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All Journal Jurnal Kedokteran Brawijaya Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Abdimas Dewantara Journal of Issues in Midwifery Al Hanin
Edy Mustofa
Laboratorium Obstetri dan Ginekologi Rumah Sakit Umum Dr .Saiful Anwar Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health

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Perbedaan Disfungsi Sexual Wanita yang Melahirkan Secara Pervaginam dengan Episiotomy Mediolateral dan Seksio Sesarea Irwanto, Yahya; Mustofa, Edy
Journal of Issues in Midwifery Vol 2, No 3 (2018)
Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (719.722 KB) | DOI: 10.21776/ub.JOIM.2018.002.03.5

Abstract

Generally, the causes of Postpartum Female Sexual Dysfunction (PPFSD) are dyspareunia, perineal pain, the discomfort of incision lesion including surgery, reduction of libido, lack of lubrication in the vagina, changes in seeing body image to be negative, and anorgasm irelated to pain and trauma. Perineal pain and dyspareunia are post partum problems which occur frequently and interfere with normal sexual function, that usually are caused by perineal trauma, episiotomy, and child birth instrumentation.This study was conducted by a cross-sectional study. Research subjects consisted of women  post vaginal delivery with mediolateral episiotomy and postcesarean section. Each group consisted of 45  people. After three months post partum sexual function as sessed using FSFI scores (Female Sexual Function Index) as well as an assess ment of demographic data include age, religion, education, employment, insurance coverage/BPJS, gestational age, birthweight, stitches condition, medical treatment, nursing, assistance of baby sitter and problems in the family. The data had to fulfill the inclusion and exclusion criteria in the form of question naires were further tested withc hi-square analysis and independent t-test.In the demographic data analysis withc hi-squareanalys is didn’t find any significant differences  between the two groups, with p>0.05. The sexual dysfunction among women after vaginal delivery  with mediolateral episiotomy and cesarean section  there was no significant difference p=0.081, and p>0.05. On the FSFI scores domains there are significant differences between the two group son the variables of sexual  desire, orgasm, pain and FSFI total scores.
Efek Stres Fisik dan Psikologis pada Kortisol, PGE , BAFF, IL-21, sIgA, dan Candidiasis 2 Vulvovaginal Mustofa, Edy
Jurnal Kedokteran Brawijaya Vol 27, No 1 (2012)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (715.526 KB) | DOI: 10.21776/ub.jkb.2012.027.01.4

Abstract

Kandidiasis  vagina  dapat  menghasilkan  morbiditas  signifikan  terhadap  kualitas  hidup.  Stresor  dapat  mempengaruhi sistem imun ini melalui efek kerja kortisol, namun mekanismenya masih belum jelas. T ujuan penelitian ini adalah untuk mengetahui  apakah  peningkatan  kadar  kortisol  karena  stres  kronis  akan  meningkatkan  Kandidiasis  vulvovagina  tikus melalui  peningkatan  kadar  PGE   dan  penurunan  kadar  BAFF ,  IL-21,  serta  kadar  sIgA.  Rancangan  penelitian  ini  adalah 2eksperimental  laboratorik  post  test  only  control  group  pada  tikus  betina  Rattus  norvegicus  strain  Wistar .  Tikus  dibagi dalam kelompok kontrol positif dan negatif , kelompok perlakuan 'electric foot shock' dan paparan predator kucing pada tiga  waktu  pengamatan.  Setelah  7,  14  dan  28  hari  (kronis),  dilakukan  pemeriksaan  kadar  kortisol  plasma,  BAFF ,  IL-21,  PGE-2,  sIg  A dengan  ELISA dan   Koloni C.albicans  mukosa dengan  pengecatan  kimia.  Analisis data  diuji menggunakan  uji t  tidak berpsangan, One Way ANOVA,  Kruskal Wallis,  dan analisis jalur .  Hasil pada penelitian ini  menunjukkan bahwa pemberian rangsang  listrik  dan  paparan  predator    selama  7,  14  dan  28  hari  meningkatkan  kadar  kortisol,  PGE2,  jumlah  kandida, jumlah sel radang pada biopsi mukosa vagina, serta menurunkan kadar IL21, BAFF dan sIgA. Analisis jalur menunjukkan stres fisik  dan psikis kronis meningkatkan kortisol yang memiliki efek tidak  langsung  terhadap jumlah  Kandida melalui penurunan BAFF dan IL-21 sebesar -0,565 dan -0,447 yang akan mempengaruhi sIgA sebesar 0,460 dan 0,364 sehingga jumlah  Kandida  meningkat.
DISKURSUS PENDIDIKAN ANAK USIA DINI: (Telaah Konsep Pemikiran Pendidikan Jalaluddin Rahmat) Mustofa, Edy; Nabil, Nabil
Al Hanin Vol. 2 No. 2 (2022): Al Hanin
Publisher : LPPM Sekolah Tinggi Ilmu Tarbiyah Al Marhalah Al Ulya Bekasi, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38153/alhanin.v2i2.30

