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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Agromedicine and Medical Sciences Global Medical and Health Communication Jurnal Kimia Mulawarman Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Molekul: Jurnal Ilmiah Kimia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Teknik Kimia Jurnal Ners Jurnal Abdi Insani Sriwijaya Journal of Ophthalmology Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis Proceedings National Conference Sisi Indonesia Global Medical and Health Communication
Fatmawati
Bagian Biokimia Dan Kimia Medik, Fakultas Kedokteran, Universitas Sriwijaya, Palembang, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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The Efficacy of Seluang Fish Oil (Rasbora agrotynea) Related Body Weight, Lipid Profile, Adiponectin and Leptin in Wistar Rats-Induced High Fat Diet Fatmawati Karim; Rachmat Hidayat; Erizka Rivani; Husnul Khotimah; Ester G Pansserga
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 2 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i2.41

Abstract

Background Rasbora agrotynea (local name : Seluang ) is a fish native to Sumatera, Malaya and Borneo. This fish has a potential as a local wisdom for supplementation of omega 3 and omega 6. In Sumatera, Seluang fish was used as traditional food. Aim of Study Aim of this study to explore the efficacy of seluang fish oil in body weight, lipid profile, adiponectin and leptin level in Wistar Rats-Induced High Fat Diet Methods This study was an experimental study , pre-post test with control group design. The sample in this study was 30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and seluang fish oil at dose of 0,1 , 0,2 and 0,4 mL/200 gr BW/day for 2 weeks. Seluang fish oil was extracted by distilation methods. The results of this study were assayed by SPSS 18. Results Seluang fish oil 0,4 mL/200 gr BW was more potent to reduce body weight gain, triglyseride level, leptin and increase adiponectin level than seluang fish oil 0,1 mL/200 gr BW, 0,2 mL/200 gr BW, negative control and positive control. Conclusion Seluang fish oil had a potention to reduce body weight, triglyceride, leptin and increase adiponectin level. Keywords: Seluang fish Oil – body weight- triglyserida – leptin - adiponectin
The Efficacy of Combination Extract Andrographis peniculata and Syzygium polyanthum on Glucose Uptake in Skletal Muscle in Diabetic Rats Fatmawati Karim; Ester Gonzales Panserga; Mgs Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.63

Abstract

Insulin resistance is impaired insulin signaling cascade in target cells to respond normal or elevated circulating insulin to the final cellular effect, such as translocation of vesicles containing GLUT4 glucose transporters, which is the major mediator of glucose removal from the circulation and a key regulator of whole-body glucose homeostasis. Among the several plants, Andrographis peniculata (sambiloto) and Syzygium polyanthum (Daun salam). In the present study, a combination was made, Andrographis peniculata (sambiloto) and Syzygium polyanthum (Daun salam), and to determine the effects of combination on tretament insulin resistance. Male Wistar rats (weight, 200-300 g) were randomized into five groups (6 rats/group). Group 1: negative group. Group 2: positive group (metformin 63 mg/kgBW ). Group 3,4 and 5: treatment with extract combination, each group 250 mg/kgBW, 500 mg/kgBW and 1000 mg/kgBW. Rats were induced by high fat diet-glucocorticoid for insulin resistance. Insulin and GLUT-4 were assayed by ELISA. Treatment with extract combination (250, 500 and 1000 mg/kgBW) and metformin for 2 weeks showed a sigificant decrease in fasting plasma insulin compare with the negative control rats with a reduction of 11,2%, 33,6%, 20% and 19,4%, respectively. Two weeks treatment either extract combination or metformin in diabetic rats, significantly increased GLUT 4 level (p<0,05) with a percentage increase of 6,68%, 15,21%, 12,76% and 1,77%.
Antibacterial Efficacy of Aloe vera Sap Against Staphylococcus aureus and Escherichia coli Safira Azahra; Nita Parisa; Fatmawati Fatmawati; Ella Amalia; Venny Larasati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 2 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i2.87

