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All Journal e-Journal Pustaka Kesehatan Jurnal Kesehatan Masyarakat (IKESMA) STOMATOGNATIC- Jurnal Kedokteran Gigi Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Warta Pengabdian Padjadjaran Journal of Dental Researchers and Students Journal of Community Service and Empowerment Odonto dental journal
Tantin Ermawati
Bagian Ilmu Kesehatan Gigi Masyarakat, Fakultas Kedokteran Gigi, Universitas Jember
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health Social Sciences Other

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Efek pemberian gel ekstrak biji kopi robusta (Coffea canephora) terhadap jumlah osteoblas dan osteoklas pada tulang alveolar tikus periodontitisThe effect of robusta coffee bean (Coffea canephora) extract gel on the number of osteoblasts and osteoclasts in the alveolar bone of periodontitis rats Nadie Fatimatuzzahro; Tantin Ermawati; Rendra Chriestedy Prasetya; Pintan Qorina Destianingrum
Padjadjaran Journal of Dental Researchers and Students Vol 4, No 2 (2020): Oktober 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v4i2.28383

Abstract

Pendahuluan: Periodontitis adalah peradangan jaringan pendukung gigi yang disebabkan oleh mikroorganisme, salah satunya Porphyromonas gingivalis, yang dapat menginduksi makrofag dan limfosit serta menstimulasi osteoblas untuk meningkatkan receptor activator of nuclear factor kβ-ligand (RANKL) dan menurunkan osteoprotegerin (OPG). Kondisi inflamasi yang berlanjut mengakibatkan OPG sedikit mengikat RANKL, sehingga RANKL berikatan dengan receptor activator of nuclear factor kβ (RANK) pada prekusor osteoklas. Hal ini akan mengaktifkan osteoklas dan menyebabkan kerusakan tulang. Osteoblas dan osteoklas berperan dalam keseimbangan resorpsi dan aposisi tulang. Biji kopi robusta mengandung senyawa aktif polifenol, alkaloid, dan saponin, yang bersifat antiinflamasi. Penelitian ini bertujuan untuk menganalisis efek gel ekstrak biji kopi robusta (C. canephora) terhadap jumlah osteoblas dan osteoklas pada tulang alveolar tikus periodontitis. Metode: Jenis penelitian eksperimental laboratoris, menggunakan teknik random sampling untuk penelitian in-vivo, diperoleh minimal sampel sebanyak 4 ekor tikus tiap kelompok; kelompok normal (KN); kelompok kontrol negatif gel plasebo K(-)7 dan K(-)14; kelompok kontrol positif gel aloclair K(+)7 dan K(+)14; dan kelompok gel ekstrak biji kopi 50% (KP7 dan KP14). Hewan coba didekapitasi pada hari ke-7 dan 14 setelah pemberian terapi gel, kemudian dilakukan pemrosesan jaringan dan pewarnaan HE. Penghitungan osteoblas dan osteoklas pada area sekitar tulang alveolar bukal M1 kiri bawah. Hasil: Terdapat perbedaan yang signifikan (p=0,001) antara rerata jumlah osteoblas kelompok gel ekstrak kopi (33,83±1,37) dibanding kontrol positif (23,24±2,31) dan kontrol negatif (18,91±2,07). Rerata jumlah osteoklas berbeda signifikan (p=0,001) pada kelompok gel ekstrak kopi (0,66±0,54) dibanding kontrol positif (3,08±1,10) dan kontrol negatif (4,00±2,07) (p=0,010). Simpulan: Pemberian gel ekstrak biji kopi robusta (C. canephora) dapat meningkatkan jumlah osteoblas dan menurunkan osteoklas pada tulang alveolar tikus periodontitis.Kata kunci: Gel ekstrak biji kopi robusta, osteoblas, osteoklas, periodontitis. ABSTRACTIntroduction: Periodontitis is an inflammatory disease affecting the teeth supporting tissues caused by specific microorganisms; one of them is Porphyromonas gingivalis, which can induce the macrophages and lymphocytes, then stimulate the osteoblasts to increase the receptor activator of nuclear factor kβ-ligand (RANKL) and decrease osteoprotegerin (OPG). Continued inflammatory conditions cause OPG to bind slightly to the RANKL; thus the RANKL will be able to binds to the receptor activator of nuclear factor kβ (RANK) in osteoclast precursors, which will activate the osteoclasts and cause bone damage. Osteoblasts and osteoclasts play a vital role in the balance of bone resorption and apposition. Robusta coffee beans contain active compounds such as polyphenols, alkaloids, and saponins, which act as anti-inflammatory agents. This research was aimed to analyse the effect of robusta coffee bean (C. canephora) extract gel on the number of osteoblasts and osteoclasts in the alveolar bone of periodontitis rats. Methods: Experimental laboratory research with simple random sampling technique for in-vivo study obtained the minimal sample number of 4 rats in each group; normal group (KN); negative control group placebo gel K(-)7 and K(-)14; positive control group of aloclair gel K(+)7 and K(+)14; and robusta coffee bean 50% extract gel group (KP7 and KP14). The rats were decapitated in the 7th and 14th days after treatment, and then the tissue processing and hematoxylin-eosin staining was carried out. Osteoblasts and osteoclasts were counted in the area around the buccal alveolar bone of the lower-left M1. Results: The results showed a significant difference (p = 0.001) between the mean number of osteoblasts in the coffee extract gel group (33.83 ± 1.37) compared to the positive control group (23.24 ± 2.31) and the negative control group (18.91± 2.07). The mean number of osteoclasts was also had a significant difference (p = 0.001) in the coffee extract gel group (0.66 ± 0.54) compared to the positive control group (3.08 ± 1.10) and (p = 0.010) with the negative control group (4.00 ± 2.07). Conclusion: Robusta coffee bean (C. canephora) extract gel can increase the number of osteoblasts and decrease the number of osteoclasts in the alveolar bone of periodontitis rats.Keywords: Robusta coffee bean extract gel, osteoblasts, osteoclasts, periodontitis.
Inhibition activity of Robusta coffee beans polyphenol extract on the production of TNF-α neutrophil cells Tantin Ermawati; Zahara Meilawaty; Happy Harmono
Majalah Kedokteran Gigi Indonesia Vol 4, No 2 (2018): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1230.046 KB) | DOI: 10.22146/majkedgiind.28352

