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All Journal Jurnal Kedokteran Syiah Kuala Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana INDONESIAN JOURNAL OF PHARMACY Jurnal Surya Medika Warta Pengabdian Jurnal Ilmu Kefarmasian Indonesia Harmony : Jurnal Pembelajaran IPS dan PKN Jurnal Pengabdian Masyarakat Asia Berkala Ilmiah Kimia Farmasi Berkala Penelitian Hayati
Sudjarwo Sudjarwo
Faculty Of Pharmacy, Airlangga University
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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8-HIDROKSI-DEOKSIGUANOSIN SEBAGAI SALAH SATU INDIKATOR INFERTILITAS PRIA Sudjarwo
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 10 No 1 (2004): December 2004
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/377

Abstract

DNA in human’s sperm is located in nucleus (nDNA) and mitochondria (mtDNA). DNA oxidation is indicated from high concentration of 8-OH-dG. It is very important to identify factors that can cause genetic dysfunction risk responsible for genetic changes. 8-OH-dG compound are a promutagenic of DNA dysfunction of deoxyguanosine oxidation by oxygen radical. ROS is an oxidation, which in high concentration can oxidize DNA. Guanine is a nucleotide, which prone to oxidation, with 8-OH-dG as the end product. Detection of 8-OH-dG can be done by HPLC method. These results indicated that there were significant differences (p < 0.01) in detection of 8-OH-dG in sperm, between normospermia with asthenospermia and normospermia with oligospermia. Correlation (r) of 8-OH-dG with motile spermatozoa is – 0.7111. Immotile spermatozoa caused by oxidation or DNA damage are shown by high concentration of 8-OH-dG. In normal physical condition, sperm produces oxidant. High oxidant is toxic to sperm, which influence their motility. Sperm’s motility is one of factors causing male infertility.
MENINGKATNYA HIDROGEN PEROKSIDA PADA VARIAN T16189C mtDNA SEMEN MANUSIA Sudjarwo Sudjarwo
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 11 No 2 (2006): June 2006
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/389

Abstract

Mitochondria are a site of cellular respiration through oxidative phosphorylation enzymatic reaction (OXPHOS), which is producing energy in the form of ATP (Adenosine Triphosphate). If abnormalities occur along cellular respiratory chain, ATP will decrease and Reactive Oxygen Species (ROS), will increase, one of which is hydrogen peroxide. ROS is an oxidation whose targets are lipid, protein and DNA, all of which may result in the decrease of spermatozoa motility. The detection of hydrogen peroxide was conducted by means of chemiluminescence using luminol, while the detection T16189C mtDNA variant was done using PCR-RFLP with restriction enzyme MnLI. In normozoospermia, hydrogen peroxide in 16189T was 4.4 ± 1.8 CPM/106 sp and in 16189C was 6.4 ± 1.8 CPM/106 sp. In asthenozoospermia, hydrogen peroxide in 16189T was 20.3 ± 8.3 CPM/106 sp while in 16189C was 62.5 ± 9.0 CPM/106 sp. Hydrogen peroxide in normozoospermia and asthenozoospermia 16189T and 16189C showed significant difference (p < 0.00; p < 0.01). In normozoospermia and asthenozoospermia, 16189T and 16189C has correlation with the decrease of motile spermatozoa motility (normozoospermia, p = 0.02; p < 0.05; asthenozoospermia p = 0.03; p < 0.05).
THE ROLE OF OXIDATIVE PHOSPHORYLATION IN THE MECHANISM OF HUMAN SPERM MOTILITY REGULATION Sudjarwo Sudjarwo; Aucky Hinting; Noor Cholies Zaini
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 12 No 1 (2006): December 2006
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/404

Abstract

Energy synthesis for sperm motility in the mitochondria with enzymatic reactions in nucleus and mitochondria is called Oxidative Phosphorylation (OXPHOS), in which the respiratory process is coordinated in nucleus and mitochondria. Enzymes in OXPHOS process are complex enzymes I, III, IV and V in the mitochondria and complex enzyme II in the nucleus. If there is OXPHOS dysfunction, the mutation of mitochondria DNA (mtDNA) will decrease energy (ATP, Adenosine Triphosphate) production and increase Reactive Oxygen Species (ROS). The characteristics of ROS are oxidant for lipid, protein and DNA, and all these reactions lead to the dysfunction of OXPHOS and, in the spermatozoa, they will decrease motility. The detection of ROS, Malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OH-dG), and sperm motility can use Chemiluminicense method, Spectroflourometric method, High Performance Liquid Chromatography (HPLC) method and Markler method, respectively, as World Health Organization (WHO) Procedures Laboratory. These results indicated there was significant indirect correlation between ROS with sperm motility and direct correlation between ROS with MDA, 8-OH-dG.
Isolasi dan Karakterisasi Agarosa dari Rumput Laut Gracilaria verrucosa ZAINAL ABIDIN; MARCELLINO RUDYANTO; SUDJARWO SUDJARWO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1720.406 KB)

