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All Journal Jurnal Respirasi (JR) World Nutrition Journal JURNAL ETIKA KEDOKTERAN INDONESIA IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) SEHAT : JURNAL KESEHATAN TERPADU Ebers Papyrus
Wiji Lestari
Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Effect of carnitine on patients with heart failure: an evidence-based case report Yosua Yan Kristian; Wiji Lestari
World Nutrition Journal Vol. 4 No. 1 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.i1.0003

Abstract

Background: Heart disease is one of the leading causes of death in Indonesia. Nutritional management plays an important role in overcoming heart disease, both as prevention and treatment. Carnitine plays a role in fat metabolism and can reduce the formation of thrombosis, resulting in improved heart function and quality of life of patients.Objectives: This study is aimed to identify the effect of carnitine in patients with heart failure.Methods: Existing research findings and articles are selected based on inclusion and exclusion criteria in three databases, namely PubMed, Cochrane and Wiley. The outcome were functional capacity and heart function.Results: One meta-analysis that address with the clinical questions was obtained, and based on that article, giving carnitine to patients with heart failure has effects on increasing functional capacity, heart function, BNP serum and NT-proBNP levels. However, no effects found on mortality. Furthermore, no significant side effects on carnitine was found.Conclusions: Carnitine supplementation at a dose of 1 up to 6 g/day has a positive impact on functional capacity, heart function, BNP serum and NT-proBNP levels in patients with heart failure, alongside with minimal side effects.
Probiotics administration as a prevention for postoperative infectious complications in colorectal cancer patients: A literature review Angela Dalimarta; Wiji Lestari
World Nutrition Journal Vol. 4 No. 2 (2021): Volume 04 Issue 2, August 2021
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.i2.0013

Abstract

Background Colorectal cancer is the third leading cause of death from cancer in adults in the United States, with increasing prevalence in other countries. Radical resection is the gold standard of treatment in most cases of colorectal cancer, with a high rate of postoperative complications. Perioperative probiotics can improve the immune response and the postoperative intestinal microbiota environment. Although several studies have shown the benefits of probiotics in preventing postoperative complications of infection, the administration of perioperative probiotics in colorectal cancer patients is still controversial. Objective. The purpose of this critical appraisal is to know the effectiveness of administering probiotics to prevent infectious complications in colorectal cancer patients. Methods. Literature research using Pubmed, Cochrane, and EBSCOhost was carried out and 2 articles were obtained in the form of meta-analysis using STATA v11 and Revman v5.2 that was critically examined using the FAITH method. A comprehensive search for all studies was done to find all relevant studies using both MeSH terms and text words. The article should describe the assessment of quality and criteria used in method section, also provide information on the quality of individual studies in result section to minimize bias. The result section should state whether heterogeneity exists and mention possible reasons. Results. Based on 2 meta-analyses that have been critically examined, which each consisting of 13 and 7 studies, giving probiotics can reduce the overall infection rate after colorectal cancer surgery. One meta-analysis showed an odds ratio (OR) of 0.51 (95% CI: 0.38 – 0.68, p = 0.00). Probiotics, such as Lactobacillus acidophilus and Bifidobacterium longum can also reduce the incidence of surgical site infections (OR = 0.59, 95% CI 0.39 – 0.88, p = 0.01) and pneumonia (OR = 0.56, 95% CI 0.32 – 0.98, p = 0.04). Probiotics did not provide statistically significant benefits in preventing urinary tract infections, leakage of anastomosis, and duration of postoperative pyrexia compared to the control group. Seven articles analyzed in the second meta-analysis showed probiotics to be useful in preventing postoperative infections with OR 0.5388 (95% CI, 0.4058-0.7154, P <0.0001). Conclusions. Combination of more than one strain of probiotics such as Lactobacillus and Bifidobacterium is promising for the prevention of infections in patients undergoing colorectal cancer surgery.
Low Dietary Omega-6 to Omega-3 Fatty Acid Intake Ratio Enhances Adiponectin Level in Obesity Helena Fabiani; Ninik Mudjihartini; Wiji Lestari
World Nutrition Journal Vol. 5 No. 1 (2021)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.i1.0005