Abstract

Abstract Background Aloe vera is a plant that has been used as an alternative drug. This plant contains various compounds, like anthraquinone, saponin, flavonoid, alkaloid, and tannin that has an antibacterial effect against Staphylococcus aureus and Escherichia coli. Both of it were responsible for the infection incident. This study aims to determine the efficacy of Aloe vera sap as an antibacterial against Staphylococcus aureus and Escherichia coli. Methods An experimental study, in vitro using post-test only control group design, has been done at laboratory of Medical Faculty of Sriwijaya University, by examining the antibacterial activity of Aloe vera sap in five different concentration (5%, 10%, 20%, 40%, dan 80%) using well diffusion and solid dillusion method to determine the minimum bactericidal concentration (MBC). And then continued with the phytocemical screening to determine the compound inside the Aloe vera sap. Results Aloe vera sap were able to kill Staphylococcus aureus at 5% and Eshcerichia coli at 80%. Compatibility test showed that Aloe vera sap with concentration of 10%, 20%, 40%, and 80% are compatible with amoxicillin, therefore 80% is compatible with cefotaxime. This ability due to the compound that it contains, which is alkaloid, flavonoid, tannin, quinone, and saponin. Conclusion Aloe vera sap is effective as an antibacterial against Staphylococcus aureus and Escherichia coli. Keyword: Aloe vera sap, antibacterial, efficacy, Staphylococcus aureus, Escherichia coli.
Correlation between the Use of Shared Goods with Pediculosis Capitis among Students in Pondok Pesantren Subulussalam Palembang Rifka Purnama Sari; Dwi Handayani; Gita Dwi Prasasty; Chairil Anwar; Fatmawati Karim
Journal of Agromedicine and Medical Sciences Vol 8 No 2 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i2.29113

Abstract

Pediculosis capitis is a parasitic infection caused by the parasite Pediculus humanus var. capitis, which commonly found in densely crowded areas such as boarding schools. It is possible to contract pediculosis capitis by coming into direct or indirect contact with sufferers' hair. The goal of this study was to assess the prevalence of pediculosis capitis in students at Pondok Pesantren Subulussalam Palembang, as well as the association between the use of shared goods and the occurrence of pediculosis capitis. This study is a cross-sectional observational analytic study including 116 students who live permanently in Pondok Pesantren Subulussalam Palembang. A questionnaire was used to collect data, as well as direct observation of hair samples. The Chi-Square test, Fisher's exact test, and logistic regression were used to examine the results. The findings revealed that 35.3% of people had pediculosis capitis, and that there was a significant association between the use of mattresses (p=0.007), combs (p=0.024), and shared veils (p=0.006) and the occurrence of pediculosis capitis. The use of combs (p=0.018) and shared veils (p=0.001) were the most influential variables on the occurrence of pediculosis capitis, according to the results of the logistic regression test. The spread of pediculosis capitis disease is predicted to be reduced and prevented with improved personal hygiene, environment sanitation, and treatment. Keywords: Pediculosis capitis, boarding schools, Subulussalam, shared goods
Sungkai Leaf Potential as Herbal Medicine Sadakata Sinulingga; Fatmawati Fatmawati; Subandrate Subandrate; Irfannudin Irfannudin; Susilawati Susilawati; Rini Yana
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (291.582 KB)

Abstract

Indonesia is a tropical country that has biodiversity. One of the biodiversity in Indonesia is the availability of many medicinal plants. The Indonesian Ministry of Health has released a formulary of Indonesian medicinal plants in 2017. One of the plants that has medicinal properties is the sungkai plant. Sungkai plants grow in most parts of Indonesia, including South Sumatra. This plant is also often planted in the yard as a shade. Empirically, sungkai leaves have been used as medicine by various tribes in Indonesia. People use boiled water from sungkai leaves or crushed sungkai leaves as herbal medicine. The phytochemical content of sungkai leaves includes alkaloids, flavonoids, triterpenoids, steroids, phenols and saponins. The results of various studies show that sungkai leaves have benefits as anti-fever, antimalarial, antibacterial and antioxidant. Sungkai leaves also have the ability to increase endurance, so they can be used to fight infectious diseases including Covid19. Sungkai leaves can be used for herbal medicine either as a preventive or therapeutic agents. Further development for the use of Sungkai plants as medicine needs to be done to assess side effects and therapeutic effects more efficiently.
PRODUCTION OF YELLOW WOOD ROOT TEA AS A BLOOD SUGAR STABILIZER Fatmawati Fatmawati; M Athiah; S Sinulingga; L.O Oswari; Safyudin Safyudin
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (398.338 KB)

