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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. e-GIGI Jurnal Kesehatan Islam : Islamic Health Journal JURNAL KAJIAN VETERINER CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal International Journal of Health, Engineering and Technology
Indra Setiawan
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Maxillary Rhinosinusitis Profil In General Hospital Of Haji Surabaya On January-December 2017 Indra Setiawan
Saintika Medika Vol. 17 No. 1 (2021): June 2021
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol17.SMUMM1.16009

Abstract

Chronic rhinosinusitis in various countries in the world and Indonesia shows an increase from time to time. At General Hospital of Haji Surabaya, the prevalence of chronic rhinosinusitis has increased from 10.13% in 2016 to 10.26% in 2017. Various factors are thought to cause chronic rhinosinusitis. Chronic rhinosinusitis can interfere with the quality of life and lead to serious complications if left untreated. To determine the profile of chronic rhinosinusitis in General Hospital of Haji Surabaya for January-December 2017 Period. Analytic observational with cross-sectional study approach. Used the total sampling method. Based on patients diagnosed with chronic rhinosinusitis with complete medical record data. The sample in this study were 132 patients. Most chronic rhinosinusitis patients were aged 36-45 years as many as 26 patients (19.69%) and the least number of patients was more than 65 years old as many as 6 patients, women (67.40%) and 43 patients in men (32, 60%). Symptoms of nasal congestion in 79 patients (59.84%), cough as many as 25 patients (18.93%), septal deviation as many as 51 patients (38.63%) and at least 4 patients (3.03%) of nasal polyps. Most rhinosinusitis patients in this study were aged 36-45 years, women with symptoms of nasal congestion and septal deviation as the most comorbidities.
The Effect of Lemon Peel (Citrus limon) Aromatherapy Inhalation as Antidepressant on Rats using Diffuser Method Indra Setiawan; Iwan Sis Indrawanto; Abi Noerwahjono; Abdi Malik Rahardjo
Jurnal Kesehatan Islam : Islamic Health Journal Vol 10, No 2 (2021): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v10i2.13824

Abstract

Abstract. Background Depression is a mood disorder that affects a person’s quality of life. This condition is influenced by the levels of monoamine compounds such as serotonin, norepinephrine, and dopamine in the brain. The decrease in monoamine levels leads to depressive symptoms. Lemon peel essential oil has an antidepressant potential, that contains phytochemicals, d-Limonene, which increase monoamine levels in the brain. Aromatherapy diffuser inhalation method is one kind of treatment route in depression. The mechanism of action is by breaking down the smaller essential oil particles so they penetrate quicker to the brain. Objective: To determine the effect of lemon peel (Citrus limon) aromatherapy inhalation diffuser method on immobility time of white rats (Rattus norvegicus Wistar strain) on the tail suspension test. Method: True Experimental with Post Test Only Control Group Design. Fifteen white male rats Wistar strain were divided into 5 groups. The positive control group was given stressors and saline induction intraperitoneally. In addition to stressors, the treatment group was also given lemon peel aromatherapy inhalation at a dose of 1%, 2.5%, and 5%. Measurement of immobility time was carried out by hanging the rats' tails through the tail suspension test method and the time of animals stopped moving for at least 1 second was calculated using a timer. Data were analyzed using the ANOVA test, Post Hoc test, Pearson correlation test, and Linear Regression test. Results and Discussion: ANOVA test showed a significant difference between groups (p = 0.017). The post Hoc test showed a significant difference (p <0.05) between the positive control and the P3 group (5%). The linear regression test obtained Adjusted R2 = 0.598 (inhalation of lemon peel aromatherapy gives an effect of 59.8%). The decrease of immobility time was due to the reduction of depression that was caused by the increase of monoamine level induced by d-limonene in lemon peel essential oil. Conclusion: The inhalation of lemon peel (Citrus limon) aromatherapy with diffuser method has the antidepressant effect that reduces the immobility time of depressed white rats (Rattus norvegicus Wistar strain).
Overview of Ear, Nose, and Throat Complaints of Covid 19 Inpatients at the University of Muhammadiyah Malang Hospital for the Period April 2021 to June 2021 Nimim Putri Zahara; Indra Setiawan; Jauhar Tajudin
Saintika Medika Vol. 18 No. 1 (2022): June 2022
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol18.SMUMM1.21604

