Garuda - Garba Rujukan Digital

Effect of tonsillectomy with or without adenoidectomy on formant sound frequency Rianto, Bambang Udji Djoko; Jenny, .; Indrasari, Sagung Rai
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

ABSTRACT Vocal tract resonance characteristics are reflected by formant frequencies which determined by the size and shape of the vocal tract. Tonsillectomy may cause changes in the structure of the oral cavity as a resonator in the speech process. The aim of this study is to determine the effect of tonsillectomy on formant sound frequency. This study used a pre-test and post-test only design experimental. The study underwent in the Otorhinolaryngology Department between August up to November 2012. Inclusion criteria were: 1) chronic tonsillitis, 2) tonsil size was T3-T4, 3) age up to 5 years. The exclusion criteria were craniofacial abnormality and neurological disorders. All patients performed a sound analysis by recording vowel / a /, / e /, / i /, / o /, and / u / in 1 day before and 4 weeks after surgery. The sample consisted of 24 (60%) women and 16 (40%) men. The T3-T3 tonsil size were 25 (62.5%) samples and the lowest than T3-T4/T4-T3 were 6 (15%) samples. Based on paired T test there was a statistically significant increase of all F1 vowels (p <0.05), except for / i / (p> 0,05) and decrease of F2 / e / and F3 / u / (p >0,05). Based on these results it can be concluded that tonsillectomy affects the F1 mean difference almost in all vowel except the vowels / i /, F2 & F3.

Photodynamic therapy (PDT) pada penderita karsinoma nasofaring: kajian angka harapan hidup Indrasari, Sagung Rai; Hariwiyanto, Bambang; Astuti, Indwiani; Sastrowijoto, Soenarto
Oto Rhino Laryngologica Indonesiana Vol 46, No 1 (2016): Volume 46, No. 1 January - June 2016
Publisher : PERHATI-KL

Latar belakang: Terapi karsinoma nasofaring (KNF) yang adekuat dan efektif tidak selalu tercapaidi negara berkembang. Ketersediaan alat radioterapi yang tidak seimbang dengan jumlah penderita KNFmenyebabkan keterlambatan jadwal terapi, sehingga berakibat pada buruknya hasil terapi. Alternatifterapi lain perlu dikembangkan untuk mengatasi permasalahan tersebut. Photodynamic therapy (PDT)telah digunakan untuk terapi tambahan pada berbagai kanker, termasuk KNF residu maupun rekuren.Tujuan: Mengetahui respon terapi lokal dan angka harapan hidup 5 tahun penderita KNF residu ataurekuren yang mendapatkan PDT.Metode: Kohort retrospektif dengan data rekam medis penderita KNFresidu atau rekuren yang mendapatkan PDT di Departemen THT-KL RSUP Dr. Sardjito Yogyakarta tahun2005–2011.Hasil: Local response rate sebesar 