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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Human Nutrition Medical Laboratory Technology Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of Issues in Midwifery Jurnal Aisyah : Jurnal Ilmu Kesehatan Asian Journal of Health Research Jurnal Info Kesehatan

Yahya Irwanto

Department Of Obstetric And Gynecology Faculty Of Medicine Brawijaya University, Malang, Indonesia/RSUD Dr. Saiful Anwar Malang, Division Of Oncology.

Author-ID : 288829

Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 29 Documents Claim Missing Document

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Survival and Clinicopathological Features of Cervical Carcinoma Patients with Radiation Therapy Yahya Irwanto; Aliesya Patricia Wulandari; Ineke Permatasari; Ainun Ganisia; Lilik Zuhriyah; I Wayan Agung Indrawan; Sutrisno .
Medical Laboratory Technology Journal Vol. 8 No. 1 (2022): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Cervical cancer has a high incidence with a low survival rate. The clinicopathological profile and risk factors cause this. Most cervical cancer sufferers are late in realizing this, contributing to the severity suffered. Radiation has a very important role because it is a therapy that can be done in cervical cancer patients who have experienced an advanced level of severity. This study aims to determine the survival and influence of the clinicopathological and risk factors of radiation patients as a consideration in selecting effective therapy to increase the survival rate of cervical cancer patients. The benefit of this research is to help evaluate cervical cancer management procedures with radiation therapy applied in many hospitals in Indonesia to increase the success of therapy for cervical cancer. An analytical observational study with a retrospective cohort type using medical record data with samples of all patients diagnosed with cervical cancer who received radiation therapy from January to December 2017. Samples in this study were 111 patients. This study revealed that the five-year survival rate of cervical cancer patients was only 53.1%. There was an influence on the clinicopathological stage (p<0.000), histopathology (p<0.000), lymph node status (p<0.000), degree of differentiation (p<0.001), and risk factors for age (p<0.038), parity (p<0.001), education (0.022), marital status (0.001), contraceptive use (p<0.000), and BMI (p<0.000) which resulted in a log-rank p-value <0.05, so it was concluded that there was an effect between these variables on cervical carcinoma survival rate. Multivariate, it was found that radiation, histopathology, lymph node status, contraception, and BMI had a significant effect (p<0.005) on the survival rate of cervical cancer patients. The results of this study indicate that the survival rate of cervical cancer patients is still low, and there is a clinicopathological and risk factors that influence the survival rate of cervical cancer patients.

Effect of Papaya Leaf Extract Gel (Carica papaya) on Incision Wound Healing in Rattus norvegicus Iin Tri Marlinawati; Siti Nurhidayah; Sanarto Santoso; Yahya Irwanto
Medical Laboratory Technology Journal Vol. 8 No. 2 (2022): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Carica papaya is one kind of herbal plant that can help the wound healing process. Scientifically, the leaves of papaya are proven to have anti-inflammatory effects. Flavonoid, alkaloid, tannin, and saponin compounds in papaya leaves have antimicrobial and antioxidant properties to accelerate the re-epithelization and cell migration needed for wound healing. This research aims to determine the effect of papaya leaf extract gel (Carica papaya) on the healing of incision wounds in Rattus norvegicus based on changes in wound morphology (signs of redness, edema, pus, granulation, moisture, and wound length). This research used female Rattus norvegicus aged 12-16 weeks weighing 180-200 grams, divided into five groups (NaCl 0,9%, povidone-iodine, papaya leaf extract gel with concentrations of 10%, 20%, and 30%). Incision wounds on the back of the rat with a length of 2 cm and depth of 1 cm. The normality test used the Shapiro-Wilk test, and the homogeneity test used the Levene test. The research data were not normally distributed nor homogeneous, so they were analyzed using the Kruskal Wallis and Mann-Whitney tests. The results showed that the extract of papaya leaves with concentrations of 10%, 20%, and 30% had significant differences in positive and negative control groups in the wound healing process with the differences in redness (p=0.038), granulation tissue (p=0.039), moistures (0,48), and wound length (p=0,049). It can be concluded that papaya leaf extract gel (Carica papaya) is effective in accelerating the healing process of incision wounds in Rattus norwegicus at concentrations of 10%, 20%, and 30%, so for further research, it is hoped that a histopathological examination can be carried out so that changes that occur in collagen, neutrophile cells, monocytes, and lymphocytes are seen.

