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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Pharmaciana: Jurnal Kefarmasian Medical Journal of Indonesia Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Majalah Patologi Indonesia Jurnal Respirasi (JR)
Wiwit Ade Fidiawati
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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GAMBARAN HASIL PEMERIKSAAN SITOLOGI SERVIKS WANITA PEKERJA SEKSUAL TIDAK LANGSUNG PADA HOTSPOT X KECAMATAN PAYUNG SEKAKI PEKANBARU Putri Deas H; Wiwit Ade Fidiawati; Amru Sofian
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 3, No 1 (2016): Wisuda Februari 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

ABSTRACTCervical cancer is most common gynecology malignancy in the world. Cervical cance is second place in deadly high cancer on female after breast cancer. Indirect female sex workers have high risk to get cervical cancer. Pap smear screening is used to identify pracancers lesion. The number of cervical cancer cases can be reduced with Pap smear screening. The purpose of this study was to know the result of cervical smear cytology examination toward indirect female sex workers at hotspot X Payung Sekaki Pekanbaru. This study was descriptive study. The population of this study were all of indirect female sex workers at hotspot X Payung Sekaki and the samples were taken with total sampling method. The result showed that there were 31 people consist 10% diagnosed with negative intraepithelial lesion or malignancy (Bacterial vaginosis), 35% diagnosed with ASCUS and 55% diagnosed with LSIL. The conclusion is LSIL was the most common intraepithelial lesion of cervical cancer.Key words: cervical smear, Pap smear, cervical cancer, indirect female sex workers, hotspot X Payung Sekaki.
GAMBARAN PEMERIKSAAN INSPEKSI VISUAL ASETAT SEBAGAI DETEKSI LESI PRAKANKER SERVIKS PADA WANITA PEKERJA SEKSUAL TIDAK LANGSUNG DI HOTSPOT X KECAMATAN PAYUNG SEKAKI PEKANBARU Monaliza "; Wiwit Ade Fidiawati; Amru Sofian
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 3, No 1 (2016): Wisuda Februari 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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ABSTRACTCervical cancer is a malignancy in the cervix who occupy the highest rank as the most common disease in women in the world. This disease can be detected earlier with Visual Inspection with Acetic Acid (VIA) examination. This paper describes an overview of VIA as the detection of cervical precancerous lesions in the indirect Female Sex Workers (FSW) at hotspot X District Payung Sekaki Pekanbaru. This disease can be detected early with inspection Visual Inspection Acetate (VIA) is a simple examination with the outward appearance of 3-5% acetic acid on the cervix. This study aims to clarify the picture VIA examination as the detection of precancerous cervical lesions and determine the characteristics of the indirect Female Sex Workers (FSW) at hotspot X District Payung Sekaki Pekanbaru. The method used is descriptive observational. Population of research are all in the indirect Female Sex Workers (FSW) at hotspot X District Payung Sekaki Pekanbaru and samples were taken using total sampling. Results of this study found respondents with positive results VIA (acethowhite) as many as 14 people (45.16%). The conclusion from this study is that the majority of indirect Female Sex Workers (FSW) at hotspot X have tested negative VIA.Key words : VIA, Cervical cancer, Indirect Female Sex Workers, Hotspot X
HUBUNGAN PENGETAHUAN DAN SIKAP TERHADAP TINDAKAN TENTANG PAP SMEAR DAN INSPEKSI VISUAL ASETAT PADA WANITA PEKERJA SEKSUAL TIDAK LANGSUNG DI HOTSPOT X KECAMATAN MARPOYAN DAMAI PEKANBARU SEBAGAI DETEKSI DINI KANKER SERVIKS Abdul Aziz; Wiwit Ade Fidiawati; Suyanto "
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 3, No 2 (2016): Wisuda Oktober 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