Abstract

Every year around the world, the prevalence of obesity is increasing. Obesity and its associated diseases have become some of the most pressing health problems in developed and developing countries. In its development, adipocytes dysfunction and chronic low-grade inflammation occur in obesity will stimulate diseases at higher risk including type 2 diabetes mellitus (T2DM), atherosclerosis, hypertension, and metabolic syndrome. Western diet and sedentary lifestyle are thought to have significantly contributed to the increase in obesity recently. Diet modification is a sound method to prevent obesity and its complications. Nevertheless, the concern lies in the ratio of omega-6 towards omega-3 fatty acids intake, which in its current state indicates an imparity. Omega-3 and omega-6 are two essential fatty acids that emerge as dominant factors in obesity through adiponectin. Adiponectin refers to a protein hormone conceived by adipocytes to prevent obesity and its subsequent complications by increasing insulin sensitivity, fatty acid oxidation, anti-inflammatory, and antiaterogenic. This study aims to determine the mechanism and the role of fatty acids in omega-6 towards those within omega-3 by using adiponectin as the indicator of advancement to obesity and its underlying diseases.
Etika Mengakhiri Hubungan Dokter-Pasien Pukovisa Prawiroharjo; Rizky Rafiqoh Afdin; Wiji Lestari
Jurnal Etika Kedokteran Indonesia Vol 5, No 1 (2021): VOL 5, NO 1 (2021)
Publisher : Majelis Kehormatan Etik Indonesia PBIDI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26880/jeki.v5i1.55

Abstract

Hubungan dokter-pasien dan keluarga pasien dilandasi asas kepercayaan antar pihak. Landasan kepercayaan antar pihak ini dapat rusak oleh berbagai faktor. Hubungan dokter-pasien mencakup kewajiban dokter untuk memberikan keberlangsungan perawatan terhadap pasien. Pengakhiran hubungan dokter-pasien merupakan suatu kesepakatan bersama dengan tanpa paksaan, mungkin tidak menjadi masalah. Namun di luar kesepakatan antara dokter dan pasien, maka pengakhiran hubungan dokter-pasien ini dapat ditinjau dari sisi pasien maupun dari sisi dokter. Dari sisi pasien, mengakhiri hubungan dokter- pasien dan fasilitas layanan kesehatan baik yang bersifat sementara lalu kembali lagi, atau untuk seterusnya merupakan bagian dari hak pasien. Pengakhiran hubungan dokter-pasien dari sisi dokter adalah intimidasi, kekerasan, serta perilaku merusak hubungan saling percaya tanpa alasan dari pasien.
EFFECTS OF PROBIOTICS ON LIPID PROFILES IN HYPERCHOLESTEROLEMIA ADULT PATIENTS: AN EVIDENCE-BASED CASE REPORT Elisa; Wiji Lestari
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 4 No 2 (2021): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v4i2.79

Abstract

Background: Hypercholesterolemia prevalence was 39% in adults and a risk factor for cardiovascular, cerebrovascular, atherosclerotic disease, leading to vertigo. Diet and specific food potentiate in dyslipidemia risk reduction. Several studies have been proposed that probiotics have a hypocholesterolemic effect. Objectives: This study aims to determine the effect of probiotics on lipid profiles in hypercholesterolemia adult patients. Methods: Electronic literature searching was conducted from Pubmed, Scopus, and Cochrane Library. MeSH Terms combined with Title/Abstract are used in advanced search based on inclusion and exclusion criteria. Results: Critical appraisal was conducted for a systematic review and meta-analysis of randomized controlled trials. Probiotic supplementation significantly decreases total cholesterol and low-density lipoprotein cholesterol levels but not statistically significant in high-density lipoprotein and triglycerides levels. Conclusion: Single strain Lactobacillus plantarum probiotics for at least six weeks can improve total cholesterol levels in hypercholesterolemia adult patients.
EFFICACY OF IMMUNONUTRITION CONTAINING OMEGA-3 FATTY ACIDS TO REDUCE MORTALITY IN ACUTE RESPIRATORY DISTRESS SYNDROME: AN EVIDENCED-BASED CASE REPORT Nita; Wiji Lestari
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 5 No 1 (2022): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v5i1.82

