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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Farmasi Klinik Indonesia IDJP (Indonesian Journal of Pharmaceutics) Majalah Farmasetika MAHESA : Malahayati Health Student Journal Indonesian Journal of Biological Pharmacy Jurnal Ilmiah Kesehatan (JIKA)
SORAYA RATNAWULAN MITA, SORAYA RATNAWULAN
Department Of Pharmaceutics, Faculty Of Pharmacy, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Artikel Ulasan: Perkembangan Metode Analisis Penetapan Kadar Albumin dalam Obat Tradisional dan Suplemen Kesehatan Mariska, Revi; Mita, Soraya Ratnawulan; Nuryani, Tri Winarsih
Indonesian Journal of Biological Pharmacy Vol 5, No 1 (2025): IJBP (April)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v4i3.62734

Abstract

Albumin merupakan protein utama dalam plasma darah yang berperan penting dalam menjaga keseimbangan cairan tubuh serta mempercepat pemulihan jaringan. Kandungan albumin menjadi indikator mutu dalam produk obat tradisional dan suplemen kesehatan yang kian banyak digunakan masyarakat. Oleh karena itu, penetapan kadar albumin secara akurat sangat diperlukan guna menjamin kualitas dan keamanan produk tersebut. Artikel ini bertujuan untuk mereview berbagai metode analisis kadar albumin yang telah mengalami perkembangan signifikan seiring kemajuan teknologi. Metode penulisan dilakukan melalui studi literatur dari berbagai sumber elektronik terpercaya dalam kurun waktu 2014–2024. Hasil kajian menunjukkan bahwa metode seperti spektrofotometri UV-Vis, reverse-phase high-performance liquid chromatography (RP-HPLC), elektrokimia, elektroforesis kapiler, dan fluoresensi memiliki karakteristik berbeda dalam hal sensitivitas, selektivitas, serta efisiensi. Masing-masing metode memiliki kelebihan dan keterbatasan yang harus disesuaikan dengan tujuan analisis serta kondisi teknis yang tersedia. Dengan demikian, pemilihan metode analisis albumin yang tepat menjadi kunci untuk memperoleh hasil yang optimal dan dapat diandalkan dalam industri farmasi maupun penelitian.
Nanoemulsion Purified Catechin Gambir (Uncaria gambir Roxb.): Formulation and Antimicrobial Activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterobacter aerogenes Muhtar, Nurul Inaya; Mita, Soraya Ratnawulan; Kusuma, Sri Agung Fitri
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1368

Abstract

Gambir (Uncaria gambir Roxb), a plant native to Indonesia, has long been recognized in traditional medicine. The primary active component in gambir is catechin, which possesses various biological activities, including broad-spectrum antimicrobial properties. However, catechin faces challenges related to low stability, necessitating its formulation into a nanoemulsion to enhance both its stability and effectiveness. This study aims to evaluate whether an optimized nanoemulsion formulation of catechin can improve its antimicrobial activity. The methodology includes assessing the antimicrobial effectiveness of catechin powder and catechin nanoemulsion using the agar diffusion method, as well as determining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) through the microdilution method. Antimicrobial activity was tested against three bacterial strains: Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 9027, and Enterobacter aerogenes ATCC 13048. The optimal formulation consisted of a combination of Tween 80 and Span 80 as surfactants (15%), PEG 400 as a co-surfactant (7%), and isopropyl myristate (IPM) as the oil phase (10%). This nanoemulsion formulation demonstrated a transmittance value of 91,9%. Based on the antimicrobial activity results, the catechin nanoemulsion exhibited enhanced antimicrobial effects compared to catechin powder. The nanoemulsion containing 2% catechin showed the highest antimicrobial activity against all three tested bacteria. These findings are expected to provide new insights into the potential application of catechin nanoemulsion as a more effective antimicrobial agent.
Optimization of Cream Base and Hedonic Evaluation of Telon Cream with Variations in Essential Oil Composition Marissa, Zahra; Mita, Soraya Ratnawulan; Kusumawulan, Cahya Khairani
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1370

