Article Per Year (5 Year)
p-Index From 2021 - 2026
3.916
P-Index
This Author published in this journals
All Journal Jurnal Anestesiologi Indonesia Jurnal Kedokteran Brawijaya Jurnal Anestesi Perioperatif Jurnal Komunikasi Hukum Journal of Anaesthesia and Pain Jurnal Anestesi Obstetri Indonesia Solo Journal of Anesthesi, Pain and Critical Care
Isngadi Isngadi
Bagian Anestesiologi Dan Terapi Intensif, Fakultas Kedokteran, Universitas Brawijaya/ RSUD Dr. Saiful Anwar Malang
Chemical Engineering, Chemistry & Bioengineering Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 41 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 41 Documents
Search

 1   2   3   4   5 
Continuous Ketamine Administration Decreases Monocyte Count in Sepsis Patients in Intensive Care Units Hartono, Ruddi; Jaya, Wiwi; Mayasari, Mayasari; Isngadi, Isngadi
Journal of Anaesthesia and Pain Vol. 4 No. 1 (2023): January
Publisher : Faculty of Medicine, Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jap.2023.004.01.01

Abstract

Background: Cytokines storm becomes the most common cause of mortality in sepsis patients treated in the intensive care unit (ICU). Cytokines storm is characterized by an excessive elevation in the immunocompetent cells, including monocyte. Ketamine, as a sedating agent, has immunosuppressive properties. This study was conducted to determine the effect of ketamine on monocyte count in septic patients in the ICU.Methods: This is a quantitative case-control  study of 30 patients treated in the ICU. The study subjects were divided into control (n=15) and treatment (n=15) groups. The treatment group received ketamine HCl therapy at 0.3 mg/kg body weight/hour. The mean monocytes were counted at 0, 24, and 48 hours post-therapy. Data analysis used an independent sample t-test with α=5%.Result: Administration of ketamine therapy in septic patients treated in the ICU showed a decrease in the monocytes during observation from 0 to 48 hours post-therapy. Administration of ketamine at 48 hours had a significantly lower monocyte (5.21%) compared to control (7.67%) (p=0.012).Conclusion: Ketamine administration reduces the monocytes count in septic patients treated in the intensive care unit. Ketamine is expected to be a therapeutic option in sepsis patients.
Co-Authors Achmad Haryanto Agung Nugroho, Yusuf Ahmad Feza Fadhlurrahman Aji, Haffidz Wahyu Anton Wuri Handayanto Arie Zainul Fatoni Azman, Radhillah Dadik Prasetya Hutama denny prasetyo Devi Ariani Dewi Puspitorini Husodo Dewi Puspitorini Husodo Djudjuk R Basuki Djudjuk Rahmad Basuki Djudjuk Rahmat Basuki Eko Nofiyanto Fanniyah Fanniyah Frilya Rachma Hari Bagianto Ilham Fadlilah Karmini Yupono Laksono RM Laksono, Buyung Hartiyo Mayasari Mayasari, Mayasari Mufti Khakim, Mufti Muhammad Irzal Muhammad Rizqan Khalidi Muhammad Rodli Mustaqiem Isda, Mustaqiem Nur Sumianto, Ainur Adi Pertiwi, Previasari Zahra Prima, Dian Rachma C Rafidya Indah Septica Rafidya Indah Septica Redhy Sindharta Ristiawan Muji Laksono Rizki, Aulia Nailufar Ruddi Hartono Rudi Hartono Scarpia P Sri Rahardjo Susilo Chandra Syaiful Yudhi Nurachman Taufiq Agus Siswagama Teddy Ferdinand Tulong, Priscilla Utomo, Jeffri Prasetyo Vidya Sulistyawan Wiwi Jaya Wiwi Jaya Yudi Hadinata Yuliandra, Yudhistira Yusmein Uyun Zakiyah Ainun Zulfakhri Zulfakhri