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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Reaktor Pharmaciana: Jurnal Kefarmasian Journal of Engineering and Technological Sciences Majalah Obat Tradisional Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry Jurnal farmasi UIN Alauddin Makassar Current Research on Biosciences and Biotechnology JURNAL BIOLOGI PAPUA Journal of Food and Pharmaceutical Sciences
Muhamad Insanu
School of Pharmacy, Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Journal : HAYATI Journal of Biosciences

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UHPLC-Q-Orbitrap HRMS-based Untargeted Metabolomics of Sida rhombifolia Leaves and Stem Extracts Alfi Hudatul Karomah; Mohamad Rafi; Dewi Anggraini Septaningsih; Auliya Ilmiawati; Utami Dyah Syafitri; Nanik Siti Aminah; Muhamad Insanu; Abdul Rohman
HAYATI Journal of Biosciences Vol. 30 No. 4 (2023): July 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.4.770-778

Abstract

Sida rhombifolia, also known as sidaguri in Indonesia, is a medicinal plant commonly used as a herbal medicine because of its metabolite and biological activities. One of the several factors that affect plant metabolite composition and concentration is the use of plant parts. In this study, the experiment aimed to identify the metabolite profile in the leaves and stem extracts of S. rhombifolia using UHPLC-Q-Orbitrap HRMS-based untargeted metabolomics. The samples were distinguished by principal component analysis (PCA). Extraction of metabolites was conducted by sonication for approximately 30 min with 70% ethanol as the extraction solvent; 28 metabolites were identified. Seven metabolites were identified only in the leaves, three were identified only in the stems, and 18 other metabolites were identified in both the leaves and stems. These metabolites were categorized as flavonoids, triterpenoids, alkaloids, coumarins, phenolic aldehydes, phenolic acids, ecdysteroids, fatty acids, and monoterpene lactones. Based on the classification results, PCA grouped the leaves and stem extracts of S. rhombifolia using the peak area variables of the identified metabolites.
Parang Romang (Boehmeria virgata (Frost.) Guill.): Correlation of Phytochemistry with Antioxidant and Xanthine Oxidase Inhibitory Activities Arsul, Muhammad Ikhlas; Fidrianny, Irda; Insanu, Muhamad
HAYATI Journal of Biosciences Vol. 31 No. 3 (2024): May 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.3.457-464

Abstract

Secondary metabolites such as phenolic and flavonoid from the plant are essential in their activity, especially activities related to the prevention of oxidation and the inhibition of xanthine oxidase. One plant that is believed to have prevention of oxidation and XOI and correlates with secondary metabolites is parang romang. The purpose of this study is to assess the antioxidant capacity and xanthine oxidase inhibitory activities of parang romang, and to examine their relationship with the TPC and TFC. Total phenolic and flavonoid were measured for all parts, and the DPPH, FRAP, and CUPRAC methods determined antioxidant capacity. The activity of xanthine oxidase inhibition was also assessed. Flavonoids, alkaloids, and coumarin were found in parang romang. The steroid/triterpenoid was found in the stem, leaves, and flower; saponin was in the roots and flower; quinone and tannin were only in the roots. The root gave the highest of TPC, while the flower had the highest TFC. The highest antioxidant capacity was found in roots, leaves, flowers, and stems. The highest xanthine oxidase inhibitory was given by leaves (9.74±0.14 µg/ml), followed by flower, steam, and rood. The correlation was shown between the phenolic and flavonoid quantities and the actions of antioxidants and xanthine oxidase inhibitors.
Co-Authors Abdu Ravi Zakaria Abdul Rohman Abdul Rohman Abdul Rohman Abdul Rohman Akhirul Kahfi Syam Alfi Hudatul Karomah Anggra Paramita Anita Artarini Ardiyan Harimawan Ardiyan Harimawan Arsul, Muhammad Ikhlas Asefin Nurul Ikhtiarini Asep Gana Suganda Asma Asma As’ari Nawawi Auliya Ilmiawati Bangar, Roy Cindra Mutia Dadan Rohdiana Dianika Lestari Dianika Lestari Dianika Lestari Diky Mudhakir Dinilah, Nabila Pandu Djoko Santosa Dwi Rokhmat Setiawan Fakar Daras Kamal Ida Maryam Indra Wibowo Irda Fidrianny Irnawati Irnawati Irnawati Irnawati Kamal, Fakar Daras Khalisa Putri Aqilah Khalisa Putri Aqilah Komar Ruslan Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Lia Marliani Maria Bintang Marliani, Lia Maryam, Ida Melia Laniwati Mohamad Rafi Mohamad Rafi Mohamad Rafi Mohamad Rafi Nabila Pandu Dinilah Nanik Siti Aminah Ningsih, Kurnia Nastira Nurma Sabila Rahmana Emran Kartasasmita Ruslan, Komar Salsafia Putri Salsafia Putri Sefni Reza Yolanda Selpida Handayani Septaningsih, Dewi Anggraini Setyaningsih, Widiastuti Shelly Shelly Sienny Wijaya Siti Kusmardiyani Suganda, Asep Gana Utami Dyah Syafitri Wijaya, Sienny Yohanes Andika Suharli