Abstract

Polyphenols are one of the active substances in the Robusta coffee beans with various benefits for humans’ health including anti-inflammation. neutrophil cell (polymorphonuclear PMN) plays a significant role as the primary immune response against foreign agent. Inflammatory response is characterized by the production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α). Hence, the purpose of this study is to determine anti-inflammation capacity of Robusta coffee beans polyphenols extract on the TNF-α production in neutrophil cells. Neutrophil was derived from human peripheral venous blood by means of gradient density method. One hundred microliter of neutrophil  (1,5x103 cell) was incubated with 3.13%, 6.25%, 12.5%, 25% polyphenol extract and exposed with 100 μl of Lipopolysaccharides (LPS) 25 mg/ml. The production of TNF-α were determined by ELISA. Data were analyzed by one way Anova. Polyphenols of Robusta coffee bean extract was shown to inhibit TNF-α production in LPS-exposed neutrophil cells compared to controls. Whereas, LPS-exposed neutrophil increased TNF-α production. The most effective concentration to inhibit TNF-α production was 12.5%. It was concluded that polyphenols of Robusta coffee beans has anti-inflammatory properties as indicated by its ability to decrease TNF-α levels.
Daya Antibakteri Ekstrak Kulit Apel Manalagi (Malus sylvestris Mill.) Terhadap Pertumbuhan Streptococcus mutans (Antibacterial Activity of Manalagi Apple Peel (Malus sylvestris Mill.) Extract on The Growth of Streptococcus mutans) Jannata Hafidata Rabbani; Gunadi Achmad; Ermawati Tantin
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Apple is a popular fruit which is consumed by many people in Indonesia. Manalagi apple's peel contains polyphenols that have antibacterial effects. Streptococcus mutans is the normal flora that can cause oral disease. One of alternative medications to prevent the disease by using natural products as antibacterial. This research is aimed to determine the antibacterial activity manalagi apple's peel extract on the growth of S. mutans and minimum concentration to inhibit growth. The method of this research is well diffusion method with 8 samples for each treatment. Samples consisted of five treatment groups which is manalagi apple's peel extract with concentration of 100%, 50%, 25%, positive control group (chlorhexidine 0.2%), and negative control group (aquadest sterile). Data were analyzed using the Kruskal-Wallis and Mann-Whitney test. The results of this research showed that manalagi apple's peel extract at all concentrations have antibacterial activity against the growth of S.mutans. Minimum inhibition concentration of manalagi apple's peel extract is 25%. The conclusion of this research proves that manalagi apple's peel extract has antibacterial activity against S.mutans growth.   Keywords: Antibacterial activity, manalagi apple's peels, Streptococcus mutans, well difussion method.
PROFIL KEBERSIHAN DAN PERILAKU MENJAGA KESEHATAN GIGI DAN MULUT PADA LANSIA DI DESA DARSONO KABUPATEN JEMBER Tantin Ermawati
Jurnal Ilmu Kesehatan Masyarakat Vol 12 No 2 (2016)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Jember

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Abstract

Pendahuluan: Pembangunan kesehatan di Indonesia dititik-beratkan untukmeningkatkan kesehatan masyarakat yang berkualitas secara menyeluruh, terpadu, danberkelanjutantermasuk didalamnya kesehatan gigi dan mulut lanjut usia (lansia).Kebersihan gigi dan mulut merupakan masalah yang sangat perlu diperhatikan pada lanjutusia, karena dapat memicu timbulnya berbagai penyakit di rongga mulut.Tujuan Penelitian: Untuk mengetahui profil kesehatan gigi dan mulut lansia denganmelihatstatus kebersihan mulut oral hygiene indeks simplified (OHI-S) didesa DarsonoKecamatan Arjasa Kabupaten Jember.Metode Penelitian: Jenis penelitian ini adalah diskriptif observasional secara crosssectional yang dilakukan pada lansia bulan september 2016. Lansia yang yang terlibatberjumlah 44 orang meliputi laki-laki dan perempuan. Pemeriksaan yang dilakukan adalah skor debris dan kalkukus menggunakan Oral Hygiene Index Simplified (OHI-S)Green and Vermillion, 1964Hasil Penelitian: menunjukkan pra lansia yang memiliki OHI-S baik hanya 2 orang (10%dari total lansia yang dilakukan pemeriksaan), dan pada kelompok lansia skor OHI-S yangbaik hanya berjumlah 2 orang (10,5 %), sisanya memiliki OHI-S buruk. Kondisi kebersihanmulut lansia di Desa Darsono Kecamatan Arjasa Kabupaten Jember dalam kondisi buruksehingga perlu dilakukan peningkatan kesehatan gigi dan mulutnya yang lebih intensive. Kata Kunci : Kesehatan gigi mulut, Lansia, Indeks OHI-S, Desa Darsono, KecamatanArjasa Jember
HUBUNGAN PENGETAHUAN KESEHATAN GIGI MULUT DENGAN STATUS KEBERSIHAN RONGGA MULUT PADA LANSIA Desi Sandra Sari; Yuliana Mahdiyah Daat Arina; Tantin Ermawati
Jurnal Ilmu Kesehatan Masyarakat Vol 11 No 1 (2015)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Jember

