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Pengaruh BDNF dan Neurotrophin Receptorpada Derajat Hidrosefalus Kongenital Pasca Ventrikulo Peritoneal Shunt Bal'afif, Farhad; Widodo, M Aris; ES, M Istiadjid; Hafid B, Abdul
Jurnal Kedokteran Brawijaya Vol 27, No 3 (2013)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.693 KB) | DOI: 10.21776/ub.jkb.2013.027.03.5

Abstract

Peningkatan  tekanan  intrakranial  (TIK)  akibat  hidrosefalus  dapat  menyebabkan  penipisan  cerebral  mantle  dan bertanggungjawab  terhadap  peningkatan  Evan's  ratio  (ER).  Apoptosis  dan  degenerasi  neuron  berperan  penting  pada perubahan patologis tersebut. Pada hidrosefalus berat terjadi ketidakpastian dari perbaikan pasca Ventrikulo-Peritoneal Shunt  (V-P  Shunt),  yang  diduga  dipengaruhi  oleh  kadar  Brain  Derived  Neurotropic  Factor  (BDNF)  dan  reseptornya. Penelitian  ini  bertujuan  untuk  membuktikan  pengaruh  Kadar  BDNF ,  solubleT yrosine  Kinase  B  (sT rkB)  dan  soluble  P75 NTRneurotrophin receptor (sP75 ) cairan serebrospinal terhadap perbaikan Evan's ratio  hidrosefalus kongenital Pasca V-P Shunt.  Cairan serebrospinal (CSS)  diambil dari 22 sampel  bayi hidrosefalus saat  dilakukan V-P Shunt,  12 jam,  24 jam  dan 3 NTRbulan  kemudian.  Kadar  BDNF ,  sT rkB  dansP75 diukur  menggunakan  tehnik  ELISA.  Derajat  hidrosefalus  di  ukur menggunakan  Evan's  ratio  dari  hasil  CT-Scan  sebelum  dan  3  bulan  pasca  V-P  Shunt.  Hasil  analisis  data  menunjukkan  bahwa delta  Evan's  ratio  3  bulan  pasca  V-P  Shunt  pada  hidrosefalus  kongenital  berkorelasi  positif  dengan  kadar  BDNF  pre  operatif dan  berkorelasi  negatif  dengan  kadar  sT rkB  pre  operatif .  Disamping  itu  delta  Evan's  ratio  3  bulan  pasca  V-P  ShuntNTRdipengaruhi  secara  negatif  oleh  delta  BDNF dan sP75   dan secara  positif  oleh  delta  sT rkB  3  bulan pasca  V-P Shunt.    Kadar NTRBDNF ,  sT rkB  dan  sP75   terlibat  pada  respon  adaptif  otak  karena  peningkatan  TIK  akibat  hidrosefalus  kongenital  dan berpengaruh  pada  perbaikan  Evan's  ratio  pasca  V-P  Shunt.
Studi Pengaruh Penambahan Chitosan terhadap Sifat Fisik dan Mekanik pada Silicone Rubber/Chitosan sebagai Injectable Biomaterial Amaliya Rasyida; Muhammad Fikri Kurniawan; Agung Purniawan; Muhammad Reza Arifianto; Abdul Hafidh Bajamal
Jurnal Teknik ITS Vol 9, No 2 (2020)
Publisher : Direktorat Riset dan Pengabdian Masyarakat (DRPM), ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23373539.v9i2.59300