Abstract

Islam as a teaching that is universal and applies throughout the ages not only regulates the affairs of the hereafter, but also the affairs of the world. Similarly, Islam regulates the sciences related to God and the sciences related to the worldly. Islam regulates both in an integrated manner. In the Qur'an and as- Sunnah there is actually no term religious science and general science, there is only knowledge itself and all of it comes from Allah SWT. We should support the effort to "educate the life of the nation" as the goal of Indonesian education. Each concept is also offered by several people/characters who of course have different heads of different thoughts. Indonesia has many figures who care about the importance of education. Besides KH. Ahmad Dahlan, KH. Hasyim Asy'ari, and Ki Hajar Dewantara as education leaders in Indonesia in the past, there are also modern education leaders, one of whom is Jalaluddin Rakhmat. Not infrequently, his thoughts on education are approved by various groups. One that is often discussed is about the concept of early childhood education. Jalaluddin Rakhmat, as a current Indonesian education leader, is also interested in offering his concept. Therefore, let us give a little attention to how important the concept of education offered by Jalaluddin Rakhmat.
PENGARUH SENAM IRAMA TERHADAP KEMAMPUAN MOTORIK KASAR ANAK USIA 5-6 TAHUN DI RA. ROUDHOTUL JANNAH BEKASI TIMUR Khonita, Nana; Mustofa, Edy; Nabil, Nabil
Al Hanin Vol. 3 No. 1 (2023): Al Hanin
Publisher : LPPM Sekolah Tinggi Ilmu Tarbiyah Al Marhalah Al Ulya Bekasi, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38153/alhanin.v3i1.34

Abstract

Children aged 5-6 years Early childhood is an individual who is undergoing a process of rapid development, so that children who are still in preschool, a child's gross motor development is needed and must be done, one of which is by using rhythmic gymnastics. Based on the results of observations that researchers have found at RA Roudhotul Jannah, East Bekasi, that the lack of gross motor skills in the development of walking children in place, the lack of development of children in standing on one leg, the lack of development of children in swinging their hands, and the lack of development of children in performing rhythmic gymnastics movements. The purpose of this study was to determine the role of rhythmic gymnastics in improving gross motor skills in motor development and to determine the development of children's gross motor skills after doing rhythmic gymnastics at RA Roudhotul Jannah, East Bekasi. The methodology in this study uses a quantitative approach with a descriptive method. Data collection techniques in this study were carried out through observation and documentation. Based on the results of data collection, it can be concluded that, when learning using rhythmic gymnastics, it can be seen that the gross motor development of children develops or increases every meeting so that children from those who cannot perform simple movements become able. Children also become more excited because of the music so that children become happy and cheerful in doing movements. Therefore, rhythmic gymnastics in children is very instrumental and important so that rhythmic gymnastics must be applied from an early age.
JUMLAH MONOSIT, KADAR INTERLEUKIN-6, DAN KADAR FAKTOR PENGHAMBAT MIGRASI MAKROFAG LEBIH TINGGI PADA KONDISI PREEKLAMPSIA DENGAN SEPSIS Rahardjo, Bambang; Mustofa, Edy; Sanggelorang, Margie Cassie; Wati, Linda Ratna
Majalah Kesehatan Vol. 11 No. 2 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.02.1

