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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN JURNAL GIZI INDONESIA Nurse Media Journal of Nursing Jurnal Kedokteran Brawijaya NUTRIRE DIAITA Majalah Kedokteran Bandung Jurnal Manajemen Keperawatan Health Notions Biosaintifika: Journal of Biology & Biology Education JI-KES (Jurnal Ilmu Kesehatan) Medica Hospitalia JI-KES (Jurnal Ilmu Kesehatan)
Edi Dharmana
Medical Faculty, Diponegoro University, Semarang, Indonesia
Agriculture, Biological Sciences & Forestry Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : JURNAL GIZI INDONESIA

 1 
Pengaruh pemberian ekstrak kedelai hitam (Glycine soja.) berbagai dosis terhadap kadar glukosa darah, kadar insulin, dan HOMA-IR Kurniawati, Dewi M; Dharmana, Edi; Rachmawati, Banundari; Pemayun, Tjokorda Gde Dalem
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 6, No 1 (2017)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.408 KB) | DOI: 10.14710/jgi.6.1.44-50

Abstract

Background: Obese is risk factor for abnormal glucose homeostasis and causes oxidative stress that can decrease insulin sensitivity resulting in hyperglycemia and hyperinsulinemia. Black soy bean contains anthocyanins and isoflavones, it is expected to reduce oxidative stress. Objective: Determine the effect of various dosage of black soybean extract (Glycine soja.) on blood glucose, insulin levels, and HOMA - IR in obese Sprague Dawley (SD) rats.Methods: True experimental study with randomized controlled pre test-post test design in male SD rats. Twenty four samples divided into 4 groups: control (K), 500 (P1), 750 (P2), and 1000 mg/kgBW (P3). Rats were induced to become obese with High Fat Sucrose Diet (HFSD) for 4 weeks then black soybean extracts were given for 2 weeks..Results: There was no difference in blood glucose before and after treatment (p> 0.05). There were differences on insulin levels in 500 (p = 0.012) and 750mg/kgBW (p = 0.020) doseges. There were differences on HOMA-IR in 500 (p = 0.043) and 750mg/kgBW (p = 0.028) dosages. There was difference in insulin levels’s difference (p = 0.009) between groups.Conclusion: There are differences on insulin levels and HOMA – IR in 500 and 750 mg/kgBW dosages groups. However, there is no difference on blood glucose before and after black soybean extract treatment. The most decreased levels of blood glucose, insulin and HOMA- IR were in 750mg/kgBW dosage.
Melatonin menurunkan berat badan tetapi tidak menurunkan kadar TNF-α pada tikus wistar jantan yang diberi minyak jelantah selama 28 hari Novianti, Anugrah; Dharmana, Edi; Widyastiti, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 5, No 2 (2017)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.997 KB) | DOI: 10.14710/jgi.5.2.127-132

Abstract

Backgound: Non Alcoholic Fatty Liver Disease (NAFLD) occurs when the intake and free fatty acid synthesis occurs more frequently than its oxidation and resecretion in the blood. Melatonin is a powerful antioxidant that can boost the synthesis of endogenous antioxidants in the body, suppress the inflammatory response and inhibit the formation of steatosis.Objective: To analyze the effect of melatonin supplementation in reducing body weight andTNF-α levels in male Wistar rats were fed by waste cooking oil.Methods: True experimental studyusing post-test only control group design. This study was done on 18 male wistar rats were divided into 3 groups : the positive control group (P0) was administrated waste cooking oil, the treated group 1 (P1) was administrated waste cooking oil and 5mg/kgBW melatonin, and the treated group 2 (P2) was administrated waste cooking oil and 10mg/kgBW melatonin for 28 days.Data analysis using One Way ANOVA test and followed by Tukey test to determine the most effective dose of melatonin.Results: There was significant difference in body weightbetween P2group and K0 group (p=0,019) with the mean body weight difference was 19,167g lower than K0 group. There was no difference in TNF-α levels between the three groups (p=0,155). Conclusion: Melatonin dose of 10mg/kgBWloses body weight male Wistar rats have given by waste cooking oil for 28 days, but does not reduce TNF-α levels.
Pengaruh suplementasi seng dan vitamin B6 terhadap kadar hemoglobin, hematokrit dan indeks eritrosit pasien malaria vivax yang anemia Sofiyetti, Sofiyetti; Dharmana, Edi; Rahfiludin, M. Zen; W, Nyoman Suci; Afifah, Diana Nur
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 5, No 1 (2016)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (509.713 KB) | DOI: 10.14710/jgi.5.1.20-25

Abstract

Background: Zinc supplementation decrease the risk of malaria parasitaemia, increasing ferritin serum level and hemoglobin in patients with malaria. Zinc influence the activity of aminolevulinic acid dehydratase (ALAD) an enzymes that catalizes heme synthesize. Vitamin B6 in pyridoxal 5-phosphate (PLP) from has a role in alpha-aminolevulinic acid (ALA) formation, which is the precursor of heme in hemoglobin. PLP also inhibit the growth of the malaria parasite.Objective: The objective was to analyze the effect of zinc and vitamin B6 supplementation on hemoglobin level, hematocrit and erythrocyte indexs (MCV, MCH and MCHC) of anemic Plasmodium vivax malaria patients.Methods: Double Blind Randomised Controlled Trial with pre and post test design. 30 subjects were divided into two groups: the suplementation group were given zinc 1x10 mg/day with vitamin B6 1x5 mg/day and the control group were given a placebo for 30 days. Data analysis by paired t-test, independent t-test and Mann Whitney.Results: There was an increase in Hb levels in the suplementation group (p=0.0001), the control group (p=0.001) and there was a significant difference on the increase between the two groups (p=0.020). Hematocrit significant increase only in the suplementation group (p=0.0001). There were no differences on erythrocyte index parameter in both groups.Conclusion: Zinc and vitamin B6 supplementation of for 30 days increase the hemoglobin level, hematocrit and there were no effect on erythrocyte indexs of anemic Plasmodium vivax malaria patients.
Co-Authors AA Sudharmawan, AA Agung Putra Agus Santoso Ainul Yaqin Amin Samiasih Arifin, Thohar Banundari Rachmawati bayu ardha, doglas rama Budi Laksono Chodidjah Chodidjah Diana Nur Afifah, Diana Nur Elfrida Ratnawati Fitriana, Vera Fransisca Prameshinta H, Fransisca Prameshinta Hardono Susanto, Hardono Hertanto Wahyu Subagio I WAYAN SUDARTA Kiss Jamiatun, Kiss Kuntardjo, Novalia Kurniawati, Dewi M Lisyani Suromo, Lisyani Maria Estela K, Maria Estela Mohamed M.Y. Gadalla, Mohamed M.Y. Mohammad Zen Rahfiludin Nani Maharani Niken Safitri Dyan Kusumaningrum Niken, Safitri Nirmalasari, Novita Novianti, Anugrah Nyoman Suci W, Nyoman Suci Nyoman Suci Widyastiti Prabowo, Erik RA Kisdjamiatun, RA Safari Wahyu Jatmiko Selamat Budijitno Sofiyetti, Sofiyetti Suci, Nyoman tadihoedojo, ersje retnowati Taufiq R Nasihun, Taufiq R Tjokorda Gde Dalem Pemayun Wibowo, Erwin