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All Journal MEDIA MEDIKA INDONESIANA Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Oto Rhino Laryngologica Indonesiana Indonesian Journal of Cancer eJournal Kedokteran Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
Sagung Rai Indrasari
Department Of Otorhinolaryngology, Head And Neck Surgery, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia/Sardjito General Hospital, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Fibrovascular Polyps of the Hypopharynx: A Case Report Camelia Herdini; I Komang Praba Edi Wirata; Sagung Rai Indrasari; Danu Yudistira; Monik Alamanda
Indonesian Journal of Cancer Vol. 19 No. 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1352

Abstract

Introduction: Fibrovascular polyps are very rare, non-cancerous growths in the hypopharynx, though they can occur anywhere in the pharynx. Surgical excision is the definitive treatment to alleviate the patient's symptoms with an excellent outcome. This case report aims to share knowledge about the clinical presentation and treatment of this rare condition. Case Presentation: A 45-year-old man complained primarily of recurrent sore throat and frequent choking episodes, particularly during sleep. He also felt a mass in his deep throat, which he felt in his mouth just before swallowing, particularly when he vomited. A pedunculated mass originating from the lateral hypopharyngeal wall is detected during physical examination. After the mass was completely resected, he received proton pump inhibitors (PPI) and postoperative antibiotics.Conclusion: For fibrovascular polyps, definitive surgical excision is the preferred treatment. It is recognized that with total resection, malignant transformation and disease recurrence are relatively rare.
The association between PD-L1 expression and the survival rate of patients with undifferentiated nasopharyngeal carcinoma Indrawati; Auliya Suluk Brilliant Sumpono; Vivin Febriani; Kartika Widyawati Taroeno-Hariadi; Sagung Rai Indrasari; Camelia Herdini; Rheza Gandi Bawono; Ery Kus Dwianingsih
Indonesian Journal of Biomedicine and Clinical Sciences Vol 58 No 3 (2026)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v58i3.19542

Abstract

Programmed cell death ligand-1 (PD-L1) plays a key role in tumor immune evasion. However, its prognostic significance in nasopharyngeal carcinoma (NPC) remains unclear. This study evaluated the association between PD-L1 expression and clinicopathological features and survival outcomes in patients with NPC. We conducted a retrospective analysis of 80 patients diagnosed with non-keratinizing undifferentiated NPC between 2015 and 2019. PD-L1 expression was assessed by immunohistochemistry using the 22C3 antibody and quantified as the tumor proportion score. Associations with clinicopathological variables were analyzed, and overall survival was evaluated using Kaplan–Meier and Cox regression analysis. PD-L1 expression was negative in 72.5% of cases, positive in 18.8% of cases, and strongly positive in 8.7% of cases. PD-L1 expression was not significantly associated with age, sex, disease stage, treatment modality, or overall survival (HR 1.71; p = 0.494). PD-L1 expression on tumor cells was not associated with clinicopathological characteristics or survival in non-keratinizing undifferentiated NPC. These findings suggest that PD-L1 alone is not a reliable prognostic biomarker for this NPC subtype, highlighting the need for integrated immune and molecular analyses in future studies.
Co-Authors Aldri Frinaldi Aminuyati Anggina Diksita Anisa Haqul Khoiria Ashadi Prasetyo Auliya Suluk Brilliant Sumpono Bambang Hariwiyanto Bambang Hariwiyanto Bambang Hariwiyanto Bambang Udji Djoko Rianto Bintang Napitupulu Bustanul Ardianto Camelia Herdini Camelia Herdini Camelia Herdini Danu Yudistira Dewo Aksoro Didik Setyo Heriyanto Eka Savitri Eka Savitri Ery Kus Dwianingsih Ery Kus Dwianingsih Feri Trihandoko Fikri Mirza Putranto Haryuna, Tengku Siti Hajar I Komang Praba Edi Wirata Indra Zachreini Indra Zachreini Indrawati Indwiani Astuti Irianiwati Widodo Jaap Middeldorp Jajah Fachiro Jenny Bashiruddin Jenny, . Juliandi Harahap Juliandi Harahap Kartika Widyawati Taroeno-Hariadi Kote Noordhianta Mary, Cynthia Mayangsari, Ika Dewi Monik Alamanda Natasha Supartono Natasha Supartono Nyilo Purnami Odhi Anggani Priyono, Harim Respati Ranakusuma Respati Ranakusuma Rheza Gandi Bawono Selfiyanti Bimantara Soenarto Sastrowijoto, Soenarto Sofia Mubarika Haryana Susanna Hutajulu Tamin, Susyana Tan IB Tjandra Manukbua Tjandra Manukbua Vivin Febriani Wahyu Tri Widayati Yussy Afriana Dewi Yussy Afriana Dewi