Abstract

Background: Acute respiratory distress syndrome (ARDS) remains one among the most reasons for ICU admission. It is related to high rates of mortality despite many recent advances in overall support. A relative increase in oxidative stress in patients with ARDS results in increased alveolar injury. Immunonutrion containing omega 3 fatty acids is one among the strategies that currently receiving attention within the management of ARDS since they are known to have anti-inflammatory effects, but the results are still inconsistent. Objective: This study aimed to find out the efficacy of immunonutrition containing omega 3 fatty acids in reducing mortality in patients with ARDS. Methodology: Electronic literature researches were performed in PubMed, Cochrane, and Scopus. MeSH term and title/abstracts were screened based on inclusion and exclusion criteria before relevant journals were reviewed. Results: Two articles were selected based on the eligibility criteria and relevance to the clinical questions. The study of Langlois P. et al. found significantly reduced mortality in patients receiving continuous enteral infusion route of immunonutrition containing omega 3 fatty acids. While Dushianthan A. et al. found little or no mortality benefit with the administration of immunonutrition containing omega 3 fatty acids. Conclusions: There is little or no mortality reduction within the administration of immunonutrition containing omega 3 fatty acids. Keywords: acute respiratory distress syndrome, ARDS, immunonutrition, omega 3 fatty acids, mortality.
Medical nutritional therapy on schizophrenic patient with grade 2 obesity and continued antipsychotic drug use Andry Kelvianto; Wiji Lestari; Diana Sunardi
World Nutrition Journal Vol. 5 No. S3 (2022): Selected conference proceedings of the Nutri Virtual Symposium 2021
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.S3.0021

Abstract

Patients suffering from schizophrenia have an elevated risk for obesity and metabolic syndrome due to multiple factors, including antipsychotic drug consumption. Diet and lifestyle modification remained the firstline modalities for management of obesity in patients with schizophrenia. Metformin has been recommended for preventing weight gain, including for schizophrenic patients with long-term consumption of psychiatric medication.
Omega-6 and Omega-3 Intake Ratio in Pulmonary Tuberculosis Patients and Its Correlation with Depression Score Nabila Fawzia; Wiji Lestari; Fariz Nurwidya; Heidy Agustin; Ammar Abdurrahman Hasyim
Jurnal Respirasi Vol. 9 No. 3 (2023): September 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.3.2023.194-199

Abstract

Introduction: Depression affects 45.19% of pulmonary tuberculosis (TB) patients' adherence to treatment, resulting in increased morbidity and death, medication resistance, and continued disease transmission. This study aimed to examine the relationship between omega-6/omega-3 (êž·-6/êž·-3) polyunsaturated fatty acids (PUFA) intake ratio and depression score in patients with pulmonary TB at Persahabatan National Respiratory Referral Hospital, Jakarta. Methods: This was a cross-sectional study of 99 subjects with pulmonary TB. Data were collected using the Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ), anthropometric measurements, and the Beck Depression Inventory-II (BDI-II). Results: Correlation analysis used the Spearman test and revealed the ratio of êž·-6/êž·-3 PUFAs intake of 7.78 ± 1.13, the median value of depression score was 9 (10-36). There was no correlation between êž·-6/êž·-3 PUFA intake and depression score (r = 0.063; p = 0.534). Conclusion: There was no correlation between êž·-6/êž·-3 PUFAs intake ratio and depression scores in pulmonary TB patients. This is the first study to examine the correlation between êž·-6/êž·-3 PUFA intake ratio and depression score in pulmonary TB patients.
EFFECTIVENESS OF PROBIOTIC SUPPLEMENT ON HELICOBACTER PYLORI INFECTION ERADICATION IN GASTRIC ULCERS Sulistyanti Dian Rachmawati; Wiji Lestari
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 6 No 1 (2023): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v6i1.114

