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All Journal Jurnal Farmasi Udayana Jurnal Tumbuhan Obat Indonesia Majalah Obat Tradisional Majalah Farmaseutik
Tatang Irianti
Department Of Pharmaceutical Chemistry, Faculty Of Pharmacy, Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Public Health

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Pembuatan Sediaan Tabir Surya Ekstrak Etanol Rimpang Temu Kunci (Boesenbergia pandurata (Roxb.) Schlecht), Aktivitas Inhibisi Fotodegradasi Tirosin dan Kandungan Fenolik Totalnya Tatang Irianti; Teuku Nanda Saifullah Sulaiman; Nanang Fakhrudin; Siluh Astuti; Nita Testikawati; Soda Farida; Jovanita Fara Addina
Majalah Farmaseutik Vol 16, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (532.999 KB) | DOI: 10.22146/farmaseutik.v16i2.49421

Abstract

Indonesia merupakan negara tropis dengan intensitas sinar matahari yang tinggi sehingga hal ini dapat memberikan dampak negatif terhadap kulit manusia. Untuk mencegah kerusakan akibat dari cahaya matahari diperlukan suatu bahan yang bersifat fotoprotektor dengan mekanisme kerja menyerap atau menghalangi cahaya matahari masuk ke kulit. Flavonoid ekstrak etanol rimpang temu kunci (Boesenbergia pandurata (Roxb.) Schlecht) diketahui memiliki aktivitas sebagai fotoprotektor. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol rimpang temu kunci dalam sediaan tabir surya yang mengandung bahan aktif oksibenson sebagai fotoprotektor; mengetahui aktivitas fotodegradasi tirosin serta kadar fenolik total ekstrak etanol rimpang temu kunci. Pada penelitian ini dilakukan dengan menguji delapan formula. Penentuan kemampuan fotoproteksi berdasarkan nilai transmisi eritema dan transmisi pigmentasi. Uji inhibisi fotodegradasi dilakukan dengan menggunakan enam kelompok komposisi tirosin dan Rhetoflam. Uji penentuan kadar fenolik total dilakukan menggunakan metode Follin-Ciocalteu. Hasil pengukuran diintrapolasikan ke dalam kurva baku asam galat. Penambahan ekstrak etanol rimpang temu kunci mampu menurunkan transmisi eritema 0,72-0,76 kali dan transmisi pigmentasi 0,57-0,61 kali dari sediaan tabir surya. Pemberian ekstrak etanol rimpang temu kunci 6% pada sediaan tabirsurya mengandung oksibenson 6% meningkatkan efektivitas tabir surya dengan menurunkan transmisi eritema 1,00 kali dan transmisi pigmentasi 1,02 kali lebih baik dari sediaan tabir surya mengandung bahan aktif oksibenson saja. Sedangkan kandungan fenolik total ekstrak etanol ripang temu kunci adalah sebesar 7,11 ± 0,15 % EAG dengan aktivitas penghambatan fotodegradasi tirosin 2,06 kali lebih besar dibandingkan dengan vitamin C pada kadar yang sama, yaitu 0,15%. Hal ini menunjukkan bahwa ekstrak etanolik rimpang temu kunci dapat dimanfaatkan sebagai bahan aktif fotoprotektor dalam sediaan kosmetik.
Antioxidant Capacity from Ethyl Acetate Fraction of Kenikir (Cosmos Caudatus K) Khrisna Pangeran; Tatang Irianti Irianti; Hari Purnomo
Majalah Obat Tradisional Vol 28, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.84604

Abstract

Antioxidant is an activity that inhibits oxidation reactions due to exposure to free radicals, the search for antioxidant compounds continues to be developed from natural sources. The purpose is to identify new sources of safe and inexpensive agents through antioxidant capacity from ethyl acetate fraction on kenikir leaves was evaluated through enzymatic and non-enzymatic in vitro models. The research began with the method of separating compounds from ethanol extracts and ethyl acetate fractions, quantification of total phenolics and flavonoids, antioxidant capacity tests with DPPH, and tyrosinase enzyme. The results of the study produced isolate E which was observed in a single stain with Rf 0,80. The compound has a typical marker worth 1734.07 cm-1 with an indication of stretching vibration movement on C-O. It has a maximum wavelength of ± 216 nm, with an abundance of 49.75% and a retention time of 27.20 minutes. TPC and TFC test results, the water fraction is the most dominant value with 0.430 mgGAE/g and 0.056 mQE/g. DPPH assay results, isolate E has an IC50 value of 162.03 ppm and a %inhibition of 12.73%. The tyrosinase inhibition test of L-DOPA substrate was resulting an IC50 value of 77.51 ppm compared to kojic acid of 16.48 ppm.
Aktivitas Penangkapan Radikal 2,2-difenil-1-pikril hidrazil Fraksi Terhidrolisis Asam Daun Duwet (Syzigium cumini L.) dan Daun Nangka (Artocarpus heterophyllus) Irianti, Tatang; Yasmin, Intan Farida; Astuti, Ratih Dwi; Purnomo, Hari
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p05

