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All Journal bionature Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Jurnal BALIRESO Window of Health : Jurnal Kesehatan Efektor Jurnal Mandala Pharmacon Indonesia Indonesian Journal of Community Dedication Pharmacoscript Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Mandala Pengabdian Masyarakat Poltekita: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Dharma Wacana KESANS : International Journal of Health and Science Jurnal Abdi Masyarakat Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmacy Reports Journal Borneo JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) International Journal of Public Health Excellence (IJPHE) Abdimas Indonesian Journal Jurnal Pengabdian Masyarakat Bangsa Journal of Pharmaceutical and Sciences. MPSJ
Andi Maulana Kamri
Fakultas Farmasi, Universitas Muslim Indonesia, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Pharmaceutical Compatibility of Non-Sterile Mixing Recipes in Pediatric Patients in Covid-19 Pandemic: Kesesuaian Farmaseutik Resep Racikan Non-Steril Pada Pasien Pediatri dalam Pandemi Covid-19 Kamri, Andi Maulana; Mirawati, Mirawati; Ningsih, Yuyun S
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 2 (2025): October 2025
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i2.16568

Abstract

Background: Drug compounding is the process of combining, mixing, or changing ingredients in the manufacture of drugs to meet patient needs. The risk of pharmaceutical incompatibility can affect the stability and efficacy of the compounded preparation.Objectives: This study aims to determine the pharmaceutical feasibility of non-sterile prescriptions in pediatric outpatients by evaluating dosage forms, concentrations, stability, and potential drug incompatibilities.Materials and Method: This study used a cross-sectional design with a purposive sampling technique and retrospective data collection. The sample in this study was 58 sheets of concoction recipes for children in Pulvere form.Results: The results showed that all prescription dosage forms were powder, and the strength of the drug was fully stated on the prescription. Based on the results of the study, several prescriptions had the potential for instability, including those containing Ambroxol (1.72%), Cetirizine (3.44%), Codeine (1.72%), Dexamethasone (1.72%), Methylprednisolone (3.44%), Isoniazid (1.72%), Metronidazole (5.17%), Nifedipine (1.72%), Omeprazole (1.72%), Paracetamol (5.17%), Prophylthiouracil (3.44%), Ranitidine (3.44%), Rifampicin (1.72%), Salbutamol (10.34%), Triprolidine HCl + Pseudoephedrine HCl (3.44%), Vitamin B complex (1.72%), and Vitamin C (3.44%). Additionally, one prescription contained drugs with potential immiscibility, namely N-acetylcysteine and Erythromycin. The drugs Erythromycin, Salbutamol, and N-acetylcysteine were identified as having the potential for incompatibility.Conclusion: Vitamin C and Vitamin B complex most frequently exhibited hygroscopic instability and photolytic degradation; therefore, it is not recommended to be mixed.
Co-Authors Ade Dede Adimi, Nurhikma Alifqah Meylia Alimuddin Aminah Aminah Andi Emelda Andi Hasriyana Andi Nadilla Arfah Andi, K. Petta Lolo, Arjuni Andini Zabrina Anil Aryandi Aslinda Septinia Asmaliani Ira Asmarani Pujawanti Asni Amin Asrul La Dongke As’ad, Nur Asyirah Avifa, Serly Awali, Muh. Noer Ayu Lestari Basri, Putri Septiani Batary Resky Bayu Putra Bayu Putra Bayu Putra Bayu Putra, Bayu Besse Ati Dahlan, Andi Muhriani Dewi Yuliana Dharmawat, Dewi Tri Dian Rahayu Dina Izza Eni, Nur Syahira Atika Filla Riski Filman Afrian Fitri Nur Awaliyah Fahmi Hamid Habbe Hasmi, Nur Hendra Herman Hendra Herman Hilman Erwin Idawati Idawati, Indira Istikamah Indra Indra Irma Rachma Hanifah Irmayani Irmayani Isma, Aidil Febryan Arya Isyanda, Kenanga Kamri, Andi Khaedhir Karisa, Astuti Khaerana Majid Kristina T. Kristina T. Lestari Novianti Mamat Pratama, Mamat Marwah Marwah MEDIATY Melly Amanda Mirawati Mirawati Muh. Reski Muhammad Ali Murniati Hasan Muzakkir Baits Nabila Said Nadiah Apriliani Nindy Precyllia Ningsih, Yuyun S Nur Azizah, Rizqi Nur Rahma Nuraenun Nuraenun Nurbaeti Asnawi Nurfadillah Nurfadillah Nurhudayah Nurhudayah Nurlina Nurlina Nurul Fadilla Octavia, Rizka Putra , Bayu Rachmat Kosman Rachmat Kosman Rachmat Kosman Rachmat Kosman Rachmat Kosman, Rachmat Rahma Khairiyani Rahmawati Rahmawati Rahmawati Rahmawati Ramli, Irawati Ratu Ananda Riskiyani Rukmana Risti Yuni Rizqi Nur Azizah Rizqi Nur Azizah Rosmayanti Rosmayanti Sadjidin, Sugiarto Safitri Ayu Safriani Rahman Shinta Ferawati Sitti Amirah Sitti Azahra Sri Wahyuni Sri Wahyuninsih Suci Pertiwi sukmawati Sukmawati Sukmawati Tadjuddin Naid Tri Kurniawati Waode Yumnal Utamil Yundari, Yundari Zainal Abidin Zakinah Aulia