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All Journal Indonesian Journal of Medicine Jurnal Biomedika Jurnal Peduli Masyarakat International Journal of Public Health Excellence (IJPHE) Indonesian Nursing Journal of Education and Clinic (Jurnal Pendidikan dan Praktik Keperawatan Indonesia) Jurnal Masyarakat Madani Indonesia Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Journal of Advanced Nursing and Health Sciences
Agnes Sri Harti
Jurusan D-III Keperawatan STIKes Kusuma Husada Surakarta
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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THE EFFECTIVENESS OF GALENIC CREAM OF DURIAN PEEL EXTRACT AND CHITOSAN FOR TREATMENT OF DIABETIC ULCERS Agustin, Wahyu Rima; Harti, Agnes Sri; Crisdian S, Hanugrah Ardya; Saputro, Sutiyo Dani; Saelan, Saelan
INDONESIAN NURSING JOURNAL OF EDUCATION AND CLINIC (INJEC) Vol 8, No 2 (2023): INJEC
Publisher : Asosiasi Institusi Pendidikan Ners Indonesia (AIPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24990/injec.v8i2.597

Abstract

Introduction: The chemical substance of durian peel (Durio zibethinus L.) is a polysaccharide polymer of D-galacturonic acid which is polar and anti-microbial. Chitosan is a derivative of chitin from the peels of Crustaceae animals, which is polycationic and antimicrobial; biodegradable, and biocompatible wit animal tissues. Diabetic ulcers are chronic wounds due to neurological disorders and vascular disorder in the legs, causing tissue damage. The purpose of the study was to analyze the effectiveness of galeni preparations of durian peel extract and chitosan for the treatment of diabetic ulcers.Method: This research is experimental including testing the quality of 5% durian peel extract cream preparations; 2% chitosan, a mixture of both ratio = 1:1; 1:2 physically, chemically, and microbiologically,and the rate of wound healing in test animals. Statistical data analysis of One Way Anova parametric test.Results: The results showed that the preparation of galenic durian peel extract cream and chitosan and their combination ratio (1:1), (1:2) could be formulated and met the quality test of cream preparations physically, chemically, and microbiologically according to the requirements of BPOM No. 32 of 2019 and is effective for healing diabetic ulcers on the 8th day.Conclusions: The preparation of galenic durian peel extract cream and chitosan and their combination ratio (1:1), (1:2) can potentially be developed as a cream preparation for healing diabetic ulcers.
Co-Authors A.A. Ketut Agung Cahyawan W Aldila Puji N Amalia Agustin Arwin Muhlishoh Bambang Abdul Syukur Crisdian S, Hanugrah Ardya Dewi Kusumawati, Dewi Eka Nursafitri Eka Nursafitri Eka Reftiana Z Estuningsih, E Heni Nur Kusumawati Ika Murni W Intan Sari A Intan Sari A. Martini Listrikawati Mellia Silvy Irdianty, Mellia Silvy Nony Puspawati Nurul Devi Ardiani, Nurul Devi Rafika Sari Rahajeng Putriningrum Saelan, Saelan Saptorini, S Saputro, Sutiyo Dani Siti Mardiyah Surya, Nella Tri Sutanto, Magdalena Utari K Wahyu Rima Agustin Wahyuningsih Safitri, Wahyuningsih Winda A. K. Yuliana, Dyah Yusup Subagio Sutanto