Abstract

Penyakit tulang belakang atau biasa disebut nyeri punggung bawah dapat terjadi pada orang dewasa yang lebih tua yang dapat mengubah anatomi nukleus pulposus (NP) dan menyebabkan degenerasi diskus intervertebralis. Baru-baru ini solusi alternatif telah dikembangkan injectable biomaterial pada operasi pasca-mikrodisektomi sebagai material pengganti NP. Penelitian ini membahas terkait studi pengaruh penambahan chitosan pada silicone rubber terhadap sifat fisik dan mekanik sebagai kandidat injectable material untuk pengganti NP. Penambahan chitosan yang digunakan sebesar sebesar 10,20,30,40, dan 50% volum dari total silicone rubber/chitosan. Sampel kemudian dilakukan pengujian FTIR, XRD, curing time, injectable performance, water content dan kekuatan tarik. Penambahan 10%chitosan memiliki nilai curing time paling cepat selama 63.30 ± 1.50 menit Sedangkan untuk water content, kandungan air terbanyak pada penambahan 50%chitosan dengan 16.71±1.41%. Seluruh sampel menunjukkan kemampuan yang baik dalam mengisi rongga-rongga cetakan saat diinjeksikan serta mampu mempertahankan bentuknya ketika berada didalam lingkungan ph7. Dalam hal pengaruhnya terhadap sifat mekanik, penambahan chitosan relatif menurunkan nilai kuat tarik.
Transformasi Struktural di Jawa Timur : Pengaruh Pertumbuhan Ekonomi Sektoral terhadap Kemiskinan Abdul Khafidzin; Nurul Istifadah
MediaTrend Vol 15, No 2 (2020): OKTOBER
Publisher : Trunojoyo University of Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21107/mediatrend.v15i2.6789

Abstract

Sectoral economic growth affects the level of poverty in the area. High economic growth does not merely reduce poverty. Equitable distribution of income is also a matter that needs to be considered in line with increased economic growth. High economic growth is the process of accumulation of sectoral economic growth that has undergone a structural shift in its journey. Changes in economic structure are marked by a decrease in the contribution of the agricultural sector and an increase in the contribution of the industrial sector, both in gross domestic product (GDP) and in employment. Economic growth needs to be directed towards economic sectors that are effective in reducing poverty and creating equitable distribution of income. The purpose of this study is to answer the question of how the influence of sectoral economic growth on poverty in East Java. For this purpose the panel data regression model is used. The selection of variables is based on research objectives. Agriculture sector GRDP (VP), industrial sector GRDP (VI) and service sector GRDP (VJ) represent sectoral economic growth. The results of the test show an increase in the contribution of the industrial sector effectively reduces poverty. In other words, between the agriculture, industry and services sectors, only the industrial sector has positive and significant parameters for poverty in East Java.
THE EFFECT OF RETURN ON ASSETS, DEBT TO EQUITY RATIO, AND CURRENT RATIO ON STOCK RETURNS OF COMPANIES LISTED IN INDONESIA’S SHARIA STOCK INDEX Abdul Hafid Martak; Ari Prasetyo
Jurnal Ekonomi Syariah Teori dan Terapan Vol. 7 No. 12 (2020): Desember-2020
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/vol7iss202012pp2339-2360

Abstract

ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh Return on Assets (ROA), Debt to Equity Ratio (DER), Current Ratio (CR), dan total asset turnover secara parsial terhadap return saham industri barang dan konsumsi perusahaan yang tergabung dalam Saham Syariah Indonesia. Periode indeks 2014-2018. Metode yang digunakan dalam penelitian ini adalah analisis regresi data panel karena data yang digunakan memiliki karakteristik gabungan antara time series dan cross section. Analisis statistik yang digunakan adalah software Econometric Views (EViews) 6.0. Populasi yang digunakan dalam penelitian ini adalah Indeks Saham Syariah Indonesia. Sampel yang digunakan dalam penelitian ini sebanyak 41 perusahaan barang dan konsumsi yang memenuhi kriteria sampel. Periode observasi penelitian dari tahun 2014 hingga 2018.Keywords: Return On Assets, Debt to Equity Ratio, Current Ratio, Return. ABSTRACTThis study aims to determine the effect of Return on Assets (ROA), Debt to Equity Ratio (DER), Current Ratio (CR), and total assets turnover partially on the stock returns of industrial goods and consumption companies incorporated in the Indonesian Sharia Stock Index period 2014-2018. The method used in this study is panel data regression analysis because the data used has the characteristics of a combination of time series and cross section. The statistical analysis used was Econometric Views (EViews) 6.0 software. The population used in this study is the Indonesian Syariah Stock Index. The sample used in this study were 41 goods and consumption companies that met the sample criteria. The research observation period is from 2014 to 2018.Keywords: Return On Assets, Debt to Equity Ratio, Current Ratio, Return.
FERTILITY RATE USING THE PALMORE FORMULA IN EAST JAVA PROVINCE: A STUDY OF 2015 SUPAS Muhammad Abdul Khafidz Maftukh; Lutfi Agus Salim; Farizah Mohd Hairi
Jurnal Biometrika dan Kependudukan (Journal of Biometrics and Population) Vol. 10 No. 2 (2021): JURNAL BIOMETRIKA DAN KEPENDUDUKAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbk.v10i2.2021.138-143

