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All Journal Jurnal Respirasi (JR) World Nutrition Journal JURNAL ETIKA KEDOKTERAN INDONESIA IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) SEHAT : JURNAL KESEHATAN TERPADU Ebers Papyrus
Wiji Lestari
Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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EFEK SUPLEMENTASI SINBIOTIK DALAM MENURUNKAN LAMA RAWAT DAN MORTALITAS PADA PASIEN SAKIT KRITIS DENGAN SEPSIS Afria Beny Safitri; Wiji Lestari
Ebers Papyrus Vol. 31 No. 2 (2025): EBERS PAPYRUS
Publisher : Fakultas Kedokteran Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/ep.v31i2.35729

Abstract

ABSTRAK Latar Belakang: Sepsis merupakan penyebab utama mortalitas global. Disbiosis usus memperberat respons inflamasi pada sepsis. Suplementasi sinbiotik (kombinasi probiotik dan prebiotik) diusulkan sebagai terapi adjuvan untuk memodulasi mikrobiota usus, namun efektivitasnya dalam menurunkan lama rawat dan mortalitas masih diperdebatkan. Metode: Pencarian sistematis dilakukan pada PubMed, Embase, dan Cochrane Library untuk systematic review (SR) dan randomized controlled trials (RCT) terbaru. Kriteria inklusi adalah pasien sakit kritis dengan sepsis yang mendapat sinbiotik, dengan luaran mortalitas dan lama rawat. Hasil: Dua SR (Gong et al., 2025; Lou et al., 2023) dianalisis. Sinbiotik menunjukkan potensi penurunan mortalitas pada pasien dewasa (Risk Ratio 0,61; 95% CI 0,34–1,08) dan insiden ventilator-associated pneumonia (VAP) (RR 0,52; 95% CI 0,31–0,87). Namun, dampaknya terhadap lama rawat di ICU tidak konsisten antar studi. Terdapat heterogenitas tinggi dalam strain, dosis, dan durasi pemberian. Kesimpulan: Sinbiotik berpotensi menurunkan mortalitas dan komplikasi infeksi pada pasien sepsis sakit kritis. Namun, bukti mengenai pengurangan lama rawat masih belum konklusif. Diperlukan RCT lebih lanjut dengan populasi besar dan protokol yang terstandarisasi untuk memastikan rekomendasi klinis yang optimal. Kata-kata kunci: lama rawat, mortalitas, perawatan intensif, sepsis, sinbiotik ABSTRACT Background: Sepsis is a leading cause of global mortality. Gut dysbiosis exacerbates the inflammatory response in sepsis. Synbiotic supplementation (a combination of probiotics and prebiotics) is proposed as an adjuvant therapy to modulate gut microbiota, but its effectiveness in reducing length of stay and mortality remains debated. Methods: A systematic search was conducted on PubMed, Embase, and Cochrane Library for recent systematic reviews (SRs) and randomized controlled trials (RCTs). Inclusion criteria were critically ill septic patients receiving synbiotics, with outcomes of mortality and length of stay. Results: Two SRs (Gong et al., 2025; Lou et al., 2023) were analyzed. Synbiotics showed a potential reduction in mortality in adult patients (Risk Ratio 0.61; 95% CI 0.34–1.08) and the incidence of ventilator-associated pneumonia (VAP) (RR 0.52; 95% CI 0.31–0.87). However, the effect on ICU length of stay was inconsistent across studies. High heterogeneity was observed in strains, dosage, and duration of administration. Conclusion: Synbiotics may reduce mortality and infectious complications in critically ill septic patients. However, evidence for reducing length of stay remains inconclusive. Further large-scale RCTs with standardized protocols are needed to establish optimal clinical recommendations. Keywords: intensive care, length of stay, mortality, sepsis, synbiotics
INTERVENSI GIZI BERBASIS MORINGA UNTUK LANSIA HIPERTENSI DI DESA RAMBONG, KABUPATEN ACEH BARAT Salma Alfina Putri Nada; Defi Selvianita; Putri Amalina Nafisa; Lia Awwalul Majida; Wiji Indah Lestari; Wanda Khairun Nasirin
SEHAT : Jurnal Kesehatan Terpadu Vol. 5 No. 3 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/s-jkt.v5i3.60895