Abstract

Covid-19 is spreading rapidly to other countries, and WHO confirmed it as a pandemic disease in March 2020. The virus enters directly to the surface of the mucosa with a high viral load, so it is clear that complaints in the nose and throat area are found. Covid-19 initially appears mainly in the airway with symptoms can be fever and dyspnea cough which can quickly switch to acute respiratory distress syndrome. RSU Universitas Muhammadiyah Malang has been one of the Covid-19 referral hospitals in East Java since April 2020, and there is no data on the description of nasal ear and throat complaints (ENT) in Covid-19 hospitalization patients at UMM Hospital. Mengetahui overview and overview of nose and throat ear complaints (ENT) experienced by Covid-19 hospitalized patients at UMM Hospital in the period April 2021 to June 2021. Descriptive retrospectively by taking data from the medical records of Covid-19 hospitalization patients of UMM Hospital in the period April to June 2021 with a total sampling method of 161 hospitalized patients with a confirmed diagnosis of Covid-19 with PCR examination during the period of April to June 2021. The study was conducted on 161 medical records with the results of 84 patients were men with 21 patients with severe degrees, 63 patients with moderate degrees, and 77 patients were women with 18 patients with severe degrees and 59 patients with moderate degrees. Mortality rates were obtained in as many as 26 (16%) with varying age ranges; 78 (48%) patients had comorbidities, with Diabetes mellitus as the highest comorbid among as many as 31 (40%) patients. Patients with ENT complaints were obtained among as many as 95 (60%) patients, and 66 (40%) patients were not accompanied by ENT complaints. The three most ENT complaints were colds (rhinitis) in as many as 62 (39%) patients, anosmia hyposmia in as many as 26 (16%) patients, and throat pain in as many as 22 (14%) patients. Most patients were men with moderate degrees, with mortality rates of 16% and 48% of patients accompanied by comorbidities. The most ENT complaints were rhinitis 39%, anosmia-hyposmia 16%, and throat pain in as much as 14% of patients.
Hubungan Lama Paparan Dan Intensitas Kebisingan Terhadap Gangguan Pendengaran Akibat Bising Nauval Halim; Indra Setiawan; Rubayat Indradi
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 3 No. 1 (2022): Juni
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v3i1.97

Abstract

One of the most common occupational diseases is noise-induced hearing loss. Noise-induced hearing loss is a decrease in the function of the sense of hearing caused by exposure to noise. Noise exposure greater than 85 dB and exposure for more than 8 hours will increase the risk of hearing loss. Hearing loss due to noise can cause an increase in the risk of work-related accidents which will have an impact on the safety of workers or the community. The purpose of this publication is to determine the relationship between duration of exposure and noise intensity to noise-induced hearing loss. The library method used is in the form of 31 literature sources consisting of 8 textbooks and 23 national and international journals with a time span of 2013-2020. From the results of the analysis there is a relationship between the length of exposure and the intensity of noise on the hearing loss of factory workers. It can be concluded that the duration of exposure and the intensity of noise affect hearing loss due to noise. Other factors that can affect the occurrence of hearing loss due to noise such as age, habits outside of work, and the use of PPE can also affect the occurrence of hearing loss due to noise.
Uji Efektivitas Antibakteri Ekstrak Kulit Batang Faloak (Sterculia quadrifida R.br) yang Tumbuh di Desa Bolok Terhadap Pertumbuhan Bakteri Salmonella Typhi Aburizal Malik; Hawin Nurdiana; Indra Setiawan
JURNAL KAJIAN VETERINER Vol 11 No 1 (2023): Jurnal Kajian Veteriner
Publisher : FAKULTAS KEDOKTERAN HEWAN UNIVERSITAS NUSA CENDANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jkv.v11i1.10387

Abstract

An impropriate use of antibiotics leads to bacterial resistance problems and side effects. To minimize resistance and adverse side effects, the faloak plant (Sterculia quadrifida R.Br.) has the potential to be used as antibacterial agents. This study aimed to determine the antibacterial effectiveness of faloak bark extract (Sterculia qudrifida R.Br.) against the growth of Salmonella typhi bacteria. This study used a static group comparison research method (Static Group Comparison), namely by measurement (observation) carried out after the treatment group received a program or intervention. According to the results of the research and discussion in this study, the following conclusions can be drawn. Extract of the bark of the faloak plant (Sterculia quadrifida R.Br.) with a concentration of 22.5%; 45%; 75%; and 100% has antibacterial effectiveness against the growth of Salmonella typhi bacteria. The stem bark extract of the faloak plant (Sterculia quadrifida R.Br.) is said to be most effective at inhibiting the growth of Salmonella typhi at a concentration of 100%.
Rhinosinusitis and Risk Factors Indra Setiawan
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 19 No. 1 (2023): June 2023
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol19.SMUMM1.27537

