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Intratympanic Corticosteroid Salvage for Pediatric Bilateral Sudden Sensorineural Hearing Loss Complicated by Methylprednisolone-Induced Hypertensive Urgency in an Obese Adolescent Jihan Mudrika Rahmi; Rossy Rosalinda
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 3 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i3.1531

Abstract

Background: Bilateral sudden sensorineural hearing loss (SSNHL) is a rare otologic emergency, accounting for less than 5% of sudden deafness cases and occurring even less frequently in pediatric populations. Unlike unilateral cases, bilateral involvement strongly implicates systemic etiologies such as autoimmune inner ear disease (AIED). Systemic high-dose corticosteroids are the standard first-line therapy but pose significant risks of toxicity, including hypertensive crisis, particularly in adolescents with metabolic risk factors. Case presentation: We report the case of a 17-year-old male (BMI 29.0 kg/m²) presenting with acute, simultaneous bilateral hearing loss (Pure Tone Average [PTA]: Right 82.5 dB, Left 81.25 dB) and severe tinnitus (Tinnitus Handicap Index [THI]: 78). Initial management with high-dose intravenous methylprednisolone (500 mg/day) was complicated on Day 7 by hypertensive urgency (Blood Pressure 150/95 mmHg) and neurological symptoms, necessitating immediate cessation of systemic therapy. Diagnostic investigation was limited by resource availability; however, elevated inflammatory markers supported a presumptive immune-mediated etiology. A salvage protocol was initiated using four weekly cycles of intratympanic Triamcinolone Acetonide. Following therapy, the patient demonstrated slight audiological recovery (PTA stabilized at 65 dB bilaterally) but achieved complete resolution of tinnitus (THI: 0). Conclusion: This case highlights the critical role of intratympanic corticosteroids as a safe salvage modality when systemic therapy is contraindicated due to toxicity. The dissociation between modest audiometric gain and complete tinnitus resolution suggests successful mitigation of cochlear synaptopathy. The case underscores the necessity of cardiovascular monitoring and BMI-adjusted risk stratification in adolescents receiving high-dose steroids.
Diagnosis and Management of Vestibular Neuritis Clarissa Fiolly Refieska; Rossy Rosalinda
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 5 No. 1 (2026): June 2026
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v5i1.105

Abstract

Diagnosis and Management of Vestibular Neuritis Background: Vestibular neuritis is one of the most common peripheral vestibular disorders, characterized by the sudden loss of unilateral vestibular function, resulting in acute vertigo without associated cochlear or neurological symptoms. Objective: To know and understand the diagnosis and management of vestibular neuritis. Literature Review: The exact etiology of neuritis vestibular remains unclear, but three main mechanisms are thought to play a role viral infection of the vestibular nerve, ischemia of the anterior vestibular artery, and immunological mechanisms. The clinical findings of neuritis vestibular include sudden-onset severe spinning vertigo lasting more than 24 hours, often accompanied by nausea and vomiting, typically occurring in middle-aged individuals, without cochlear symptoms or other neurological manifestations. Accurate diagnosis of neuritis vestibular requires supportive examinations such as the head impulse test (HIT), caloric test, and vestibular-evoked myogenic potential (VEMP) Treatment for vestibular neuritis includes symptomatic therapy, specific pharmacological therapy, and vestibular rehabilitation, which have been studied and applied to reduce symptoms, accelerate vestibular compensation, and improve patients’ quality of life. Conclusion: Vestibular neuritis, also known as vestibular neuronitis, is a distinctive form of peripheral vertigo and a major cause of acute vestibular dysfunction. Its etiology remains uncertain but is thought to involve viral infection, ischemia, and immunological mechanisms. Clinically, the main symptom is severe spinning vertigo lasting more than 24 hours, often accompanied by nausea and vomiting in middle-aged patients. Diagnosis is established through physical examination and ancillary tests. Treatment consists of specific pharmacological therapy and vestibular rehabilitation.
Diagnosis and Management of Superior Canal Dehiscence Syndrome Rio Mulya Riharta; Rossy Rosalinda; Muhammad Dilga Caesario
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 5 No. 1 (2026): June 2026
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v5i1.108

