Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

1.829

P-Index

This Author published in this journals

All Journal Acta Interna : The Journal of Internal Medicine Journal of the Medical Sciences (Berkala Ilmu Kedokteran) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Gizi Klinik Indonesia Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Journal of Innovation in Management, Accounting and Business The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Journal of Mandalika Literature

Neneng Ratnasari

Division Of Gastroenterology And Hepatology, Department Of Internal Medicine, Faculty Of Medicine, Gadjah Mada University-Sardjito General Hospital, Yogyakarta

Author-ID : 2968414

Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

Published : 47 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3 4 5

Correlation Between Neutrophil To Lymphocyte Ratio With Child Turcotte Pugh In Liver Cirrhosis Patients Wiwiek Probowati; Putut Bayupurnama; Neneng Ratnasari
Acta Interna The Journal of Internal Medicine Vol 6, No 1 (2016): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Background: Neutrophil to lymphocyte ratio (NLR) is an index that iswidely used these days. RNL has been widely studied as a predictor of poor survival and outcome in patients with liver cirrhosis, hepatocellular carcinoma, coronary heart disease, rheumatoid arthritis, sepsis and malignancy.Objective: To determine whether there is a correlation between NLR with a score of Child turcotte pugh (CTP) in patients with liver cirrhosis in Dr. Sardjitogeneral Hospital.Methods :The study design was cross-sectional study. The study began in December 2014 until the number of samples are met. The subjects of this study were patients with liver cirrhosis at affordable populations undergoing inpatient and outpatient care in the Dr. Sardjito Hospital that meet the inclusion and exclusion criteria. Venous blood test to measure neutrophils,lymphocytes, albumin, total bilirubin, INR (Internationale normalized ratio). Data presented in the form of descriptive analysis of the characteristics of the study subjects such as the mean and standard deviation values of lymphocyte and neutrophil ratio scores CTP. For analyze the correlation between NLR with CTP scores Spearman nonparametric analysis p <0.05.Results : There are 33 subjects in the study. Based on the results of this study found a positive significant correlation between the ratio of neutrophils to lymphocytes CTP with r = 0.749 andp= <0.0001 and obtained the formula Y = 7.797 + 0,067x. Thus increasing of neutrophils to lymphocytes ratio positive correlated with the severity of liver cirrhosis.Conclusion. There are positive correlation between the neutrophil to lymphocyte ratio with CTP scores in patients with liver cirrhosis.

Overlap in Patient with Functional Dyspepsia and Unspecified Functional Anorectal Pain Suharjo B Cahyono; Neneng Ratnasari; Siti Nurdjanah
Acta Interna The Journal of Internal Medicine Vol 6, No 2 (2016): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Functional gastrointestinal disorders (FIGD) represent a common and important class of disorders within gastroenterology. FIGD are a cause of great anxiety, distress and morbidity. FIGD disorders maybe manifest as overlapping syndrome. Patients with functional dyspepsia (FD) show frequent overlapping of other gastrointestinal disease, such as functional anorectal pain. These overlap patients have more frequent or more severe symptoms, poor health related quality of life and higher somatization scores, and they are more likely to experience anxiety, depression or insomnia compared to non-overlap patients. These disorders were diagnosed according Rome III criteria and excluded structural diseases. Multimodalities approach should be used during treatment patient with FGID. It was reported a male patient with functional dyspepsia and unspecified functional anorectal pain overlap. Keywords: Functional gastrointestinal disorders, functional dyspepsia, functional anorectal pain

