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All Journal Biospecies iBuss Management JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Jurnal Visual Jurnal EduHealth Kajian Branding Indonesia Buletin Kedokteran dan Kesehatan Prima International Journal of Health and Pharmaceutical (IJHP)
Janice Janice
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Tests of Burn Wound Healing with Nanogel Preparations from Ethanol Extract of Andaliman Fruit Janice, Janice; Erwina Putri, Riri; Fioni, Fioni
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Andaliman (Zanthoxylum acanthopodium DC) is a plant known for its diverse bioactive compounds, including antimicrobial and anti-inflammatory properties. Nano-gel formulations were prepared using appropriate techniques, and their physicochemical properties, including particle size, pH, viscosity, and centrifugation stability, were evaluated. Additionally, organoleptic tests were conducted to assess the sensory characteristics of the nano-gels. Furthermore, an irritation test was performed to ensure the formulation's safety when applied to the skin. The percentage of wound closure was evaluated at various time points, including days 2, 4, 6, 8, 10, 12, and 14, comparing it to a commercially available wound healing product, Bioplacenton. Initial findings showed that the nano gel formulations exhibited favorable physicochemical properties, including appropriate particle size within the nano-scale range. The pH values were within an acceptable range, and the formulations demonstrated suitable viscosity and stability during centrifugation. Organoleptic tests indicated good sensory characteristics, and the irritation test showed the formulation's safety without significant skin irritation. The percentage of wound closure increased over time for all three concentrations (F1: 5%, F2: 10%, F3: 20%). In conclusion, nano gel formulations containing various concentrations of Andaliman extract exhibited good physicochemical properties, favorable sensory characteristics, and safe application on the skin. Moreover, they demonstrated promising wound healing effects, potentially comparable to commercial wound healing agents.
- EFEKTIVITAS PRP TERHADAP PERUBAHAN PROFIL LIPID DARAH TIKUS PUTIH JANTAN (Rattus Norvegicus) DIABETES MELITUS YANG DI INDUKSI STREPTOZOTOCIN: EFEKTIVITAS PRP TERHADAP PERUBAHAN PROFIL LIPID DARAH TIKUS PUTIH JANTAN (Rattus Norvegicus) DIABETES MELITUS YANG DI INDUKSI STREPTOZOTOCIN Simarmata, Hans Pangestu; Saragih, Reyini Namora L.; Pasaribu, Jelita Pebriani; Sitorus, Josua Panangian; Chiuman, Linda; Janice, Janice
Biospecies Vol. 14 No. 1 (2021): Januari 2021
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/biospecies.v14i1.11252

Abstract

Diabetes mellitus is a disease problem in Indonesia due to the inability of the pancreas to produce insulin so the body's metabolic processes are disrupted. Platelet Rich Plasma is widely known to be a treatment in various fields of medicine because it contains many growth factors (GFs) which are useful for triggering growth, tissue, and cell regeneration. This study was conducted to determine the effectiveness of PRP at doses of 0.5, 1.0, and 1.5 ml/kg BW for improving lipid profiles. This study used an experimental method where PRP was made twice centrifugation, then divided into each treatment, each group was given twice a week for three weeks. The Shapiro-Wilk test was used for normally distributed data followed by the Kruskal-Wallis test followed by the analysis Mann-Whitney with a significant value of P <0.05, that is, there was an effect of PRP administration on improving levels of lipid profiles. The PRP dose of 0.5 ml/kg BW gave the effect of increasing the lipid profile except for HDL levels and a higher PRP dose was required to significantly increase HDL levels compared to the control group.  
Effectiveness Test of White Skin Extract Cream from Red Watermelon (Citrullus Lanatus) on Increasing Elasticity, Sebum and Hydration in White Mice (Mus Musculus) Skin SR Simamora, Farida; Janice, Janice; Pasca Amir, Widya
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 2 (2023): May 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i3.173

Abstract

Skin moisturizing gel can provide a moisturizing effect on the skin. One of the natural ingredients that can be made into gel preparations is the white peel of watermelon (Citrullus Lanatus) because it contains a lot of citrulline, vitamin A, vitamin B2, vitamin B6, vitamin E, vitamin C, and protein, beta-carotene, lycopene, and water. The purpose of this study was to determine the activity of the ethanol extract of watermelon rind on increasing elasticity, sebum, and hydration in the skin of male white mice. This study used the Pretest-Posttest Control Group Design method. The stages of the research were sample collection, extraction, formulation of various concentrations of moisturizing gel preparations (0, 2.5%, 5%, and 10%). Tests were carried out on the skin of male mice for 4 weeks by measuring levels of elasticity, sebum, and hydration. The results of the phytochemical screening extracts contained flavonoids, saponins, steroids, triterpenoids, and glycosides. The evaluation results showed that all formulas met good preparation parameters and did not irritate the skin. The measurement results in the fourth week of each cream preparation group showed an increase in the levels of elasticity, sebum and hydration and differed significantly from the blank group (p <0.05) and the highest increase occurred in cream with watermelon rind extract concentration 10 %. The results of this study indicate that the cream preparation of ethanol extract of watermelon rind can increase the levels of elasticity, sebum, and hydration of the skin.
Co-Authors Agustin Riagara, Restoe Amelia, Novi Amir, Widya Pasca Angie, Evelyn Arhamni, Ade Augustina Ika Widyani Bestari, Welas Bukit, Christin Debora Chiuman, Linda Djauhari Sumintardja Erwina Putri, Riri Fioni, Fioni Fransisca, Silvia Handyanto Widjojo Jessica Inez Leosaputro Kunardi, Sidharta Kurniawan, Evan Nasution, Syamsul Arifin Pasaribu, Jelita Pebriani Pasca Amir, Widya Polem, Fahmi Putri, Lenni Dianna Rosa, Tamara Saragih, Reyini Namora L. Sebayang, Robby Gunawan Sihombing, Bungaran Simarmata, Hans Pangestu Siregar, Hesti Despita Sitorus, Josua Panangian SR Simamora, Farida Tarigan, Antje Irmella Yosefa, Stephanie Renata