Abstract

Diagnosis and Management of Superior Canal Dehiscence Syndrome Background: Superior Canal Dehiscence Syndrome (SCDS) is a vestibulocochlear disorder caused by a bony defect in the superior semicircular canal, creating a pathological third window in the labyrinth. This condition produces a variety of vestibular and auditory manifestations that significantly impair quality of life. Objective: To know and understand the diagnosis and management of superior canal dehiscence syndrome. Literature Review: The etiology of SCDS may be congenital or acquired. The primary pathophysiology relates to the third window mechanism that disrupts acoustic energy transmission and generates abnormal pressure pathways within the labyrinth. Characteristic vestibular symptoms include the Tullio phenomenon, Hennebert sign, oscillopsia, and disequilibrium, while cochlear symptoms encompass autophony, bone-conduction hyperacusis, pulsatile tinnitus, and low-frequency conductive hearing loss. Diagnosis is established based on the Barany Society triadic criteria: clinical symptoms, neurophysiological testing (VEMP, audiometry), and High-Resolution Computed Tomography (HRCT) imaging with multiplanar reconstruction. Conservative management is indicated for mild cases, while surgical treatment, via the middle cranial fossa (MCF) or transmastoid (TM) approach, is recommended for patients with severe, debilitating symptoms. Conclusion: Superior canal dehiscence syndrome (SCDS) is a third mobile window disorder caused by a bony defect of the superior semicircular canal, resulting in vestibular and auditory symptoms. Diagnosis is established through an integrative approach based on the Bárány Society criteria, incorporating clinical correlation, VEMP and/or audiometry, and high-resolution CT imaging. Management is stepwise, with surgical intervention (plugging or resurfacing) serving as the definitive treatment in severely symptomatic cases to eliminate the pathological pathway and improve clinical outcomes.
Diagnosis and Management of Autoimmune Inner Ear Disease Muhammad Arifudin; Rossy Rosalinda
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 5 No. 1 (2026): June 2026
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v5i1.109

Abstract

Diagnosis and Management of Autoimmune Inner Ear Disease Background: Autoimmune Inner Ear Disease is an autoimmune disease of sensorineural hearing loss, with an incidence of less than 1% worldwide. Symptoms of Autoimmune Inner Ear Disease often resemble the symptoms of other types of sensorineural hearing loss, making the diagnosis difficult. Objective: To understand all aspects of Autoimmune Inner Ear Disease. Literature Review: Autoimmune Inner Ear Disease is a rare autoimmune disease characterized by progressive and fluctuating sensorineural hearing loss. Autoimmune Inner Ear Disease is more common in women, aged between 20 and 50 years. Autoimmune Inner Ear Disease can be primary or secondary. The mechanism of Autoimmune Inner Ear Disease can be damage mediated by autoantibodies, immune complex deposition, T-cell inflammation. Typical symptoms and signs include bilateral sensorineural hearing loss, tinnitus, sometimes vestibular disorders and response to corticosteroid treatment. Complete blood count, erythrocyte sedimentation rate, antinuclear antibodies, and other immunological profiles can confirm the diagnosis. Magnetic resonance imaging was performed to rule out retrocochlear pathology and demyelination. High-dose corticosteroids are the first-line treatment. Conclusion: Autoimmune Inner Ear Disease is an autoimmune disease characterized by progressive sensorineural hearing loss, which may be accompanied by tinnitus and vestibular disorders. Corticosteroids are the first-line treatment.
Intratympanic Corticosteroid Salvage for Pediatric Bilateral Sudden Sensorineural Hearing Loss Complicated by Methylprednisolone-Induced Hypertensive Urgency in an Obese Adolescent Jihan Mudrika Rahmi; Rossy Rosalinda
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 3 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i3.1531

Abstract

Background: Bilateral sudden sensorineural hearing loss (SSNHL) is a rare otologic emergency, accounting for less than 5% of sudden deafness cases and occurring even less frequently in pediatric populations. Unlike unilateral cases, bilateral involvement strongly implicates systemic etiologies such as autoimmune inner ear disease (AIED). Systemic high-dose corticosteroids are the standard first-line therapy but pose significant risks of toxicity, including hypertensive crisis, particularly in adolescents with metabolic risk factors. Case presentation: We report the case of a 17-year-old male (BMI 29.0 kg/m²) presenting with acute, simultaneous bilateral hearing loss (Pure Tone Average [PTA]: Right 82.5 dB, Left 81.25 dB) and severe tinnitus (Tinnitus Handicap Index [THI]: 78). Initial management with high-dose intravenous methylprednisolone (500 mg/day) was complicated on Day 7 by hypertensive urgency (Blood Pressure 150/95 mmHg) and neurological symptoms, necessitating immediate cessation of systemic therapy. Diagnostic investigation was limited by resource availability; however, elevated inflammatory markers supported a presumptive immune-mediated etiology. A salvage protocol was initiated using four weekly cycles of intratympanic Triamcinolone Acetonide. Following therapy, the patient demonstrated slight audiological recovery (PTA stabilized at 65 dB bilaterally) but achieved complete resolution of tinnitus (THI: 0). Conclusion: This case highlights the critical role of intratympanic corticosteroids as a safe salvage modality when systemic therapy is contraindicated due to toxicity. The dissociation between modest audiometric gain and complete tinnitus resolution suggests successful mitigation of cochlear synaptopathy. The case underscores the necessity of cardiovascular monitoring and BMI-adjusted risk stratification in adolescents receiving high-dose steroids.
Peran Audiometri Tutur pada Otitis Media Supuratif Kronis Esmaralda Nurul Amany; Rossy Rosalinda; Jacky Munilson; Yan Edward
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 1 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v1i1.8

