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All Journal Microbiology Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Enrichment : Journal of Management Lumbung Farmasi : Jurnal Ilmu Kefarmasian Medical Sains : Jurnal Ilmiah Kefarmasian
Shirly Kumala
Universitas Pancasila
Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Pengembangan Produk Gel Sabun Wajah Ekstrak Buah Belimbing Wuluh (Averrhoa bilimbi L.) dan Daun Sosor Bebek (Kalanchoe pinnata (Lam.) Per.) sebagai Anti Bakteri Penyebab Jerawat ANARISA BUDIATI; ANNY VICTOR PURBA; SHIRLY KUMALA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.098 KB)

Abstract

Averrhoa bilimbi L. fruits and Kalanchoe pinnata (Lam.) Per. leaves are useful as anti bacterial. The extracts containing the compound bufadienolides have the potential to be used as an anti bacterial. The purpose of this study to fi nd the best formula of the preparation facial wash gel with the active substance from the combination of extracts. Search methods extract concentration using the agar diff usion to obtain regional Diameter Inhibition (DDH) of each extract and the combinations. Research conducted with 3 forrmula containing extracts with diff erent concentrations. The results of the evaluation of the preparation at room temperature storage does not change the color, shape and scent. Retrieved best formula is the formula I containing a concentration of 0.7% resulting extract preparations light green and scented perfume. The results of the evaluation of the formula I at room temperature after 3 month storage include: high foam in hard water 17 mL, high foam in distilled water >25 mL, the specifi c gravity 1.0386 g/cm3, surface tension 19, 3627 dyne/cm, viscosity 853,33-1103,33 cPs, pseudoplastis fl ow properties, pH 5.16, anti bacterial test results using Diameter test Inhibitory Region shows constraints on Staphylococcus aureus by 5,0±0 mm.
Efek Pasca Antibiotik Ciprofloxacin terhadap Staphylococcus aureus ATCC 25923 dan Escherichia coli ATCC 25922 SHIRLY KUMALA; AMEILIA AMEILIA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 2 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Post antibiotic effect is the period required by bacteria to physiologically recover after exposure to antibiotics at certain concentrations and exposure time. This study investigated the post antibiotic effect of ciprofloxacin, one of quinolon derivative with broad spectrum antibiotic activity and highest sensitivity towards both Gram positive and Gram negative bacteria, Staphylococcus aureus ATCC 2593 and Escherichia coli ATCC 25922. Lorian gel membrane filtration technique was used and bacteria were exposed to the antibiotic at a concentration of 10 times of the minimum inhibitionconcentration (MIC) for 2 hours. The findings demonstrated strongly that post-antibiotic effect of the two bacterial strain were different. The Staphylococcus aureus (ATCC 25923) had shorter recovery time Within 2-3 hours When compared to the Escherichia coli (ATCC 25922) which recovered from the post-antibiotic effect Within 3-4 hours.
Evaluating the Use of Warfarin Using the HAS-BLED Score and INR on Atrial Fibrillation Patients at Harapan Kita National Heart Center Meva Sari Chandra; Shirly Kumala; Sesilia Andriani Keban
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 14, No 2 (2020): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v14i2.1671

Abstract

Patients with atrial fibrillation are associated with a 4-5-fold risk of having a stroke. The most effective treatment for atrial fibrillation is to prevent the formation of blood clots by administering anticoagulant drugs. Warfarin is an anticoagulant drug that has a narrow therapeutic index with side effects of the risk of bleeding; hence it needs supervision in its use. In this study, the HAS-BLED score was used to measure major bleeding risk and as a value representing each risk factor for bleeding. The bleeding risk can be prevented by maintaining a warfarin response in the therapeutic range with an INR (International Normalized Ratio) measurement 2-3. This study was an observational study conducted with retrospective data collection through medical records of patients with a primary diagnosis of atrial fibrillation who received oral warfarin anticoagulant therapy at Harapan Kita National Heart Center in the period of January-December 2017. Using a sample of 40 patients who met the inclusion criteria. According to the data, found that atrial fibrillation patients who received oral warfarin therapy 55% were male patients, while 45% were female patients. Patients with atrial fibrillation who got the most oral warfarin therapy were patients who were over 40 years old with 90% of the total sample, with the highest group in patients aged 50-54 years with 22.5%. The HAS-BLED values arranged from 0-9, the percentage of patients who had HAS-BLED values of 0, 1, 2 respectively at 7.5%, 42.5%, 30%. The HAS-BLED score ≥ 3 showed patients classified as at high risk of bleeding by 20%. The most risk factors based on HAS-BLED score from all study samples were 18 patients with abnormal kidney or 45%. The average INR score in patients at high risk of bleeding showed that 37.5% had an average INR score in the target ratio score of INR 2-3.
Penghambatan Enzim Asetilkolinesterase dari Ekstrak Herba Pegagan (Centella asiatica (L.) Urb), Ekstrak Daun Kelor (Moringa oleifera Lam.) dan Kombinasinya Yonathan Tri Atmodjo Reubun; Shirly Kumala; Siswa Setyahadi; Partomuan Simanjuntak
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.9052