Abstract

Preeklampsia merupakan komplikasi kehamilan yang ditandai dengan peningkatan tekanan darah >140/90 mmHg, proteinuria, dan edema, yang terjadi setelah 20 minggu kehamilan. Penyebab terjadinya preeklampsia tidak diketahui secara pasti, tetapi kemungkinan terkait dengan respons inflamasi sistemik. Monosit dan makrofag yang telah distimulasi oleh endotoksin akan menghasilkan interleukin-6 (IL-6) yang dapat  memicu respons inflamasi berlebih, dan mungkin memainkan peran sentral dalam respons inflamasi pada preeklampsia dan sepsis.  Tujuan penelitian ini adalah untuk membandingkan jumlah sel monosit, kadar IL-6, dan kadar macrophage migration inhibitory factors (MIF) pada preeklampsia dan preeklamsia dengan sepsis. Penelitian ini menggunakan desain penelitian cross-sectional. Sampel darah dikumpulkan dari partisipan di RSUD dr. Saiful Anwar Malang dan Bangil yang dikategorikan dalam kelompok normotensif, preeklampsia, dan preeklampsia dengan sepsis. Sel monosit dinilai pada hitung darah lengkap dengan metode flow cytometry. Kadar IL-6 dan kadar MIF dinilai menggunakan enzyme-linked immunosorbent assay. Hasil penelitian menunjukkan bahwa jumlah sel monosit, kadar IL-6, dan MIF pada kelompok preeklampsia dengan sepsis secara signifikan lebih tinggi dibanding kelompok kontrol (p < 0,001) dan preeklampsia (p < 0,001).  Didapatkan hubungan yang signifikan antara jumlah monosit dengan  kadar IL-6 (r = 0,781; p < 0,001), jumlah monosit dengan kadar MIF (r = 0,798; p < 0,001), dan kadar IL-6 dengan kadar MIF (r = 0,654; p = 0,003)  pada kelompok preeklampsia dengan sepsis. Pada kondisi preeklamsia dengan sepsis, peningkatan jumlah sel monosit dan MIF dapat memicu peningkatan kadar IL-6.
The expression of immunohistochemical biomarkers PAX8 and CD117 in platinum resistant ovarian cancer at Saiful Anwar General Hospital, Malang, Indonesia Widodo, Robby Rinaldi; Nurseta , Tatit; Mustofa, Edy; Arianto, Onni Dwi; Dewi, R. A. Rose Khasana
Majalah Obstetri & Ginekologi Vol. 33 No. 1 (2025): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I12025.1-10

