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All Journal Medicina journal of internal medicine E-Jurnal Medika Udayana Berkala Kedokteran Journal of Medicine and Health Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Indonesian Journal of Rheumatology ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Neurologico Spinale Medico Chirurgico Jurnal Kesehatan Saintika Meditory Jurnal Ilmu Kesehatan Indonesia (JIKSI) GANESHA MEDICINA MEDICINUS Jurnal Kedokteran Meditek Journal of Medicine and Health Technology Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD) Journal of Medicine and Health
Wira Gotera
Department Of Endocrinology And Metabolism, Medical Faculty, Udayana University/ Sanglah General Hospital, Denpasar, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Medicina

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Agranulositosis sekunder karen apropylthiouraci lpada seorang penderita penyakit graves Irianto, Petrus; Gotera, Wira
Medicina Vol 47 No 3 (2016): September 2016
Publisher : Medicina

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Abstract

Penyakit Graves merupakan penyakit autoimun yang spesifik mengenai organ tiroid. Hipersekresi hormontiroid dari kelenjar tiroid distimulasi oleh antibodi reseptor tirotropin. Pada terapi tirotoksikosis, penggunaanpropylthiouracil (PTU)dapat menyebabkan efek samping yang fatal yaitu agranulositosis. Dilaporkankasusseorang wanita penderita penyakit graves denganbadanlemas, hangat, sukar tidur, agak cemas, berdebardebar,dan riwayat pemakaian PTU lama. Hasil laboratorium didapatkan hitung jumlah granulosit yangrendah. Pasien dirawat inapdiruang isolasi, mendapat antibiotik propilaksis, injeksi filgastrim, serta terapiPTU diganti dengan metimasol. Perawatan hari ke-7 hitung jumlah granulosit kembali normal, pasiendipulangkan.[MEDICINA.2016;50(3):1-5] Graves disease is autoimune disease that is spesific about the thyroid organ. Hypersecretion thyroid hormonefrom the thyroid gland stimulated by thyrotropin receptor antibody. In treatment of thyrotoxicosis, the use ofpropylthiouracil (PTU) can causeagranulocytosis, afatal side effects. Wereportedacase of woman withGraves' disease with body limp, warm, difficulty sleeping, a little anxiety, palpitations,and long history of theuse of PTU. The laboratory resultsfoundlowgranulocytescount. Patients treated in isolation room, receiveantibiotics prophilaksis, injection filgastrim, danPTU therapy was replaced with methimasol. Onday-7ofcare,granulocytescountreturns to normal, the patient was discharged.[MEDICINA.2016;50(3):1-5].
Co-Authors A Santoso AAG Budhiarta Anak Agung Gede Budhiarta Anak Agung Wiradewi Lestari Anwar Santoso Budhiarta, Anak Agung Gde Dewa Gde Agung Budiyasa Dewi, Ni Made Ratih Purnama Dian Daniella Dwijo Anargha Sindhughosa Elizabet Haryant Gede Kambayana Gunadi, Hendra H Taniguchi I Ketut Mariadi I Ketut Suastika I Made Pande Dwipayana I Made Siswadi Semadi I Nyoman Wande I. K. Suastika Ida Bagus A Nugraha Ida Bagus Aditya Nugraha Ida Bagus Putu Putrawan IGN Gunadi IMR Saraswati Irianto, Petrus K Badjra Nadha K Rina Komang Agus Wira Nugraha LP Dea Sasmita P Luh Gede Sri Yenny Made Nian Anggara MADE RATNA SARASWATI . Mia Felina Prasetya Muhammad Ridwan N Kajiwara Ni Kadek Mulyantari Ni Made A Yudhawati Ni Made D Adnyani Novia, Juvita Nugraha, Ida Bagus Pande Ketut Kurniari Parastan, Rovie Hikari Prabawa, I Putu Yuda R. A.T. Kuswardhani RIONALDO ANTHONIUS S., Hantono Saraswati, Putu Ayu Indah Sianny Herawati Siorcani, Putu Tasha Sudana, I Nyoman Gde Sutanegara - W Wita Wan Muhamad Syafiq Wardana, Rr. Cattleya Allayka Wayan Evie Frida Yustin Widya Utama, I Putu Sista Yenny Kandarini