Abstract

Latar Belakang: Otitis media supuratif kronis adalah infeksi pada telinga tengah berkepanjangan yang ditandai dengan adanya sekret telinga dan perforasi membran timpani yang menetap dengan masalah utama yaitu gangguan pendengaran. Gangguan pendengaran akibat otitis media supuratif kronis dapat mengganggu perkembangan bahasa, kemampuan komunikasi dan menurunkan kualitas hidup. Pemeriksaan audiometri nada murni merupakan pemeriksaan pendengaran yang rutin dilakukan, tetapi dengan audiometri tutur dapat menilai kemampuan komunikasi pada pasien otitis media supuratif kronis. Tujuan : Mengetahui dan memahami peran pemeriksaan audiometri tutur pada pada pasien otitis media supuratif kronis. Tinjauan Pustaka: Pasien dengan otitis media supuratif kronis biasanya memiliki gambaran audiogram gangguan pendengaran konduktif, namun bisa juga terjadi gangguan pendengaran sensorineural. Audiometri tutur berguna untuk menilai kemampuan komunikasi dan memungkinkan penilaian aspek konduksi dan sensoris pada organ pendengaran serta memberikan gambaran fungsi pendengaran sentral. Pada pasien otitis media supuratif kronis dapat ditemukan gangguan pemahaman percakapan yang tidak dapat digambarkan oleh pemeriksaan audiometri nada murni. Kesimpulan : Otitis media supuratif kronis dapat menyebabkan gangguan pendengaran yang mempengaruhi aktivitas sehari-hari dan kualitas hidup seseorang. Pemeriksaan audiometri tutur penting dilakukan pada pasien otitis media supuratif kronis karena dapat mengevaluasi pendengaran dengan menilai kemampuan komunikasi, menilai prognosis terapi, dan rehabilitasi setelah dilakukan tindakan operatif. Kata kunci : Audiometri nada murni, audiometri tutur, otitis media supuratif kronis
Diagnosis dan Penatalaksanaan Penyakit Meniere Opi Akbar; Rossy Rosalinda
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 1 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v1i1.13

Abstract

ABSTRACT Background: Meniere's disease is the third leading cause of vertigo after Benign Paroxysmal Positional Vertigo and vestibular neuritis. Meniere's disease is also known as endolymphatic hydrops. Acute symptoms of Meniere's disease are characterized by triad of vertigo, tinnitus and hearing loss. This disease is a challenge for ENT specialist in making a diagnosis and determining the right and optimal management. Objective: Provides knowledge about the diagnosis and management of Meniere's disease, so that it can be handled appropriately. Literature Review: Meniere's disease is an inner ear disorder characterized by spontaneous vertigo attacks, fluctuating low-tone sensorineural hearing loss, aural fullness and tinnitus. The most consistent finding and still being used as the basic mechanism of Meniere's disease to date is the discovery of endolymphatic hydrops. Diagnostic tests to diagnose Meniere's disease include audiometry, glycerol test, caloric test and electrocochleography. Meniere's disease can significantly affect quality of life and generally managed with dietary modifications such as a low-salt diet, medical therapy such as diuretics and surgery such as intratimpani injection and endolymphatic sac surgery. Conclusion: Meniere's disease is characterized by a triad of vertigo symptoms, low-tone sensorineural hearing loss and tinnitus. Making the diagnosis requires a detailed history with a complete audiology and vestibular examination. The management of Meniere's disease consists of dietary modifications, medical therapy and surgery. Keywords: meniere’s disease, endolymphatic hydrops, diuretics, intratimpani injection, endolymphatic sac surgery
Penatalaksanaan Otitis Media Supuratif Kronis (OMSK) Tipe Kolesteatoma dengan Timpanomastoidektomi Dinding Runtuh dan Rekonstruksi Dinding Posterior Liang Telinga Yayan Akhyar; Rossy Rosalinda
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 1 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v1i1.15