83,9% dan angka harapan hidup 5 tahun penderita sebesar60,7%. Angka harapan hidup 5 tahun penderita laki-laki lebih tinggi (73,5%) dibandingkan penderitaperempuan (42,2%), perbedaan ini bermakna secara statistik (p=0,045). Angka harapan hidup 5 tahunpenderita berusia <40 tahun lebih tinggi (76,2%) dibandingkan penderita berusia > 40 tahun (53,0%),meskipun tidak signifikan (p=0,417). Angka harapan hidup penderita yang masih terdapat tumor padanasofaring lebih baik (80%) dibandingkan penderita dengan hasil biopsi nasofaring negatif (57,8%),namun tidak signifikan (p=0,638). Angka harapan hidup penderita berdasarkan stadium saat ditegakkandiagnosis KNF, penderita stadium awal mempunyai angka harapan hidup lebih kecil (53,3%) dibandingkanpenderita stadium lanjut (62,1%), meskipun tidak signifikan (p=0,521).Kesimpulan: Local responserate PDT 83,9% dan angka harapan hidup 5 tahun sebesar 60,7%. PDT merupakan modalitas terapi yangefektif untuk KNF residu maupun rekuren. Kata kunci: Karsinoma nasofaring, photodynamic therapy, angka harapan hidup ABSTRACTBackground: Adequate and effective nasopharyngeal carcinoma (NPC) treatment cannot bereached in developing countries. The lack of radiotherapy apparatus cause delayed treatment thatbring about bad treatment results. An alternative treatment modality should be created to overcome theproblem. Photodynamic therapy (PDT) has been conducted for many malignancies including recurrentor residual NPC. Purpose: To find out the local response rate and 5-year overall survival amongrecurrent or residual NPC patients who got PDT. Method: Retrospective cohort, data was taken frommedical records of patients with PDT in ENT-H&N Surgery Department Sardjito Hospital since 2005until 2011. Results: Local response rate was 83.9%. Five-year overall survival was 6.7%. The 5-yearoverall survival among men was significantly higher than women (73.5%:42.2%) p=0.045. The 5-yearoverall survival among patients <40 years old was higher than patients > 40 years old (76.2%:53.0%)even though it was not significant (p=0.417). The 5-year overall survival among patients with tumor washigher than patients without tumor (80%:57.8%) although it was not significant (p=0.638). The 5-yearoverall survival among patients with previous early stage NPC was lower than previous advanced stage (53.3%:62.1%) although it was not significant (p=0.521). Conclusion: Local response rate of PDT was83.9% and the 5-year overall survival was 60.7%. PDT was found as an effective treatment modalityfor recurrent or residual NPC. Keywords: Nasopharyngeal carcinoma, photodynamic therapy, 5-year overall survival