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Abstract

Oral health among elderly people needs a specially attention because it will affect their general health. A good knowledge of oral hygiene is essential to prevent oral disease. Therefor maintenance of oral hygiene was the best way to maintain the health condition of the elderly people. The purpose of this research was to determine the correlation between oral health knowledge of elderly people with oral health status in the working area ofPuskesmas Kalisat Jember. This study was observasional research on 80 elderly people aged 50-70 years old who came to 12 elderly posyandu of Puskesmas Kalisat Jember. Data were collected by structured questionnaires about oral health knowledge and clinical examination to determine oral hygiene status based on Oral Hygiene Index-simplified (OHIS). Pearson correlation was used for statistical analysis. Most of participant demontratedoral health knowledge score as sufficient category (52,5%) and the oral hygiene status was moderate (57,5%). The correlation between the level of oral health knowledge with OHI-S index was significant (p< 0,05). Among elderly people, the knowledge of oral health correlated with the oral hygiene.Keywords: elderly, dental health, Index OHI-S, Puskesmas Kalisat Jember
EFFECTS OF ROBUSTA COFFEE BEAN EXTRACT (Coffea robusta) ON THE VIABILITY OF NEUTROPHILS EXPOSED BY Porphyromonas gingivalis Tantin Ermawati
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

The new paradigm evolving today in thetreatment of periodontal infection is the use a hostmodulator therapy i.e. therapy that aims to improvethe host immune response to bacterial infection.Good immune response is necessary in increasingthe phagocytic function that in this case is played byneutrophil cells, monocytes and macrophages, whichserved as the first line of defense against bacterialinfections. One of the bacteria causing periodontalinfection is P. gingivalis. It has the biggest role incausing periodontal disease, where in the proteolyticenzyme such as gingipain contributes to thebacterial pathogenicity.1, 2 During the initial invasionP. gingivalis will colonize the gingival sulcus andinvade into the gingival tissues and will induce aninflammatory response and continue to alveolarbone resorption.3The immune response that acts first againstinvading bacteria is neutrophils. The presence ofbacterial adhesion to neutrophils allows neutrophilssecrete microbicidal substance by destroying thebacterial membrane and fagocyting bacteria. Aneutrophil can phagocyte bacteria before becominginactive or cell lysis. Phagocytosis that occurs canaffect the lysis of neutrophils. This can emerge veryfatal impacts because if the neutrophils undergo lysisthen chemical components and enzymes may breakinto the tissue leading to degradation of variousorganic molecules of its adjacent tissue.4 NowdaysIndonesia has developed a lot of research onmedicinal plants, such as Robusta coffee beans.Robusta coffee beans naturally have substances suchas caffeine, phenolic compounds, trigonellin andchlorogenic acid which have antibacterial activity.Besides as antibacterial chlorogenic it also hasantioxidant properties.5 Based on the abovebackground, the researchers want to developRobusta coffee beans as host modulator therapy tomaintain the viability of neutrophils by observingneutrophil cell viability against P. gingivalis appliedby Robusta coffee bean extract which will be usefulfor preventing periodontal tissue infections of theoral cavity.
Antimicrobial effect of chlorine dioxide on Actinobacillus actinomycetemcomitans in diabetes mellitus rats treated with insulin Tantin Ermawati; Kwartarini Murdiastuti
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 1 (2012): March 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.191 KB) | DOI: 10.20473/j.djmkg.v45.i1.p22-27

