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Journal : Smart Medical Journal

Potensi Padina australis sebagai Marine Drug untuk Aterosklerosis I Gusti Ayu Stiti Sadvika; Ni Wayan Ari Wulansari; Ni Putu Elsinthia Suryaningsih; Agung Nova Mahendra
Smart Medical Journal Vol 5, No 1 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i1.55479

Abstract

Atherosclerosis is characterized by endothelial dysfunction, altered lipid accumulation, inflammation, and foam cells deposition. Fucoxanthin and fucoidan that are contained in Padina australis are known to have potential anti-atherosclerotic effects. This review aims to see the activity and potential of Padina australis as an anti-atherosclerotic marine drug. This literature review article was obtained through a online-based scientific database using terms or phrases relevant to the topic. Fucoxanthin reduces ROS and inhibits production of NO, PGE2, TNF-α, IL-6, and IL-1β. Meanwhile, fucoidan can regulate the development of atherosclerosis by preventing SMC from forming foam cells, LOX-1 expression, and proinflammatory molecules significantly. A decrease in total cholesterol, triglycerides, LDL, and increased HDL-c also shown to be one of the effects of fucoidan in modulating lipid metabolism. Fucoxanthin can increase thermogenesis by increasing PRDM16, UCP-1, and UCP-3 in BAT and decreasing adipocyte size, leptin, and increasing adiponectin in WAT. Fucoidan can lower the cholesterol index, triglycerides, LDL, and increase the expression of PPARγ which can increase lipid metabolism and inhibit hyperlipidemia. In conclusion, Padina australis is potential anti-atherosclerosis agent due to its fucoxanthin and  fucoidan exhibiting antioxidant, anti-inflammatory effects, and modulation of lipid metabolism.Keywords: Padina australis, fucoxanthin, fucoidan, atherosclerosis, marine drug
Co-Authors Agatha Putra, Gusti Ngurah Agung Ari Chandra Wibawa Agung Wiwiek Indrayani Agung Wiwiek Indrayanti Anak Agung Bintang Astridwiyanti Anak Agung Dewi Megawati, Anak Agung Dewi Aris Mudariani, Ni Wayan Ary Puspitasari, Made Aryasa, Mahesa Ajisaka Ayuti Bulaan Bagus Komang Satriyasa Bagus Putra Manuaba, Ida Desak Gede Vicsilia Mahambara Gita Desak Ketut Ernawati Desak Made Wihandani Dewi, Ni Wayan Sucindra Dharmajaputra, Gede Bagus Diana Putri Dinda Anggita Meiwita Sari Dwi Vedanta, I Gusti Ngurah Ananta Elvina Veronica Gede Agung Dhimasena Widyananda Gede Sri Darma Gede Wirata Gita Almira Putri Gusti Ngurah Bagus Wira Gunawan I Gede Krisna Putra Yasa I Gusti Ayu Artini I Gusti Ayu Stiti Sadvika I Gusti Made Aman I Made Jawi I P G. Adiatmika I Wayan Gede Sutadarma I Wayan Putu Sutirta Yasa I Wayan Sumardika I Wayan Surudarma I Wayan Weta Indrayan, Agung Wiwiek Irene Amelia Ita M. Nainggolan Ita M. Nainggolan Kezia Angelina Yunatan Meylana Ayu Melinda Nanis S. Marzuki Nanis S. Marzuki, Nanis S. Ni Kadek Sinta Dwi Chrismayanti Ni Made Dwi Putri Nadi Ni Putu Elsinthia Suryaningsih Ni Wayan Ari Wulansari Ni Wayan Sucindra Dewi Ni Wayan Sucindra Dewi Nila Wahyuni Nyoman Mantik Astawa, I Pangala, Gustinara Bakti Pratiwi, Kadek Prastiti Surya Putrawan, Ida Bagus Indra Shadnyana Putri, Kadek Wina Santhya Putu Ayu Melati Widyasari Putu Diah Saraswati Rahayu Putu Resika Melarosa Saraswati, Ni Made Ayu Sokawati Kesuma, Nyoman Diah Asvini Sumardika, Wayan syahida, iin kurnia Tresnayanthi, Kadek Ayu Sri Vittala, Govinda W. Riski Widya Mulyani Winanti, Kadek Dinda Ayu Sri