies from 2012 to 2025. All studies measuring the effect of oliveoil in preventing pressure ulcers in bedridden patients and calculating the risk using the Braden Scale Score were included. The RoB 2 and ROBINS-I quality assessment tools assessed the risk of bias. Results: Ten studies with a low risk of bias, comprising 662 participants, were included. Nine studies showed a preventive effect of pressure ulcers, while one study showed that pressure ulcers were still developing despite olive oil application. Conclusion: Olive oil is beneficial in reducing pressure ulcer risk factors and preventing pressure ulcers in bedridden patients.
Co-Authors -, William Adella, Abigail Sherolyn Adevita, Stella Adisuhanto, Marcella Alvianto, Steven Angelina Yuwono Astri Parawita Ayu Christiani, Yoseveline Daniel Ardian Soeselo Hadiyanto, Jessica Novia Isabella, Maria Victoria Isadora Gracia, Isadora Jessica Novia Jessica Novia Hadiyanto Karina Anindita Lilis, Lilis Lorettha Wijaya Loviana, Bernadetta Belvania Margareth Gracia Maria R. Iryaningrum Maria Riastuti Iryaningrum Mario Steffanus Nicholas Adrianto Patricia Michelle Lukito Raesa Yolanda, Raesa Rensa Subagio, Stephanie Widodo Sudiyono, Nelson Wilda, Friska Yolanda, Rennie Yuwono, Angelina