Abstract

Penelitian ini bertujuan untuk efektivitas intervensi gizi berbasis kelor melalui edukasi hipertensi dan pemberian makanan tambahan (PMT) perkedel kentang daun kelor rendah garam terhadap pengetahuan dan tekanan darah lansia di Desa Rambong, Kecamatan Bubon, Kabupaten Aceh Barat. Penelitian ini menggunakan desain intervensi komunitas dengan pendekatan pretest-posttest tanpa kelompok kontrol. Penelitian ini menggunakan teknik total sampling, dengan total 21 lansia yang berpartisipasi dalam penelitian. Intervensi dilakukan melalui edukasi gizi tentang hipertensi dan pemberian PMT berupa perkedel kentang daun kelor rendah garam. Analisis data dilakukan secara deskriptif menggunakan distribusi frekuensi dan persentase.66,7% responden berjenis kelamin perempuan (66,7%) berusia 60–74 tahun (81,0%). Sebelum intervensi, sebanyak 66,7% lansia mengalami hipertensi. Status gizi normal ditemukan pada 61,9% responden, namun masih ditemukan masalah gizi kurang dan gizi lebih. Setelah intervensi, proporsi lansia dengan tekanan darah normal meningkat dari 33,3% menjadi 52,9%, sedangkan proporsi hipertensi menurun dari 66,7% menjadi 47,1%. Selain itu, terjadi peningkatan pengetahuan yang signifikan, yang disebabkan oleh pergeseran skor dari kategori rendah pada pretest menjadi kategori tinggi pada post-test, dengan 50,0% peserta memperoleh skor maksimal. Intervensi gizi berbasis kelor yang dikombinasikan dengan edukasi hipertensi mampu meningkatkan pengetahuan lansia dan mendukung perbaikan status tekanan darah. Pemanfaatan daun kelor sebagai pangan lokal fungsional berpotensi menjadi strategi yang efektif dan berkelanjutan dalam upaya pengendalian hipertensi pada lansia di masyarakat.
Effect of omega−3 fatty acdid supplementation on reduce body weight and body fat mass in obesity: A case study with an evidence-based approach Lidya Anissa; Wiji Lestari
World Nutrition Journal Vol. 8 No. 2 (2025): WNJ. Volume 08 Issue 2, February 2025
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i2.0002

Abstract

Background: Obesity is a public health problem, especially in developing countries. Providing Omega−3 supplementation has benefits to reduce body weight and body fat mass. Objective: This study aims to determine the effect of omega−3 supplementation on weight loss and body fat mass in obesity. Methods: This study used a literature search using advanced queries in the databases PubMed, Scopus, ProQuest, Cochrane Library, and combined MeSH terms with Title/Abstract. The collected literature is discarded if there are duplicates, then literature that meets the eligibility criteria is filtered. We used the Oxford Center for Evidence-Based Medicine as a means of critical appraisal and determining the level of evidence of the selected literature. Results: Four chosen study were selected. The first study involved 39 adults with obesity, there was a weight loss of 6.04 kg in the group given omega−3 supplementation of 6 g/day for 8 weeks compared to the placebo group 5.4 kg and there was a decreased in body fat mass in the intervention group. The second study did not show a significant result. The third study on 65 women showed a weight loss of 3.07 kg in the group given omega−3 consisting of 1.08 g EPA and 0.72 g DHA compared to 1.16 kg in the placebo group for 12 weeks. In the fourth study, a systematic review study, there was no conclusive result. Conclusion: Omega−3 fatty acid supplementation could be beneficial in reducing weight in obese patients with dietary modification.
Effects of probiotics supplementation on reducing inflammation in burn patients: Evidence based case report Nadhira Nuraini Afifa; Wiji Lestari
World Nutrition Journal Vol. 9 No. 1 (2025): WNJ. Volume 9 Issue 1, Agustus 2025
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V09.i1.0001