Abstract

Telon cream was developed as an alternative to traditional telon oil for infants to lower the risk of skin irritation from high essential-oil content while retaining its characteristic warming effect. This study optimized the cream base using the Simplex Lattice Design (SLD) and evaluated the effect of different essential-oil compositions on physical stability and sensory acceptance, focusing on the warming sensation. The base was optimized by varying the ratio of Olivem® 1000 and Flocare™ SK 425 to achieve suitable viscosity, spreadability, and adhesiveness. The optimized base was used to prepare four telon-cream formulas containing cajuput, fennel, ginger, and lavender oils. Stability was assessed by organoleptic observation, pH, viscosity, and spreadability under three storage conditions for four weeks. A hedonic test with 30 caregivers evaluated color, texture, aroma, and warming sensation using a 5-point liking scale. The optimal base ratio (Olivem® 1000:Flocare™ SK 425 = 4:1) yielded a desirability value of 1,0. All formulas met pH (5,9–6,1), viscosity (38,000–46,000 mPa·s), and spreadability (5,0–5,4 cm) requirements and remained stable. Hedonic testing showed no significant differences in color (p-value = 0,939) or texture (p-value = 0,665); aroma showed a borderline difference (p-value = 0,060), whereas the warming sensation differed significantly (p-value = 0,010). Formula F4 (cajuput 0,4%, fennel 0,4%, ginger 0,1%, lavender 0,1%) achieved the highest warming-sensation score with a favorable aroma. The optimized telon cream demonstrated good stability and was well accepted by users. The warming sensation emerged as a key attribute influencing consumer preference for telon creams.
Encapsulation Natural Oils Plant Based Using Freeze-Drying Alyanis Mufid SWM; Soraya Ratnawulan Mita; Patihul Husni
MAHESA : Malahayati Health Student Journal Vol 6, No 3 (2026): Volume 6 Nomor 3 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i3.21306

Abstract

ABSTRACT Natural oils, such as essential oils and oils with high unsaturated fatty acids, can be derived and extracted from plant sources. Essential oils contain aromatic compounds commonly used in the food industry, while oils rich in unsaturated fatty acids, such as omega-3, -6, and -9, along with vitamin E, are highly beneficial in industrial sectors. Furthermore, natural oils possess antimicrobial and antioxidant properties that are valuable in daily life. However, degradation of natural oils is inevitable due to various external factors such as temperature, humidity, and light. Therefore, an effective technique is required to enhance the stability of natural oils, with one of the methods being freeze drying, using wall materials made from various polymers depending on the intended application. This review aims to summarize the development of natural oils encapsulated by freeze dryingThe literature search in this review was conducted using the search engines Google Scholar and ScienceDirect. The selected papers used for this review consist of original research articles published between 2021 and 2025, focusing on natural oils unsaturated fatty acids or essential oils as the primary subject of study. Stability can be improved by examining thermal analysis parameters in various natural oils, such as walnut, sacha inchi, rose damascena, mandarin, and boswellia sacra. Storage at low temperatures helps enhance the chemical stability of natural oils. In natural oils, both essential oils and oils with high unsaturated fatty acids, stability improvement can be achieved through freeze drying using polymers as wall materials such as polysaccharides, proteins, gums, lignin, or other polymers. The use of proper machine freeze drying parameter settings is also necessary to obtain the best results with high encapsulation efficiency Keywords: Encapsulation, Essential Oils, Freeze Drying, Natural Product, Unsaturated fatty Acids.
TINJAUAN YURIDIS TERHADAP PEREDARAN OBAT-OBAT TERTENTU YANG SERING DISALAHGUNAKAN TANPA IZIN EDAR DI SARANA TIDAK BERIZIN DALAM PERSPEKTIF UU NOMOR 17 TAHUN 2023 TENTANG KESEHATAN Muntashir, Ilham Mohammad; Mita, Soraya Ratnawulan
Farmaka Vol 24, No 2 (2026): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v24i2.71100

Abstract

Peredaran obat-obat tertentu yang sering disalahgunakan (OOT) tanpa izin edar melalui sarana yang tidak berizin masih menjadi permasalahan yang banyak ditemukan di Indonesia dan berpotensi membahayakan kesehatan masyarakat. Selain tidak menjamin aspek keamanan, khasiat, dan mutu, praktik tersebut juga bertentangan dengan ketentuan hukum di bidang kesehatan dan kefarmasian. Tinjauan ini bertujuan untuk menganalisis peraturan mengenai peredaran OOT tanpa izin edar di sarana yang tidak berizin serta sanksi hukum yang dapat dikenakan terhadap pelaku berdasarkan Undang-Undang Nomor 17 Tahun 2023 tentang Kesehatan. Metode tinjauan yang digunakan yaitu yuridis normatif dengan pendekatan perundang-undangan melalui penelaahan berbagai peraturan yang berkaitan dengan sediaan farmasi, praktik kefarmasian, dan ketentuan pidana di bidang kesehatan. Hasil tinjauan menunjukkan bahwa OOT, seperti Dekstrometorfan, Haloperidol, Klorpromazin, Amitriptilin, Ketamin, Tramadol, dan Triheksifenidil, sebagian besar termasuk golongan obat keras yang peredarannya harus dilakukan melalui sarana pelayanan kefarmasian yang berizin dan oleh tenaga kefarmasian yang berwenang. Peredaran OOT tanpa izin edar bertentangan dengan ketentuan mengenai keamanan, khasiat, dan mutu sediaan farmasi, sedangkan peredarannya di sarana tidak berizin merupakan bentuk praktik kefarmasian tanpa kewenangan. Pelaku dapat dikenakan Pasal 435 dan Pasal 436 ayat (2) Undang-Undang Nomor 17 Tahun 2023 tentang Kesehatan dengan ancaman pidana penjara dan/atau denda. Dengan demikian, penegakan hukum yang tegas diperlukan untuk memastikan masyarakat aman dari risiko penyalahgunaan dan peredaran obat ilegal.
TINJAUAN REGULASI KOSMETIKA DI INDONESIA DAN PERBANDINGANNYA DENGAN REGULASI INTERNASIONAL (ASEAN, EU, & FDA) Priana, Diva Dhaifina Mazaya; Mita, Soraya Ratnawulan
Farmaka Vol 24, No 2 (2026): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v24i2.70413

