Article Per Year (5 Year)
p-Index From 2021 - 2026
0.888
P-Index
This Author published in this journals
All Journal Indonesian Journal of Applied Sciences International Journal of Integrated Health Sciences Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia Global Medical and Health Communication Padjadjaran Journal of Dentistry Jurnal Kreativitas PKM Majalah Patologi Indonesia Folia Medica Indonesiana
Bethy Suryawathy Hernowo
Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
SOX2 expression in the primary tumor of castration-naive metastatic prostate adenocarcinoma in association with metastasis extent Saraswati, Meilania; Kekalih, Aria; Lisnawati; Rahadiani, Nur; Asmarinah; Hernowo, Bethy Suryawathy; Hamid, Agus Rizal Ardy Hariandy; Mochtar, Chaidir Arif
Medical Journal of Indonesia Online First
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247588

Abstract

BACKGROUND Poor prognosis in patients with metastatic prostate adenocarcinoma (mPCa) may be due to the expression of stem cell-related genes. This study aimed to demonstrate the association between the expression of cancer stem cell markers and metastasis in patients with castration-naive mPCa. METHODS This cross-sectional, analytical study investigated a formalin-fixed paraffin-embedded prostate specimens from patients diagnosed in Cipto Mangunkusumo Hospital. Patients aged ≥50 years old were grouped based on the extent of metastases (high-volume disease [HVD] and low-volume disease [LVD]). In each case, immunohistochemical staining for CD133, CD44, SOX2, and androgen receptor was performed and analyzed using H-score. All data were recorded and analyzed using SPSS software version 20.0. RESULTS A total of 61 patients were recruited from 2020 to 2023 and divided into the HVD (n = 38) and LVD (n = 23) groups, with a mean age of 67.9 years. 45 of the patients had International Society of Urological Pathology (ISUP) grade 5 disease, while 16 of them had grade <5. A significant difference of ISUP grade and PSA serum level was observed in the HVD versus LVD group (p = 0.017 and <0.001, respectively). Additionally, a significant association was found between SOX2 expression and metastatic extent. CONCLUSIONS The LVD group showed higher SOX2 expression in the primary tumor compared to the HVD group. Different SOX2 expressions in various sites and stages may be due to the cancer cells’ systemic network.
Co-Authors . Afiati, . A, Muhammad Naufal Achmad Biben Afiati Afiati Agus Rizal Ardy Hariandy Hamid, Agus Rizal Ardy Hariandy Alfi, Mohammad Abyan Aria Kekalih Asmarinah Asri, Lia Amelia Tresna Wulan Assangga Guyansyah Astuti, Intan Widya Ayni, Tutik Nur Azhar, Yohana Azzahra, Fadhilla Zakya Bambang Pontjo Priosoeryanto Bambang Sunendar Purwasasmita, Bambang Sunendar Chaidir Arif Mochtar Dahlia Sutanto Edhyana Sahiratmadja Fadillah, Viki Faliq, Muhammad Faza Fifi Akwarini Harmas Yazid Yusuf Hasrayati Agustina Hermin Aminah Usman Johanes C. Mose Koesoemah, Raden Erwin Affandi Soeriadi Laniyati Hamijoyo, Laniyati Lestari, Frida Dwi Lisnawati Maharani, Khalista Ismaya Meilania Saraswati Meta Maulida Damayanti Mieke Hemiawati Satari Nurhidayat, Ade Apon Oki Meilani Dewi Patuti, Deece Putri, Rahmania Devina Rahadiani, Nur Rifki Septawendar Shadrina, Siti Azyyati Nur Sri Suryanti Susi Susanah Tear, Alveron Andreas Trinugroho Heri Fadjari