Photodynamic Therapy As an Adjuvant Therapy for Local-Partial Remission of Nasopharyngeal Carcinoma After Standard Therapy in Sardjito Hospital Yogyakarta A Five-Year-Overall Survival Rate Analysis Study Bambang Hariwiyanto; Sagung Rai Indrasari; Camelia Herdini; Tan IB
MEDIA MEDIKA INDONESIANA 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.62 KB)

Background: The foremost problems of nasopharyngeal carcinoma (NPC) management are high loco-regional remission, local recurrence and spreading rate post therapy. Photodynamic therapy (PDT) has been done for treatment of tumors less than 1 cm in size and depth in a very difficult location, where radical excision by surgery was not possible. The aim of this study is determining 5-year-overall survival rate of local-partial remission of NPC after standard therapy followed by additional PDT.Method: The survival study is subjected to the 5 years-overall survival rate of local-partial remission. Photosensitizer (FoscanR) 0,15mg/kgBW was injected to NPC patients and followed by 20 joule/cm2, 642 wave length and 100 watts/cm2 irradiants non thermal laser illumination 96 hours after injection. The PDT result was confirmed with biopsy, CT scan, upper abdominal USG, thoracic radiograph and bone survey for 12 weeks after treatment. Follow up was done every 3 months in first year, continued every 6 months in the second year, and followed once a year. The sample collected from January 2005 to December 2010, and 33 cases met the inclusion and exclusion criterias, but only 20 cases were eligible inclusion criteria. The 5 years-overall survival was defined as the time from diagnosis to death from any cause or last follow up, calculated by Kaplan Meier survival analysis.Results: The 5-year-overall survival rate was 50%.Conclusion: PDT as an additional treatment for small local-partial remission in NPC post treatment is an alternative therapy to improve the treatment outcome and survival rate.Keywords: NPC, PDT, 5-year-survival rate ABSTRAK Photodynamic therapy sebagai terapi ajuvan karsinoma nasofaring remisi lokal-parsial setelah terapi standar di RSUP Dr. Sardjito Yogyakarta: Studi analisis angka kehidupan lima tahunLatar belakang: Problem utama terapi standar karsinoma nasofaring (KNF) adalah rendahnya angka keberhasilan terapi, terutama adanya remisi parsial, baik pada tumor primer maupun metastasis. Photodynamic therapy (PDT) telah digunakan untuk pengobatan tumor di superfisial, dengan diameter kurang dari 1 cm, terutama pada tumor yang letaknya tersembunyi dan sulit dioperasi secara radikal. Penelitian ini bertujuan menentukan angka kehidupan 5 tahun pada penderita KNF dengan remisi parsial pada tumorprimernya, setelah diterapi secara standar dan dilakukan PDT sebagai terapi tambahan.Metode: Studi analisis kesintasan terhadap kehidupan 5 tahun penderita KNF yang mengalami remisi lokal-parsial setelah terapi standar dan PDT. Photosensitizer (FoscanR) 0,15mg/kgBW diinjeksikan pada penderita KNF, dan setelah 96 jam, dilanjutkan dengan irradiants non thermal laser illumination sebesar 20 joule/cm2, panjang gelombang 642 dan 100 watts/cm2. Hasil PDT dikonfirmasi dengan biopsi, CT scan, USG abdomen, rontgen thoraks dan bone survey pada 12 minggu setelah terapi. Tahun pertama, dilakukan follow up setiap 3 bulan, di tahun kedua setiap 6 bulan, dan selanjutnya setiap setahun sekali. Sampel didapat dari Januari 2005 sampai Desember 2010, dimana 33 pasien KNF post PDT memenuhi kriteria inklusi dan eksklusi, namun hanya 20 pasien yang memenuhi kriteria inklusi 5-tahun-follow up. Angka kehidupan 5 tahun ditentukan berdasarkan saat diagnosis sampai kematian penderita, atau sampai folllow up terakhir, dihitung dengan analisis kesintasan Kaplan Meier.Hasil: Angka kehidupan keseluruhan selama 5 tahun adalah 50%.Simpulan: PDT sebagai tambahan terapi terhadap KNF yang