Abstract

: Agar is complex polysaccharide which could be isolated from group Rhodophyta of seaweeds, sucs as Gracilaria verrucosa. Agar consists of two components, namely agarose and agaropectin. Agarose is neutral polysaccharide, while agaropectin is polysaccharide that contain sulphate, so agarose could be used for gel electrophoresis. The use of NaOH solution was aimed to hydrolyzes the agar to form 3,6-anhydro-L-galactose, whereas the use of propylene glycol was to separates agarose from agaropectin. This research was aimed to isolate agarosa from Gracilaria verrucosa using NaOH solution with the concentrations of 4%, 6%, 8%, 10% and propylene glycol of 30, 50 and 70 mL. The agarose obtained was giving specivic absorbtion band in IR spectrum with wave number in the region of 930 and 890 cm-1, and there were absorbtion band in the region of 860 and 830 cm-1, indicated that the agarose still contained sulphate. The increase of NaOH concentration and propylene glycol volume caused drawback sulphate and ash content, constant melted temperature and gel temperature but increase gel strength. The best amount of agarose was obtained with the use of NaOH 10% and 70 mL of propylene glycol, with the characteristics were: ash content of 2.0035±0.0429% (w/w), sulphate content of 0.3236±0.0131% (w/w), melted temperature of 34 oC, gel temperature of 90 oC, gel strength of 432.195±26.172 g/cm2 and degree of electroendosmosis of 0.20±0.005.
Comparison of Antifungal Susceptibility Basil Leaves Extract (Ocimum sanctum Linn.), Eugenol, and Nystatin against Isolates of Candida spp. as Important Agent causing Oral Candidiasis in HIV/AIDS Patient Emma Hidayati Sasmito; Afif Nurul Hidayati; Rahmadewi; Sawitri; Budi Utomo; Sudjarwo; Pepy Dwi Endraswari; Diah Mira Indaramaya; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 3 (2022): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.3.2022.162-168

Abstract

Background: Oral candidiasis is an infection caused by Candida sp. in areas of the oral mucosa that are often found in HIV/AIDS patients. Increased antifungal resistance, it was important to find new antifungal candidates, especially from natural ingredients, basil leaf extract (Ocimum sanctum Linn.) which had major compound of eugenol that had an antifungal effect in inhibiting of Candida sp. Purpose: To evaluate the comparison of the antifungal susceptibility of nystatin, basil leaf extract (Ocimum sanctum Linn.) and eugenol against isolates of Candida sp. Methods: This study examined the comparison of the antifungal susceptibility of nystatin 100 IU, basil leaf extract (Ocimum sanctum Linn.) with doses equivalent to 800 µg/mL and 400 µg/mL eugenol, and eugenol 800 µg/mL and 400 µg/mL against 40 stored isolates of Candida sp. from the oral cavity of HIV/AIDS patient which was reactivated. Result: The mean inhibition zone of nystatin for all isolates was 22.98 mm, while the mean inhibition zone of eugenol with doses of 800 µg/mL and 400 µg/mL were 17.07 mm and 15.89 mm, and the mean inhibition zone of basil leaf extract (Ocimum sanctum Linn.) with doses equivalent to 800 µg/mL and 400 µg/mL eugenol are 14.87 mm and 14.01 mm. The inhibition zone of basil leaf extract (Ocimum sanctum Linn.) and eugenol was significantly lower than nystatin (p = 0.001; p < 0.05). Conclusion: The zone of inhibition of nystatin was significantly higher compared to basil leaf extract (Ocimum sanctum Linn.) and eugenol against Candida albicans and Candida non-albicans isolates.
Pelatihan Pembuatan Jamu pada Siswa SMA di Kabupaten Banyuwangi sebagai Upaya Pelestarian Budaya dan Menanamkan Enterprenuership Suciati Suciati; Wiwied Ekasari; Neny Purwitasari; Rice Disi Oktarina; Lidya Tumewu; Yanu Andhiarto; Hanifa Rahma Putri; Tutiek Purwanti; Sudjarwo Sudjarwo
Jurnal Pengabdian Masyarakat Vol 4 No 1 (2023): Jurnal Pengabdian Masyarakat
Publisher : Institut Teknologi dan Bisnis Asia Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32815/jpm.v4i1.1333

