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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Lingkungan AL KAUNIYAH Jurnal Kimia dan Kemasan Journal of Tropical Biodiversity and Biotechnology Caraka Tani: Journal of Sustainable Agriculture BIOEDUSCIENCE Spektra: Jurnal Fisika dan Aplikasinya Pharmacoscript Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Kimia dan Kemasan Biodiversitas Journal of Biological Diversity Nusantara Bioscience
Windri Handayani
Department Of Biology, Faculty Of Mathematics And Natural Sciences, Universitas Indonesia, Depok
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Other

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QUANTIFICATION OF TOTAL FLAVONOID CONTENT IN FRACTIONATED YOUNG LEAF EXTRACTS OF RED SHOOT LEAVES (Syzygium myrtifolium) USING UV-VIS SPECTROPHOTOMETRY Vilya, Syafriana; Rika, Amelia; Nissa, Maftucha; Munawarohthus, Sholikha; Windri, Handayani; Yasman, Yasman
Pharmacoscript Vol. 8 No. 1 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i1.2075

Abstract

Syzygium myrtifolium (red shoot leaves) is widely known for its rich phytochemical profile, particularly flavonoids, which exhibit various pharmacological properties. This study aimed to determine the total flavonoid content in the crude extract, n-hexane fraction, ethyl acetate fraction, and water fraction of red shoot leaves (Syzygium myrtifolium) using a colorimetric method with quercetin as a standard. The results revealed that the ethyl acetate fraction had the highest flavonoid content (65.781 ± 6.365 mgQE/g), followed by the crude extract (26.093 ± 0.961 mgQE/g), n-hexane fraction (18.293 ± 2.925 mgQE/g), and water fraction (12.583 ± 0.824 mgQE/g). The study also found that the solvent polarity significantly influenced the flavonoid extraction efficiency, with ethyl acetate, a moderately polar solvent, being most effective for isolating flavonoid aglycones. The n-hexane fraction contained polymethyl flavonoids, which are more soluble in nonpolar solvents, while flavonoid glycosides were more soluble in polar solvents like water and alcohol mixtures. Furthermore, the research highlights the importance of extraction methods, as the total flavonoid content in mature red shoot leaves was found to be higher than in younger leaves, likely due to increased secondary metabolite production in mature tissues. This study emphasizes the role of solvent polarity in flavonoid extraction and provides insights into the phytochemical composition of S. myrtifolium leaves for potential applications in natural product research.
Zooremediation: Utilizing Animals for Environmental Purification and Pollution Mitigation Aini, Fadita Nurul; Nisa, Upi Chairun; Handayani, Windri; Maryenti, Tety; Yasman, Yasman
BIOEDUSCIENCE Vol 9 No 2 (2025): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/18376

Abstract

Background: The global human population continues to grow rapidly, leading to increasing urban waste and environmental contamination. One emerging and promising approach to mitigating this pollution is zooremediation, which utilizes animals as biological agents for environmental cleanup. This review aims to critically assess the effectiveness of various animal species in removing specific classes of pollutants, with particular attention to their mechanisms of action—zooextraction, zootransformation, and zooaccumulation—and the environmental conditions under which they operate. Effectiveness is evaluated based on pollutant removal efficiency, adaptability to contaminated environments, and ecological safety. Methods: Through systematic literature analysis, we identified key species, including Geukensia demissa, Daphnia magna, and Anadara granosa, which demonstrated measurable success in the remediation of aquatic environments contaminated with heavy metals and organic pollutants. Additionally, soil-dwelling nematodes such as Caenorhabditis elegans and Cephalobus persegnis play critical roles in hydrocarbon degradation and in enhancing microbial synergy in polluted substrates. These findings highlight the diverse functional capacities of animals in bioremediation efforts. The methodology employed in this study is a comprehensive literature review, focusing on peer-reviewed articles published over the last two decades. Results: This review synthesizes findings related to pollutant types, animal species used in zooremediation, remediation outcomes, and ecological impacts. By critically examining existing studies, the evaluation identifies trends, gaps, and challenges in the application of zooremediation. Conclusion: Future research should focus on understanding the long-term impacts, optimizing protocols, and safeguarding both ecological and animal health to fully realize the potential of zooremediation in managing environmental pollution on a global scale.
Comparative Study of The Physiological Condition of Six Tree Species to Air Pollution in Depok City, West Java Ayunda, Ajenk; Yuniati, Ratna; Handayani, Windri
BIOEDUSCIENCE Vol 7 No 2 (2023): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/9749