ABSTRACTCervical cancer is a malignancy grows in the cervix. Cervical cancer ranks as the fourth most common cancer in women worldwide. This disease can be detected early by Pap smear and Visual Inspection with Acetic Acid (VIA). Indirect female sex worker (FSW) have a higher risk of cervical cancer. The aim of this study is to reveal the correlation between knowledge and attitude towards the behaviour of indirect FSW at hotspot X District Marpoyan Damai Pekanbaru about Pap smear and VIA as an early detection of cervical cancer. The method of this research is analytic corss sectional. Population is indirect FSW living in the hotspot X and samples were taken with total sampling method to 43 people trough interviews using questionnaire. The results showed that among 43 FSWs, 28 people (65.1%) aged less than 26 years old, 25 people (58.2%) have Junior High School (JHS), 21 people (48.8%) have poor knowledge, 24 people (55.8%) have a negative attitude and 33 people (76.7%) did test. There is no correlation between knowledge and attitude (p=0.063), no correlation between knowledge and behaviour (p=1.000) and no correlation between attitude and behaviour (p=0.302). it is concluded that the majority of indirect FSW at hotspot X have bad knowledge, negative attitude but have behaviour an early detection of cervical cancerKeywords: Knowledge, Attitude, Behaviour, Cervical Cancer, Indirect Female Sex Worker, Pap Smear, VIA, Hotspot X
PROFIL PENDERITA KARSINOMA ENDOMETRIUM DI RSUD ARIFIN ACHMAD PEKANBARU PERIODE 2008 - 2013 Anggelina Effendi; Wiwit Ade Fidiawati; Ruza P. Rustam
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 1, No 2 (2014): Wisuda Oktober Tahun 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Endometrium carcinoma is epitel primer malignant tumour in endometrium, generaly the differential of grandular and have potential into myometrium. There are two kind histological type of endometrium carcinoma, 1) endometrium adecarcinoma type I with histological type (endometrioid adenocarcinoma) with well differentiated caracteristic and supervitial invasion. 2) endometrium adecarcinoma type 2 with poorly differentiated or agresif histologic type (clear cell, papiler serous) invasion into myometrium. Most of endometrium carcinoma cases commonly related to cronic endometrium estrogen stimulation which is related to type I of endometrium carcinoma. the purpose of this research is to indentified patient’s profile of endometrium carcinoma in RSUD arifin ahmad pekanbaru period 2008-2013. Sample were taken by a histopatologic diagnose in patologic anatomy department of RSUD arifin ahmad pekanbaru. The amount of carcinoma patient period 2008-2013 is about 58 cases and just 43 cases have complete profile. The profile is about age, parity and histopatologic type. Based on the result of the data , it can be concluded that the most amount of endometrium carcinoma is in range of age 41-50 years old (45%), the most parity is in 0 parity (nuliparitas) (54%), and the most histopatologic type is endometrioid adenocarcinoma (90%).Key words : Endometrium Carcinoma, Endometrium carcinoma type 1, Endometrium carcinoma Type 2PENDAHULUANKarsinoma endometrium adalah tumor ganas epitel primer
DISTRIBUSI KEGANASAN NASOFARING BERDASARKAN PEMERIKSAAN HISTOPATOLOGI PADA RUMAH SAKIT DI KOTA PEKANBARU TAHUN 2009-2013 Alni Diniati; Wiwit Ade Fidiawati; Harianto "
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 3, No 1 (2016): Wisuda Februari 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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ABSTRACTNasopharyngeal carcinoma is a malignant tumor derived from epithelial cells in the nasopharynx. The rates of nasopharyngeal carcinoma has increased in the region of the head and neck. In 2010, nasopharyngeal carcinoma ranks 5th out of 10th. This study is descriptive with retrospective design that aimed to determine the distribution of nasopharyngeal carcinoma at hospitals in Pekanbaru from 2009-2013. The data collected from anatomical pathology laboratory center and hospitals in Pekanbaru, including: gender, age, histopathologic types and occupation. The result showed that there was 199 cases of nasopharyngeal carcinoma with the highest case found in 2013 were 92 (24,6%). The highest case found in Arifin Achmad Hospital were 92 (46,2%) and the lowest rates was in the Army hospital and Bhayangkara with 1 (0.5%) case. Nasopharyngeal carcinoma mostly infected male 130 (65,3%) cases than female 69 (34,7%) cases. The age range of 45-54 years had 56 (28.1%) cases. Most of histopathologic types had found in the type of undifferentiated carcinoma (WHO type III) as many as 136 (68,3%) cases. The most occupation is farmer and housewifes as many as 32 (16.1%) cases.Key words : nasopharyngeal carcinoma, distribution, histopathologic type.
Lung Abscess Located in Lesion of Lung Tumor and Multiple Cavities due to Pulmonary Tuberculosis: A Case Report Indriani, Sri Indah; Simatupang, Elvando Tunggul Mauliate; Wibowo, Adityo; Makmur, Andreas; Fidiawati, Wiwit Ade
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.55-60