Abstract

Diabetes mellitus is a disease or metabolic disorder that is increasing year by year, characterized by high blood sugar levels as a result of insulin function insufficiency. Diabetes mellitus, which is often referred to as diabetes, is a disease or metabolic disorder that is increasing year by year, characterized by high blood sugar levels as a result of insulin function insufficiency. Treatment is by using drugs. Currently, a treatment using herbal medicine is being developed, one of which is Kayu kuning, where in previous studies it was found that the roots of Kayu kuning can reduce blood glucose levels. This has triggered the Biochemistry and Medical Chemistry section of the Faculty of Medicine to introduce to the public the preparations of this herbal medicine with ready-to-use packaging and the right dosage. The process of making tea is carried out at the Chemical Basic Medicine Laboratory, Faculty of Medicine, Sriwijaya University. About 5.6 kg of yellow wood root, washed and cut into small pieces then dried and ground to obtain a coarse powder (simplicia) of about 2.5 kg. Yellow wood root simplicia is put into tea bags weighing 10 g per bag. One tea bag can be brewed with 200 mL of hot water and drunk once a day. In this service, 250 tea bags were produced which were packaged in 50 packages (5 tea bags/package). The production of this yellow wood root tea has been carried out in the Komplek Azhar Lama, Kenten Laut, Palembang. Keywords: Herbal medicine, yellow root (Arcangelisia flava)
Cytotoxicity Effects of Benalu Tea Extract (Scurrula oortina) on Hella cells Kusumo Hariyadi; Fatmawati; Subandrate; Fahira Aninditia; Dazakiah
Biomedical Journal of Indonesia Vol. 6 No. 2 (2020): Vol 6, No 2, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10281

Abstract

Tea garden waste has been investigated in the form of parasite tea Squrula oortina Species Family: Loranthaceae from the Dempo Pagar Alam tea plantation, Lahat Regency, South Sumatra. Stem and leaf samples are then dried and powdered, then isolated with 70% water-ethanol subfraction. The extract was then dried by vacuum distillation at 70oC until a concentrated extract without ethanol was obtained. The results of the study were tea parasite extract, and the extract was tested for phytochemicals (monounsaturated fatty acids and double, theobromine derivates, quercetin derivates and Epicatekin derivates). Next, it would be taken to the Laboratory of Biological Sciences at Gajah Mada University to be tested for cytotoxic effects on Hella cells, with control positive doxorubicin. The results of the research were tea leaves extract IC50 = 2538 ug/mL and the standard of doxorubicin IC50 = 0.88 ug/mL so that it could be concluded that the parasite of the tea parasite had cytotoxic and proliferative effects.
Xanthine oxidase inhibitory activity of Arcangelisia flava Fatmawati; Subandrate; Safyudin; Medina Athiah; M Fitra Romadhon; Aulia Firdha Tariza
Acta Biochimica Indonesiana Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.71

Abstract

Background: Hyperuricemia is characterized by elevated levels of uric acid in the blood, produced from its precursor's xanthine and hypoxanthine via xanthine oxidase. Arcangelisia flava, an herbal medicine containing flavonoids, may decrease uric acid levels by inhibiting the xanthine oxidase. Objective: This study was to determine the effectiveness of ethanol extracts of A. flava leaves and stems in inhibiting xanthine oxidase. Methods: The leaves and stems of A. flava were extracted using ethanol 96%. Xanthine oxidase activity was measured using UV Vis spectrophotometry and represented as IC50 value. Allopurinol was used as a positive control. Results: The IC50 value of xanthine oxidase inhibitory of ethanol extract of A. flava leaves and stems as well as allopurinol was 174.62, 30.44, 24.03 ppm. Conclusion: The stems of A. flava have the activity of lowering uric acid levels better than the leaves.
Overview of Primary Angle-Closure Glaucoma Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Mohammad Fazel Iftikhar Syahdafy; Prima Maya Sari; Fatmawati; Fidalia; Muhammad Usman Salim
Sriwijaya Journal of Ophthalmology Vol. 6 No. 1 (2023): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v7i1.92

Abstract

Introduction: Glaucoma is a disturbance of part or all of the visual field caused by damage to the optic nerve and increased intraocular pressure, and obstruction of the outflow of aqueous humor, which causes optic neuropathy, loss of visual field, and in the final stages, can lead to complete blindness. This study aimed to provide an overview of primary angle-closure glaucoma patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This research was a descriptive observational study with secondary data, where there were 37 research subjects with 61 eyes. This study presents clinical, sociodemographic, and management data of angle-closure glaucoma patients. Data analysis was carried out univariately with SPSS. Results: The majority of angle-closure glaucoma patients are aged 40-64 years and are female. Family history with glaucoma disorders has not provided optimal data because the majority of these data are not found. The majority of glaucoma patients have intraocular pressure ≤ 21 mmHg. The majority of research subjects do not have refractive disorders. The majority of patients receive medical therapy in the form of 2-3 types of eye drops. The majority of patients are diagnosed with PACG. Conclusion: The majority of angle-closure glaucoma patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, have normal intraocular pressure without refractive errors and receive combination therapy of 2-3 eye drops.
HUBUNGAN ANTARA GEJALA KLINIS DAN LOKASI PERLENGKETAN LESI PADA PENDERITA ENDOMETRIOSIS Qherine Bhelqis; Hartati Hartati; Fatmawati Fatmawati; Firmansyah Seta Basyir; Rara Inggarsih
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I2.19953