Abstract

Background: Air pollution is a threat to the environment. Sources of air pollutants in urban environments can be in the form of dust, heavy metals, and hydrocarbons. Plants can help clean air pollutants from the atmosphere by absorption through the stomata, accumulating them, or by adsorption on the leaf surface. The Air Pollution Tolerance Index (APTI) is used as an evaluation benchmark for the Physiological conditions of plants exposed to air pollution. This research aims to study the physiological conditions of six tree species in air conditions in the Depok City area and to assess the plants' tolerance level based on the APTI calculation. Methods: The physiological parameters measured to calculate APTI were ascorbic acid, total chlorophyll, leaf extract pH, and Relative Water Content (RWC). The six tree species used as objects in this study were Artocarpus altilis, Artocarpus heterophyllus, Bauhinia purpurea, Ficus septica, Filicium decipiens, and Nephelium lappaceum. Results: Differences in the physiological conditions of six tree species in the Depok City area based on the average ascorbic acid values, total chlorophyll, leaf extract pH, and RWC. In addition, there are also differences in APTI parameters between the two research locations. Conclusions: Filicium decipiens is the plant species with the highest APTI, while Artocarpus heterophyllus has the lowest. Based on the APTI scores, Bauhinia purpurea, Ficus septica, Filicium decipiens, Nephelium lappaceum belong to moderately tolerant category, Artocarpus altilis belongs to an intermediate category, Artocarpus heterophyllus belongs to sensitive category.
Metabolite Profiling and Bioprospecting of Acrolejeunea fertilis (Reinw., Blume & Nees) Schiffn. from Kebun Raya Cibodas, West Java Ramadhani, Nadhifa Tazkia; Handayani, Windri; Yasman, Yasman; Putrika, Afiatry
BIOEDUSCIENCE Vol 8 No 1 (2024): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/13187

Abstract

Background: Acrolejeunea fertilis (liverwort) is known for having various potential natural products. However, its abundance is limited, and its secondary metabolites have not been extensively investigated. The in vitro culture technique might enhance its biomass. Methods: This study aimed to investigate the metabolite profile of A. fertilis from Kebun Raya Cibodas grown in situ and in vitro. The bioactivity, including antioxidant, total phenolic, and flavonoid content and antibacterial activity, was also evaluated. The in vitro culture of A. fertilis used ½ MS media with the addition of 0,1 mg/L of 2,4-D and one mg/L of Kinetin. Methanol and n-hexane were used for extraction. Gas Chromatography-Mass spectrometry (GC-MS) is used for metabolite profiling. Results: The optimum IC50 value from n-hexane extract is 68,18±2,65 mg/L. The highest yield of total phenolic and flavonoid content from in situ methanol extract, which resulted in 130,68±0,002 µgGAE/gr and 5,97±0,01 µgQE/gr, respectively. Antibacterial activities were evaluated by measuring the zone of inhibition for S. aureus and E. coli. The optimum area measured from in situ n-hexane extract was 23,91±1,54 and 13,08±0,23 cm, respectively. Conclusions: These findings carry important implications for the further development of natural products obtained from liverwort regarding its potential as a bioactive compound.
Exploring the Pharmacological Potential of Centella asiatica: A Metabolomic Perspective on a Traditional Medicinal Plant Aini, Fadita Nurul; Yuwana, Cynthia Putri; Maryenti, Tety; Nisa, Upi Chairun; Yuniati, Ratna; Handayani, Windri; Yasman, Yasman
BIOEDUSCIENCE Vol 10 No 1 (2026): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/18857