Abstract

Rhinosinusitis is clinical syndrome characterized by ongoing or persistent symptoms of inflammation of the nasal mucosa and paranasal sinuses, namely nasal congestion, mucopurulent nasal mucus, facial pain, disturbance of smell, or cough for more than 12 weeks. The purpose of this study was to determine the risk factors affecting Chronic Rhinosinusitis. A search of studies was conducted in the main databases such as GoogleScholar, Pubmed, and Cochraine with publication time within the last 8 years and a total of 9 articles were found. Articles are selected by titles, abstracts and full text. Data is extracted by population/patient, interventions/indicators, outcome, impact and study type as well as general information from articles are also included.
PENGARUH PENGGUNAAN ALAT PELINDUNG DIRI TERHADAP DERMATITIS KONTAK PADA PETANI TEBU Amalla, Fadilatul Khusna; Pravitasari, Dwi Nurwulan; Setiawan, Indra; Setyawan, Febri Endra Budi
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 5 No. 1 (2024): Juni
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar Belakang : Dermatitis kontak akibat kerja (DKAK) adalah penyakit kulit akibat paparan bahan iritan dan alergen selama bekerja. DKAK tidak menular dan berbahaya tetapi menyebabkan penurunan kualitas hidup dan rasa tidak nyaman akibat gejala yang ditimbulkan. Petani tebu selama bekerja seringkali terkena bulu yang menempel pada daun dan batang tebu, serta pupuk kimia sehingga beresiko terkena DKAK. Hal ini dapat dicegah dengan menggunakan APD selama bekerja. Penggunaan APD dapat mengurangi paparan bahan iritan dan kimia selama selama bekerja. Tujuan : Mengetahui pengaruh faktor resiko penggunaan alat pelindung diri terhadap kejadian dermatitis kontak akibat kerja apada petani tebu Desa Pakisjajar Kecamatan Pakis Kabupaten Malang. Metode : Metode penelitian menggunakan observasional analitik dengan rancangan cross-sectional. Alat pengambilan data menggunakan kuesioner. Analisis data menggunakan SPSS. Hasil : Hasil analisis menggunakan uji statistik koefisien kontingensi diperoleh hasil p 0,000 ; p < 0,05 maka terdapat pengaruh penggunaan APD terhadap kejadian DKAK pada petani tebu Desa Pakisjajar Kec. Pakis Kab. Malang. Berdasarkan nilai value koefisien kontingensi sebesar 0,508, dapat disimpulkan bahwa kekuatan hubungan antara penggunaan APD dengan kejadian DKAK termasuk dalam kategori hubungan sedang. Kesimpulan : Terdapat pengaruh faktor resiko penggunaan APD terhadap kejadian DKAK pada petani tebu Desa Pakisjajar Kec. Pakis Kab. Malang
Effectiveness of Petai (Parkia speciosa) Ethanol Extract in Controlling Foam Cell Numbers in Atherosclerosis-Induced Male Wistar Rats Ikhwan Handirosiyanto; Indra setiawan; Seftiana Khaerun Nisa; Dian Yuliartha Lestari
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 20 No. 1 (2024): June 2024
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol20.SMUMM1.38652

Abstract

Atherosclerosis is a chronic inflammatory disease that causes the narrowing of the arterial lumen, and it is considered the primary cause of cardiovascular diseases such as myocardial infarction (MI), heart failure, and stroke. Cardiovascular disease is the leading of death globally. Atherosclerosis has a complex pathophysiology, such as endothelial dysfunction, thickening of the tunica intima, and the formation of atheromatous plaques. After that process, foam cells will form, which is the key to the development of atherosclerosis. Petai ethanol extract contains antioxidants, which are flavonoids, saponins, and tannins, that can reduce the number of Low-Density lipoproteins (LDL). The purpose of this study was to evaluate the effect of petai ethanol extract on the number of atherosclerotic foam cells in male white rats (Rattus norvegicus strain wistar) induced by lard. The method of this study was a genuinely experimental and post-test-only control group design with 25 rats divided into five control groups, which are one negative control group, one positive control group, and three treatment groups with extract doses of 100mg/kgBW, 200mg/kgBW and 400mg/kgBW. Observation of foam cells was carried out using a microscope with 400x magnification. Data were analyzed using Oneway ANOVA and Post Hoc Tamhane's test. The results of the study using the Oneway ANOVA test showed that there were significant differences between groups (p: 0.000). Post Hoc Tamhane's test between the positive control group and treatment groups 1, 2, and 3 can be seen that there is a significant difference between the formation of foam cells due to the administration of petai ethanol extract compared to positive control (p <0.05). This study concludes that Petai ethanol extract was effective in reducing the number of atherosclerotic foam cells formed.
Effect of Red Apple Peel Extract on Serum Histamine Levels in a Rat Model of Allergic Rhinitis Indra Setiawan; Tara Mandirica; Arindo Kusuma; Rosalia Dwi Permatasari; Miftha Churochman
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 22 No. 1 (2026): June 2026
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol22.SMUMM1.44828