Abstract

Background: Periodontitis is a chronic inflammatory disease of periodontal tissues. Etiology of periodontal disease includes Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) which is the most predominant disease-causing bacteria found in the gingival sulcus. Periodontitis can be exacerbated by the systemic disease, such as diabetes mellitus considered as a metabolic disease characterized by hyperglycemia due to insulin deficiency. Treatment of periodontitis is then required in patients with type I diabetes to avoid radical reaction that can not only cause bleeding, but can also prevent infection, as a result, topical antimicrobial therapy and blood glucose control are required. Topical antimicrobial chlorine dioxide is a disinfectant that is effective in killing A. actinomycetemcomitans. Purpose: This study is aimed to determine the effects of topical antimicrobial chlorine dioxide gel or rinse on the number of A. actinomycetemcomitans in DM rats treated with insulin. Methods: 20 three month old male Wistar rats with weight of 170–200 grams were divided into four groups. First, periodontitis and DM were manipulated into all groups through aloksan injection with dose of 170 mg/kg. Those rats in group I were treated with insulin and chlorine dioxide gel, those in group II were treated with insulin and chlorine dioxide rinse, those in group III were treated with insulin only, and those in group IV were without treatment. In the third and seventh weeks, the number of A. actinomycetemcomitans was measured. The data was tested by using One-Way ANOVA test followed by LSD test. Results: The study showed that chlorine dioxide gel has a greater ability in reducing the number of A. actinomycetemcomitans than chlorine dioxide rinse although both are antimicrobials. Conclusion: It can be concluded that the use of chlorine dioxide gel can more effective to decrease the number of A. actinomycetemcomitans than chlorine dioxide rinse in DM rats treated with insulin therapy.Latar belakang: Periodontitis adalah suatu penyakit inflamasi kronis jaringan periodontal. Etiologi penyakit periodontal diantaranya adalah A. actinomycetemcomitans yang merupakan bakteri paling dominan penyebab penyakit yang terdapat pada actinomycetemcomitans yang merupakan bakteri paling dominan penyebab penyakit yang terdapat pada sulkus gingiva. Periodontitis yang terjadi diperparah adanya penyakit sistemik yaitu diabetes mellitus (DM) yang merupakan penyakit metabolik yang ditandai dengan hiperglikemi akibat defisiensi insulin. Perawatan periodontitis pada penderita DM tipe I adalah untuk Perawatan periodontitis pada penderita DM tipe I adalah untuk menghindari tindakan radikal yang dapat menyebabkan perdarahan dan mencegah terjadinya infeksi, sehingga digunakan terapi antimikroba topikal serta kontrol glukosa darah. Antimikroba topikal chlorine dioxide merupakan desinfektan yang efektif dalam membunuh A. actinomycetemcomitans. Tujuan: Penelitian ini bertujuan untuk mengetahui efek antimikroba topikal chlorine dioxide gel atau rinse terhadap jumlah A. actinomycetemcomitans pada tikus DM dengan insulin. Metode: Dua puluh ekor tikus Wistar, jantan, usia 3 bulan, berat 170–200 gram, dibagi menjadi empat kelompok. Semua kelompok sebelumnya dimanipulasi periodontitis serta DM dengan injeksi aloksan dosis 170 mg/kgBB. Kelompok I adalah tikus yang diterapi insulin dan chlorine dioxide gel, kelompok II diterapi insulin dan chlorine dioxide rinse, kelompok III diterapi insulin, serta kelompok IV adalah tikus tanpa dilakukan terapi apapun. Pada minggu ke-3 dan ke-7 dilakukan penghitungan jumlah A. actinomycetemcomitans. Hasil pengukuran di analisis menggunakan uji Anava 1 jalur dilanjutkan dengan uji LSD. Hasil: Penelitian menunjukkan bahwa chlorine dioxide gel mempunyai kemampuan lebih besar dalam menurunkan jumlah A. actinomycetemcomitans dibandingkan chlorine dioxide rinse, walaupun keduanya bersifat antimikroba. Kesimpulan: Dapat disimpulkan bahwa pemberian chlorine dioxide gel lebih efektif menurunkan jumlah A. actinomycetemcomitans dibandingkan kelompok yang diberi chlorine dioxide rinse pada tikus DM dengan terapi insulin.
Efektivitas perasan daun seledri (Apium graveolens Linn.) sebagai pembersih gigi tiruan terhadap pertumbuhan Candida albicans pada basis gigi tiruan nilon termoplastikThe effectiveness of celery leaf juice (Apium graveolens Linn.) as a denture cleaner against the growth of Candida albicans on thermoplastic nylon denture base Dhilan Purna Aji; Achmad Gunadi; Tantin Ermawati
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 32, No 3 (2020): Desember 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v32i3.28877