Abstract

Background: Centella asiatica, also known as Gotu Kola or Pennywort, is a medicinal herb with a long history of use in traditional systems such as Mediterranean Herbal Medicine, Ayurveda, and Traditional Chinese Medicine. Its longstanding use highlights its importance as a natural remedy for various health conditions.   Methods: Recent metabolomics-based studies have advanced our understanding of its pharmacological potential by identifying key bioactive compounds—including phenolics, triterpenoids, and saponins—through analytical techniques such as GC-MS, LC-MS, and NMR.   Results: These compounds contribute to a range of therapeutic effects, notably antioxidant and antibacterial activities. C. asiatica has demonstrated efficacy against antibiotic-resistant pathogens like Staphylococcus aureus and Pseudomonas aeruginosa, as well as the ability to mitigate oxidative stress.   Conclusions: The integration of pharmacological and metabolomics approaches has highlighted its potential for development into herbal medicines and health supplements. While further research is warranted to optimize formulation and clinical application, existing evidence provides a solid foundation for the advancement of C. asiatica as a natural product for promoting human health and addressing antimicrobial resistance.
The Threat of Aquatic Invasive Species: Understanding and Addressing Biological Pollution Cynthia Putri Yuwana; Windri Handayani; Upi Chairun Nisa; Tety Maryenti; Ratna Yuniati; Yasman Yasman
Jurnal Ilmu Lingkungan Vol 23, No 3 (2025): May 2025
Publisher : School of Postgraduate Studies, Diponegoro Univer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jil.23.3.678-687

Abstract

This review explores the impact of aquatic invasive species as biological pollutants that disrupt ecosystems globally, including in Indonesia. Invasive species often exhibit rapid growth and reproduction due to their adaptive advantages, which, combined with human activities and favorable environmental conditions, accelerate their spread. These species alter the balance of marine and freshwater ecosystems, posing significant challenges for biodiversity conservation and resource management. Various regulatory measures have been implemented internationally, such as the European Union’s blacklist of invasive species and Indonesia’s legislative framework, to prevent their spread. Additionally, remediation techniques like zooremediation, using bivalves to mitigate biological pollutants, have been applied to manage these species. The review also highlights challenges in controlling invasive species, including the need for comprehensive ecosystem assessments and strategies like Top-Down and Bottom-Up modeling for management. Ultimately, a deeper understanding of the invasive species' ecological effects is essential for developing more effective control measures and policies, ensuring the protection of aquatic environments and mitigating the global spread of invasive species.
The Effect of Silver Nanoparticles Stabilized with Tannic Acid for Nano-Priming on Zea mays L. Seeds Germination Windri Handayani; Richard Owen Tanadi; Aminah Umar
Caraka Tani: Journal of Sustainable Agriculture Vol 40, No 1 (2025): January
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/carakatani.v40i1.85977

Abstract

Silver nanoparticles (AgNPs) have various benefits for application in the agricultural sector, such as nano-seed priming to enhance seedling growth and development. In this research, the effectiveness of AgNPs sizes and concentration to enhance Zea mays seeds germination has been investigated. The AgNPs were synthesized using various concentrations of tannic acid (0.025, 0.25, and 5 mM) to produce AgNPs with different sizes to know their optimum size and concentration. The synthesized AgNPs were characterized using a UV-Vis spectrophotometer to determine the absorption spectrum of AgNPs within 400 to 500 nm. Besides that, a transmission electron microscope (TEM) was used to determine the size and shape of the AgNPs, and an atomic absorption spectrophotometer was used to determine the concentration. The results show AgNPs with sizes of 13.39±2.40, 27.25±4.09, and 46.7±10.75 nm, respectively. Subsequently, AgNPs with concentrations of ~8, ~16, and ~24 mg l-1 were exposed to Z. mays seeds for 24 hours, then germinated for 14 days. The results revealed that AgNPs with a size of ~27 nm and a concentration of ~24 mg l-1 showed the highest germination rate and growth despite the control and other treatments. This indicates that the AgNPs with those properties have the potential as a seed nano-priming agent.
The capacity of trees to remove particulate matter and lead and its impact on tree health RATNA YUNIATI; WINDRI HANDAYANI; LAELIA NUGRAHANI; ITA KHOERUNNISA; HALIMAH HALIMAH; AFIATRY PUTRIKA; NIARSI MERRY HEMELDA
Biodiversitas Journal of Biological Diversity Vol. 25 No. 8 (2024)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d250826

