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All Journal Medula Jurnal Kesehatan JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Rodiani Rodiani
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Agriculture, Biological Sciences & Forestry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : medula

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PENGARUH PEMBERIAN EKSTRAK BUAH PLUM (Prunus domestica L.) TERHADAP BERAT BADAN FETUS TIKUS PUTIH (Rattus norvegicus) Galur Sprague-dawley PADA TIKUS PUTIH (Rattus norvegicus) HAMIL YANG DIBERI PAPARAN ALKOHOL Arinda Rifana Nabillah; Rodiani Rodiani
Medula Vol 13 No 5 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i5.771

Abstract

Alcohol is a source of free radicals that come out from outside of the body. Alcohol consumed during pregnancy can cause various teratological effects on the fetus, one of which is low birth weight (LBW). Plum as a food that contains a lot of antioxidants can prevents oxidative stress caused by alcohol. The purpose of this study was to determine the effect of giving plum (Prunus domestica L.) extract on the fetal body weight of white rats (Rattus norvegicus) Sprague-Dawley strain in pregnant white rats (Rattus norvegicus) induced by alcohol. This study used Post-test Only Control Group Design using 30 pregnant rats divided into 5 groups. The KP group was a group of rats that was not given alcohol or plum extract. The KN group was exposed to 0.27 ml/day of alcohol for days 6-15 of pregnancy. The P1group was exposed to 15% alcohol 0.27 ml/day for days 6-15 of pregnancy and plum extract 40mg/day for 21 days of pregnancy. The P2 group was exposed to 15% alcohol 0.27 ml/day for days 6-15 of pregnancy and plum extract 80 mg/day for 21 days of pregnancy. The P3 group was exposed to 15% alcohol 0.27 ml/day for days 6-15 of pregnancy and plum extract 160 mg/day for 21 days of pregnancy. Data were analyzed using One-Way ANOVA and Post Hoc-LSD tests. The One-Way ANOVA test result showed the value of p = 0.000 (p <0.05). The result of Post Hoc-LSD test showed that there are significant avegare differences in some groups except between KN and P1; P2 and P3.  Plum (Prunus domestica L.) extract had an effect on fetal body weight of white rats (Rattus norvegicus) Sprague-Dawley strain in pregnant white rats (Rattus norvegicus) induced by alcohol.
Pengaruh Pemberian Ekstrak Buah Plum (Prunus domestica L.) Terhadap Panjang Badan Fetus Tikus Putih (Rattus novergicus) Galur Sprague Dawley Pada Tikus Putih (Rattus novergicus) Hamil Yang Dipapar Alkohol Dewi Tri Atmaningsih; Rodiani Rodiani
Medula Vol 13 No 6 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i6.827

Abstract

Alcohol consumption during pregnancy cause fetal alcohol syndrome and increases oxidative stress. Plum contains polyphenols as an antioxidant which can prevent oxidative stress by affecting the activity of osteoblasts and osteoclasts. This study aims to determine the effect of plum extract (Prunus domestica L.) on body length of fetal white rats (Rattus norvegicus) Sprague Dawley strain in pregnant white rats exposed by alcohol. This research used 30 white female rats of Sprague Dawley strain which divided into 5 groups. The positive control (KP) not given treatment, the negative control (KN) was given alcohol 0,27 ml/day on the 6th-15th day of pregnancy, the treatment group (P1, P2, P3) was given alcohol 0,27 ml/day and plum extract with respective dose 0f 40, 80, 160 mg orally for 21 days of gestation. Then the fetus was taken surgically on 21 days of gestation. This research showed that the average length of KP=41,34; KN=38,67; P1=39,22; P2=39,65; and P3=40,02 in mm. Then, the data were tested by One Way Anova test and resulting p value<0,05 and F count>F table for all data, then it followed by post hoc LSD test and the results showed p value<0,05 on measurements of body length except on KN-P1, P1-P2, dan P2-P3. There was effect of plum extract (Prunus domestica L.) on body length of fetal white rats (Rattus norvegicus) Sprague Dawley strain in pregnant white rats exposed by alcohol.
Co-Authors Agam Anggoro Analia Analia Annisa Rusfiana Arinda Rifana Nabillah Bella Yanita Clara Asifa Desti Wulan Handayani Dewi Tri Atmaningsih Dwi Indria Anggraini Dwita Oktaria Erisa Senthya Br Surbakti Evi Kurniawaty Gemayangsura Gemayangsura Gheavani Legowo Giska Tri Putri Merry Indah Sari Muhammad Ikhlasul Akbar Natasyah Hana Zafirah Nurul Utami Oktadoni Saputra Rika Lisiswanti Siti masruroh Susianti Susianti Wildan Kautsar Irawan Wivan Havilian Djohan