Abstract

Background: Helicobacter pylori colonizes the gastric mucosa in 50% of the human population. H. pylori infection causes several upper gastrointestinal tract diseases such as chronic gastritis, peptic ulcer, duodenal ulcer, and gastric cancer. H. pylori is also associated with a high risk of developing gastric adenocarcinoma. The World Health Organization classifies H. pylori infection as a class 1 carcinogen. Giving probiotics may improve the immune system and suppress the effects of pathogens. However, mixed results were obtained from the use of various kinds of bacteria and fungi as probiotics. Objective: To determine the effectiveness of probiotic supplementation against the eradication of Helicobacter pylori infection in gastric ulcers. Conclusion: The effectiveness uses of probiotics to eradicate H. pylori has not been proven. It will take clinical trials with a sufficient number of subjects and certain probiotic strains to be able to determine the type of strain, dosage, duration of use, and side effects that can be caused.
The impact of omega-3 on recurrent seizures in epileptic patients: A case study with evidence-based approaches Nadiyah Wijayanthie; Wiji Lestari
World Nutrition Journal Vol. 7 No. 2 (2024): WNJ. Volume 07 Issue 2, February 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V07.i2.0006

Abstract

Background: Epileptogenesis is also associated with increased production of excessive pro-inflammatory cytokines” which shows connection between pro-inflammatory cytokines as triggering factor with omega-3 which has anti-inflammatory effect. Omega-3, known for its neuroprotective and anticonvulsant properties, exhibits promising effects on epileptic seizure attacks. Objective: This study aimed to evaluate the effect of omega-3 supplementation on the incidence of seizures in epilepsy patients. Methods: This study used a literature search using advanced queries in the databases PubMed, Scopus, ProQuest, and Cochrane Library, and combined MeSH terms with Title/Abstract. The collected literature is discarded if there are duplicates, then literature is filtered that meets the eligibility criteria. We used the Oxford Center for Evidence-Based Medicine as a means of critical appraisal and determining the level of evidence of the selected literature. Results: Four chosen literatures were critically assessed. Two articles indicating no significant difference between omega-3 and placebo and two articles showed had a significantly higher number of seizure-free days than placebo. The first article, involving 78 adults, reported a 50% reduction in seizure risk with a frequency RR of 0.57, 95% CI 0.19 to 1.75 (IS = 0%) indicating no significant difference between omega-3 and placebo groups after 12 weeks of treatment. The second study, comprising mostly non-significant findings, demonstrated no significant correlation between omega-3 and epilepsy attacks in epilepsy patients. The third literature revealed seizure occurrences per month in the EPA group (9.7±1.2), DHA group (11.7±1.5), and placebo group (16.6±1.5). Incidence rate ratio (IRR) adjusted for seizure type in EPA and DHA groups compared to the placebo group were 0.61 (CI = 0.42–0.88, p = 0.008, a 42% reduction) and 0.67 (CI = 0.46–1.0, p = 0.04, a 39% reduction), respectively. Both treatment groups had a significantly higher number of seizure-free days compared to the placebo group (p < 0.05). The fourth study reported intervention group frequency (4.72 ± 1.6, p= 0.014) and placebo frequency (11.64 ± 1.63, p=0.014) with intervention group seizure duration (6.64 ± 1.39, p=0.009) compared to placebo group (14.36 ± 2.18, p=0.009). Conclusion: Omega-3 supplementation may be considered for management in patients with recurrent epileptic seizures, although its effect on reducing seizure frequency remains inconsistent.
Co-Authors Afria Beny Safitri Agustin, Heidy Ammar Abdurrahman Hasyim Andry Kelvianto Angela Dalimarta Chandra, Dian Novita Da Costa Hornay Florencia Grifit Joiner Defi Selvianita Diana Sunardi Elisa Fariz, Nurwidya Fiastuti Isbandi Witjaksono Helena Fabiani Ibrahim Agung Krisadelfa Sutanto Lia Awwalia Majida Lidya Anissa Nabila Fawzia Nadhira Nuraini Afifa Nadiyah Wijayanthie Ninik Mudjihartini Nita Nurul Ratna Mutu Manikam Pukovisa Prawiroharjo Putri Amalina Nafisa Putri Nuraini Rizky Rafiqoh Afdin Rizqa Febriliany Putri Salma Alfina Putri Nada Sri Widia A.Jusman Sulistyanti Dian Rachmawati Tarafainy Basalamah Tirza Z Tamin Wanda Khairun Nasirin Yosua Yan Kristian