Sinonasal or nasopharyngeal undifferentiated Carcinoma?: diagnostic pitfall and the role of Epstein-Barrvirus (EBV) and human papillomavirus(HPV) examination Wahyu Tri Widayati; Ery Kus Dwianingsih; Bustanul Ardianto; Didik Setyo Heriyanto; Sagung Rai Indrasari; Camelia Herdini; . Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 2 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Undifferentiated carcinoma of the head and neck is frequently observed in nasopharynx, however it may also occur in oropharynx, salivary gland and sinonasal. Overlapping lesions in those regionscreate difficulty in determining the origin of the tumor. Thus, it causes diagnostic pitfall not only for pathologists, but also for clinicians. A 40 yearold man, presented with nasal obstruction, epistaxis, diplopia, and headache for a yearand showed nasal cavitysinistra and nasopharynx masses on CT-scan. Lymph node enlargement was not detected. First biopsywas performed and histopathologically diagnosed as nasopharyngeal undifferentiated carcinoma(NPC), extended into nasal cavity. Chemo-radiation protocol for NPC was conducted, and showing uncomplete response. Second biopsy was done, and reviewed with the first biopsy result. Thetumourwas arranged insolid, syncytial and trabecular pattern, with vesicular nuclei, prominent nucleoli, and lack of lymphoplasmacytic infiltrat. Immunohistochemistry (IHC) analysis of p16, EBNA1 and LMP1 were negative. PCR analysis of HPV-18 was positive, while EBV detection showed negative result. General association of EBV with NPC suggests that the presence of latent EBV infection can serve as a positive marker for NPC. Therefore, in this case, the EBV negativity and strong HPV association led to diagnosis of SNUC. The distinction of sinonasal undifferentiated carcinoma (SNUC) or from NPC was important for appropriate management and therapy.