Abstract

Introduction: People with tuberculosis (TB) have an increased risk of pulmonary cancer. They are also disproportionately affected by risk factors like immune suppression, smoking, and alcohol misuse. A lung tumor is reported to have occurred after an episode of TB, but we reported a patient with a lung tumor with co-infection TB and lung abscess at the same time. Case: A 73-year-old man was hospitalized at Arifin Achmad General Hospital, Pekanbaru, with a 3-day history of bloody cough 2-3 times a day, 1-2 tablespoons estimated by the patient for blood from the cough. The patient had a cough with white phlegm in the last 4 months before the bloody cough. The patient also had a fever, night sweats, a limp body, decreased appetite for 6 months, and decreased body weight by 15 kg in the last year. Heterogenic consolidation on the superior lobe of the lung with prominence compression and irregular boundaries in the apex was found. We found an air bronchogram and multiple cavities with air-fluid levels inside the lesion. We also found a satellite nodule in the inferior lung and a mass connected with the chest wall. GeneXpert showed low detection for Mycobacterium tuberculosis. The patient was diagnosed with a left lung abscess, pulmonary TB, left lung tumor T4N2M1a, unspecified type of tumor stage IVA PS2, and osteoporosis. Conclusion: Lung tumors could also be diagnosed with co-infection TB. Proper diagnosis to make sure cancer and TB are co-infected is necessary. Therefore, it will not be just a single disease that is treated.
Repurposing drugs in endometrial cancer using genomic variants database Darmawi, Darmawi; S, Donel; Suhandri, Wiwin; Winarto, Winarto; Adikusuma, Wirawan; Irham, Lalu Muhammad; Fidiawati, Wiwit Ade; Razali, Renardy Reza; Nathania, Auren; Zahra, Leina Putri
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
Estrogen receptor expression in type 1 endometrial cancer and its association with lymphovascular space invasion Fidiawati, Wiwit Ade; Andrijono; Siregar, Nurjati Chairani; Prihartono, Joedo; Purwoto, Gatot; Hellyanti, Tantri
Medical Journal of Indonesia Online First
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257842

Abstract

BACKGROUND Endometrial cancer (EC) ranks sixth in female genital malignancy and originates in the endometrial lining. Estrogen receptor (ER) expression is important in EC prognosis and recurrence, influenced by the presence of lymphovascular space invasion (LVSI). This study aimed to determine the association between ER expression and LVSI in type 1 EC. METHODS A retrospective analysis was conducted on 135 patients with type 1 EC who underwent surgery at the Cipto Mangunkusumo Hospital, Jakarta, Indonesia, between January 2012 and December 2022. Immunohistochemistry (IHC) with ER antibodies was performed on all samples in April 2023. ER expression was evaluated using the Allred scoring system, and its association between ER expression (percentage and intensity stain) and LSVI was statistically analyzed. RESULTS Of 135 samples, 44 (32.6%) were LVSI-positive. No significant association was found between IHC percentage stain and LVSI (p = 0.994). However, a significant association was found between IHC stain intensity and LVSI-positive in patients with type 1 EC (p = 0.022). ER intensity score 2 had a higher LVSI risk compared to score 1 and score 3 (from 51%, 26%, and 26%, respectively). CONCLUSIONS ER expression is associated with LVSI of type 1 EC. While IHC stain percentage showed no correlation with LVSI, stain intensity was significantly linked to LVSI-positive in patients with type 1 EC. Regular assessment of ER expression can provide significant prognostic information, support hormonal therapy, and identifying clinical characteristics of tumors.
Co-Authors Abdul Aziz Adityo Wibowo, Adityo Alni Diniati Amru Sofian Andreas Makmur, Andreas Andrijono Anggelina Effendi Aulia Wiradi Bhelprinosa Arwen Darmawi . Dedi Afandi Dhini Aiyuli Novri Dhini Aiyulie Novri Dyah Astrid Astrid Effif Syofra Tripriadi, Effif Syofra Eka Sri Indra Putri Enikarmila Asni Ening Krisnuhoni Erwin Syahputra Gatot Purwoto Harianto " Hellyanti, Tantri Hermanto " Heru Ardila Putra Indriani, Sri Indah Joedo Prihartono Lalu Muhammad Irham Laode Burhanuddin Monaliza " Nathania, Auren Nodia Adillah Syukri, Nodia Adillah Nurjati Chairani Siregar Nursida Islami, Nursida Ovinitha, Sarah Putri Deas H Razali, Renardy Reza Renti Sulvia Niza Rifqi Rahmadhan Ruza P. Rustam S, Donel Shinta Puja Tilusari Simatupang, Elvando Tunggul Mauliate Sri Melati Munir Suhandri, Wiwin SUINDRA " Suyanto " TB Odih Rhomdani Wahid Venni Oktary Amir VONY BESTARI Wilda Arfiana Winarto Winarto Wirawan Adikusuma Zahra, Leina Putri