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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Farmasi Klinik Indonesia IDJP (Indonesian Journal of Pharmaceutics) JSFK (Jurnal Sains Farmasi & Klinis) Majalah Farmasetika MAHESA : Malahayati Health Student Journal Indonesian Journal of Biological Pharmacy Jurnal Ilmiah Kesehatan (JIKA)
SORAYA RATNAWULAN MITA, SORAYA RATNAWULAN
Department Of Pharmaceutics, Faculty Of Pharmacy, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Formulation of Serum Sunflower (Helianthus annuus L.) Seed Oil as Antiacne Preparation Mita, Soraya Ratnawulan Mita; Sri Agung Fitri Kusuma; Devani Olivia Winardi; Patihul Husni; Yoshihito Shiono
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.197-207.2024

Abstract

Acne is caused by a microbial imbalance due to the overgrowth of Propionibacterium acnes in the skin microbiome. Sunflower seed oil (Helianthus annuus L.), which contains linoleic acid and terpenoids, has an antibacterial activity against P. acnes. This study aimed to increase the availability of anti-acne compounds from natural resources by formulating an anti-acne serum containing sunflower seed oil. The research methods included antibacterial activity testing of sunflower seed oil, serum formulation, product evaluation, and serum effectiveness testing. The results of the antibacterial activity test of sunflower seed oil against P. acnes ATCC 6919 showed a minimum inhibitory concentration (MIC) of 100 mg/mL and a minimum bactericidal concentration (MBC) of 200 mg/mL. The result of serum evaluation and stability testing during the freeze-thaw cycling test depicted stable formulation for all formulas based on organoleptic parameters, homogeneity, pH, viscosity, and spreadability. The effectiveness test results of the serum preparation showed that formula 3, containing 200 mg/L of sunflower seed oil, was the best formula with an inhibition zone diameter of 12.76 ± 0.03 mm. In conclusion, sunflower seed oil demonstrates the ability to prevent and treat acne-prone skin, making it a suitable alternative anti-acne compound.
Artikel Ulasan: Perkembangan Metode Analisis Penetapan Kadar Albumin dalam Obat Tradisional dan Suplemen Kesehatan Mariska, Revi; Mita, Soraya Ratnawulan; Nuryani, Tri Winarsih
Indonesian Journal of Biological Pharmacy Vol 5, No 1 (2025): IJBP (April)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v4i3.62734

Abstract

Albumin merupakan protein utama dalam plasma darah yang berperan penting dalam menjaga keseimbangan cairan tubuh serta mempercepat pemulihan jaringan. Kandungan albumin menjadi indikator mutu dalam produk obat tradisional dan suplemen kesehatan yang kian banyak digunakan masyarakat. Oleh karena itu, penetapan kadar albumin secara akurat sangat diperlukan guna menjamin kualitas dan keamanan produk tersebut. Artikel ini bertujuan untuk mereview berbagai metode analisis kadar albumin yang telah mengalami perkembangan signifikan seiring kemajuan teknologi. Metode penulisan dilakukan melalui studi literatur dari berbagai sumber elektronik terpercaya dalam kurun waktu 2014–2024. Hasil kajian menunjukkan bahwa metode seperti spektrofotometri UV-Vis, reverse-phase high-performance liquid chromatography (RP-HPLC), elektrokimia, elektroforesis kapiler, dan fluoresensi memiliki karakteristik berbeda dalam hal sensitivitas, selektivitas, serta efisiensi. Masing-masing metode memiliki kelebihan dan keterbatasan yang harus disesuaikan dengan tujuan analisis serta kondisi teknis yang tersedia. Dengan demikian, pemilihan metode analisis albumin yang tepat menjadi kunci untuk memperoleh hasil yang optimal dan dapat diandalkan dalam industri farmasi maupun penelitian.
Encapsulation Natural Oils Plant Based Using Freeze-Drying SWM, Alyanis Mufid; Mita, Soraya Ratnawulan; Husni, Patihul
MAHESA : Malahayati Health Student Journal Vol 6, No 3 (2026): Volume 6 Nomor 3 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i3.21306

Abstract

ABSTRACT Natural oils, such as essential oils and oils with high unsaturated fatty acids, can be derived and extracted from plant sources. Essential oils contain aromatic compounds commonly used in the food industry, while oils rich in unsaturated fatty acids, such as omega-3, -6, and -9, along with vitamin E, are highly beneficial in industrial sectors. Furthermore, natural oils possess antimicrobial and antioxidant properties that are valuable in daily life. However, degradation of natural oils is inevitable due to various external factors such as temperature, humidity, and light. Therefore, an effective technique is required to enhance the stability of natural oils, with one of the methods being freeze drying, using wall materials made from various polymers depending on the intended application. This review aims to summarize the development of natural oils encapsulated by freeze dryingThe literature search in this review was conducted using the search engines Google Scholar and ScienceDirect. The selected papers used for this review consist of original research articles published between 2021 and 2025, focusing on natural oils unsaturated fatty acids or essential oils as the primary subject of study. Stability can be improved by examining thermal analysis parameters in various natural oils, such as walnut, sacha inchi, rose damascena, mandarin, and boswellia sacra. Storage at low temperatures helps enhance the chemical stability of natural oils. In natural oils, both essential oils and oils with high unsaturated fatty acids, stability improvement can be achieved through freeze drying using polymers as wall materials such as polysaccharides, proteins, gums, lignin, or other polymers. The use of proper machine freeze drying parameter settings is also necessary to obtain the best results with high encapsulation efficiency Keywords: Encapsulation, Essential Oils, Freeze Drying, Natural Product, Unsaturated fatty Acids.
Nanoemulsion Purified Catechin Gambir (Uncaria gambir Roxb.): Formulation and Antimicrobial Activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterobacter aerogenes Muhtar, Nurul Inaya; Mita, Soraya Ratnawulan; Kusuma, Sri Agung Fitri
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1368

