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Molecular Toxicology of Organophosphate Poisoning Fery Setiawan; Arif Rahman Nurdianto; Heribertus Agustinus B Tena; Ahmad Yudianto; Jenny Sunariani; Achmad Basori; Acrivida Mega Charisma
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v11i1.1596

The use of organophosphates (pesticides and other compounds to eradicate pests), currently, to increase the fulfillment of the population's consumption needs has a double-edged sword effect, on the one hand it can increase the need for food to be consumed by the population. The negative effect that can arise is the safety of organophosphate drugs which can contaminate the soil and water sources around the place where organophosphate drugs are used. The negative effects of organophosphates are associated with the effects of xenobiotics on humans who consume them. Xenobiotics are associated with toxicdynamic effects where organophosphates cause irreversible inhibition of the enzyme acetylcholinesterase (ACh). ACh is one of the main enzymes in the nervous system that terminates impulse conduction through the hydrolysis process of acetylcholine enzymes. Acetylcholinesterase is a specific molecular target of organophosphate pesticides. The inhibition of the Ach enzyme causes the inhibition of the acetylcholine enzyme which is normally always hydrolyzed by the Ach enzyme and is a specific biological marker of pesticide poisoning. Inhibition of ACh will cause the accumulation of the enzyme acetylcholine, resulting in negative effects of organophosphate poisoning which can lead to death. In this paper, the authors collect from various sources related to the study of molecular toxicology toxidynamic effects of drug safety and organophosphate poisoning. The results of this review article show that organophosphate poisoning is associated with irreversible inhibition of the acetylcholinesterase enzyme which results in death in the individual concerned.

Pelatihan Peningkatan Ketrampilan Akupresure pada Tunanetra di Masjid Cheng Hoo Surabayao Surabaya Jenny Sunariani; Raden Tatang Santanu Adikara
Jurnal Abdi Masyarakat Indonesia Vol 3 No 5 (2023): JAMSI - September 2023
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jamsi.899

Penyandang disabilitas menyangkup mereka yang memiliki keterbatasan fisik mental, intelektual atau sensoris dalam jangka waktu yang tidak sebentar (lama). Mereka seringkali dianggap sebagai masyarakat yag tidak produktif bahkan tidak mampu menjalankan tugas dan tanggung jawab secara optimal sehingga menimbulkan hak-hak yang dimilikinya diabaikan. Masih banyaknya penyandang disabilitas yang hidup dibawah garis kemiskinan disertai tingkat pendidikan yang sangat rendah. Kemudian peran usaha yang masih kurang maksimal dapat menimbulkan penghasilan yang tidak mencukupi kebutuhannya. Pelatihan bertujuan untuk memperbaiki dan memungkinkan individu yang mengalami kekurangan dalam penglihatannya dapat mencukupi kehidupan dengan menerapkan ilmu kedokterannya pada akupresure, nantinya akan dilakukan pada pelatihan peningatan akupressur tunanetra bertempat di Masjid Cheng Hoo Surabaya. Rencana yang ingin diadakan pada 20 anggota peserta tunanetra beserta pendamping adalah pelatihan peningkatan akupressur pada tunanetra yang merupakan rangkain usaha berproses mencakup suatu bidang ilmu yang sesuai dengan bidang kedokteran dan dilakukan oleh sebuah tim yang memiliki keahlian. Metode dilakukan dengan cara meragakan gerakan yang disertai suara yang nantinya pedamping tunanetra tersebut akan membantu mengarahkan sesuai gerakan yang diperagakan oleh narasumber. Hasil dari kegiatan pengabdian masyarakat ini adalah penghasilan mereka dapat bertambah, berguna untuk orang lain dan juga kegiatan ini bisa dilaksanakan lagi di tahun depan sehingga para penyandang tunanetra dapat mengembangkan potensi dan kemampuan untuk dapat hidup mandiri secara sosial dan ekonomi melalui pelatihan peningkatan keterampilan akupresur.

Determination of ABO blood group based on secretors or non-secretors analysis in body fluids Fery Setiawan; Ahmad Yudianto; Arif Rahman Nurdianto; Jenny Sunariani; Latief Mooduto
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.20561

Criminal acts often leave traces analyzed by law enforcement, especially by the Indonesian National Police (POLRI). Sometimes, various items were found and analyzed to link the victim and the perpetrator. Blood, the most abundant body fluid, found in crime scenes, consists of cellular and liquid elements. The forensic focuses on red blood, which can be wet or dried at the crime scene. Sometimes, there was no blood or bloodstains found, but objects related to other body fluids, such as: condoms, toothbrushes, the mouth of glass cups, straws, etc, could be found. Blood group analysis could still be carried out based on secretor gene (Se) considering that 80% of the population was of the secretor group. There are two chromosomes related to blood regulation, namely: chromosomes no. 9 and 19. The former relates to the ABO blood group and the latter relates to the secretory phenotype. The basic principle of secretors was antigens found on the surface of red blood cells and all body fluids, except cerebrospinal fluid. The pattern of inheritance on chromosomes 9 and 19 is based on the probability law by Mendell. It stated that all of genotypes (homozygous dominant-recessive or heterozygous) would be passed on to their offspring.