Abstract

Penyakit Alzheimer (Alzheimer Disease, AD) adalah suatu penyakit dimana terjadinya kerusakan otak yang ditandai dengan penurunan dari perhatian, memori, dan kepribadian. AD merupakan salah satu akibat dari ganguan fungsi asetilkolin. Dalam hal ini, Asetilkolinesterase (AChE) merupakan enzim yang berfungsi sebagai katalisator pada pemecahan asetilkolin (ACh) menjadi bentuk yang tidak aktif yaitu asetat dan kolin. Pengukuran aktivitas enzim AChE dapat menggambarkan akumulasi ACh dalam tubuh dimana pada hasil ini menunjukkan pada penderita AD dengan adanya aktivitas AChE yang lebih besar. Tujuan penelitian ini adalah untuk mengetahui aktivitas dalam pengobatan AD melalui penghambatan AChE oleh ekstrak Centella asiatica L. Urb, ekstrak Moringa oleifera Lam. dan kombinasinya. Herba pegagan dan daun kelor yang diperoleh masing-masing diekstraksi dengan menggunakan etanol 96% dengan metode maserasi. Maserat yang diperoleh kemudian dipekatkan dengan menggunakan rotary evaporator dan dikeringkan menggunakan metode freeze drying. Kandungan metabolit sekunder dalam ekstrak diuji menggunakan metode skrining fitokimia standar. Uji aktivitas penghambatan AChE dilakukan menurut metode Ellman yang didasarkan pada hidrolisis reaksi substrat ATCh oleh AChE dengan DTNB yang menghasilkan warna kuning dan diukur serapannya pada panjang gelombang 410 nm. Hasil pengujian penghambatan AChE menunjukan bahwa kombinasi ekstrak herba pegagan dan ekstrak daun kelor 1:1 memberikan penghambatan terbaik dengan nilai IC50 sebesar 217,588 ppm. Sementara itu, kontrol positif eserin dengan nilai IC50 sebesar 5,010 ppm. Kombinasi ekstrak herba pegagan dan daun kelor diduga mempunyai efek positif dalam pengobatan penyakit alzheimer melalui mekanisme aksi penghambatan AChE.
Analysis of Emergent Strategy Business Network Clinic PT. Amalia Jannah Medika During the Covid-19 Pandemic Afrini Saraswati; Shirly Kumala; Indah Masri
Enrichment : Journal of Management Vol. 12 No. 2 (2022): Management Science and Field
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (484.336 KB) | DOI: 10.35335/enrichment.v12i2.552

Abstract

The Covid-19 pandemic has had an unhealthy impact on the economy, in line with this many companies are updating and adjusting their corporate strategies in order to survive or to continue to grow in these circumstances. The purpose of this study was to analyze the internal and external environmental factors of PT. Amalia Jannah Medika so that she can find out alternative strategies that can be used during the Covid-19 Pandemic. This type of research uses an exploratory descriptive method. Collecting data using direct observation, structured interviews and focus group discussions (FGD). The population and research sample are policy makers and PICs in each clinical branch of PT. Amalia Jannah Medika. Analysis of the data on the strength and weakness factors used the Internal Factor Evaluation (IFE) matrix and the External Factor Evaluation (EFE) matrix, then to look for alternative strategies using the Strength, Weakness, Opportunity, Threat (SWOT) matrix and to determine the most appropriate strategy for implemented using the Quantitative Strategic Planning Matrix (QSPM). The results of the SWOT analysis of PT. Amalia Jannah Medika is in quadrant I with aggressive criteria so that the recommended alternative strategy to be implemented is the strength-opportunities strategy. Furthermore, based on the results of the QSPM analysis, the selected strategy was obtained, namely increasing the marketing of PT. Amalia Jannah Medika through digital marketing by joining various health and tourism marketplaces and platforms.
Formulasi Sediaan Gel Antijerawat Ekstrak Herba Meniran (Phylanthus niruri L) Dan Ekstrak Daun Sirsak (Annoni muricata L). Dimas Adrianto; Shirly Kumala; Teti Indrawati
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 2 (2022): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i2.8041