Abstract

Abstract. Yuniati R, Handayani W, Nugrahani L, Khoerunnisa I, Halimah, Putrika A, Hemelda NM. 2024. The capacity of trees to remove particulate matter and lead and its impact on tree health. Biodiversitas 25: 2541-2551. In urban areas, common air pollutants include particulate matter (PM) and lead (Pb) particles. Plants offer a solution to mitigate both PM and Pb particles. However, PM and Pb deposition in plant leaf organs can have an impact on tree health, which can be evaluated from plant physiological aspects. A study was conducted to compare the capacity of several plant species to absorb PM and lead particles and to determine the impact of these pollutants on the physiological aspects of plants in two locations. The selected plant species were Cerbera odollam, Polyalthia longifolia, Swietenia macrophylla, and Terminalia mantaly. The four species were chosen based on their occurrence in two distinct locations: the Universitas Indonesia (UI) campus, which represents a low-pollution area, and the Bantargebang waste landfill, which represents a highly polluted area. The method employed involves using the Gravimetric Method and observing leaf morphology to evaluate the ability to capture PM, analyzing heavy metal accumulation to assess Pb particle adsorption, and examining leaf anatomy and physiology to determine tree health. Physiological aspects were observed, including chlorophyll content, carotenoid content, relative water content (RWC), and pH of leaf extract. The results showed that the highest PM deposit on plants leaf was observed in P. longifolia, followed by S. macrophylla, C. odollam, and T. mantaly. Pb analysis revealed the order of plants that accumulate Pb, from highest to lowest, is S. macrophylla>P. longifolia>C. odollam. The PM deposits significantly affected RWC (r=-0.522, p<0.01) and it affected the content of chlorophyll (r=-0.28) and carotenoids (r=-0.017). Of all the plants studied, S. macrophylla was the most impacted, with two physiological aspects affected: pigments (chlorophyll and carotenoids), and RWC. The selection of the four tree species as pollutant absorbers in Bantargebang landfill and UI Campus is appropriate, as tree health indicators, based on the analysis of leaf anatomy and physiological characteristics, detect minimal impact from environmental stress. Polyalthia longifolia (mast tree) would be the best performer among all the tree species.
Macroalgal community structure and beta diversity in the coastal waters of East Lombok, Indonesia ABDULLAH RASYID; MASTERIA YUNOVILSA PUTRA; WINDRI HANDAYANI; YASMAN YASMAN
Biodiversitas Journal of Biological Diversity Vol. 26 No. 7 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260703

