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All Journal Jurnal Kimia (Journal of Chemistry) Indonesia Medicus Veterinus Biology, Medicine, & Natural Product Chemistry Jurnal Ilmiah Medicamento Prosiding Workshop dan Seminar Nasional Farmasi (WSNF)
Anak Agung Gede Rai Yadnya Putra
Progam Studi Farmasi Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Udayana
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Kandungan Fitokimia dan Aktivitas Farmakologi dari Ulva lactuca Ni Luh Linda Sukrawati; Putu Oka Samirana; Anak Agung Gede Rai Yadnya Putra
Prosiding Workshop dan Seminar Nasional Farmasi Vol. 3 (2024): Prosiding Workshop dan Seminar Nasional Farmasi 2024
Publisher : Program Studi Farmasi Fakultas MIPA Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/WSNF.2024.v03.p15

Abstract

Ulva lactuca adalah salah satu alga laut yang termasuk ke dalam genus Ulva dan keluarga Ulvaceae. Ulva lactuca memiliki komposisi kimia bernilai ekonomis tinggi yang dapat membuka peluang pemanfaatan dalam aplikasi kosmetik, farmasi, kimia, makanan, dan energi. Artikel ulasan ini bertujuan untuk memeriksa profil fitokimia dan aktivitas farmakologi dari Ulva lactuca. Pencarian data diperoleh dari jurnal internasional dan nasional melalui website dan database berbasis ilmiah yaitu PubMed dan Google Scholar. Berdasarkan literatur yang telah dikumpulkan, terdapat sebanyak 7 artikel yang memenuhi kriteria inklusi. Hasilnya menunjukkan Ulva lactuca memiliki berbagai metabolit sekunder meliputi alkaloid, terpenoid, steroid, saponin, dan flavonoid. Beberapa senyawa seperti asam sinapik, naringin, rutin, dan quercetin diisolasi dari rumput laut ini. Aktivitas farmakologi dari Ulva lactuca yang paling umum ditemukan dalam literatur adalah antioksidan, antibakteri, antijamur, anticancer, dan antidiabetes. Meskipun alga laut ini menawarkan sumber yang menjanjikan dalam dunia farmakologi dan fitokimia, namun perlu dilakukan penelitian lebih lanjut untuk mengeksplorasi potensi Ulva lactuca sebagai produk alami yang bermanfaat bagi kesehatan manusia. Mengingat bahwa penelitian terkait kandungan fitokimia dan aktivitas farmakologi Ulva lactuca masih sangat terbatas.
Green Extraction of Corn Silk Flavonoids Using NADES-UAE: Optimizing Conditions for Agricultural Waste Valorization Anak Agung Sagung Intan Kwanira Gayatri; Anak Agung Gede Rai Yadnya Putra; Putu Oka Samirana
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1039-1045

Abstract

Corn silk (of Zea mays L.) is an agricultural waste that has not been optimally utilized, even though it is known to contain flavonoid compounds with various pharmacological activities, such as antioxidant, anti-inflammatory, and antidiabetic effects. The flavonoid compounds in corn silk have the potential to be developed as natural raw materials for applications in the pharmaceutical and cosmetic fields. However, the extraction process for these active compounds often still uses organic solvents like methanol, which are toxic, flammable, and have negative impacts on health and the environment. Therefore, this study aimed to optimize the Ultrasound Assisted Extraction (UAE) method using a more environmentally friendly alternative solvent, namely Natural Deep Eutectic Solvent (NADES). The study was conducted in two main stages: selection of the best NADES composition and molar ratio from combinations of choline chloride with urea, glycerol, lactic acid, and malic acid; and optimization of UAE parameters including ultrasonic power, time, and temperature using the Response Surface Methodology (RSM) with the Box-Behnken Design (BBD) model. The determination of total flavonoid content was performed using the colorimetric method with AlCl? reagent and quercetin standard, and the measurements were taken using a UV-Vis spectrophotometer. The results showed that the NADES combination of choline chloride:urea (1:2) with the addition of 30% aquades produced the highest flavonoid content compared to 80% methanol solvent. The optimal conditions for UAE extraction were obtained at 100 % ultrasonic power, 30 minutes of extraction time, and a temperature of 70°C, resulting in a total flavonoid content yield of 96.02 ± 0.48 mgQE/g of corn silk powder. This study concluded that the combination of NADES and UAE method can significantly enhance the extraction yield of total flavonoids while also providing a more sustainable and environmentally friendly solution for the utilization of agricultural waste, such as corn silk.
Photoprotective Activities of Standardized Anredera scandens (L.) Moq. Leave Extract: an In-Vitro Study on UVB Absorption and UVA Protection Samirana, Putu Oka; Nugraha, I Gusti Agung Anom Krisna; Putra, Anak Agung Gede Rai Yadnya
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13690

