Article Per Year (5 Year)
p-Index From 2020 - 2025
1.006
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Indonesia Indonesian Journal of Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Academic Journal of Computer Science Research (AJCSR) Journal of Social Research Emitor: Jurnal Teknik Elektro
Ayu Kusuma Dewi
RS Dr. Oen Solo Baru
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
Pengaruh Suplementasi Vitamin C, Vitamin E, dan Kombinasinya Terhadap Penurunan Kadar Low Density Lipoprotein Serum pada Pasien Penyakit Ginjal Kronis Stadium V yang Dilakukan Hemodialisis Dewi, Ayu Kusuma; Purwanto, Bambang; Wiboworini, Budiyanti
Jurnal Kedokteran Indonesia Vol 3, No 1 (2012)
Publisher : Jurnal Kedokteran Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background:Low density lipoprotein (LDL) cholesterol is a prognostic factor for hemodialysis mortality through atherosclerosis mechanism. Vitamin C and E have been well known as anti-oxidants that reduced LDL cholesterol. However, there were no studies have been done to address the effectiveness of vitamin C, E, and its combination on lowering LDL in patients with hemodialysis. This study aimed to determine the effect of vitamin C, E, and C and E combination on LDL cholesterol. Methods:A randomized controlled trial was conducted in 64 patients receiving hemodialysis at RSUD Dr.Moewardi(RSDM) Surakarta. The sample was taken at random and then divided into 4 groups: placebo, vitamin C (500 mg), vitamin E (400 mg), and vitamin C + E combination. The treatment lasted for 30 days. LDL cholesterol before and after treatment were analyzed at the Clinical Pathology division, RSDM. The reduction in LDL cholesterol before and after treatment was analyzed using One Way Anovaand (pair-wise) Post-Hoc Test. Results:One Way Anovashowed statistically significant reduction in LDL cholesterol between groups (p<0.001). Post hoc testshowed that vitamin C, vitamin E, or its combination reduced LDL cholesterol more than the placebo (p<0.001). Vitamin C and E administered in combination led to statistically significant lower LDL cholesterol than administered alone (p=0.002). There was no statistically difference in LDL cholesterol level between those provided with vitamin C and vitamin E. Conclusion: Vitamin C and E, individually or in combination, reduces LDL cholesterol. The highest reduction was achieved by vitamin C and E combination.Keywords: vitamin C, vitamin E, LDL cholesterol
Successful Combination Therapy with Phototherapy and Topical Corticosteroid in a Rare Case : 57 Years Old Male Patient with Lichen Amyloidosis Sambodo, Shelly Lavenia; Mawardi, Prasetyadi; Tansil, Ivana; Dewi, Ayu Kusuma; Utama, Rahmat Firdaus Dwi; Octarica, Stella Gracia; Adjie, Sugih Primas
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.745

Abstract

Background: : Lichen Amyloidosis (LA) is one of the most common forms of primary localized cutaneous amyloidosis, with clinical manifestations of itchy blackish brown hyperkeratotic papules. The most predilection site is the upper extensor of the legs. This case report aims to improve the clinician’s knowledge regarding clinical features and supporting examinations to the provision of appropriate therapy in LA. Case Report: A 57 years old farmer presented to dermatology and venereology outpatient clinic of Dr. Moewardi general hospital with itchy black spots on nearly all over his body since 2 years ago. Dermatology examination obtained generalized papules and scaly hyperpigmented patches. Dermoscopy revealed a scar-like center with a whitish color in the center. Histopathological examination showed an amorphous eosinophilic (amyloid) in the dermis. Congo red examination demonstrated a reddish-orange amyloid. We treated the patient with oral cetirizine 10 mg/day, desoximetasone 0.25% cream applied twice a day in the morning and in the evening, Carmed® cream 20% cream applied twice a day in the afternoon and night, phototherapy 350 MJ/cm2 twice a week. We observed for 14 weeks. The lesion and itching started improving in week 8. Result: Lichen amyloidosis is resulted from amyloid deposits in the papillary dermis which are derived from degradation of basal keratinocytes. The diagnosis is based on history taking, clinical examination, dermoscopy and skin biopsy. The combination of phototherapy and topical corticosteroid can be an option for LA therapy, especially for the symptom of pruritus. Conclusion: Lichen Amyloidosis is the most common type of primary localized cutaneous amyloidosis, presents as blackish brown hyperkeratotic papules. The combined therapy of topical corticosteroids and phototherapy can significantly improve pruritus and skin lesions.
The Clinical Relevance of Serum Interleukin-21 in Grading Acne Vulgaris Dewi, Ayu Kusuma; Irawanto, Muhammad Eko; Kusumawardani, Arie; Dharmawan, Nugrohoaji; Mulianto, Nurrachmat
Journal of Social Research Vol. 4 No. 11 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i10.2795

