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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. e-GIGI CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal
Indra Setiawan
Universitas Muhammadiyah Malang
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Effectiveness of Petai (Parkia speciosa) Ethanol Extract in Controlling Foam Cell Numbers in Atherosclerosis-Induced Male Wistar Rats Ikhwan Handirosiyanto; Indra setiawan; Seftiana Khaerun Nisa; Dian Yuliartha Lestari
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 20 No. 1 (2024): June 2024
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol20.SMUMM1.38652

Abstract

Atherosclerosis is a chronic inflammatory disease that causes the narrowing of the arterial lumen, and it is considered the primary cause of cardiovascular diseases such as myocardial infarction (MI), heart failure, and stroke. Cardiovascular disease is the leading of death globally. Atherosclerosis has a complex pathophysiology, such as endothelial dysfunction, thickening of the tunica intima, and the formation of atheromatous plaques. After that process, foam cells will form, which is the key to the development of atherosclerosis. Petai ethanol extract contains antioxidants, which are flavonoids, saponins, and tannins, that can reduce the number of Low-Density lipoproteins (LDL). The purpose of this study was to evaluate the effect of petai ethanol extract on the number of atherosclerotic foam cells in male white rats (Rattus norvegicus strain wistar) induced by lard. The method of this study was a genuinely experimental and post-test-only control group design with 25 rats divided into five control groups, which are one negative control group, one positive control group, and three treatment groups with extract doses of 100mg/kgBW, 200mg/kgBW and 400mg/kgBW. Observation of foam cells was carried out using a microscope with 400x magnification. Data were analyzed using Oneway ANOVA and Post Hoc Tamhane's test. The results of the study using the Oneway ANOVA test showed that there were significant differences between groups (p: 0.000). Post Hoc Tamhane's test between the positive control group and treatment groups 1, 2, and 3 can be seen that there is a significant difference between the formation of foam cells due to the administration of petai ethanol extract compared to positive control (p <0.05). This study concludes that Petai ethanol extract was effective in reducing the number of atherosclerotic foam cells formed.
Effect of Red Apple Peel Extract on Serum Histamine Levels in a Rat Model of Allergic Rhinitis Indra Setiawan; Tara Mandirica; Arindo Kusuma; Rosalia Dwi Permatasari; Miftha Churochman
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 22 No. 1 (2026): June 2026
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol22.SMUMM1.44828

Abstract

Allergic rhinitis (AR) remains a prevalent inflammatory disorder for which long-term pharmacological management is often constrained by adverse effects. This study investigated the impact of red apple peel extract (Malus domestica 'Rome Beauty'), a quercetin-rich by-product sourced from Malang–Batu, on serum histamine concentrations in an established AR rat model. Employing a true-experimental, post-test-only control group design, 25 male Wistar rats were randomized into five groups: negative control, positive control (OVA-induced AR), and three treatment arms receiving 10, 25, or 80 mg/kg body weight of extract over 16 days. Serum histamine was quantified via ELISA, and data were subjected to Kruskal-Wallis analysis with subsequent Dunn-Holm corrected Mann-Whitney tests; dose-response was further evaluated using the Jonckheere-Terpstra test. Statistically significant intergroup differences were observed (H = 22.347; p < 0.001), with the positive control group exhibiting the highest histamine levels (33.0 ng/mL). Treatment groups demonstrated a progressive reduction in histamine (29.4, 25.4, and 19.0 ng/mL), with the 80 mg/kg dose yielding a 42.4% decrease relative to control (p = 0.011). The presence of a significant dose-dependent trend (p = 0.031) underscores the potential of red apple peel extract as a cost-effective adjunctive strategy in AR management.
Co-Authors A.A. Ketut Agung Cahyawan W Amalla, Fadilatul Khusna Arindo Kusuma Dian Yuliartha Lestari Dwi Nurwulan Pravitasari Faullya Zein, Dinda Febri Endra Budi Setyawan Heriyanti, Sinta Sundari Ikhwan Handirosiyanto Jauhar Tajudin Michael A. Leman Miftha Churochman Nauval Halim Ni Wayan Mariati Nimim Putri Zahara Raniasari Bimanti Esthi Rosalia Dwi Permatasari rubayat indradi Seftiana Khaerun Nisa Tara Mandirica