Effect of Vitamin C Exposure to Fibroblast Cells on Woman Uterosacral Ligament Culture Rahajeng Rahajeng; Tatit Nurseta; Edy Mustofa; Yahya Irwanto; Aditiya Fendi Uji Pamungkas; Dhian Eka Putri Harnandari; Putu Arik Herliawati
Medical Laboratory Technology Journal Vol. 9 No. 2 (2023): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v9i2.521

Pelvic Organ Prolapse (POP) occurs when the uterosacral ligaments weaken. Vitamin C plays a major role in forming the extracellular matrix (collagen) and stimulates fibroblast cell proliferation. This study aimed to examine how a woman's uterosacral ligament culture was affected by vitamin C exposure to fibroblast cells. A straightforward experimental design investigation that is non-blind and includes analysis after exposure (Post-test control group design). This study's sample used uterosacral ligament from a woman who underwent at least two vaginal deliveries through a hysterectomy procedure. Several doses of vitamin C were given and repeated for 72 hours, followed by examining the number of fibroblast cells; then, the data was analyzed starting with the parametric prerequisite test and the one-way ANOVA test. There was a significant effect of vitamin C exposure on fibroblast cells of the uterosacral ligament at a dose of 50 μg/ml and 100 μg/ml. In contrast, at doses of 150 μg/ml and 200 μg/ml, there was no significant effect. From this study, it is hoped that the administration of vitamin C according to the optimal dose found in the study (significant impact at doses of 50 μg/ml and 100 μg/ml, can increase the proliferation of fibroblast matrix supporting the sacrouterine ligament in women, to prevent prolapse of the pelvic organs in women, and can maintain the quality of life of women.

The Impact of Phaleria macrocarpa Fruit Flavonoid Extract on Endometrial Thickness in Mice Menopausal Model Wijaya, Dyah Ayu Septika; Dwi Wulandari, Recavery; Sutrisno, Sutrisno; Irwanto, Yahya; Anita, Kenty Wantri
Medical Laboratory Technology Journal Vol. 10 No. 1 (2024): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i1.584

This study aims to determine how the effect of flavonoid phaleria macrocarpa fruit extract on the endometrial thickness of Mus musculus which is used as an experimental animal with a menopause model. This study employed a randomized post-test-only control group design on 32 female mice. Ovariectomy simulated menopause, followed by treatment with flavonoid from Phaleria macrocarpa fruit extract. Post-observariectomized, follicle-stimulating hormone levels indicated menopausal status. Hematoxylin-Eosin methods assessed endometrial thickness. The result indicated reduced endometrial thinning in the positive control group (K+). Conversely, the treatment group (P1-P4) exhibited increased endometrial thickness post-flavonoid extract administration. Ovariectomized-induced estrogen decline resulted in reduced endometrial thinning, mimicking menopausal conditions. Statistically, flavonoid extract administration increased endometrial thickness in ovariectomized-induced menopausal mice, with optimal effect observed at 7.5 mg/mice/day for 14 days. The preferred intervention dose for altering endometrial thickness in menopausal conditions was identified as P1 (3.75 mg/mice/day). In conclusion, a flavonoid from Phaleria macrocarpa fruit extract mitigates endometrial thinning in the menopausal mice model. For implication in menopausal women, clinical trials need to be conducted to evaluate the dosage of these flavonoids for their potential as a natural SERM (Selective Estrogen Receptor Modulator) before clinical application in managing endometrial health. Additionally, research on molecular effects particularly regarding ER (Estrogen Receptors) in the endometrial organ, is needed to confirm their phytoestrogenic effect.

Co-Authors A.A. Ketut Agung Cahyawan W Aditiya Fendi Uji Pamungkas Ainun Ganisia Ainun Ganisia Aliesya Patricia Aliesya Patricia Wulandari Anggia Prameswari Wardhana Annissa Febriani Arif Satria Hardika Bambang Rahardjo Cholili, Muhamad Nofa Dewi, Rose Khasana Dhian E. P. Harnandari Dhian Eka Putri Harnandari Diah Ayuningtyas Dionisius Christian Bria Seran Dwi Wulandari, Recavery Edy Mustofa Edy Mustofa Eviana Norahmawati Fadilah, R. A. Rahmawati Nurul Fatmawati, Fatmawati Herliawati, Putu Arik I Wayan Agung Indrawan I Wayan Subage Iin Tri Marlinawati Imelda Imelda Ineke Permatasari Irfani Baihaqi Kenty Wantri Anita, Kenty Wantri Khasanah, Wasingatin Catur Khoirinda, Ani KUSUMA WARDANI Kusworini Handono Lilik Zuhriyah Mudinillah, Adam Muhamad Nofa Cholili Nugrahanti Prasetyorini Purba, Irene Silvia Puspita Handayani Putu A. Herliawati Rahajeng Rahajeng Rahajeng Rahajeng Rahmi Utami Ratnawati, Putu A.R. Sanarto Santoso Siti Nurhidayah Soetomo Soewarto Sutrisno . Sutrisno Sutrisno Sutrisno Sutrisno Sutrisno, Sutrisno Tatit Nurseta Tatit Nurseta Tatit Nurseta Tatit Nurseta Wahyuni, Rizki Wijaya, Dyah Ayu Septika Wiyasa, I W.A. Wiyasa, I Wayan Arsana Wiyono , Teguh

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