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All Journal Althea Medical Journal Majalah Kedokteran Gigi Indonesia Sari Pediatri Paediatrica Indonesiana Padjadjaran Journal of Dental Researchers and Students
Dzulfikar Djalil Lukmanul Hakim
Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran Unpad,Rumah Sakit Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Faktor-Faktor Penentu Vaccine Hesitancy pada Orang Tua Anak Usia 6-12 Tahun terhadap Vaksin COVID-19 di Kabupaten Bandung Nirwani, Bunga; Dhamayanti, Meita; Solek, Purboyo; Lukmanul Hakim, Dzulfikar Djalil; Alam, Anggraini; Tarigan, Rodman
Sari Pediatri Vol 25, No 5 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.5.2024.283-91

Abstract

Latar belakang. Hingga 18 Mei 2020, 584 anak terkonfirmasi positif COVID-19 di Indonesia, mendorong upaya pencegahan melalui vaksinasi anak. Kendati Ikatan Dokter Anak Indonesia mendukung vaksinasi COVID-19 pada anak usia 6–11 tahun, terdapat keraguan (hesitancy) dan penolakan vaksin yang perlu dipahami faktornya.Tujuan. Penelitian bertujuan mengeksplorasi adanya keraguan terkait vaksinasi COVID-19 pada anak dan menganalisis faktor-faktor yang memengaruhi orang tua.Metode. Penelitian analitik kuantitatif dengan desain potong lintang, menggunakan data sekunder yang diperoleh dari penelitian sebelumnya yang merupakan bagian dari riset Academic Leadership Grant meliputi data demografis subjek penelitian, tingkat pengetahuan subjek penelitian mengenai COVID-19, serta status keraguan subjek penelitian terhadap vaksin COVID-19. Hasil. Didapat 613 subjek penelitian yaitu orang tua yang memiliki setidaknya satu orang anak berusia 6-12 tahun yang memenuhi kriteria inklusi dan tidak memenuhi kriteria eksklusi. Dari 613 subjek, sebagian besar memiliki skor pengetahuan COVID-19 yang baik pada 419 orang (68,4%) dan sebagian besar menunjukkan tanpa keraguan pada 546 (89,1%). Pendidikan terakhir (p=0,002 <0,05) dan riwayat infeksi COVID-19 pada keluarga (p=0,007 <0,05) merupakan faktor yang secara signifikan berpengaruh terhadap skor pengetahuan COVID-19.Kesimpulan. Tingkat pendidikan dan riwayat infeksi COVID-19 pada keluarga merupakan faktor yang signifikan secara statistik terhadap tingkat pengetahuan orangtua anak usia 6-12 tahun mengenai COVID-19. Tidak terdapat faktor yang signifikan secara statistik terhadap vaccine hesitancy pada orangtua anak usia 6-12 tahun.
Early Left Ventricular Structural Changes With Preserved Function in Overweight and Obese Adolescents: A Speckle-Tracking Echocardiography Study Nurfandi, Wendi; Hafsah, Tisnasari; Rahayuningsih, Sri Endah; Apandi, Putria Rayani; Hakim, Dzulfikar Djalil Lukmanul; Ghrahani, Reni; Kuswiyanto, Rahmat Budi; Gurnida, Dida Akhmad
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4343

Abstract

Background: Overweight and obesity in adolescents are associated with dyslipidemia and may contribute to early cardiovascular remodelling. Speckle-tracking echocardiography (STE) is a sensitive imaging technique capable of detecting early myocardial functional alterations before the onset of clinical symptoms. This study aimed to evaluate the correlation between cardiac chamber dimensions, left ventricular (LV) geometry and function, and lipid profiles in overweight and obese adolescents. Methods: A cross-sectional study was conducted from June to September 2023, involving 51 overweight and obese adolescents aged 15–18 years in Bandung, Indonesia. Anthropometric measurements, fasting lipid profiles (triglycerides, total cholesterol, LDL, HDL), and transthoracic echocardiography were obtained. LV dimensions, LV mass index (LVMI), ejection fraction (EF), fractional shortening (FS), and global longitudinal strain (GLS) were assessed. Associations were analyzed using Pearson correlation.Results: Participants were predominantly male (64.7%) with a mean age of 16.3±0.6 years. Overweight (47.1%) and obesity (52.9%) were almost equally distributed with a mean BMI of 29.6±4.1 kg/m². LVMI correlated negatively with total cholesterol (r=−0.356; p=0.005), HDL (r=−0.351; p=0.006), and LDL (r=−0.280; p=0.023). The LV posterior wall thickness and LV end-diastolic diameter were also inversely correlated with selected lipid parameters. Interventricular septal thickness in systole correlated positively with triglycerides (r=0.270; p=0.028). No significant correlations were found between lipid profiles and LV function parameters, including EF, FS, and GLS (p>0.05).Conclusions: In overweight and obese adolescents, lipid profiles are associated with early alterations in LV structural dimensions while LV systolic function remains preserved. These findings support the importance of early cardiovascular screening and lifestyle modification to reduce future cardiometabolic risk.
Co-Authors Adri Zamany Anwary Adrizain, Riyadi Anggraini Alam Anggraini Alam, Anggraini Dany Hilmanto Dewi Marhaeni Diah Herawati Dewi, Anggun Puspita Dida A. Gurnida Dida Akhmad Gurnida Djatnika Setiabudi Dwi Andriyani Dwi Prasetyo Elza Noviani Elza Noviani, Elza Esti Istiqomah Fransisca Sri Susilaningsih Fransisca Sri Susilaningsih Idham Fadhillah Iis Rosita Meita Dhamayanti Nanan Nur&#039;aeny Nanan Nur&#039;aeny Nelly Amalia Risan, Nelly Amalia Nirwani, Bunga Nurfandi, Wendi Prima Nanda Fauziah Putria Rayani Apandi, Putria Rayani Rahmat Budi Kuswiyanto, Rahmat Budi Reni Ghrahani Robby Godlief Rodman Tarigan Solek, Purboyo Sri Endah Rahayuningsih Susi Susanah Tisnasari Hafsah, Tisnasari