Abstract

Gambir (Uncaria gambir Roxb), a plant native to Indonesia, has long been recognized in traditional medicine. The primary active component in gambir is catechin, which possesses various biological activities, including broad-spectrum antimicrobial properties. However, catechin faces challenges related to low stability, necessitating its formulation into a nanoemulsion to enhance both its stability and effectiveness. This study aims to evaluate whether an optimized nanoemulsion formulation of catechin can improve its antimicrobial activity. The methodology includes assessing the antimicrobial effectiveness of catechin powder and catechin nanoemulsion using the agar diffusion method, as well as determining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) through the microdilution method. Antimicrobial activity was tested against three bacterial strains: Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 9027, and Enterobacter aerogenes ATCC 13048. The optimal formulation consisted of a combination of Tween 80 and Span 80 as surfactants (15%), PEG 400 as a co-surfactant (7%), and isopropyl myristate (IPM) as the oil phase (10%). This nanoemulsion formulation demonstrated a transmittance value of 91,9%. Based on the antimicrobial activity results, the catechin nanoemulsion exhibited enhanced antimicrobial effects compared to catechin powder. The nanoemulsion containing 2% catechin showed the highest antimicrobial activity against all three tested bacteria. These findings are expected to provide new insights into the potential application of catechin nanoemulsion as a more effective antimicrobial agent.
Optimization of Cream Base and Hedonic Evaluation of Telon Cream with Variations in Essential Oil Composition Marissa, Zahra; Mita, Soraya Ratnawulan; Kusumawulan, Cahya Khairani
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1370

Abstract

Telon cream was developed as an alternative to traditional telon oil for infants to lower the risk of skin irritation from high essential-oil content while retaining its characteristic warming effect. This study optimized the cream base using the Simplex Lattice Design (SLD) and evaluated the effect of different essential-oil compositions on physical stability and sensory acceptance, focusing on the warming sensation. The base was optimized by varying the ratio of Olivem® 1000 and Flocare™ SK 425 to achieve suitable viscosity, spreadability, and adhesiveness. The optimized base was used to prepare four telon-cream formulas containing cajuput, fennel, ginger, and lavender oils. Stability was assessed by organoleptic observation, pH, viscosity, and spreadability under three storage conditions for four weeks. A hedonic test with 30 caregivers evaluated color, texture, aroma, and warming sensation using a 5-point liking scale. The optimal base ratio (Olivem® 1000:Flocare™ SK 425 = 4:1) yielded a desirability value of 1,0. All formulas met pH (5,9–6,1), viscosity (38,000–46,000 mPa·s), and spreadability (5,0–5,4 cm) requirements and remained stable. Hedonic testing showed no significant differences in color (p-value = 0,939) or texture (p-value = 0,665); aroma showed a borderline difference (p-value = 0,060), whereas the warming sensation differed significantly (p-value = 0,010). Formula F4 (cajuput 0,4%, fennel 0,4%, ginger 0,1%, lavender 0,1%) achieved the highest warming-sensation score with a favorable aroma. The optimized telon cream demonstrated good stability and was well accepted by users. The warming sensation emerged as a key attribute influencing consumer preference for telon creams.
Co-Authors Anggia Diani Amalia Anis Yohana Chaerunisaa APRINI, AMELIA Aulia, Gina Azzahra, Ratu Wifaira BETHARY KESUMAWARDHANY DESI MARIANA PURBA Devani Olivia Winardi Elizabeth Rosalina Suwalie Fanni Syawli Omandra FIKAMILIA HUSNA Fil Ayatil Karimah, Naqiyyah Handi Purnama Handi Purnama HURIYATUS TSANIYAH Elfa Hendri IMAS LAILI LESTARI Indah Puspita Syafitri, Raden Karimah, Naqiyyah Fil Ayatil Kurniawan Syah, Insan Sunan KUSUMAWULAN, CAHYA KHAIRANI Luthfia Azzahra Mariska, Revi Marissa, Zahra Marline Abdassah Muhtar, Nurul Inaya Nadhira Mahda Dinar Lubis NADYA NUR KUSUMO Nichairin, Wilda Norisca Aliza Putriana Noviandhani, Wanda NUR RAHAYU Nuryani, Tri Winarsih Patihul Husni Patihul Husni Patihul Husni Putri, Ramadhania Ariza Ratnawati, Aini SALMA ALAINA ATISHA Santi Rukminita Anggraeni, Santi Rukminita SITI NURROHMAH Siti Sahirah Ulfah Sri Agung Fitri Kusuma, Sri Agung Sriwidodo Sriwidodo Sriwidodo Sriwidodo SWM, Alyanis Mufid Syafitri, Raden Indah Puspita Yoshihito Shiono Yuli Agung Prasetyo Yuniati, Wiwiet YUNISTYA DWI CAHYANI