Abstract

ABSTRAKHerba meniran dan daun sirsak mengandung senyawa flavonoid, triterpenoid, saponin, polifenol dan metabolit sekunder lainnya. Secara tradisional herba meniran dan daun sirsak tanaman yang berkhasiat sebagai Obat jerawat. Tujuan penelitian ini dilakukan dengan cara uji aktifitas antibakteri dari kombinasi ekstrak herba meniran dan daun sirsak sebagai antibakteri penyebab jerawat agar didapatkan efek sinergi sehingga bisa memperkuat kerja antibakteri dan memformulasi sediaan gel obat jerawat dengan bahan aktif kombinasi ekstrak herba meniran dan daun sirsak yang efektif sebagai antijerawat terhadap bakteri P.acne dan S.aureus. Metode Penelitian dilakukan dengan menentukan aktifitas antijerawat dari ekstrak meniran dan daun sirsak menggunakan bakteri P.acne dan S.aureus, dilanjutkan dengan pembuatan gel kombinasi ekstrak meniran dan daun sirsak. Evaluasi terhadap sediaan gel meliputi uji organoleptik, homogenitas, pH, viskositas, daya sebar, iritasi dan aktifitas antibakteri sediaan gel. Sediaan gel kombinasi ektrak daun sirsak dan meniran  (3% : 4,5%) memiliki aktivitas menghambat pertumbuhan bakteri P.acne dan S.aureus terbaik dengan nilai DDH P.acne sebesar 32 mm dengan kategori aktivitas sangat kuat dan S.aureus  21 mm dengan kategori aktivitas sangat kuat.  Sediaan gel ekstrak daun sirsak dan meniran dapat memenuhi parameter fisika dan kimia sediaan gel serta stabil selama 12 minggu pada suhu penyimpanan 4oC, suhu 27oC dan suhu 40oC. Sediaan gel kombinasi ekstrak meniran dan daun sirsak memiliki indeks iritasi primer sebesar 0,40 dan termasuk kategori respon iritasi sangat ringan.  Kata kunci : Daun sirsak; Gel antijerawat; Jerawat; Meniran. ABSTRACTMeniran herbs and soursop leaves contain flavonoids, triterpenoids, saponins, polyphenols and other secondary metabolites. Meniran herbs and soursop leaves were traditionally used as an acne medication. This study aimed to formulate carried out by testing the antibacterial activity of a combination of extracts from meniran herbs and soursop leaves as an antibacterial that causes acne with the aim of getting a synergistic effect so that it can strengthen antibacterial work and antiacne  gel formulation containing the active ingredients of a combination of meniran herb and soursop leaf extract which is effective as an anti-acne against P.acne and S.aureus bacteria. The research method was conducted by determining the antibacterial activity of extract to P.acne and S.aureus, followed by formulate a gel combination of meniran and soursop leaf extract. The evaluation of gel formulation included organoleptic tests, homogeneity, pH, viscosity, spreadability, irritation and antibacterial activity. The gel preparation of the combination of soursop leaf extract and meniran (3%: 4.5%) had the best activity inhibiting the growth of P.acne and S.aureus bacteria with a DDH value of P.acne of 32 mm with very strong activity category and S.aureus 21 mm with a very strong activity category. The gel formulations we meet to the physical and chemical parameters of the gel formulation and were stable for 12 weeks at storage temperature of 4oC, temperature of 27oC and temperature of 40oC. The gel formulation had a primary irritation index of 0.40 and was included in the very mild irritation response category. Keywords : Acne; Antiacne gel; Meniran; Soursop leaf. 
Co-Authors . Suhaimi Adefira Elisyia Juniharti Afrini Saraswati AMEILIA AMEILIA Anarisa Budiati Anny Victor Purba Atut Ruswita Handayani Aulia Tisna Dewi Desi Nadya Aulena Diah Dethriani Dimas Adrianto Dimas Adrianto EDY MEIYANTO ENDRO BUDI SISWANTO I. G.A. Ayu Wiratih Indah Masri Meva Sari Chandra Miftahurrohmah, Nur Muthi Ikawati Noviyantih, Noviyantih NUR ANNISA FITRI Partomuan Simanjuntak Peny Budiarti RIRIS ISTIGHFARI JENIE Sesilia Andriani Keban Simanjuntak, Partomuan Siswa Setyahadi Sofyan Ramani Syarmalina Syarmalina Teti Indrawati Teti Indrawati Wibowo Mangunwardoyo Yonathan Tri Atmodjo Reubun Yun Astuti Nugroho