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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Pharmaciana: Jurnal Kefarmasian Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Majalah Patologi Indonesia Jurnal Respirasi (JR)
Wiwit Ade Fidiawati
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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Journal : Jurnal Ilmu Kedokteran (Journal of Medical Science)

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Gambaran Histopatologi Paru Mencit (Mus musculus) Setelah Pemaparan Paraquat Aulia Wiradi; Wiwit Ade Fidiawati; Sri Melati Munir
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.152 KB) | DOI: 10.26891/JIK.v11i2.2017.7-11

Abstract

Paraquat destroys organs including lung. Purpose of this study was to determine the effect of paraquat on histopathologyof lung, exspecially fibrosis in mice (Mus musculus). This study was an experimental study with post-test only withcontrol design and using 15 mice as sample. Samples were divided into 5 groups consist of one control group and fourdifferent doses of paraquat treatment group (25 mg / kg / day, 50 mg / kg / day, 75 mg / kg / day and 100 mg / kg / day for7 days with spraying). Analysis of the data have used One-Way ANOVA then post-hoc test with tukey to assesseddifferences of each groups. The results showed increasing of lung fibrosis with increasing doses and have significantcorrelations (p = 0.000). In conclusion, there are significant changes in lung histopathology of mice (Mus musculus)after paraquat exposure for 7 days.
Co-Authors Abdul Aziz Adityo Wibowo, Adityo Alni Diniati Amru Sofian Andreas Makmur, Andreas Anggelina Effendi Aulia Wiradi Bhelprinosa Arwen Darmawi . Dedi Afandi Dhini Aiyuli Novri Dhini Aiyulie Novri Dyah Astrid Astrid Effif Syofra Tripriadi, Effif Syofra Eka Sri Indra Putri Enikarmila Asni Ening Krisnuhoni Erwin Syahputra Harianto " Hermanto " Heru Ardila Putra Indriani, Sri Indah Lalu Muhammad Irham Laode Burhanuddin Monaliza " Nathania, Auren Nodia Adillah Syukri, Nodia Adillah Nursida Islami, Nursida Ovinitha, Sarah Putri Deas H Razali, Renardy Reza Renti Sulvia Niza Rifqi Rahmadhan Ruza P. Rustam S, Donel Shinta Puja Tilusari Simatupang, Elvando Tunggul Mauliate Sri Melati Munir Suhandri, Wiwin SUINDRA " Suyanto " TB Odih Rhomdani Wahid Venni Oktary Amir VONY BESTARI Wilda Arfiana Winarto Winarto Wirawan Adikusuma Zahra, Leina Putri