Abstract

Plants contain secondary metabolites, including flavonoids, whose molecules are still bound to glycosides or are not free molecules. Hydrolysis treatment to form free molecules in this study is expected to increase antioxidant activity. The antioxidant activity test used the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenger test. The value of Inhibitory Concentration 50% (IC50) obtained will show the antioxidant activity of the acid hydrolyzed water fraction of duwet (Syzigium cumini L.) leaf and the insoluble hexane fraction of jackfruit (Artocarpus heterophyllus) leaf acid hydrolysis. The results of the hydrolysis of the water fraction of duwet leaves and the insoluble fraction of jackfruit leaf hexane were measured for their antioxidant activity by DPPH radical scavenging test using UV-Vis spectrophotometer. To identify compounds in the water fraction and insoluble hexane fraction that act as antioxidants, qualitative analysis was used TLC and determined total phenolic compounds and flavonoids. The highest antioxidant activity of duwet leaves was in the hydrolyzed water fraction for 3 hours, while in jackfruit leaves the insoluble hexane fraction was hydrolyzed for 3 hours. Thus, the hydrolysis carried out in this study was able to increase the antioxidant activity.
Identification of Compounds and Antidiabetic Activities of the Ethyl Acetate Fraction of Yacon (Smallanthus sonchifolius) Leaves using In Silico and In Vitro Approaches Pratama, Binar; Irianti, Tatang; Purnomo, Hari
Majalah Obat Tradisional Vol 28, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.85748

Abstract

Yacon (Smallanthus sonchifolius) is a plant that is vastly cultivated in Indonesia and has anti-diabetic activity. The purpose of this study was to isolate the compounds from the semipolar fraction of yacon leaves, as well as test them in silico and in vitro approaches. In this study, we use maceration for extraction, fractionation with n-hexane and ethyl acetate as solvent, and separation by preparative TLC method. The compounds tested were in silico by molecular docking using plant applications and in vitro by alpha-glucosidase inhibition assay. The difference between the molecular docking scores of an obtained molecule was calculated with Pair T-test methods. The results of the separation of the ethyl acetate fraction yielded a fraction, namely the H fraction. GC-MS analysis and IR spectroscopy showed that the H fraction contained the dominant compound called phthalic acid, di(2-propyl pentyl) ester. The docking score of the phthalic acid di(2-propyl pentyl) ester molecule and the alpha-glucosidase receptor, it is showed lower potency than 1-deoxynojirimycin as an alpha-glucosidase inhibitor. The in vitro test results showed that isolate H (IC50 = 130.479 ppm) from yacon leaves was no better than acarbose as an alpha-glucosidase enzyme inhibitor because the IC50 value was > 100 ppm.
Formulasi Krim Tabir Surya Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) Terenkapsulasi Nanopartikel Kitosan: Uji Aktivitas Secara In Vitro Irianti, Tatang
Majalah Farmaseutik Vol 20, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i2.86085

Abstract

Hylocereus polyrhizus peel contains many flavonoid compounds that have potential to become sunscreen. Nanoparticle technology in sunscreen preparations has the advantage of increasing activation, surface area, and better diffusivity in protecting the skin. The purpose of this study was to identify the physical properties and determine the effectiveness of sunscreen cream with Ki-Ekubuname nanoparticles as an active substance. The ionic gelation method is used in the manufacture of nanoparticles by optimizing the speed and duration of stirring. Then made formulations with varying levels of active substance. Formulations were prepared with varying levels of the active substance (FA without active substance, FB with 6% Ekubuname, F1, F2, and F3 with 2%, 4%, and 6% Ki-Ekubuname, respectively). The creams formed were observed for physical, chemical properties and sunscreen activity with in vitro. The results showed that Ekubuname has a total flavonoids of 2.034 ± 0.094 mg QE/g. All sunscreen formulas with Ki-Ekubuname nanoparticle active substances meet SNI 16-4399-1996 standard. Nano-size active substances have better performance, as evidenced by higher SPF values. Formula F3 has the best characterization with a homogeneous appearance, light brown color, soft texture, distinctive aroma, pH 5, viscosity 4,768.25 ± 210.80 cps, adhesiveness 6.15 ± 0.25 seconds, spreadability 6.01 ± 0.10 cm, O/W cream type, and SPF value 17.41 (ultra protection category).
Co-Authors Andayana Puspitasari Andayana Puspitasari Andayana Puspitasari Argandita Meiftasari Astuti, Ratih Dwi Damiana Nitya Kanistri Damiana Nitya Kanistri Desi Riza Pratiwi Dharmastuti Cahya Efendi Efendi Ema Suryani Ema Suryani Fatmarahmi Fatmarahmi HARI PURNOMO Hari Purnomo Hari Purnomo Jovanita Fara Addina Khrisna Pangeran Kuswandi Kuswandi Kuswandi Kuswandi Kuswandi Kuswandi Machwiyyah L. Nanan Tresnaasih Nanang Fakhrudin, Nanang Nita Testikawati Nita Testikawati Nur Amalia Choironi Pratama, Binar Rabbani HR. Ratih Anggar Kusumaningtyas Ratih Anggar Kusumaningtyas Retno Wahyuningrum Ritmaleni, Ritmaleni Sari Rosiati Nur Khasanah Sigit Hartomo Siluh Astuti Siluh Astuti Siluh Putu Yuni Astuti Sindu Nuranto Soda Farida Sofa Farida Sofa Farida Subagus Wahyuono Sylvia Utami Tanjung Pratiwi T. N. Syaifullah Sulaiman Takushi Kaneko Teuku Nanda Saifullah Sulaiman Titik Nuryastuti Yasmin, Intan Farida Yosi Bayu Murti Yulia Paramitha