Abstract

Acne vulgaris (AV) is an inflammatory skin disorder with multifactorial pathogenesis involving genetics, hormones, and immune dysregulation. Interleukin-21 (IL-21), a pleiotropic cytokine mainly secreted by T follicular helper and Th17 cells, has been implicated in various inflammatory skin diseases. However, its role in AV remains unclear. This cross-sectional study included 46 patients with AV, classified into mild (n=19), moderate (n=16), and severe (n=11) groups. Serum IL-21 levels were measured using an enzyme-linked immunosorbent assay (ELISA). Baseline characteristics were compared across groups, and interobserver reliability of AV severity grading was evaluated using Cohen’s kappa test. One-way ANOVA was applied to assess differences in IL-21 levels among severity groups, with a significance level set at p<0.05. The mean serum IL-21 level was highest in the severe AV group (303.53 pg/mL), followed by the moderate (223.7 pg/mL) and mild (213.2 pg/mL) groups. Although there was a trend toward increasing IL-21 levels with higher AV severity, statistical analysis revealed no significant difference among the three groups (p=0.130). Serum IL-21 levels were elevated in AV patients compared with previously reported healthy controls but did not differ significantly across severity levels. These findings suggest that IL-21 may play a role in the pathophysiology of AV, though it is not a reliable marker of clinical severity. Further case-control and tissue-based studies are needed to clarify its role.
Penggunaan Metrik Software Defect dalam Pengembangan Perangkat Lunak: Literature Review Dewi, Ayu Kusuma; Azmina, Hilma Yasmin; Sugiarti, Yuni
Academic Journal of Computer Science Research Vol 6, No 2 (2024): Academic Journal of Computer Science Research (AJCSR)
Publisher : Institut Teknologi dan Bisnis Bina Sarana Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38101/ajcsr.v6i2.15649

Abstract

Penggunaan metrik pada software defect adalah sebagai alat pengukur untuk membantu mengidentifikasi risiko dalam memprediksi cacat dalam perangkat lunak. Metrik perangkat lunak membantu berbagai pelaku industri agar memastikan produk akhir berkualitas tinggi. Metrik ini mampu melakukan mitigasi risiko sejak awal hingga akhir proses pengembangan perangkat lunak dan membantu dalam pencegahan dan perbaikan cacat perangkat lunak. Tujuan penulisan ini adalah untuk mengetahui pemilihan metrik, teknik dan model yang sesuai sebelum melakukan pengujian pada perangkat lunak. Metodologi yang digunakan dalam penulisan ini adalah studi literatur. Hasil penulisan tersebut adalah untuk mengetahui bahwa terdapat banyak jenis metrik yang dapat digunakan dalam suatu penelitian. Pada permasalahan yang ada mengenai pemilihan jenis metrik untuk cacat perangkat lunak, langkah yang perlu dilakukan adalah dengan mengidentifikasi permasalahan tersebut. Lalu dilakukannya diskusi mengenai jalan keluar yang tepat dengan pemangku kepentingan untuk menjadi jalan keluar dari sebuah permasalahan.
Profile of Urticaria and Angioedema Patients at Dr. Moewardi General Hospital Surakarta, Indonesia Dewi, Ayu Kusuma; Muhammad Eko Irawanto; Stella Gracia Octarica; Shelly Lavenia Sambodo; Rahmat Firdaus Dwi Utama; Sugih Primas Adjie
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 5 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i5.994

Abstract

Background: Urticaria is a heterogeneous inflammatory skin disease that results from the activation and degranulation of cutaneous mast cells, followed by the release of histamine and other mediators that cause sensory nerve activation, vasodilation, plasma extravasation, and recruitment of immune cells. The prevalence and incidence of urticaria and angioedema have been extensively studied worldwide, but there is still limited data in Indonesia, especially regarding the profile of urticaria and angioedema patients. The purpose of this study was to determine the profile of urticaria and angioedema patients at Dr. Moewardi General Hospital for the period January 1st, 2020 - December 31st, 2022. Methods: This study is a cross-sectional retrospective study with secondary data derived from medical records of urticaria and angioedema patients. Results: There were 152 patients with urticaria, most of whom were in the age group >60 years (20.39%), female with a male to female ratio of 1:1.92, and worked as housewives (17.76%) and students (16.45%). Most cases were diagnosed with urticaria (86.84%) with some patients having angioedema (13.16%). The most common comorbidities rhinoconjunctivitis (2.63%), atopic dermatitis (1.97%) and asthma (1.32%). The dominant symptoms were itching and bumps (100%). The main treatment received by patients was single AH1 (71.71%) followed by combination therapy of AH1 and systemic corticosteroids (14.47%), combination therapy of AH1 and topical corticosteroids (10.53%), and the rest received combination therapy of AH1, topical corticosteroids, and systemic corticosteroids (3.29%). The skin prick test was positive in 16 patients (35.56%), with the most common allergens found being peanut (37.5%), egg yolk (37.5%), and tomato (37.5%). Conclusion: The characteristics of urticaria patients were dominated by elderly patients, female gender, and working as housewives or not working. Patients were predominantly diagnosed with urticaria with the most common comorbidities being diabetes mellitus. The main treatment received was AH1 class drugs. The most common types of allergens identified were peanuts, egg yolks, and tomatoes.
Desain dan Analisis PID Controller Menggunakan Metode Genetic Algorithm pada Boost Converter Tipe CCM Dewi, Ayu Kusuma; Dyah Lestari; Muhammad Afnan Habibi
Emitor: Jurnal Teknik Elektro Vol 24, No 1: Maret 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/emitor.v24i1.2817