Abstract

HIGHLIGHTS Ovarian cancer, a prevalent gynecologic malignancy affecting women, poses a significant challenge due to the development of resistance to platinum-based therapy in its management. PAX8 and CD117 have demonstrated potential as predictive biomarkers for platinum resistance in ovarian cancer; however, studies exploring their immunohistochemical expression in relation to platinum resistance in ovarian cancer patients remain limited. This study aims to evaluate the immunohistochemical expression of CD117 and PAX8 in ovarian cancer tissues and investigate their association with the emergence of platinum resistance.   ABSTRACT Objective: Ovarian cancer, a prevalent gynecologic malignancy, frequently presents challenges due to platinum therapy resistance. This study aims to investigate a monitoring approach for post-operative ovarian carcinoma and evaluate the immunohistochemical expression of PAX8 and CD117 in ovarian cancer tissues, assessing their association with platinum resistance development. Materials and Methods: Employing a cross-sectional observational analytical design, this study utilized consecutive sampling of patients meeting predefined inclusion and exclusion criteria. Tissue samples, obtained from biopsy or surgical procedures and processed into representative paraffin blocks, underwent immunohistochemical analysis at the Anatomical Pathology Department of Saiful Anwar Hospital, Malang, Indonesia. Expressions of PAX8 and CD117 were evaluated using immunohistochemistry. Diagnostic performance was assessed through receiver operating characteristic (ROC) curves and Youden index calculations to determine sensitivity and specificity. Results: The study findings revealed that the area under the curve (AUC) for PAX8 and CD117 was 0.785 and 0.809, respectively. PAX8 expression exhibited a positive predictive value of 53.125%, negative predictive value of 87.50%, sensitivity of 18.75%, specificity of 51.85%, and accuracy of 60.0%. For CD117 expression, the corresponding values were 71.4%, 72.73%, 70%, 72.73%, and 70% for positive predictive value, negative predictive value, sensitivity, specificity, and accuracy, respectively. Conclusion: The immunohistochemical expression of PAX8 and CD117 in ovarian cancer tissues may serve as prognostic biomarkers for platinum resistance. Despite these findings, the study acknowledges several limitations that warrant refinement in future research.
Pemberdayaan anak usia dini melalui bermain sains dalam mengembangkan kemampuan saintifik di SPS Bunga Mawar Pujianti, Yuli; Suharti, Suharti; Wijaya, Purwani Kusumawati; Mustofa, Edy
ABDIMAS DEWANTARA Vol 7 No 2 (2024)
Publisher : Universitas Sarjanawiyata Tamansiswa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30738/ad.v7i2.17882

Abstract

Anak usia dini adalah masa kritis dalam perkembangan kognitif dan pengetahuan saintifik. Pengenalan sains melalui metode bermain dapat memberikan dasar yang kuat untuk keterampilan berpikir kritis dan analitis pada anak. SPS Bunga Mawar menyediakan lingkungan yang kondusif untuk mengimplementasikan program pemberdayaan ini melalui aktivitas bermain sains. Tujuan kegiatan ini  untuk pengembangan kemampuan saintifik anak usia dini melalui bermain sains. Metode yang digunakan adalah pendekatan partisipatif, melibatkan anak-anak, orang tua, dan guru dalam aktivitas bermain sains, seperti demonstrasi, eksperimen sederhana, dan permainan interaktif. Evaluasi program dilakukan melalui observasi dan penilaian perkembangan kemampuan saintifik anak setelah mengikuti kegiatan. Hasil menunjukkan bahwa program ini efektif dalam meningkatkan kemampuan saintifik anak usia dini, termasuk kemampuan mengamati, menanya, menalar, dan berkomunikasi. Simpulan dari program ini adalah bahwa bermain sains dapat menjadi metode yang efektif untuk memperkenalkan konsep-konsep saintifik kepada anak-anak sejak dini, serta program serupa direkomendasikan untuk diimplementasikan di berbagai institusi pendidikan anak usia dini di Indonesia.   Development of early childhood scientific abilities through science play at SPS Bunga Mawar   Abstract: Early childhood is a critical period in cognitive development and scientific knowledge. Introducing science through play can provide a strong foundation for children's critical and analytical thinking skills. SPS Bunga Mawar provides a conducive environment for implementing this empowerment program through science play activities. The purpose of this activity is to develop early childhood scientific abilities through science play. The method used is a participatory approach, involving children, parents, and teachers in science play activities, such as demonstrations, simple experiments, and interactive games. The program evaluation was conducted through observation and assessment of children's scientific skills development after participating in the activities. The results show that the program is efficacious in improving children's scientific skills, including the ability to observe, question, reason, and communicate. This program concludes that science play can be an effective method to introduce scientific concepts to young children, and similar programs are recommended to be implemented in various early childhood education institutions in Indonesia.
Co-Authors Arianto, Onni Dwi Bambang Rahardjo Dewi, Rose Khasana Khonita, Nana Nabil Nabil, Nabil Nurseta , Tatit Sanggelorang, Margie Cassie Suharti Wati, Linda Ratna Widodo, Robby Rinaldi Wijaya, Purwani Kusumawati Yahya Irwanto YULI PUJIANTI