Soehartati Gondhowiardjo
Department of Radiology, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta

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Journal : Medical Journal of Indonesia

Evaluation of EBV-LMP1 as prognostic indicator of nasopharyngeal carcinoma in Indonesian patients Kurniawan, A. N.; Kodariah, Ria; Elisabeth, Meryanne; Roezin, Averdi; Gondhowiardjo, Soehartati
Medical Journal of Indonesia Vol 11, No 2 (2002): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.776 KB) | DOI: 10.13181/mji.v11i2.57

Abstract

Forty eight cases of nasopharyngeal carcinoma patients who had been treated with radiotherapy were analysed for the expression of EBER in the nucleus of the tumor cells by in situ hybridization technique. EBER was expressed in 69% of the cases. Histologic specimens positive for EBER were then examined for the expression of EBV-LMP1 by immunohistochemistry, which showed 68% positivity. Clinical staging of 48 cases and radiation response of 32 cases were collected. Data of up to 2 years of survival of 16 cases were obtained through postal and phone communication. Statistical analysis showed that the Working Formulation histologic classification of NPC correlated significantly with radiation response. The expression of EBV-LMP1 was correlated significantly with the survival of the patients. Thus EBV-LMP1 which has been shown to possess influence on lymphoid and epithelial cells, clinicopathologically proved to have a function as prognostic indicator. (Med J Indones 2002; 11: 81-6)Keywords: nasopharyngeal carcinoma, histopathologic types, EBER, EBV- lmp1, survival
Papillary and follicular thyroid carcinoma: Impact of treatment in 44 patients at the Cipto Mangunkusumo Hospital Badri, Cholid; Kuswanto, Olivia; Gondhowiardjo, Soehartati; Astarto, Bangun; Kusumawijaya, Kahar
Medical Journal of Indonesia Vol 3, No 1 (1994): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (619.528 KB) | DOI: 10.13181/mji.v3i1.941

Abstract

[no abstract available]
Breast-conserving treatment versus mastectomy in T1-2N0 breast cancer: which one is better for Indonesian women? Nugroho, Rafiq S.; Soediro, Ratnawati; Siregar, Nuryati C.; Djoerban, Zubairi; Poetiray, Evert D.C.; Gondhowiardjo, Soehartati
Medical Journal of Indonesia Vol 21, No 4 (2012): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.811 KB) | DOI: 10.13181/mji.v21i4.508

Abstract

Background: This study aimed to compare the treatment outcomes between the use of breast-conserving treatment (BCT) and mastectomy for T1-2N0 breast cancer patients.Methods: This study retrospectively reviewed T1-2N0 breast cancer patients who received treatment between January 2001 and December 2010 at Department of Radiotherapy Cipto Mangunkusumo Hospital and Jakarta Breast Center. The endpoints of this study were overall survival (OS), local  recurrence (LR), contra-lateral breast cancer (CBC), distant metastasis (DM), and disease-free survival (DFS).Results: Among the 262 eligible patients, 200 (76.3%) patients underwent BCT while 62 (23.7%) patients underwent mastectomy. There were no differences between BCT and mastectomy groups in 5-Y OS (88.2% vs 86.7%, p = 0,743), LR (7.4% vs 2.7%, p = 0.85), CBC (3.4% vs 5.3%, p = 0.906), DM (17.7% vs 37.7%, p = 0.212), and DFS (78.5% vs 60.7%, p = 0.163). In multivariate analysis, grade 3 was associated with worse OS (HR 2.79; 95% CI 1.08 – 7.21, p = 0.03) and DFS (HR 2.32; 95% CI 1.06 – 5.06). Premenopausal women were associated with decreased risk of DM (HR 0.37; 95% CI 0.17 – 0.80) and DFS (HR 0.38; 95% CI 0.19 – 0.78).Conclusion: BCT and mastectomy showed similar outcome in terms of OS, LR, CBC, DM, and DFS. (Med J Indones. 2012;21:220-4)Keywords: Breast-conserving treatment, mastectomy, outcomes