Abstract

Background: Burn injuries cause significant physical trauma and complex inflammatory responses, accounting for more than 300,000 deaths per year. Probiotics may help modulate inflammation in burn patients by improving biomarkers such as hs-CRP and IgA levels. This case report aims to investigate the effect of probiotics supplementation on reducing inflammation in burn patients. Methods & Materials: A literature search was on three large databases: PubMed, Cochrane Library, and Google Scholar. MeSH terms, advanced search, and eligibility criteria were used for title and abstract screening after removing duplicates. Critical assessment tools and levels of evidence of the final articles are based on the Oxford Center for Evidence-Based Medicine. Results: Two randomized controlled trials (RCTs) met the PICO and eligibility criteria. One RCT found that probiotics supplementation significantly reduced hs-CRP levels (21.38 ± 44.45 vs 36.36 ± 79.03; p < 0.001) and improved wound healing in burn patients. The other RCT found that single and mixed strain probiotic administration significantly increased IgA levels (p < 0.001 and p = 0.025, respectively) in burn patients. Conclusions: Probiotics supplementation demonstrates significant benefits in reducing systemic inflammation and enhancing immune function. Further research is necessary to provide recommendations of probiotic use in burn care.
Association between maternal anemia and low birth weight among stunting children 12−23 months in Dili, Timor Leste Da Costa Hornay Florencia Grifit Joiner; Dian Novita Chandra; Wiji Lestari
World Nutrition Journal Vol. 8 No. 2 (2025): WNJ. Volume 08 Issue 2, February 2025
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i2.0014

Abstract

Background: Stunting is a chronic malnutrition problem primarily occurring during the first 1000 days of life. Iron deficiency anemia during pregnancy can threaten fetal growth and may affect the baby's birth weight and length. According to the Timor-Leste Food and Nutrition Survey 2020, stunting in Timor-Leste is 47.1%. Objectives: To determine the relationship between a history of anemia during the third trimester of pregnancy and low birth weight with the incidence of stunting in children aged 12-23 months in Dili city. Methods: This study was a case-control design conducted in five health centers in Dili City, Timor-Leste. The sample consists of 180 children aged 12-23 months, with 90 stunted cases and 90 controls selected consecutively. Data collected encompasses both child-related and maternal information. Results: Anemia during the third trimester of pregnancy OR 95%CI 7.18 (3.38-15.23) and low birth weight OR 95%CI 5.39 (2.09 – 13.90) are significantly associated with the incidence of stunting (p < 0.01). Based on logistic regression analysis, anemia during pregnancy and low birth weight are not significantly associated with an increased risk of stunting. However, there are characteristics of the mother and child that are significantly associated with the risk of stunting. Conclusion: Children with a history of low birth weight are 5.3 times more likely to experience stunting, and children whose mothers had anemia during pregnancy are 7.2 times more likely to experience stunting. The results show that low birth weight and maternal anemia are related to the incidence of stunting in Timor-Leste.
Paradoxical rise in interleukin-6 following brown rice intake: A postprandial study in sedentary workers Rizqa Febriliany Putri; Sri Widia A. Jusman; Wiji Lestari
World Nutrition Journal Vol. 10 No. 1 (2026): WNJ. Volume 10 Issue 1, Agustus 2026
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V10.i1.0008