Abstract

Fertility is an important indicator for the success of state development, especially in the health sector. It can be estimated through direct and indirect methods. This study aimed to determine the fertility rate in East Java province indirectly using the Palmore Formula. This study was a descriptive analysis using secondary data from the 2015 Inter-census Population Survey / Survei Penduduk Antar Sensus (SUPAS). It calculated the rate directly and manually. The Total Fertility Rate (TFR) was at 2.02 per two children born by each mother in East Java province. It was compared with the national average published by the Central Bureau of Statistics within 5 periods of SP1990, SUPAS 1995, SP2000, SUPAS 2005, and SP2010. In each period, the rate was lower without any difference. The Palmore Formula is considered a good method for estimating fertility rates.
The Effect of Thymoquinone Administration on Local Immunoglobulin-G Levels of Rattus norvegicus Strain Wistar Sciatic Nerve Crush Injury Model Valentinus Besin; Abdul Hafid Bajamal; Mohammad Hasan Machfoed; Jusak Nugraha; Budi Utomo; Paulus Budiono Notopuro
The Indonesian Biomedical Journal Vol 14, No 1 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i1.1772

Abstract

BACKGROUND: Immunoglobulin-G (IgG) is a product of the initial response to secondary immune response, which accumulates in distal segment of the nerve after crush injury. Thymoquinone modulates the adaptive immune response. Effect of thymoquinone administration on local IgG levels of Rattus norvegicus Wistar rats sciatic nerve crush injury model has not been elucidated.METHODS: This was an experimental study, with 63 Rattus norvegicus Wistar rats that divided into 9 groups. Three groups were given placebo, 3 groups were given 100 mg/kg/day thymoquinone, and 3 groups were given 250 mg/kg/day thymoquinone. The rats were terminated based on the assigned group at 5x24, 6x24, and 7x24 hours and then the IgG levels were measured using sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: There was a significant difference in IgG levels after administration of 100 and 250 mg/kg/day thymoquinone at 5x24 hours and 7x24 hours post-injury compared to the rats that were given no treatment. A significant difference of IgG levels was also found after administration of 100 mg/kg/day thymoquinone group at 6x24 hours post-injury. Critical point of decreasing local IgG of all groups happened at 6x24 hours after injury, however, there was no significant difference in the median levels of thymoquinone at doses of 100 mg/kg and 250 mg/kg.CONCLUSION: Local IgG levels in distal segment of the sciatic nerve crush injury is lower in rats that were given 100 mg/kg thymoquinone treatment compared to the rats that receive no thymoquinone treatment since 5x24 hours after injury. Thymoquione administration should be given immediately after the crush injury until before 6x24 hours post-injury to decrease antibodies in degeneration process.KEYWORDS: thymoquinone, immunoglobulin-G, crush injury, sciatic nerve
MANAJEMEN TRAUMA TEMBUS OTAK : LAPORAN KASUS Asadullah Asadullah; Endra Wibisono Harmawan; Resi Prastikarunia; Gunna Hutomo Putra; Heru Kustono; Setia Utama; Komang Sena Adistira Artha; Tedy Apriawan; Abdul Hafid Bajamal
Molucca Medica VOLUME 12, NOMOR 2, OKTOBER 2019
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (885.194 KB) | DOI: 10.30598/molmed.2019.v12.i2.34