Risk factors of sensory hearing loss in nasopharyngeal carcinoma patients obtaining conventional radiotherapy Odhi Anggani; Sagung Rai Indrasari; Feri Trihandoko; Anisa Haqul Khoiria; Ashadi Prasetyo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 3 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Previous studies proven that cochlear hair cells’ death plays an important role in sensorineural hearing loss due to radiation exposure. Other studies compared the differences between the impact of conventional radiotherapy (CRT) and intensity modulated radiation therapy (IMRT) on hearing loss in patients with nasopharyngeal carcinoma. Although, few differences found in some clinical manifestation, however no statistical analysis had been carried out. The aim of study was to evaluate the risk of sensory hearing loss in nasopharyngeal carcinoma patients who received CRT compared to IMRT. A case control study was performed on nasopharyngeal carcinoma patients who received radiotherapy at Dr. Sardjito General Hospital, Yogyakarta. The result of DPOAE between NPC patients who received CRT and IMRT was compared in this study. Statistical analysis was performed using chi square test and multivariate analysis. The result showed that patients who received CRT significantly altered the risk for sensory hearing loss in the contralateral ear as much as 11.2 times according to the multivariate analysis (CI 95%: 2.2 – 56.6; p=0.004). In conclusion, the risk of sensory hearing loss in patients with nasopharyngeal carcinoma who received CRT is a greater compared to IMRT.

Uji serologi IgA karakter KNF EBNA1+VCA p-18 pada penderita keluhan kronis kepala leher Camelia Herdini; Susanna Hutajulu; Sagung Rai Indrasari; Bambang Hariwiyanto; Jajah Fachiro; Sofia Mubarika; Jaap Middeldorp
Oto Rhino Laryngologica Indonesiana Vol 41, No 2 (2011): Volume 41, No. 2 July - December 2011
Publisher : PERHATI-KL

Background: Nasopharyngeal carcinoma (NPC), especially the WHO type III, is correlated almost100% with Epstein Barr Virus (EBV) infection. This is indicated by high IgG and IgA antibody responsesagainst viral capsid antigen (VCA), early antigen (EA) and Epstein Barr Nuclear antigen (EBNA).Increased IgA NPC character antibodies may be detected 2-10 years before the presence of the tumor. Thisoccurs as a result of reactivation of EBV infection. Purpose: To find out the level of IgA NPC characterantibodies (EBNA1+VCA p-18) in patients with chronic symptoms in the head and neck and to determine whether the level of IgA can be used as an early sign of NPC. Methods: Observational analytic study on 218 patients with chronic symptoms in the head and neck. The research was conducted from July 2006to September 2010. ELISA technique was used as serology test for IgA (EBNA1+VCA p-18). Result: Samples were 90 males and 128 females. High level of IgA by ELISA was found in 28 males (31.1%) and 45 females (35.2%). The IgA level tended to increase with age. The most common chronic symptoms inthe head and neck were chronic rhinitis (15.6%) and nasal obstruction (7.8%). From all patients who hadhigh level of IgA, 3 patients (4.1%) were found positive of early stage NPC. Conclusion: More than 33%of patients with chronic symptoms of head and neck had high level of IgA NPC character. This methodcan be used as an early detection of NPC. Keywords: serology test in NPC, EBNA1, VCA p-18, NPC symptoms in head and neck Abstrak : Latar belakang: Karsinoma nasofaring (KNF) terutama tipe WHO III berkorelasi hampir 100%dengan infeksi Epstein Barr Virus (EBV). Hal ini ditunjukkan dengan tingginya respons antibodi IgGdan IgA terhadap viral capsid antigen (VCA), early antigen (EA) EBV serta antibodi Epstein BarrNuclear Antigen (EBNA). Kenaikan antibodi IgA dengan karakter KNF dapat terjadi 2-10 tahun sebelumterjadinya tumor. Hal ini terjadi sebagai akibat adanya reaktivasi infeksi EBV. Tujuan: Mengetahui kadarIgA karakter KNF (EBNA1+VCA p-18) pada penderita dengan gejala kronis di daerah kepala dan leherdan mengetahui apakah kadar IgA dapat digunakan sebagai tanda awal terjadinya KNF. Metode: Suatukajian analitik observasional terhadap 218 penderita dengan gejala kronis di daerah kepala dan leher.Penelitian ini dilakukan Juli 2006 sampai dengan September 2010. Pemeriksaan serologi IgA (EBNA1+VCA-p18)dilakukan denganteknik ELISA.Hasil:Terdapat90penderita laki-lakidan128 penderitaperempuan.HasiltesserologiIgAELISAdengankadartinggiditemukanpada28laki-laki(31,1%)dan45perempuan (35,2%). Kadar IgA cenderung meningkat pada peningkatan usia. Gejala kronis yangterbanyak dikeluhkan penderita adalah rinitis kronis, yaitu sebanyak 34 penderita (15,6%), diikuti denganobstruksi hidung sebanyak 17 penderita (7,8%). Pemeriksaan klinis lebih lanjut dari penderita yangmempunyai kadar IgA tinggi menunjukkan bahwa 3 penderita (4,1%) positif terkena kanker nasofaringstadium awal. __ Lebih dari 33% penderita dengan gejala kronis di daerah kepala dan lehermemiliki kadar IgA karakter KNF yang tinggi. Kadar IgA karakter KNF yang tinggi dapat digunakansebagai penanda awal kejadian KNF. Kata kunci: uji serologi KNF,EBNA1, VCA p-18, gejala KNF

