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All Journal Majalah Obat Tradisional Pharmascience Jurnal Fitofarmaka Indonesia Jurnal Jamu Indonesia Majalah Farmasetika Jurnal Pengabdian Kepada Masyarakat (Mediteg) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Nusantara Berbakti Borneo Journal of Pharmacy
Sutomo Sutomo
Universitas Lambung Mangkurat
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Jurnal Fitofarmaka Indonesia

 1 
AKTIVITAS PENGHAMBATAN POLIMERISASI HEM DARI FRAKSI ETIL ASETAT DAUN MANURAN, Coptosapelta tomentosa Valeton ex K.Heyne (Rubiaceae) Arnida Arnida; Sutomo Sutomo; Lia Rosyidah
Jurnal Fitofarmaka Indonesia Vol 6, No 1 (2019): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (118.338 KB) | DOI: 10.33096/jffi.v6i1.459

Abstract

Malaria is a serious disease caused by Plasmodium parasites and is transmitted by the salivary glands of female Anopheles mosquito. The manuran (Coptosapelta tomentosa Valeton ex K.Heyne) is empirically used as a malarial treatment. The study aimed to determine the IC50 value of ethyl acetate fraction and the coumpounds contained on the C. tomentosa Valeton ex K. Heyne leaf ethyl acetat fraction. The identification of chemical composition used tube test method. The inhibitory activity of heme polymerization in vitro did by Basillico modified method. The identification of chemical contents on the ethyl acetate fraction of C. tomentosa leaf Valeton ex K. Heyne showed positive results containing flavonoid, tannin, saponin, terpenoid, and anthraquinone. The average percentage heme polymerization inhibition of C. tomentosa valeton ex K. Heyne leaf ethyl acetate fraction respectively from large to small concentrations of 97.94; 96.94; 95.01; 91.63; 86.19; 76.12; and 44.83 %. Result of probit analysis, that it has HPIA IC50 value of 0.252±0.009 mg/mL and chloroquine diphosphate was 0.214±0.012 mg/mL. The independent sample T-test showed that there was significant difference between IC50 value of them. The ethyl acetate fraction of C. tomentosa leaf Valeton ex K. Heyne has heme polymerization inhibition activity.
ISOLASI SENYAWA KIMIA FRAKSI n-HEKSANA DAUN BILARAN TAPAH (Argyreia nervosa (Burm. F.) ASAL KALIMANTAN SELATAN Sutomo Sutomo; Putri Helena Junjung Buih; Arnida Arnida
Jurnal Fitofarmaka Indonesia Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i2.527

Abstract

ABSTRACTOne of the plants that is used empirically by people in South Kalimantan as a traditional medicine is bilaran tapah (Argyreia nervosa (Burm. F.). This plants that has purposed antiinflamation, antimicroba, antidiabetic, diuretic, and aphrodisiac. This research aims to isolate and explore the chemical compounds of n-hexana fraction of A. nervosa leaves. Extraction is conducted by using maceration method. Isolation is conducted by using Vacumn Liquid Chromatography and gravity chromatography column. Identification qualitative assay of compound used TLC test, UV-Vis and FTIR spectrophotometry. The extraction of 500 grams A. nervosa leaves rough powder with 96% ethanol extracts produces 16,92% of rendement. The fractionation of 30 grams ethanol extracts with n-hexane produces 23,60% of rendement. N-hexane fraction by using VLC with n-hexane : ethyl acetate eluent 25:1; 20:1; 15:1; 10:1; 9:1; 8:2; 7:3 ; 6:4) v/v and methanol : etyl acetate (1:4) v/v produces fractions A, B, C, D, E, F, G, H, and I. Fraction F was chosen for isolation using PTLC with n-hexane :etyl acetate eluent (8:2) v/v. Fraction C is chosen to be isolated by using gravity chromatography column with n-hexane : ethyl acetate eluent (25:1) v/v. TLC qualitative test with H2SO4 10% and Liebermann-Burchard reagent shows that C-4 isolates contains terpenoid compounds. Analysis of C-4 isolates by using UV-Vis spectrophotometry reach peak at λ 245 nm. Analysis FTIR spectra shows that the functional groups of C-4 isolates are -OH (3309.85 cm-1), -CH aliphatic (2939.52 cm -1 and 2870.08 cm-1), C = C (1635.64 cm- 1) and C-O (1033,85 cm-1).
Co-Authors Agung Nugroho Agung Sriyono Al Madani Amalia Khairunnisa Amida Amida Arnida Arnida Arnida Arnida Aulea Rahmawati Buih, Putri Helena Junjung Dina Noor Kamali Eka Rahmawaty Sahi Evi Mintowati Fadilaturrahmah Fadilaturrahmah Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah Fadlillahturrahmah Fahriah Fahriah Faisal Faisal Hadi Azhari Herwina Dita Lestari Lia Rosyidah Liling Triyasmono Maulidia Maulidia Mia Fitriana Muhammad Ikhwan Rizki Muhammad Rafi Nadya Agustina Najat Su'aida Nanang Fakhrudin, Nanang Nani Kartinah Nhaya Riskita Normaidah, Normaidah Nurlely, Nurlely Nurmalita Sari Peni Susilowati Putri Prima Happy Ratnapuri Rahmat Yunus Salamiah Salamiah Siti Humairah Z.A Subagus Wahyuono Utsna Uhdatul Khoriah Viogenta, Pratika Vita Vitriana Awaliyah