Abstract

Pendahuluan: Otitis media supuratif kronis (OMSK) merupakan infeksi kronis di telinga tengah dengan perforasi membran timpani dan sekret yang keluar dari telinga tengah terus menerus atau hilang timbul selama lebih dari 2 bulan. Tatalaksana bedah merupakan pilihan pada kasus-kasus OMSK tipe kolesteatoma. Dalam usaha mendapatkan kombinasi tindakan dengan paparan yang baik seperti pada mastoidektomi dinding runtuh dengan tetap memperservasi dinding posterior liang telinga seperti pada mastoidektomi dinding utuh, timpanomastoidektomi dinding runtuh dengan rekonstruksi dinding posterior liang telinga telah dikembangkan. Laporan kasus: Dilaporkan satu kasus anak perempuan 15 tahun dengan OMSK AS tipe kolesteatoma dengan destruksi dinding posterior liang telinga dan gangguan pendengaran. Kesimpulan: Tindakan timpano mastoidektomi dinding runtuh dengan rekonstruksi dinding posterior liang telinga selain memiliki keuntungan memaksimalkan eksplorasi jaringan patologis, juga dapat menjadi solusi untuk menciptakan dry ear, tidak memerlukan debridemaen rutin, dan lebih mudah dalam pemasangan alat bantu dengar bila dibutuhkan nantinya. Kata kunci: otitis media supuratif kronis tipe kolesteatoma, timpanomastoidektomi dinding runtuh, rekonstruksi dinding posterior liang telinga
Ototoksisitas akibat Penggunaan Cisplatin dan Pendekatan Otoprotektif untuk Pencegahannya Rizki Saputra; Rossy Rosalinda; Sukri Rahman; Gestina Aliska
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 2 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v2i1.36

Abstract

Latar Belakang: Peningkatan secara statistik angka harapan hidup pasien kanker setelah diterapi membuat pemantauan efek samping jangka panjang kemoterapi sangat dibutuhkan. Cisplatin menjadi agen kemoterapi pilihan pada kanker kepala dan leher karna sifatnya yang sangat poten. Bertentangan dengan manfaat terapiutik tersebut, pemakaian cisplatin memiliki potensi masalah ototksik yang dapat menyebabkan gangguan pendengaran. Tujuan: Untuk mengetahui dan memahami mekanisme ototoksisitas akibat penggunaan cisplatin dan upaya otoprotektif. Tinjauan Pustaka: Sebagai agen kemoterapi, cisplatin memiliki beberapa efek samping salah satunya bersifat ototoksik. Mekanisme ototoksik akibat cisplatin dihubungkan dengan pembentukan radikal bebas yang menyebabkan apoptosis pada sel rambut luar koklea dan jaringan penunjang di organ Corti. Pasien yang menerima pengobatan cisplatin harus dilakukan evaluasi fungsi pendengaran secara berkala. Sampai saat ini belum ada obat-obatan yang menjadi pilihan utama dalam upaya preventif ototoksik akibat cisplatin. Penggunaan obat golongan seperti N-asetilsistein, sodium tiosulfat, vitamin E, amifostin membuka harapan untuk pengembangan terapi preventif ototoksik. Kesimpulan: Efek samping ototoksik yang ditimbulkan merupakan salah satu masalah yang harus ditatalaksana. Monitoring pendengaran dibutuhkan untuk mendeteksi pemasalahan ini. Beberapa agen otoprotektif seperti antioksidan dan kortikosteroid dapat menjadi pilihan tatalaksana dalam upaya preventif. Pemberian agen otoprotektif secara sistemik dan intratimpani memiliki kelebihan dan kekurangan dalam penggunaannya. Kata kunci: ototoksik, cisplatin, preventif, intratimpani
Diagnosis dan Tatalaksana Terbaru Presbikusis Meilia Ghinasari; Rossy Rosalinda
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 4 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v4i1.84

Abstract

Latar Belakang: Presbikusis didefinisikan sebagai gangguan pendengaran sensorineural progresif yang terkait dengan penuaan. Beberapa studi menunjukkan bahwa kerentanan genetik, stres oksidatif dan peradangan kronik dalam sel rambut dapat memicu respons inflamasi, yang menyebabkan kerusakan pada sel rambut seiring bertambahnya usia. Tujuan: untuk lebih memahami diagnosis dan tatalaksana terbaru presbikusis. Tinjauan Pustaka: Presbikusis ditandai dengan gangguan pendengaran sensorineural yang progresif, bilateral dan simetris, dengan sebagian besar pasien mulai mengalami kehilangan pendengaran pada frekuensi tinggi. Individu dengan presbikusis sering mengalami “cocktail party effect”, disertai gejala seperti tinnitus, vertigo, ketidak-seimbangan dan jatuh. Diagnosis presbikusis ditegakkan dengan pada penurunan pendengaran di atas frekuensi 2000 Hz pada audiometri nada murni dan didapatkan abnormalitas pada audiometri tutur dan speech-in-noise test. Tatalaksana presbikusis mencakup alat bantu dengar, implan koklea, medikamentosa, terapi stem cell dan terapi gen. Kesimpulan: Kerentanan genetik, stres oksidatif dan peradangan kronik terlibat dalam perkembangan presbikusis. Diagnosis presbikusis ditegakkan dengan audiometri nada murni, audiometri tutur dan speech-in-noise test. Tatalaksana presbikusis meliputi rehabilitasi pendengaran, medikamentosa dan terapi gen.