Article Per Year (5 Year)
p-Index From 2021 - 2026
2.462
P-Index
This Author published in this journals
All Journal PHARMACON Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Lentera: Penelitian dan Pengabdian Masyarakat
Irma Antasionasti
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
Studi In Silico Senyawa Aktif Minyak Ikan Tindarung Sebagai Penurun Kolesterol Melalui Inhibitor HMG-KoA CHRISTHALIA IEWANDA RUMALUTUR; PUTRI MARGARETHA GLAUDY PANI; DESHANDA KURNIAWAN PRAYOGA; ALDA JULISTY GABRIELA LAPIAN; BRIGITA CHRISTANIA AURORA GONI; FATIMAWALI; IRMA ANTASIONASTI
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 1 (2024): Volume 7, No 1, Tahun 2024
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i1.46260

Abstract

Tindarung fish oil contains omega-3 fatty acids, namely DHA (Docosahexaenoic acid) and EPA (Eicosapentaenoic acid). Therefore, tindarung fish oil has the potential to be developed as a cholesterol drug. This study aims to determine the activity of HMG-CoA reductase from fatty acids of tindarung fish oil using an in silico study with molecular docking. The receptor used was the enzyme HMG-CoA reductase (PDB ID: 1HW9) with the native ligand simvastatin prepared using YASARA. The fatty acid compounds were drawn using MarvinSketch at pH 7.4 with 10 confirmations. In the molecular anchoring process, the PLANTS program was used and visualized in 2D with Discovery Studio Visualizer and in 3D with Pymol. The native ligand showed a docking value of -76.4052. Compounds 1,2,3,8,11, and 12 had relative values for simvastatin of more than 95%. These compounds have molecular anchoring activity similar to simvastatin so it is predicted to be able to reduce cholesterol levels by inhibiting the HMG-CoA reductase enzyme.
Physicochemical Profile of Red Ginger (Zingiber officinale) SNEDDS as Potential Antidiabetic Surya Sumantri Abdullah; Sri Sudewi; Irma Antasionasti; Rezky Putri Indarwati Abdullah
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64731

Abstract

This study developed a Self-Nanoemulsifying Drug Delivery System (SNEDDS) of red ginger (Zingiber officinale var. rubrum) to enhance its stability and bioavailability. 8 formulations (F1–F8) were tested with varying Tween 80 : PEG 400 ratios (Smix 4.5 mL). Formula F7 (2.8 : 1.8 mL) produced a water-clear emulsion with pH 5.20 ± 0.02 and excellent stability for 28 days. PSA results showed droplet size 20.33 ± 0.57 nm, PDI 0.430 ± 0.053, and zeta potential −19.58 ± 1.50 mV. These findings indicated that F7 is the optimum, physicochemically stable SNEDDS formulation, potentially improving solubility and oral bioavailability of red ginger’s active compounds as a phytopharmaceutical antidiabetic candidate Keywords: red ginger, SNEDDS, nanoemulsion, physicochemical stability
Co-Authors Abdullah, Rezky Putri Indarwati Adelien Zefanya Mawikere ALDA JULISTY GABRIELA LAPIAN BRIGITA CHRISTANIA AURORA GONI CHRISTHALIA IEWANDA RUMALUTUR Defny Silvia Wewengkang DESHANDA KURNIAWAN PRAYOGA Elly Suoth Fatimawali . Fatimawali Fatimwali Gleam Yordan Grenshannya Anasthasya Pua Herny E.I. Simbala Imam Jayanto Irma Febrianti Wahongan Jayanto I Khairunnisa Mutiara Thaib Meilani Jayanti Putri Margaretha Glaudy Pani Rizky Ramadhan Maulana Sri Sudewi Stevana F.A. Paat Surya Sumantri Abdullah Surya Sumantri Abdullah Tjandra A. Rumagit Trina Tallei Valensia J. Takapaha Weny Indayany Wiyono Widya Hana Putri Gerung