Abstract

Pendahuluan: Basis gigi tiruan nilon termoplastik merupakan alternatif pengganti basis gigi tiruan resin akrilik. Pembersihan gigi tiruan diperlukan untuk menjaga basis gigi tiruan agar tetap bersih dari kontaminasi mikroorganisme. Daun seledri merupakan bahan alam yang memiliki kandungan flavonoid, saponin, tanin, dan minyak atsiri yang sudah terbukti bersifat antijamur. Penelitian sebelumnya hanya melihat zona hambat saja. Tujuan penelitian adalah menganalisis efektivitas perasan daun seledri sebagai pembersih gigi tiruan terhadap pertumbuhan Candida albicans pada basis gigi tiruan nilon termoplastik. Metode: Eksperimental laboratoris dengan rancangan penelitian post-test only control group design. Sampel nilon termoplastik berbentuk cakram dengan diameter 10 mm dan tebal 2 mm  sebanyak 25 dibagi menjadi 5 kelompok. Sampel dikontaminasi dengan C. albicans setelah direndam dalam kontrol negatif (akuades) selama 6 jam, kontrol positif (tablet effervescent) selama 15 menit, dan perasan daun seledri konsentrasi 25, 50, dan 100% selama 6 jam. Sampel selanjutnya diletakkan dalam media sabouraud dextrose broth (SDB). Pengujian efektivitas perasan daun seledri dilakukan dengan menentukan nilai absorbansi kekeruhan media SDB menggunakan spektrofotometer. Data dianalisis menggunakan one-way ANOVA dan Least Significant Difference (LSD). Hasil: Nilai konsentrasi C. albicans pada kelompok kontrol negatif mendapatkan hasil 0,380 x 108 CFU/mL, kontrol positif mendapatkan hasil 0,310 x 108 CFU/mL, perasan daun seledri konsentrasi 25% mendapatkan hasil 0,243 x 108 CFU/mL, konsentrasi 50% mendapatkan hasil 0,160 x 108 CFU/mL, dan konsentrasi 100% mendapatkan hasil 0,236 x 108 CFU/mL. Simpulan: Perasan daun seledri efektif sebagai pembersih gigi tiruan untuk menghambat  pertumbuhan C. albicans, dengan konsentrasi yang efektif sebesar 50%.Kata kunci: Nilon termoplastik, perasan daun seledri, Candida albicans. ABSTRACTIntroduction: Thermoplastic nylon denture base is an alternative to the acrylic resin denture base. Denture cleaning is needed to keep the denture base clean from contamination by microorganisms. Celery leaves are natural ingredients that contain flavonoids, saponins, tannins, and essential oils that have been proven to have antifungal properties. Previous research only observed the inhibitory zone. This research was aimed to analyse the effectiveness of celery leaf juice as a denture cleaner against the growth of Candida albicans on thermoplastic nylon denture base. Methods: Experimental laboratory with a post-test only control group design was conducted towards 25 disc-shaped thermoplastic nylon samples with a diameter of 10 mm and a thickness of 2 mm, and divided into five groups. Samples were contaminated with C. albicans after immersion in the negative control (aquadest) for 6 hours, positive control (effervescent tablets) for 15 minutes, and celery leaf juice with the concentrations of 25, 50, and 100% for 6 hours. The sample was then placed in the Sabouraud-dextrose broth (SDB) medium. The effectiveness of celery leaf juice was tested by determining the absorbance value of SDB media turbidity using a spectrophotometer. Data were analysed using one-way ANOVA and Least Significant Difference (LSD). Results: The concentration value of C. albicans in the negative control group was 0.380 x 108 CFU / mL, the positive control was 0.310 x 108 CFU / mL, the juice of celery leaves with the concentration of 25% was 0.243 x 108 CFU / mL, the concentration of 50% was 0.160 x 108 CFU / mL, and the concentration of 100% was 0.236 x 108 CFU / mL. Conclusion: Celery leaf juice is effective as a denture cleaner to inhibit the growth of C. albicans, with an effective concentration of 50%.Keywords: Thermoplastic nylon, celery leaf juice, Candida albicans.
Daya Hambat Ekstrak Biji Kopi Robusta (Coffea canephora) terhadap Pertumbuhan Fusobacterium nucleatum Anisa Nur Hakima; Tantin Ermawati; Happy Harmono
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 17 No 1 (2020)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v17i1.23608