Abstract

Pendahuluan. Trauma tembus otak merupakan kegawatan medis yang meskipun jarang terjadi namun sering mengakibatkan mortalitas dan morbiditas yang tinggi. Penanganan trauma tembus otak sendiri masih menjadi tantangan bagi para ahli bedah saraf di seluruh dunia. Menajemen yang optimal pada penaganan trauma tembus otak memerlukan pemahaman yang komprehensif terhadap mekanisme dan patofisiologi terjadinya cedera tersebut. Sampai saat ini penanganan standar pada kasus trauma tembus otak masih menjadi perdebatan. Metode. Artikel ini berbentuk serial kasus, kami melaporkan 3 kasus trauma tembus pada institusi kami. Artikel ini disusun dari berbagai referensi dan pengalaman kasus yang pernah ditangani di Rumah Sakit Umum AkademikDr. Soetomo. Hasil. Pada pasien trauma tembus yang dilakukan kraniotomi debridement kurang dari 12 jam post trauma diikuti pemberikan antibiotik profilaksis empirik dengan ceftriaxone dan metronidazole selama 7 hari dan antikejang phenytoin selama 7 hari didapatkan keluaran yang memuaskan. Kesimpulan Manajemen trauma tembus otak memerlukan metode diagnostic yang cepat dan tepat. Pemeriksaan CT scan kepala menjadi wajib untuk penegakan diagnosis trauma tembus kepala. CT angiografi diperlukan pada kasus kasus yang dicurigai menyebabkan lesi vaskular. Yang kemudian iikuti dengan penangan operasi segera dan pemberian antibiotic yang tepat. Kata Kunci: Trauma tembus otak, kraniotomi debridement, antibiotik profilaksis empiri, CT angiografi
Thoracic myeloradiculopathy due to multilevel ossification of ligamentum flavum Yunus Kuntawi Aji; Abdul Hafid Bajamal; Rizki Meizikri; Muhammad Faris
Neurologico Spinale Medico Chirurgico Vol 3 No 3 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i3.118

Abstract

Ossification of ligamentum flavum (OLF) is calcification of the ligamentum flavum, which might narrow the spinal canal and causes myeloradiculopathy. This condition mainly affects the lower thoracal segment. Published reports on OLF are mostly from East Asia. There was only one Indonesian OLF case that had been published. The majority of OLF involves a single level only. This is the first Indonesian case-report on multilevel OLF. Through this case report, we aim to describe the natural history of the patient and our treatment strategy in managing the multilevel OLF case. Delayed time to surgery is the key contributory factor in unfavorable surgical outcome in thoracic OLF. Choosing an appropriate surgical procedure is important. The neurological symptoms of the patient may not improve or worsen when an inadequate surgical procedure is used.
Rupture of the recurrent thoracic intramedullary spinal cord cavernoma Galih Indra Permana; Eko Agus Subagio; Muhammad Faris; Abdul Hafid Bajamal
Neurologico Spinale Medico Chirurgico Vol 4 No 3 (2021)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v4i3.169

Abstract

The intramedullary spinal cord cavernoma is a rare vascular disease that occur within spinal cord or intramedullary and account for about 5%-12% of all pathology in the spinal vascular disease. We report a clinical progression of disease and evolution of the haemorrhage every years until patient underwent surgical procedure. A 63-years old male with progressive weakness of the lower extremity since 1 month before admission, worse in the left side He also complained loss of sensation at the level of the T4 and below it. Patient suffer three times rebleeding before underwent surgery. MR imaging showing intramedullary spinal cord cavernoma and a histology examination exhibited the characteristics of a cavernoma. Intramedullary spinal cord cavernoma is a rare disease that should be treated before rebleeding occur and enlargement of the lesion. Postoperative neurological function in intramedullary spinal cord cavernoma patient is determined by the preoperative neurological status.
Modified Laminoplasty After Excision of Cervical Schwannoma with Large Extravertebral Extension Muhammad Faris; Abdul Hafid Bajamal; Zaky Bajamal; Krisna Tsaniadi Prihastomo
Neurologico Spinale Medico Chirurgico Vol 1 No 1 (2018)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1614.472 KB)

Abstract

Tumour excision and laminoplasty are commonly performed as surgical treatment of extra vertebral extension of cervical schwannoma. It is worth knowing that the conventional technique of multilevel laminectomy may hinder younger patients in the long-term. This article reports a 30-year old man with an intradural-extramedullary tumour which extended from C4 to T1 that underwent modified laminoplasty. This modified technique is preferable in maintaining the anteroposterior diameter of spinal canal as well as reducing the displacement of guttered laminae