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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Reaktor Pharmaciana: Jurnal Kefarmasian Journal of Engineering and Technological Sciences Majalah Obat Tradisional Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry Jurnal farmasi UIN Alauddin Makassar Current Research on Biosciences and Biotechnology JURNAL BIOLOGI PAPUA Journal of Food and Pharmaceutical Sciences
Muhamad Insanu
School of Pharmacy, Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Journal : Current Research on Biosciences and Biotechnology

 1 
Phytochemistry and pharmacological activities of Annona genus: A review Siti Kusmardiyani; Yohanes Andika Suharli; Muhamad Insanu; Irda Fidrianny
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/KNIA7708

Abstract

Plants have been significantly used in traditional medicine by a variety of societies since antiquity, and knowledge of their safety, efficacy, and quality value can be developed through further research. The Genus Annona consisting of 119 species has been extensively researched and proven to have a diverse range of pharmacological activities such as antioxidant, antiulcer, antidiarrheal, and antiparasitic. This is because the Annona plants possess a great number of phytochemicals found in almost every part of the plant, which can be isolated to be developed into herbal medicine. Phytochemicals are classified into several classes, such as Annonaceous acetogenin, alkaloids, flavonoids, and essential oils. This article was created by collecting 137 research articles which discuss phytochemical compounds from 38 species and the pharmacological activity from 13 species.
Isolation of α-glucosidase enzyme inhibitor from titanus (Leea aequata L.) Bangar, Roy; Ningsih, Kurnia Nastira; Kartasasmita, Rahmana Emran; Insanu, Muhamad
Current Research on Biosciences and Biotechnology Vol. 6 No. 1 (2024)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2024.6.1/XCGSRS5W

Abstract

Diabetes mellitus is a metabolic disease characterized by high blood glucose levels. Indonesia was ranked fourth globally, with over 12 million people suffering from diabetes. Natural-based drugs can be an alternative for treating diabetes with fewer side effects and are expected to be more economical than conventional drugs. One of the plant families used to reduce blood glucose levels is the Vitaceae family. One of the Vitaceae species currently used for traditional medicine is Leea aequata. This study aimed to isolate active compounds with α-glucosidase inhibitor activity from titanus plant. This study began with collecting leaf, fruit, and stem samples from titanus plants that grow in North Sumatra. The extraction method used was maceration using ethanol 96%. The isolation stage started with fractionation, followed by purification with column chromatography, in which TLC monitored for each process. α-glucosidase in testing was carried out on extracts, fractions, and isolates using a reagent Multiscan microplate reader at 400 nm. Compound identification was done using spectrodensitometry and 1H-NMR spectroscopy. The IC50 value of the ethyl acetate fraction (2.4±0.02 µg/mL) was higher than the ethanol extract (8.96 ± 0.44 µg/mL), n-hexane fraction (21±0.61 µg/mL), and water fraction (16.96 ± 0.38 µg/mL), so it was continued to the isolation stage. The isolated compound was characterized as 3,3′,4′,5,7-Pentahydroxyflavone 3-rhamnoside (quercitrin) with the IC50 was 12.25 ± 0.2 µg/mL.
Co-Authors Abdu Ravi Zakaria Abdul Rohman Abdul Rohman Abdul Rohman Abdul Rohman Akhirul Kahfi Syam Alfi Hudatul Karomah Anggra Paramita Anita Artarini Ardiyan Harimawan Ardiyan Harimawan Arsul, Muhammad Ikhlas Asefin Nurul Ikhtiarini Asep Gana Suganda Asma Asma As’ari Nawawi Auliya Ilmiawati Bangar, Roy Cindra Mutia Dadan Rohdiana Dianika Lestari Dianika Lestari Dianika Lestari Diky Mudhakir Dinilah, Nabila Pandu Djoko Santosa Dwi Rokhmat Setiawan Fakar Daras Kamal Ida Maryam Indra Wibowo Irda Fidrianny Irnawati Irnawati Irnawati Irnawati Kamal, Fakar Daras Khalisa Putri Aqilah Khalisa Putri Aqilah Komar Ruslan Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Lia Marliani Maria Bintang Marliani, Lia Maryam, Ida Melia Laniwati Mohamad Rafi Mohamad Rafi Mohamad Rafi Mohamad Rafi Nabila Pandu Dinilah Nanik Siti Aminah Ningsih, Kurnia Nastira Nurma Sabila Rahmana Emran Kartasasmita Ruslan, Komar Salsafia Putri Salsafia Putri Sefni Reza Yolanda Selpida Handayani Septaningsih, Dewi Anggraini Setyaningsih, Widiastuti Shelly Shelly Sienny Wijaya Siti Kusmardiyani Suganda, Asep Gana Utami Dyah Syafitri Wijaya, Sienny Yohanes Andika Suharli