MECHANISMS OF PERIODONTITIS - INDUCED ATHEROSCLEROSIS Hudyono, Rikko; Sunariani, Jenny
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 3 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Nowadays CVD become the most common cause of death in US and worldwide. Atherosclerosis plays an important role in CVDs pathogenesis. Atherosclerosis decreases the elasticity of the vascular. Atherosclerosis shares the same risk factor as CVD, in which obesity, hyperlipidemia, hypertension and lack of physical activity may initiate it. However, 50% of all CVD patients are lack of the usual causes of CVD. The purpose of this review is to reveal the mechanism of periodontitis-induced atherosclerosis. Inflammation and autoimmune disease might play an important role in initiate the CVD. Periodontitis is one of the oral diseases which can cause systemic inflammation and may induce the atherosclerosis. Porphyromonas gingivalis (Pg) which is the major cause of periodontitis can induce it by expressing protein gp130 in its fimbriae. Periodontics patients are prone to have bacteremia by daily routine oral hygiene activity. Chronic bacteremia may alter the endothelial physiology, which is resulted in neointima formation, EC dysfunction, and lipid accumulation. It is concluded that periodontitis may play an important role in initiation and progression of atherosclerosis.

THE EFFECTS OF NICOTINE ON THE PERIODONTAL TISSUE Herawati, Herawati; Sunariani, Jenny
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 3 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Tobacco contains thousands of chemical substances which known to be harmful to periodontal tissues. Nicotine was considered as the most toxic substances to periodontal tissues. The datas in this review indicate that smoking may have a significant role in the initiation and progression of periodontal destruction. The conclusion of this and the other studies indicate that smokers have a less favorable response to periodontal therapy than non smoker. Nicotine is potentially toxic substances that have a detrimental effect on periodontal tissue, by altering the host response or directly damage the cells of normal periodontium.

Determination of ABO blood group based on secretors or non-secretors analysis in body fluids Setiawan, Fery; Yudianto, Ahmad; Nurdianto, Arif Rahman; Sunariani, Jenny; Mooduto, Latief
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.20561

Criminal acts often leave traces analyzed by law enforcement, especially by the Indonesian National Police (POLRI). Sometimes, various items were found and analyzed to link the victim and the perpetrator. Blood, the most abundant body fluid, found in crime scenes, consists of cellular and liquid elements. The forensic focuses on red blood, which can be wet or dried at the crime scene. Sometimes, there was no blood or bloodstains found, but objects related to other body fluids, such as: condoms, toothbrushes, the mouth of glass cups, straws, etc, could be found. Blood group analysis could still be carried out based on secretor gene (Se) considering that 80% of the population was of the secretor group. There are two chromosomes related to blood regulation, namely: chromosomes no. 9 and 19. The former relates to the ABO blood group and the latter relates to the secretory phenotype. The basic principle of secretors was antigens found on the surface of red blood cells and all body fluids, except cerebrospinal fluid. The pattern of inheritance on chromosomes 9 and 19 is based on the probability law by Mendell. It stated that all of genotypes (homozygous dominant-recessive or heterozygous) would be passed on to their offspring.

DNA TOUCH STR CODIS AS LEGITIMATE EVIDENCE IN UNCOVERING CRIMINAL ACTS Nurdianto, Arif Rahman; Setiawan, Fery; Yudianto, Ahmad; Nurdianto, Rizal Fauzi; Sunariani, Jenny
Jurnal Biosains Pascasarjana Vol. 26 No. 1 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i1.2024.77-86

The identification process at the crime scene (TKP) is one of the essential tasks carried out by police investigators. One critical aspect is the collection and analysis of evidence found at the crime scene, referred to as biological evidence (BB). This evidence serves as a crucial source for determining whether an incident occurred and, if so, whether it was a suicide or another criminal act (such as murder, etc.). The biological evidence found can be analyzed using molecular serobiology approaches, which are rapidly advancing in the fields of forensic medicine and medicolegal practice. One such approach involves utilizing DNA traces, although a common challenge is that often the DNA recovered at crime scenes is degraded. Therefore, a DNA amplification method utilizing the Polymerase Chain Reaction (PCR) technique, along with the short tandem repeat (STR) – CODIS identification approach, is necessary. The analysis of DNA traces using the STR-CODIS approach enables investigators to determine whether the incident was purely criminal, a suicide, or another type of accident involving the victim. Furthermore, the DNA analysis using the STR-CODIS method can also aid in identifying the victims discovered at the crime scene.

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