A survey of Indonesian otolaryngologist behavior in medical service during the CoVid-19 pandemic Indra Zachreini; Jenny Bashiruddin; Susyana Tamin; Harim Priyono; Ika Dewi Mayangsari; Respati Ranakusuma; Natasha Supartono; Fikri Mirza Putranto; Dewo Aksoro; Selfiyanti Bimantara; Yussy Afriana Dewi; Kote Noordhianta; Bintang Napitupulu; Sagung Rai Indrasari; Nyilo Purnami; Tengku Siti Hajar Haryuna; Juliandi Harahap; Eka Savitri; Tjandra Manukbua
Oto Rhino Laryngologica Indonesiana Vol 51, No 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.444

Background: World Health Organization (WHO) announced a newly discovered virus that first identified in Wuhan, China on December 2019, namely SARS-CoV-2 as the cause of corona virus disease (COVID-19) which had become global pandemic. Doctors as medical practitioners are categorized as vulnerable group to be infected by corona virus, and many otorhinolaryngologists had been infected and even died in performing medical services. Among the causative factors why otorhinolaryngologists could get infected by corona virus is their behavior. Purpose: To assess the behavioral level of otorhinolaryngologists in medical services during Covid-19 pandemic. Method: Descriptive study with a cross sectional design. Research samples were otorhinolaryngologists in Indonesia who met the inclusions criteria. The samples were selected by consecutive sampling method, and obtained 1299 subjects. Behavioral level was assessed from 3 aspects: knowledge, attitude, and practice, which comprised of 12 questions. Result: It was found that 461 respondents had a good behavioral level (35.5%), 677 respondents had moderate levels (52.1%) and 161 respondents had low level (12.4%). There was a statistically significant correlation between knowledge with behavioral level, attitude with behavioral level, and practice with behavioral level (p=0.001). Conclusion: The study of behavioral level of otorhinolaryngologists in medical service during Covid-19 pandemic obtained the highest number was moderate level 677 respondents (57.2%), and there was a statistically significant correlations between the variable of knowledge with behavioral level, the variable of attitude with behavioral level, and the variable of practice with behavioral level (p=0.001).ABSTRAK Latar belakang: Organisasi kesehatan dunia (WHO) mengumumkan virus baru yang pertama kali muncul di Wuhan China, pada Desember 2019, yaitu SARS-CoV-2 sebagai penyebab corona virus disease 19 (Covid 19) dan menyatakan sebagai pandemi. Dokter sebagai tenaga kesehatan merupakan kelompok yang rentan terinfeksi virus corona dan berdasarkan laporan, sudah banyak dokter Telinga Hidung Tenggorok - Bedah Kepala Leher (THT-KL) yang terinfeksi bahkan meninggal dunia dalam pelayanan medis. Salah satu faktor penyebab dokter THT-KL terinfeksi oleh virus corona adalah tingkat perilaku dokter THT-KL. Tujuan: Mengetahui tingkat perilaku dokter THT-KL dalam melakukan pelayanan medis saat pandemi Covid 19. Metode: Penelitian deskriptif dengan rancangan studi potong lintang. Sampel penelitian adalah dokter THT-KL di Indonesia yang memenuhi kriteria inklusi. Teknik pengambilan sampel secara berurutan, dan mendapatkan 1299 sampel. Tingkat perilaku dinilai dari 3 aspek yaitu dimulai dari pengetahuan, sikap dan tindakan yang terdiri dari 12 pertanyaan. Hasil: Didapatkan tingkat perilaku responden dokter THT-KL dalam pelayanan medis pada pandemi Covid 19, tingkat perilaku baik sebanyak 461 responden (35,4%), tingkat sedang 677 responden (52,1%), dan tingkat kurang 161 responden (12.4%). Terdapat hubungan yang signifikan antara pengetahuan dan tingkat perilaku, sikap dengan tingkat perilaku dan tindakan dengan sikap perilaku (p=0,001). Kesimpulan: Didapatkan tingkat perilaku dokter THT-KL dalam pelayanan medis pada pandemi covid 19, terbanyak adalah tingkat perilaku sedang sebanyak 677 responden (57,2%), dan terdapat hubungan yang bermakna antara variabel pengetahuan dengan tingkat perilaku, variabel sikap dengan tingkat perilaku dan variabel tindakan dengan tingkat perilaku dokter THT-KL dalam pelayanan medis pada pandemi Covid 19, dimana nilai p = 0,001. Kata kunci: perilaku, dokter THT-KL, pandemic, Covid-19