Abstract

Fusobacterium nucleatum is a bacteria found in normal flora of the oral cavity that plays a role in the occurrence of periodontal disease. The prevalence of periodontal disease in Indonesia reaches 70%. One treatment by using medicinal plants is robusta coffee beans. Robusta coffee beans contain volatile acids, chlorogenic acids, caffeine acids, phenols and caffeine suspected to be antibacterial. The aim was to determine the inhibition of coffee robusta extract on growth of Fusobacterium nucleatum. This study used disc diffusion method with 4 samples in each study group. The study group consisted of 6 treatment groups (12,5%, 25%, 50% and 100% coffee robusta extract), positive control group (chlorhexidine gluconate 0,2%), and negative control group (sterile aquades). Data were analyzed using One Way Anova test and LSD (Least Significant Difference) test. Coffee robusta extract has the ability to inhibit the growth of Fusobacterium nucleatum. The concentration of coffe robusta extract 100%, 50%, 25%, 12,5% have same ability to inhibit the growth of Fusobacterium nucleatum.
HUBUNGAN KADAR GLUKOSA DARAH DENGAN PERTUMBUHAN A. actinomycetemcomitans PADA TIKUS DIABETES MELITUS Tantin Ermawati
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 9 No 1 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Diabetes mellitus is a systemic disease characterized by insulin deficiency. Common symptoms in people with diabetes is elevated blood glucose is called hyperglycemia. Manifestations in the oral cavity are inflammation of gingival tissue or periodontitis. The bacteria that play a role in the severity of periodontal disease is A. actinomycetemcomitans. The purpose of this study was to determine the relationship of blood glucose levels with the growth of A. actinomycetemcomitans in DM rats treated with insulin therapy. Methode 20 three month old male Wistar rats with weight of 170-200 grams were divided into two groups. First, periodontitis and DM were manipulated into all groups through aloksan injection with dose of 170 mg/kg. Those rats in group I were treated with insulin, those in group II were without treatment. In the third and seventh weeks, the blood glucose levels and the number of A. actinomycetemcomitans was measured. The data was tested by using Pearson test. The results showed that there is a strong relationship between blood glucose levels with the growth of A. actinomycetemcomitans. Conclusion: The increasing blood glucose levels are very strongly associated with an increase in the number of A. actinomycetemcomitans and otherwise in DM rats with insulin therapy.
Co-Authors Achmad Gunadi Anisa Nur Hakima Depi Praharani Desi Sandra Sari Dessy Rachmawati Dhilan Purna Aji Dwi Warna Aju Fatmawati Favinas Octa Nuri Tsalats Febriana Tria N Hakima, Anisa Nur Happy Harmono Ika Wahyu Purnamasari Jannata Hafidata Rabbani Kartikasari, Dania Kwartarini Murdiastuti M Melok M Melok, M Mei Syafriadi Nadie Fatimatuzzahro Nazilatur Rohmah Nazilaturrohmah Nulend, Jenneke Klein Nurul Iffah, Astrid Ganadya Peni Pujiastuti Pintan Qorina Destianingrum Pudji Astuti Rendra Chriestedy Prasetya Riezki Dwianggraini W Riezki Dwianggraini W, Riezki Ristya Widi Endah Yani Suhartini Suhartini Suhartini Suhartini Tecky Indriana Yuliana Mahdiyah Daat Arina Zahara Meilawati Zahara Meilawaty Zahreni Hamzah