Abstract

Boost converter merupakan DC-DC Converter yang berfungsi untuk menaikkan tegangan. Namun untuk menghasilkan tegangan keluaran yang stabil dan sesuai dengan nilai yang diinginkan diperlukan suatu controller, salah satunya PID controller. Apabila penentuan konstanta PID tepat, maka akan didapatkan respon tegangan yang memiliki settling time cepat serta mampu menghilangkan overshoot. Namun, tuning PID controller menggunakan metode konvensional kurang optimal jika digunakan untuk sistem nonlinear dan memiliki orde tinggi. Penelitian yang dilakukan bertujuan untuk mendesain dan menganalisis PID controller menggunakan metode genetic algorithm yang diterapkan pada boost converter. Tahapan dalam penelitian ini yaitu, (1) studi literatur; (2) desain open loop boost converter; (3) analisis perhitungan boost converter; (4) tuning PID controller menggunakan metode genetic algorithm dan ziegler nichols; (5) simulasi desain rangkaian; (6) membandingkan respon tegangan output antara metode genetic algorithm dan ziegler nichols; (7) analisis hasil simulasi. Proses pembuatan desain boost converter tipe CCM dilakukan dengan menggunakan bantuan software MATLAB/SIMULINK. Perbandingan dilakukan berdasarkan nilai overshoot dan settling time yang dihasilkan. Hasil penelitian menunjukkan bahwa nilai overshoot yang dihasilkan oleh boost converter tanpa. PID controller adalah 55,7% dengan settling time 0,0767s. Overshoot paling kecil dari metode genetic algorithm adalah 0%, sedangkan settling time paling singkat adalah 0,000294s. Overshoot yang dihasilkan metode ziegler nichols adalah 3,35% dengan settling time 0,1302s. PID controller dapat memperbaiki overshoot serta settling time pada respon tegangan output boost converter tipe CCM. Penggunaan genetic algorithm dalam proses tuning PID controller mampu memberikan overshoot yang lebih kecil dan settling time yang lebih singkat jika dibandingkan dengan metode ziegler nichols.
Profile of Urticaria and Angioedema Patients at Dr. Moewardi General Hospital Surakarta, Indonesia Dewi, Ayu Kusuma; Muhammad Eko Irawanto; Stella Gracia Octarica; Shelly Lavenia Sambodo; Rahmat Firdaus Dwi Utama; Sugih Primas Adjie
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 5 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i5.994

Abstract

Background: Urticaria is a heterogeneous inflammatory skin disease that results from the activation and degranulation of cutaneous mast cells, followed by the release of histamine and other mediators that cause sensory nerve activation, vasodilation, plasma extravasation, and recruitment of immune cells. The prevalence and incidence of urticaria and angioedema have been extensively studied worldwide, but there is still limited data in Indonesia, especially regarding the profile of urticaria and angioedema patients. The purpose of this study was to determine the profile of urticaria and angioedema patients at Dr. Moewardi General Hospital for the period January 1st, 2020 - December 31st, 2022. Methods: This study is a cross-sectional retrospective study with secondary data derived from medical records of urticaria and angioedema patients. Results: There were 152 patients with urticaria, most of whom were in the age group >60 years (20.39%), female with a male to female ratio of 1:1.92, and worked as housewives (17.76%) and students (16.45%). Most cases were diagnosed with urticaria (86.84%) with some patients having angioedema (13.16%). The most common comorbidities rhinoconjunctivitis (2.63%), atopic dermatitis (1.97%) and asthma (1.32%). The dominant symptoms were itching and bumps (100%). The main treatment received by patients was single AH1 (71.71%) followed by combination therapy of AH1 and systemic corticosteroids (14.47%), combination therapy of AH1 and topical corticosteroids (10.53%), and the rest received combination therapy of AH1, topical corticosteroids, and systemic corticosteroids (3.29%). The skin prick test was positive in 16 patients (35.56%), with the most common allergens found being peanut (37.5%), egg yolk (37.5%), and tomato (37.5%). Conclusion: The characteristics of urticaria patients were dominated by elderly patients, female gender, and working as housewives or not working. Patients were predominantly diagnosed with urticaria with the most common comorbidities being diabetes mellitus. The main treatment received was AH1 class drugs. The most common types of allergens identified were peanuts, egg yolks, and tomatoes.
Co-Authors Adjie, Sugih Primas Azmina, Hilma Yasmin Bambang Purwanto Budiyanti Wiboworini Dharmawan, Nugrohoaji Dyah Lestari Irawanto, Muhammad Eko Kusumawardani, Arie Muhammad Afnan Habibi Muhammad Eko Irawanto Nurrachmat Mulianto Octarica, Stella Gracia Prasetyadi Mawardi Rahmat Firdaus Dwi Utama Shelly Lavenia Sambodo Stella Gracia Octarica Sugih Primas Adjie Tansil, Ivana Utama, Rahmat Firdaus Dwi Yuni Sugiarti, Yuni