Abstract

Background: Skin cancer is a worldwide disease caused by exposure to ultraviolet radiation, both UVA and UVB rays. Interest in discovering new natural ingredients with photoprotective activity has increased research to find plants containing high amounts of phenolic and flavonoid compounds.Objective: This research aimed to assess the in vitro photoprotective activity of ASL (ethanol extract of Anredera scandens (L.) Moq. leaves) standardized based on the Indonesian Herbal Pharmacopoeia.Methods: Extraction was performed using the maceration method with 70% ethanol as the solvent. Parameters used to determine quality are drying loss, water content, total ash content, acid insoluble ash content, total flavonoid content, and total phenolic content. Photoprotective activity against UVB rays was determined by measuring SPF value using the Mansur spectrophotometric method, while activity against UVA rays was tested using the trans-resveratrol degradation model.Results: Results indicate that ASL extract fulfilled quality requirements based on total flavonoid content (9.983 ± 0.090%) and total phenolic content (13.098 ± 0.611%). The SPF value was increased proportional to the increase in concentration. The sample showed an SPF value of 5.96 when tested at a concentration of 200 µg/mL. SPF value reached 27.9 at 1,000 µg/mL. The UVA photoprotection assay indicated that the ASL extract provided limited protection against trans-resveratrol degradation, with a reduction of 18.90%, which was lower than the positive control but still significantly better than the negative control.Conclusion: ASL extract can be developed as a candidate for a natural-based photoprotective active ingredient, used as a single agent or supportive component for sunscreen products.
Co-Authors A. A. P. Febriyana A. F. Febriana-Putra A. N. Mahendra Amin, Amirul Anak Agung Sagung Intan Kwanira Gayatri Ayu Irayanti Ayundita, Ni Putu Trisna D. A. A. Andhini D. A. Satriawati D. M. N. Pratiwi Dewa Ayu Angghy Andhini Dewa Ayu Satriawati Dewa Ayu Swastini Fatturochman, Firlyandhika Dwi Firlyandhika Dwi Fatturochman G. M. D. Putra I Gde Pande Aninditha Putra Wicaksana I Gede Bangkit Adi Sentosa I Gusti Agung Krisna Larashati I Kadek Suardiana I Kadek Suardiana I Putu Aditya Mahaputra I Wayan Adith Yoga Saputra Jayantini, Ni Luh Putu Erika Putri K. W Astuti Ketut Widyani Astuti Kusuma, Lalu Angga Sadi Luh Pande Putu Tirta Mahaputra, I Putu Aditya N. K. M. Ariani, N. L. P. V. Paramita N.W. Musdwiyuni Ni Komang Cahyaningsih Ni Luh Linda Sukrawati Ni Luh Putu Erika Putri Jayantini Ni Made Udayani Dwi Yadnya Ni Nyoman Fabby Sukarmini Ni Putu Sinta Mahasuari Ni Putu Trisna Ayundita Nugraha, I Gusti Agung Anom Krisna P. K. S Devi Putu Oka Samirana Putu Oka Samirana Putu Siska Angelina Pramesti Santri Yulita Shaswati, Gusti Ayu Prianka Adi Widnyana, I Putu Sudiatmika Yustiantara, Putu Sanna