Factors Affecting Adverse Events Following SARS-CoV-2 Vaccine among Indonesian Ear, Nose, and Throat Specialist, and Residences Susyana Tamin; Jenny Bashiruddin; Indra Zachreini; Harim Priyono; Ika Dewi Mayangsari; Respati Ranakusuma; Natasha Supartono; Khoirul Anam; Anggina Diksita; Yussy Afriana Dewi; Sagung Rai Indrasari; Nyilo Purnami; Tengku Siti Hajar Haryuna; Juliandi Harahap; Eka Savitri; Tjandra Manukbua
eJournal Kedokteran Indonesia Vol. 10 No. 2 - Agustus 2022
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.10.165.129-37

This study’s objectives were to investigate factors affecting the adverse events of the COVID-19 vaccine in Indonesia among health care workers and compare adverse events following SARS-CoV-2 vaccine using CoronaVac as the first and second dose and Moderna used as the booster third dose. A cross-sectional study was conducted using the Self-reporting Online Survey Platform (Google Form) from August to October 2021. Subjects included in the study were ENT specialists and residents all over Indonesia who had been vaccinated with both doses of CoronaVac COVID-19 vaccine and Moderna COVID-19 vaccine as a booster dose. Among a total of 1394 participants, 51.2% and 43.7% of subjects experienced adverse events following the first and second dose of the CoronaVac vaccine. Adverse events are significantly higher following the third dose of Moderna vaccine (95.3%) with p-value <0.001, odds ratio (OR) 26.63 (95% CI 19.87-35.7). Adverse events following the CoronaVac vaccine were significantly higher in females and individuals with comorbidities in the first dose (p=0.002 and p=0.04), and the second dose (p=0.008 and p=0.042). Adverse events following the Moderna vaccine were significantly higher in females (p=0.01) and lower in individuals ≥40 years of age (p=0.017). Comorbidity status did not affect adverse events following the Moderna vaccine. Keywords: adverse events, SARS-CoV-2, COVID-19, vaccine, otorhinolaryngology. Faktor yang Mempengaruhi Efek Samping Vaksin SARS-CoV-2 terhadap Dokter Spesialis dan Residen Telinga, Hidung, dan Tenggorok di Indonesia Abstrak Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi efek samping vaksin COVID-19 di Indonesia pada petugas kesehatan dan membandingkan efek samping setelah vaksin SARS-CoV-2 menggunakan CoronaVac sebagai dosis pertama dan kedua dan Moderna sebagai booster dosis ketiga. Studi potong lintang dilakukan dengan menggunakan self-reporting survei online (Google Form) dari Agustus-Oktober 2021. Subjek yang termasuk dalam penelitian adalah dokter residen dan spesialis THT di Indonesia yang telah divaksinasi dengan kedua dosis vaksin CoronaVac COVID-19 dan vaksin Moderna COVID-19 sebagai dosis tambahan. Dari total 1394 peserta, 51,2% dan 43,7% subjek mengalami efek samping setelah dosis pertama dan kedua vaksin CoronaVac. Efek samping secara signifikan lebih tinggi setelah dosis ketiga vaksin Moderna (95,3%) dengan p-value <0,001, rasio odds (OR) 26,63 (95% CI 19,87-35,7). Efek samping setelah vaksin CoronaVac secara signifikan lebih tinggi pada wanita dan individu dengan penyakit penyerta pada dosis pertama (p=0,002 dan p=0,04), dan dosis kedua (p=0,008 dan p=0,042). Efek samping setelah vaksin Moderna secara signifikan lebih tinggi pada wanita (p=0,01), dan lebih rendah pada individu ≥ 40 tahun (p=0,017). Status komorbiditas tidak mempengaruhi efek samping setelah vaksin Moderna. Kata kunci: efek samping, SARS-CoV-2, COVID-19, vaksin, otorinolaringologi.

A survey of Indonesian otolaryngologist behavior in medical service during the CoVid-19 pandemic Indra Zachreini; Jenny Bashiruddin; Susyana Tamin; Harim Priyono; Ika Dewi Mayangsari; Respati Ranakusuma; Natasha Supartono; Fikri Mirza Putranto; Dewo Aksoro; Selfiyanti Bimantara; Yussy Afriana Dewi; Kote Noordhianta; Bintang Napitupulu; Sagung Rai Indrasari; Nyilo Purnami; Tengku Siti Hajar Haryuna; Juliandi Harahap; Eka Savitri; Tjandra Manukbua
Oto Rhino Laryngologica Indonesiana Vol. 51 No. 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.444