Abstract

Allergic rhinitis (AR) remains a prevalent inflammatory disorder for which long-term pharmacological management is often constrained by adverse effects. This study investigated the impact of red apple peel extract (Malus domestica 'Rome Beauty'), a quercetin-rich by-product sourced from Malang–Batu, on serum histamine concentrations in an established AR rat model. Employing a true-experimental, post-test-only control group design, 25 male Wistar rats were randomized into five groups: negative control, positive control (OVA-induced AR), and three treatment arms receiving 10, 25, or 80 mg/kg body weight of extract over 16 days. Serum histamine was quantified via ELISA, and data were subjected to Kruskal-Wallis analysis with subsequent Dunn-Holm corrected Mann-Whitney tests; dose-response was further evaluated using the Jonckheere-Terpstra test. Statistically significant intergroup differences were observed (H = 22.347; p < 0.001), with the positive control group exhibiting the highest histamine levels (33.0 ng/mL). Treatment groups demonstrated a progressive reduction in histamine (29.4, 25.4, and 19.0 ng/mL), with the 80 mg/kg dose yielding a 42.4% decrease relative to control (p = 0.011). The presence of a significant dose-dependent trend (p = 0.031) underscores the potential of red apple peel extract as a cost-effective adjunctive strategy in AR management.
Effectiveness Test of Ethanol Extract of Petai (Parkia speciosa) on the Number of Atherosclerotic Foam Cells in Male Wistar Rats (Rattus norvegicus strain Wistar) Atherosclerosis Model Ikhwan Handirosiyanto; Seftiana Khaerun Nisa; Indra Setiawan; Dian Yuliartha Lestari
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.714

Abstract

Atherosclerosis is a chronic inflammatory disease that causes narrowing of the arterial lumen and is a dominant cause of cardiovascular diseases such as myocardial infarction (MI), heart failure, and stroke. Cardiovascular disease itself is the leading cause of death worldwide. Atherosclerosis has a complex pathophysiology, starting from endothelial dysfunction, thickening of the tunica intima, and the formation of atheromatous plaques. During its progression, foam cells are formed, which play a key role in the development of atherosclerosis. The ethanol extract of petai (Parkia speciosa) contains compounds such as flavonoids, saponins, and tannins that function to reduce the levels of Low-Density Lipoprotein (LDL). The purpose of this study was to determine the effectiveness of petai ethanol extract in reducing the number of atherosclerotic foam cells formed in male Wistar rats (*Rattus norvegicus strain Wistar) induced by lard. This study used a true experimental method with a post-test only control group design. A total of 25 rats were divided into five groups: one negative control group, one positive control group, and three treatment groups receiving petai ethanol extract at doses of 100, 200, and 400 mg/kg body weight. The formation of foam cells was observed using a microscope with 400× magnification. Data were analyzed using the One-Way ANOVA test and Post Hoc Tamhane’s test. The results of the One-Way ANOVA test showed a significant difference among the groups (p = 0.000). The Post Hoc Tamhane’s test between the positive control group and treatment groups 1, 2, and 3 indicated significant differences in foam cell formation due to the administration of petai ethanol extract compared to the positive control group (p < 0.05). In conclusion, the administration of petai ethanol extract was effective in reducing the number of atherosclerotic foam cells formed.
Co-Authors A.A. Ketut Agung Cahyawan W Abdi Malik Rahardjo Abi Noerwahjono Aburizal Malik Amalla, Fadilatul Khusna Arindo Kusuma Dian Yuliartha Lestari Dinda Faullya Zein Dwi Nurwulan Pravitasari Faullya Zein, Dinda Febri Endra Budi Setyawan Hawin Nurdiana Heriyanti, Sinta Sundari Ikhwan Handirosiyanto Irma Suswati Iwan Sis Indrawanto Jauhar Tajudin Michael A. Leman Miftha Churochman Moch. Bahrudin Nauval Halim Ni Wayan Mariati Nimim Putri Zahara Raniasari Bimanti Esthi Rosalia Dwi Permatasari rubayat indradi Seftiana Khaerun Nisa Seftiana Khaerun Nisa Senja Ristya Hertanti Tara Mandirica