Abstract

Abstract. Rasyid A, Putra MY, Handayani W, Yasman. 2025. Macroalgal community structure and beta diversity in the coastal waters of East Lombok, Indonesia. Biodiversitas 26: 3115-3124. Coastal ecosystems in East Lombok, Indonesia, are home to diverse macroalgal communities influenced by local environmental factors. This study investigates macroalgal community structure and beta diversity across three distinct locations: Station 1 (Dasan Ujung Beach), Station 2 (Telong Elong Beach), and Station 3 (Pinky Beach). The survey categorized macroalgae into Chlorophyta, Rhodophyta, and Phaeophyta, and employed Simpson and Sørensen dissimilarity indices alongside the nestedness-resultant component (?sne) to assess community variability. The results show that Station 2, with a complex substrate of coral rubble and calcareous mud, supported a more diverse macroalgal community, including calcifying species like Halimeda spp. In contrast, eutrophic conditions at Station 3 promoted the dominance of Ulva lactuca, a species indicative of nutrient-rich waters. The beta diversity indices reveal that substrate type and nutrient enrichment play critical roles in shaping macroalgal diversity and community composition, rather than water chemistry alone. These findings suggest that habitat heterogeneity and local anthropogenic pressures significantly influence coastal biodiversity. This study contributes new insights into the ecological drivers of macroalgal distribution in East Lombok and offers a framework for future marine conservation and monitoring.
Allelopathic activity of Dendrophthoe pentandra as a potential bioherbicide to inhibit seed germination and seedling growth of Eleusine indica Lutfan Alharits; Niarsi Merry Hemelda; Yasman; Windri Handayani
Nusantara Bioscience Vol. 12 No. 1 (2020)
Publisher : Smujo International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/nusbiosci/n120106

Abstract

Abstract. Alharits L, Hemelda NM, Yasman, Handayani W. 2020. Allelopathic activity of Dendrophthoe pentandra as a potential bioherbicide to inhibit seed germination and seedling growth of Eleusine indica. Nusantara Bioscience 12: 33-39. Dendrophthoe pentandra (L.) Miq. is a common parasitic plant in Southeast Asia. As a parasitic plant, it exhibits phytochemicals important for infecting its host, which may be potential as bioherbicide. This study was aimed to evaluate allelopathic activity of D. pentandra (stem and leaf extracts) to control Eleusine indica (L.) Gaertn. seed germination and growth. Methanolic extracts of D. pentandra stem and leaf (0, 1, 2, 3, 4 and 5 mg/mL in water) were treated on E. indica seeds in a petri dish for 10 days. After 10 days, germination of treated E. indica seeds was significantly reduced and reached >80% inhibition at 5 mg/mL. Moreover, E. indica roots were more sensitive compared to E. indica shoots, indicated by root inhibition >50% at 1 mg/mL and reached >90% inhibition at 5 mg/mL. Leaf extract presented stronger inhibition than stem extract, but not significant. It may be related to the higher accumulation of phenolic and flavonoid compounds in leaf extract than in stem extract. This is the first report of allelopathic activity in D. pentandra to inhibit E. indica germination and growth. Therefore, further study in a greenhouse, as well as metabolism effects of D. pentandra on the target weeds are important to provide comprehensive evaluation of D. pentandra potential as bioherbicide.
Co-Authors ABDULLAH RASYID Adhi Harmoko Saputro Aini, Fadita Nurul Ajenk Ayunda Aminah Aminah Aminah Umar Andi Salamah Anna Widyastuti ASIH PERWITA DEWI, ASIH PERWITA Astari Dwiranti Ayunda, Ajenk Baidlowi, Muhammad Hisyam Cuk Imawan Cynthia Putri Yuwana Dian Rosleine, Dian Dwinna Rahmi HALIMAH HALIMAH Irsyam, Arifin Surya Dwipa ITA KHOERUNNISA LAELIA NUGRAHANI Lutfan Alharits Maryenti, Tety MASTERIA YUNOVILSA PUTRA Mega Atria Mouleidi Dwi Putri Muhammad Rifqi Hariri Munawarohthus, Sholikha Niarsi Merry Hemelda Nissa, Maftucha Panggabean, Prima Ria Rumata Peniwidiyanti, Peniwidiyanti Putrika, Afiatry Ramadhani, Nadhifa Tazkia RATNA YUNIATI Ratna Yuniati Ratna Yuniati Retno Yunilawati Retno Yunilawati Richard Owen Tanadi Rika, Amelia Rista, Rista Sarah Tsabituddinillah Syafriana, Vilya Tianara, Alexander Upi Chairun Nisa Yasman Yasman Yuniati, Ratna Yuwana, Cynthia Putri