Abstract

Pesatnya perkembangan industri kosmetik saat ini menuntut penguatan regulasi yang mampu menjamin keamanan dan mutu produk, terutama di tengah maraknya peredaran kosmetik ilegal. Tinjauan ini bertujuan untuk menganalisis secara komprehensif kerangka regulasi kosmetika di Indonesia yang diatur oleh Badan Pengawas Obat dan Makanan (BPOM), serta membandingkannya dengan standar internasional guna memetakan arah peningkatan daya saing produk domestik dan meningkatkan keamanan konsumen. Metode yang digunakan adalah studi literatur deskriptif komparatif yang membandingkan enam aspek regulasi yaitu: dasar hukum, mekanisme registrasi, labeling, pengaturan bahan, serta pengawasan pra-pemasaran dan pasca-pemasaran. Objek perbandingan mencakup ASEAN Cosmetic Directive (ACD), Regulasi European Cosmetic (EC) No. 1223/2009, dan Federal Food, Drug, and Cosmetics Act (FD&C Act) yang diperkuat oleh Undang-Undang Modernisasi Regulasi Kosmetik (Modernization of Cosmetics Regulation Act (MoCRA)). Hasil perbandingan menunjukkan bahwa Indonesia telah mengadopsi sistem Notifikasi dan kewajiban Cara Pembuatan Kosmetik yang Baik (CPKB) yang sejalan dengan ketentuan yang berlaku di ACD. Namun, regulasi Uni Eropa dinilai jauh lebih ketat, dalam mengaplikasikan prinsip kehati-hatian dengan mewajibkan Laporan Kemanan Produk Kosmetik (Cosmetic Product Safety Report (CPSR)) serta menetapkan daftar bahan terlarang yang lebih luas. Sementara itu, regulasi FDA Amerika Serikat cenderung menitikberatkan pengawasan pada fase pasca-pemasaran, meskipun MoCRA telah menetapkan kewajiban pendaftaran produk (product listing). Penelitian ini menunjukan bahwa Indonesia telah menerapkan sistem pengawasan kombinasi, yaitu lebih proaktif dari FDA tetapi tidak lebih ketat dari EU. Oleh karena itu, Indonesia masih dapat memperkuat aspek keamanan pra-pemasaran untuk meningkatkan daya saing global dan mempermudah jalur ekspor.
Co-Authors Alyanis Mufid SWM Anggia Diani Amalia Anis Yohana Chaerunisaa APRINI, AMELIA Azzahra, Ratu Wifaira BETHARY KESUMAWARDHANY DESI MARIANA PURBA Elizabeth Rosalina Suwalie Fanni Syawli Omandra FIKAMILIA HUSNA Fil Ayatil Karimah, Naqiyyah Gina Aulia Handi Purnama Handi Purnama HURIYATUS TSANIYAH Elfa Hendri IMAS LAILI LESTARI Indah Puspita Syafitri, Raden Karimah, Naqiyyah Fil Ayatil Kurniawan Syah, Insan Sunan KUSUMAWULAN, CAHYA KHAIRANI Luthfia Azzahra Mariska, Revi Marissa, Zahra Marline Abdassah Muhtar, Nurul Inaya Muntashir, Ilham Mohammad Nadhira Mahda Dinar Lubis NADYA NUR KUSUMO Nichairin, Wilda Norisca Aliza Putriana Noviandhani, Wanda NUR RAHAYU Nuryani, Tri Winarsih Patihul Husni Patihul Husni Patihul Husni Patihul Husni Priana, Diva Dhaifina Mazaya Putri, Ramadhania Ariza Ratnawati, Aini SALMA ALAINA ATISHA Santi Rukminita Anggraeni SITI NURROHMAH Siti Sahirah Ulfah Sri Agung Fitri Kusuma, Sri Agung Sriwidodo Sriwidodo Sriwidodo Sriwidodo Syafitri, Raden Indah Puspita Yuli Agung Prasetyo Yuniati, Wiwiet YUNISTYA DWI CAHYANI