Abstract

Endometriosis merupakan kondisi kronik dimana terjadi implantasi jaringan fungsional endometrium di luar kavum uterus.Diagnosis endometriosis cukup sulit dan sering tidak terdeteksi dalam waktu lama sehingga penelitian ini bertujuan untuk membantu penegakkan diagnosis lebih cepat karena dapat memperkirakan lokasi lesi lebih awal. Penelitian ini berjenis observasional analitik dengan pendekatan cross sectional dengan jumlah sampel berjumlah 102 pasien. Lokasi perlengketan terbanyak berada di uterus sebanyak 54 pasien (52,9%) dan gejala klinis yang paling banyak adalah dismenore yaitu sebanyak 71 pasien (69,6%).  Hubungan gejala dismenore dengan lokasi perlengketan di uterus didapatkan nilai p sebesar 0,732 dan hubungan gejala dispareunia dengan lokasi perlengketan di cul de sac didapatkan nilai p sebesar 0,525. Sedangkan penelitian tentang hubungan antara gejala klinis diskezia dengan lokasi di rektum menghasilkan nilai p value 0,031 dan nilai PR 10,90 (95% CI 1,19 – 99,78). Tidak ada hubungan yang bermakna antara gejala klinis dismenore dengan letak perlengketan di uterus dan hubungan antara gejala klinis dispareunia dengan letak perlengketan di cul de sac. Namun, terdapat hubungan antara gejala klinis diskezia dan lokasi perlengketan di rektum.
Co-Authors Alderiantama Akhmad Aliah Ramadhani Puteri Anwar, Chairil Ardesy Melizah Kurniati Athiah, Medina Aulia Firdha Tariza Dalilah Dazakiah Dwi Handayani Dwi Handayani Dzakiyah Dzakiyah Dzakiyah Ella Amalia Ella Amalia, Ella Erizka Rivani Ester G Pansserga Ester Gonzales Panserga Fadiya Fadiya Fadiya Fahira Anindita Fahira Anindita Fahira Aninditia Fidalia Firmansyah Basir Firmansyah Seta Basyir Gita Dwi Prasasty Gita Dwi Prasasty Hafid Syahputra Hartati Humairah Binti Huda HUSNUL KHOTIMAH Irfannudin Irfannudin Izzah, Puspita Nurul Jayawarsa, A.A. Ketut Kusumo Hariyadi Kusumo Hariyadi L.O Oswari Liniyanti D Oswari Liniyanti D. Oswari Liniyati D Oswari Liniyati D Oswari M Athiah M Fakhri Altiyan M Fitra Romadhon M. Ivan Pratama Maharani Natasya Maharani Puspita Sari HS Mgs Irsan Saleh Mohammad Fazel Iftikhar Syahdafy Muhammad Irsan Saleh Muhammad Rusdi Muhammad Usman Salim Nadia Permata Sari Nadya Nadya Nadya Naomi W Tioline Nita Parisa Nurlutfiyyah Aini Prima Maya Sari Putra Ramadhan Algiffary Irianto Dunda Qherine Bhelqis Qherine Bhelqis RACHMAT HIDAYAT Radiyati Umi Partan Rara Inggarsih Rara Inggarsih Rifka Purnama Sari Rini Yana Rini Yana Rini Yana Rizka Amelia Rona Hawa Kamilah Rona Hawa Kamilah S Sinulingga Sadakata Sinulingga Safira Azahra Safyudin Safyudin Salni Salni Siti Devita Utami Siti Rusdiana Puspa Dewi Sri Hartati Sri Wahyuni Subandrate Subandrate Susilawati Susilawati Susilawati Susilawati Susilawati Susilawati Susilawati Syarif Husin Theodorus Theodorus Venny Larasati Yundari, Yundari Ziske Maritska