Article Per Year (5 Year)
p-Index From 2021 - 2026
1.383
P-Index
This Author published in this journals
All Journal BALI MEDICAL JOURNAL (BMJ) E-Jurnal Medika Udayana E-Jurnal Udayana Medica Indonesian Journal of Urology Syntax Literate: Jurnal Ilmiah Indonesia JBN (Jurnal Bedah Nasional) ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Journal of Anesthesiology and Clinical Research Journal of Global Pharma Technology Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute E-Amal: Jurnal Pengabdian Kepada Masyarakat Folia Medica Indonesiana
Gede Wirya Kusuma Duarsa
Bagian Bedah Urologi Fakultas Kedokteran Universitas Udayana
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

Published : 32 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 32 Documents
Search

 1   2   3   4 
Comprehensive Histopathological Properties of Dartos Tissue Associated with Hypospadias Severity and Chordee: A Prospective Study Raharja, Putu Angga Risky; Birowo, Ponco; Rachmadi, Lisnawati; Wibowo, Heri; Kekalih, Aria; Duarsa, Gede Wirya Kusuma; Wahyudi, Irfan
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 8 No. - (2024): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v8i-.243

Abstract

Background: The cause of chordee in hypospadias is not fully understood. Dartos fascia resection has been shown to correct penile curvature, suggesting its potential involvement. This study aimed to evaluate the histopathological properties of dartos tissue and their association with hypospadias severity and chordee.Methods and Materials: Dartos tissue samples were collected from 37 children with hypospadias and ten controls undergoing circumcision between March and October 2024. Histopathological analysis using hematoxylin-eosin and Masson’s trichrome staining assessed for collagen, smooth muscle, and vascular density. Assessment and quantification of all histopathological components were blinded. Results: The hypospadias group showed lower collagen density (60.85±6.75% vs. 67.31±4.61%; p=0.003) and higher smooth muscle density (7.34±4.92% vs. 2.51±2.24%; p<0.001) compared to controls, with no significant difference in vessel density. Sub-analysis showed severe chordee was linked to lower collagen density compared to mild (Mean Difference [MD] -6.24±2.41%; p=0.014) and moderate chordee (MD -5.73±2.54%; p=0.031). Conclusions: The dartos tissue in hypospadias patients exhibited lower collagen density and higher smooth muscle density, with chordee severity specifically linked to decreased collagen density.
The Effects of Purple Sweet Potato (Ipomoea Batatas L.) Ethanol Extract on Bladder Urothelial Layer and Smooth Muscle Thicknesses in Menopausal Female Wistar Rats Putra, Bismantara Aditya; Santosa, Kadek Budi; Niryana, I Wayan; Golden, Nyoman; Duarsa, Gede Wirya Kusuma; Suryawisesa, Ida Bagus Made
Folia Medica Indonesiana Vol. 59, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: Purple sweet potatoes cultivated in Bali, Indonesia, were found to be rich in phytoestrogen due to the high levels of anthocyanin-type flavonoids. The phytoestrogen in purple sweet potato ethanol extract demonstrated estrogenic activity and the potential to substitute hormone replacement therapy (HRT) as the treatment of lower urinary tract symptoms. Abstract Postmenopausal women experience estrogen hormone deficiency, which can cause thinning of the smooth muscle and urothelial layer of the bladder, leading to lower urinary tract symptoms (LUTS). Hormone replacement therapy (HRT) has been the primary choice for addressing these problems. However, long-term prescription of HRT can result in several adverse effects, including a higher risk of breast cancer and cardiovascular diseases. Phytoestrogen, an estrogen-like compound derived from plants such as purple sweet potatoes (Ipomoea batatas L.), contains anthocyanin that could serve as a better alternative to estrogen replacement therapy. This study aimed to demonstrate the effects of phytoestrogens in purple sweet potatoes on the histomorphology of the bladder in menopausal female Wistar rats (Rattus norvegicus). This experimental study used a posttest-only control group design. A total of 36 Wistar rats undergoing ovariectomy were randomly assigned into two groups, with 18 samples in each group. The experimental group received the purple sweet potato ethanol extract orally, while the control group received a placebo. The structures of the smooth muscle and urothelial layer of the bladder were observed using a microscope. Data were analyzed using an independent t-test to compare bladder smooth muscle and urothelial layer thickness between groups, with a significance of p<0.05. A normality test was performed to determine the normal distribution of the data. Normally distributed data were assessed to find the mean and standard deviation (SD). Significant differences were found in the mean thickness of the smooth muscle and urothelial layer between both groups (p=0.00), with both being thicker in the experimental group. In conclusion, phytoestrogens in purple sweet potatoes can influence the histomorphology of the bladder. Ovariectomized female Wistar rats that received purple sweet potato ethanol extract exhibited thicker smooth muscle and urothelial layer of the bladder.
Co-Authors Anak Agung Gde Oka Aria Kekalih Bramastha A Rosadi, Bramastha A Cita Rosita Sigit Prakoeswa Citra Gading Dea Emmanuel Djodi Sidartha Donny Oktavius Gde Oka, A A Gede Andi Aditya Gede Wirata Gede Wirya Diptanala Putra Duarsa Gede Wirya Diptanala Putra Duarsa Gede Wirya Diptanala Putra Duarsa Gede Wirya Diptanala Putra Duarsa Gusti Ayu Putu Nilawati Heri Wibowo I Gde Raka Widiana I Gusti Ayu Irma Vitriani I Gusti Ayu Putri Purwanthi I Gusti Bagus Dharma Prakasa Musti I Ketut Widiana I Made Nugraha Gunamanta Sabudi I Nengah Wiadi I Nyoman Semadi I Wayan Niryana I Wayan Yudiana I.G. Darma-Kusuma Ida Bagus Putra Manuaba Ida Bagus Putra Pramana Irfan Wahyudi Kadek Budi Santosa Ketut Putu Yasa Krishna, I Komang O. Lisnawati Rachmadi Marleen Nurhaen - Nyoman Golden Nyoman Khrisna Dharmawan Oka Udrayana Oka, AA Gde Oka, Anak A.G. Paksi Satyagraha Pande Made Wisnu Tirtayasa Pande Putu Yuli Anandasari Paulina Magdalena Ponco Birowo Pontisomaya Parami Pradiptha, I Nyoman Tri Pramana, Putu Bagus Gin Gin Prayudi, I Nyoman Gede Putra, Bismantara Aditya Putu Astri Novianti Putu Kurnia Darma Pratama Putu Primeriana Nugiaswari Raharja, Putu Angga Risky Rika Lesmana, Rika S. F. Laura, S. F. Sri Maliawan Sugianto, Ronald Suryawisesa, Ida Bagus Made Teguh Dwi Nugroho, Teguh Dwi Tjokorda Gde Agung Senapathi Tjokorda Gde Bagus Mahadewa Udiyana, Nyoman Dwi Maha Wayan Sudana Yenny Kandarini