Background: World Health Organization (WHO) announced a newly discovered virus that first identified in Wuhan, China on December 2019, namely SARS-CoV-2 as the cause of corona virus disease (COVID-19) which had become global pandemic. Doctors as medical practitioners are categorized as vulnerable group to be infected by corona virus, and many otorhinolaryngologists had been infected and even died in performing medical services. Among the causative factors why otorhinolaryngologists could get infected by corona virus is their behavior. Purpose: To assess the behavioral level of otorhinolaryngologists in medical services during Covid-19 pandemic. Method: Descriptive study with a cross sectional design. Research samples were otorhinolaryngologists in Indonesia who met the inclusions criteria. The samples were selected by consecutive sampling method, and obtained 1299 subjects. Behavioral level was assessed from 3 aspects: knowledge, attitude, and practice, which comprised of 12 questions. Result: It was found that 461 respondents had a good behavioral level (35.5%), 677 respondents had moderate levels (52.1%) and 161 respondents had low level (12.4%). There was a statistically significant correlation between knowledge with behavioral level, attitude with behavioral level, and practice with behavioral level (p=0.001). Conclusion: The study of behavioral level of otorhinolaryngologists in medical service during Covid-19 pandemic obtained the highest number was moderate level 677 respondents (57.2%), and there was a statistically significant correlations between the variable of knowledge with behavioral level, the variable of attitude with behavioral level, and the variable of practice with behavioral level (p=0.001).ABSTRAK Latar belakang: Organisasi kesehatan dunia (WHO) mengumumkan virus baru yang pertama kali muncul di Wuhan China, pada Desember 2019, yaitu SARS-CoV-2 sebagai penyebab corona virus disease 19 (Covid 19) dan menyatakan sebagai pandemi. Dokter sebagai tenaga kesehatan merupakan kelompok yang rentan terinfeksi virus corona dan berdasarkan laporan, sudah banyak dokter Telinga Hidung Tenggorok - Bedah Kepala Leher (THT-KL) yang terinfeksi bahkan meninggal dunia dalam pelayanan medis. Salah satu faktor penyebab dokter THT-KL terinfeksi oleh virus corona adalah tingkat perilaku dokter THT-KL. Tujuan: Mengetahui tingkat perilaku dokter THT-KL dalam melakukan pelayanan medis saat pandemi Covid 19. Metode: Penelitian deskriptif dengan rancangan studi potong lintang. Sampel penelitian adalah dokter THT-KL di Indonesia yang memenuhi kriteria inklusi. Teknik pengambilan sampel secara berurutan, dan mendapatkan 1299 sampel. Tingkat perilaku dinilai dari 3 aspek yaitu dimulai dari pengetahuan, sikap dan tindakan yang terdiri dari 12 pertanyaan. Hasil: Didapatkan tingkat perilaku responden dokter THT-KL dalam pelayanan medis pada pandemi Covid 19, tingkat perilaku baik sebanyak 461 responden (35,4%), tingkat sedang 677 responden (52,1%), dan tingkat kurang 161 responden (12.4%). Terdapat hubungan yang signifikan antara pengetahuan dan tingkat perilaku, sikap dengan tingkat perilaku dan tindakan dengan sikap perilaku (p=0,001). Kesimpulan: Didapatkan tingkat perilaku dokter THT-KL dalam pelayanan medis pada pandemi covid 19, terbanyak adalah tingkat perilaku sedang sebanyak 677 responden (57,2%), dan terdapat hubungan yang bermakna antara variabel pengetahuan dengan tingkat perilaku, variabel sikap dengan tingkat perilaku dan variabel tindakan dengan tingkat perilaku dokter THT-KL dalam pelayanan medis pada pandemi Covid 19, dimana nilai p = 0,001. Kata kunci: perilaku, dokter THT-KL, pandemic, Covid-19

Prevalence of Sinonasal Cancer in Dr. Sardjito General Hospital Yogyakarta in The Period between January 2017 and December 2022 Indrasari, Sagung Rai; Herdini, Camelia; Yudistira, Danu; Mary, Cynthia
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1087

Background: Sinonasal cancer is considered a rare disease and data concerning the disease in Indonesia still requires extensive research. This study aimed to describe the factors that contribute to the incidence and outcome of sinonasal cancer. Methods: This was a descriptive study conducted at the Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Sardjito General Hospital Yogyakarta between January 2017 and December 2022. Data regarding histopathological type, sex, age, location of tumor, presence of metabolic syndrome, staging, treatment, overall survival, and cancer recurrence were extracted from the patient’s medical records. All patients diagnosed with sinonasal cancer within the period were included in the study. Results: A total of 117 patients were included in this study ranging from 11 to 85 years of age and averaging 54,5 years. Most patients were diagnosed within the age range of 51 – 60 years. SCC was found to be the most common and it was more prevalent in males than in females. More patients were found to have suprastructure tumors. Most patients were not recorded to have metabolic syndrome. The majority of patients were diagnosed in the late stage of sinonasal cancer and overall survival for most cases was death. More patients received 2 or less therapy, followed by patients who received all 3 types of treatment. Recurrency was found in only 1,7% of all cases. Conclusion: Several conditions can affect the incidence and outcome of sinonasal cancer which include sex, age of diagnosis, presence of risk factors (e.g. metabolic syndrome), location of tumor, staging, treatment, recurrence, and the histopathological type.

Title

Found 12 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 12 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 12 Documents
Search