Abstract

Siswa SMA sebagai generasi penerus bangsa berperan penting dalam upaya kesehatan masyarakat. Jamu merupakan warisan budaya bangsa yang harus terus dikenalkan kepada generasi muda supaya dapat dijaga kelestariannya. Peran jamu dalam upaya pemeliharaan kesehatan masyarakat sudah tidak diragukan lagi. Tujuan dari kegiatan ini adalah untuk memberikan pelatihan pembuatan jamu kepada siswa SMA di Kabupaten Banyuwangi. Sebanyak 39 orang siswa SMA sebagai peserta mendapatkan materi tentang cara pembuatan jamu yang baik dan benar serta keamanan produk jamu yang beredar di masyarakat. Selain itu peserta juga melakukan praktek pembuatan jamu kunyit asam dan masker wajah. Kegiatan ini diharapkan untuk meningkatkan pengetahuan dan keterampilan siswa SMA dalam pembuatan jamu serta meningkatkan jiwa kewirausahaan siswa SMA yang secara tidak langsung dapat meningkatkan perekonomian keluarga. Hasil yang diperoleh menunjukkan antusiasme peserta dalam mengikuti kegiatan ini serta hasil pretest dan postest menunjukkan peningkatan pengetahuan yang signifikan.
REPRESENTASI ETNISITAS TERHADAP TRADISI MITONI Kurniawan, Hanif; ., Sudjarwo; Sinaga, Risma Margaretha
Harmony: Jurnal Pembelajaran IPS dan PKN Vol 8 No 1 (2023): Volume 8 Nomor 1 Mei 2023
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/harmony.v8i1.70108

Abstract

Penelitian ini dimaksudkan untuk mengkaji representasi tradisi mitoni masyarakat Jawa yang tinggal di Kab. Lampung Tengah Kec. Trimurjo Kel. Simbarwaringin. Metode penelitian ini bersifat deskriptif kualitatif yang bertujuan untuk menggambarkan, menjelaskan dan menjawab secara lebih rinci masalah yang akan diteliti dengan mempelajari sebanyak mungkin individu, kelompok atau peristiwa. Hasil penelitian menunjukkan bahwa Mitoni merupakan salah satu cara berkomunikasi orang Jawa dengan menggunakan simbol. Nilai-nilai spiritual mitoni merupakan simbol ideologi Jawa eskatologis yang berfungsi menjaga keharmonisan sosial. This research is intended to examine the representation of the mitoni tradition of the Javanese people who live in the Kab. Central Lampung Kec. Trimurjo Kel. Simbarwaringin. This research method is descriptive qualitative which aims to describe, describe, explain, explain and answer in more detail the problems to be studied by studying as much as possible an individual, a group or an event. The results of the study show that Mitoni is one of the Javanese ways of communicating by using symbols. The spiritual values ​​of mitoni are symbols of eschatological Javanese ideology which functions to maintain social harmony.
Co-Authors Achmad Toto Poernomo Afif Nurul Hidayati Angerina N Ashon Sa’adi Asri Darmawati Aucky Hinting Budi Utomo Dasrul Dasrul Diah Mira Indaramaya Didik Rio Pambudi Doddy M. Soebady Dwi Murtiastutik Emma Hidayati Sasmito Hanifa Rahma Putri Hardjopranjot Hardjopranjot Irvan Ipandi Isnaeni Kurniawan, Hanif Lidya Tumewu Mahaputra L Marcellino Rudyanto Muhammad Hakim Rafiga Muhammad Muslich Noor Cholies Zaini Pepy Dwi Endraswari, Pepy Dwi Poedjiarti S Purwitasari, Neny Rahmadewi Rice Disi Oktarina Risma Margaretha Sinaga Sawitri Suciati Suciati Sukarjati Sukarjati Sukarjati Susie Amilah Tutiek Purwanti Wiwied Ekasari Yanu Andhiarto ZAINAL ABIDIN