Abstract

Background: Brown rice is thought to have anti-inflammatory effects due to its high dietary fiber and phenolic content; however, evidence in sedentary populations is limited. IL-6 is a key pleiotropic cytokine responsive to postprandial inflammation. Objective: This study compared postprandial IL-6 levels after brown vs. white rice consumption in sedentary workers. Methods: In this open-label, parallel-group trial, 28 normoweight participants (22 women, 6 men) consumed 150 g of rice, 60 g of fried eggs, and 70 g of tofu stew. Nutritional composition was determined from available sources, with fat content of brown rice (2.4 g/100 g) obtained from the manufacturer’s laboratory report and that of white rice (0.5 g/100 g) from published data. Participants were randomized by gender into brown rice (n=13, age 30.15 ± 6.71) and a white rice groups (n=15, age 27 [23-48]). IL-6 levels were measured at baseline (10-hour fast) and 4 hours post-meal. Previous-day intake (24-hour food recall) and physical activity (IPAQ-SF) were recorded. Non-parametric tests were applied. Results: Participants averaged 321.5 ± 181.2 METs. Despite higher fat content in brown rice, intake did not differ significantly between groups. IL-6 changes were not statistically significant (p=0.069). However, the brown rice group showed a numerically higher postprandial IL-6 level, while the control group remained relatively stable. Conclusions: No significant IL-6 differences were observed, however the paradoxical elevation following brown rice consumption is probably due to subtle influences of nutrient composition or participant characteristics. Further studies with stricter dietary control and biomarkers are warranted.
Protein and branched-chain amino acid intake are associated with functional capacity in malnourished head and neck cancer patients undergoing chemoradiotherapy Tarafainy Basalamah; Nurul Ratna Mutu Manikam; Tirza Z. Tamin; Wiji Lestari; Krisadelfa Sutanto; Ibrahim Agung
World Nutrition Journal Vol. 10 No. 1 (2026): WNJ. Volume 10 Issue 1, Agustus 2026
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V010.i1.0003

Abstract

Introduction: Head and neck cancer (HNC) patients are at high risk of malnutrition and functional decline. Protein and branched-chain amino acids (BCAA) are key nutrients for muscle protein synthesis and may influence functional capacity. This study examined the association between protein and BCAA intake and functional capacity in malnourished HNC patients receiving chemoradiotherapy. Methods: A cross-sectional study was conducted at a radiotherapy outpatient clinic among malnourished HNC patients undergoing chemoradiotherapy (week 4–5). Energy and protein intake were assessed using three non-consecutive 24-hour food recalls, while BCAA intake was estimated using a semi-quantitative FFQ. Functional capacity was evaluated using the six-minute walk test (6MWT). Associations were analyzed using Spearman’s correlation test. Results: A total of 94 participants were included (mean age 46.9 ± 11.9 years; 61.7% male), with most diagnosed at stage IV disease. Median protein intake was 40.65 g/day (0.79 g/kg BW/day), with 74.5% classified as having inadequate protein intake. Median total BCAA intake was 9.08 g/day. The mean 6MWT distance was 332.9 ± 123.9 m. Significant moderate positive correlations were found between protein intake and 6MWT distance (r = 0.444; p < 0.001) and between BCAA intake and 6MWT distance (r = 0.419; p < 0.001). Conclusion: Protein and BCAA intake showed a moderate association with functional capacity among malnourished HNC patients undergoing chemoradiotherapy. These findings support the importance of optimizing protein and BCAA intake to preserve functional status during active cancer treatment.
Co-Authors Afria Beny Safitri Agustin, Heidy Ammar Abdurrahman Hasyim Andry Kelvianto Angela Dalimarta Chandra, Dian Novita Da Costa Hornay Florencia Grifit Joiner Defi Selvianita Diana Sunardi Elisa Fariz, Nurwidya Fiastuti Isbandi Witjaksono Helena Fabiani Ibrahim Agung Krisadelfa Sutanto Lia Awwalia Majida Lidya Anissa Nabila Fawzia Nadhira Nuraini Afifa Nadiyah Wijayanthie Ninik Mudjihartini Nita Nurul Ratna Mutu Manikam Pukovisa Prawiroharjo Putri Amalina Nafisa Putri Nuraini Rizky Rafiqoh Afdin Rizqa Febriliany Putri Salma Alfina Putri Nada Sri Widia A.Jusman Sulistyanti Dian Rachmawati Tarafainy Basalamah Tirza Z Tamin Wanda Khairun Nasirin Yosua Yan Kristian