Interleukin-8 expression differences in chronic and active chronic inflammation gastric mucosa biopsy with helicobacter pylori infection Muhammad Arif; Siti Nurdjanah; Neneng Ratnasari
Acta Interna The Journal of Internal Medicine Vol 7, No 1 (2017): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Background: Infection with Helicobacter pylori (HP) estimated to occur in 50% of the population in the world. Helicobacter pylori infection causes inflammation of the gastric mucosa and gastric epithelial release of interleukin-1β, interleukin-6, interleukin-8 and tumor necrosis factor α. Interleukin-8 plays a role in the degree of chronic inflammation of the gastric mucosa and gastric cancer risk. There has been no research on differences in the expression of interleukin-8 is based on chronic and chronic active inflammation on biopsy of the gastric mucosa with Helicobacter pylori infection in Hospital Dr. Sardjito.Objective: To prove the differences in the expression of interleukin-8 of chronic inflammation and gastric mucosal biopsy active chronic infection with Helicobacter pylori.Methods: This study used a cross-sectional design. Examined the expression of interleukin-8 on the rest of the biopsy sample HP (+) in August 2009 to March 2014. Classification of chronic inflammatory and chronic active obtained through histopathology report. Categorical numerical data from the two groups, unpaired, the distribution is not normal: Mann-Whitney test. Differences were considered significant if it was obtained p <0.05 with a confidence interval of 95%.Results: There were 41 samples of gastric mucosa biopsy preparations, comprising 9 samples of chronic inflammation and 32 samples of chronic inflammatory active of the gastric mucosa. The median value of the expression of IL-8 eptitel surface on chronic inflammation by 83 (40-94)% and the active chronic inflammation by 82 (19-94). Comparison test with Mann Whitney U test. From the statistical calculations p value = 0.887 with p> 0.05Conclusion: There is no difference in the expression of interleukin-8 in inflammatory chronic active and chronic inflammation of the gastric mucosa with Helicobacter pylori infection.Keywords: Helicobacter pylori, interleukin-8, chronic inflammation and chronic inflammatory active.

Effectiveness Combination of Ginger Extract (Zingiber officinale) and Ranitidine Compared with Combination of Ranitidine and Placebo against Severity of Functional Dyspepsia Dite Ari Prapti; Neneng Ratnasari; Siti Nurdjanah
Acta Interna The Journal of Internal Medicine Vol 7, No 1 (2017): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

ABSTRACTBackground: Efficacy ranitidine as dyspepsia functional treatment was 8-35 % and ginger extracts as a traditional recipe in various countries for generations could be used as a therapy dyspepsia, antinausea, spasm, colic, and other stomach complaints. Ginger therapeutic effectiveness could reach 68-77% in vivo studies (animal models).Objective: To determined how much influence combination of ginger extract and ranitidine could improve severity of dyspepsia compared with combination of ranitidine and placebo in patients with functional dyspepsia.Method: This study was a quasi experimental. The research was conducted from December 2015 until April 2016 with 26 participants.Results: After getting therapy for 2 weeks in group I, mean SODA score in the pain scale decreased (8.4 %) of 29.07 ± 7.29 to 25.08 ± 8.22, statistically significant (p <0.046). Mean SODA score in the pain scale group II decreased (7.2%) of 25.38 ± 6.19 to 24 ± 6.01 (p=0.302). Mean SODA score in the non pain scale in group I decreased (7.7%) of 16.84 ± 2.44 to 15.15 ± 2.64 (p=0.074), while in the group II decreased (1.6%) of 15.77 ± 2.71 to 15.23 ± 2.94 (p=0.470). Mean SODA score in the satisfaction scale in group I increased (19.9%) of 7.77 ± 3.63 to 10.08 ± 3.59 (p=0.053) while in the group II increased (8.4%) of 9.62 ± 2.72 to 10.92 ± 2.46 (p=0.072). Comparison decline of SODA score in the pain scale between group I was 4.31 ± 6.3 and in group II is 1.23 ± 4.91, greater in group I but not significantly (p=0.178) at baseline to week 2nd. Comparison decline of SODA score in the non pain scale between group I was 1.69 ± 3.11 and in group II was 0.54 ± 2.6, greater in group I but not significantly (p=0.316) at baseline to week 2nd. Comparison increasing of SODA score in the satisfaction scale between group I was – 2.31 ± 3.88 and in group II was -1.31 ± 2.39, greater in group I but not significantly (p=0.437). Conclusion: Combination of ginger extract and ranitidine could decrease pain scale, non pain scale and increase satisfaction scale more effective clinically than plasebo and ranitidine for functional dyspepsia patient, but not statistic significantlyKeywords: ginger extract, severity of dyspepsia, and functional dyspepsia

Effects of Erdosteine Administration in Serum C-Reactive Protein Level in Stable Chronic Obstructive Pulmonary Disease Patients Eko Budiono; Neneng Ratnasari; Lina Tjandra
Acta Interna The Journal of Internal Medicine Vol 7, No 1 (2017): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Background. Systemic inflammation contributes to the development of intrapulmonary and extra pulmonary disorders, and as an independent risk factor for exacerbation of chronic obstructive pulmonary disease (COPD) has proven. The use of corticosteroids as anti-inflammatory agents has limitation for their undesirable side effects and different efficacy among the patients. Erdosteine, a mucolytic agent widely used in COPD, has been proven to be able to inhibit several mediators such as reactive oxygen species (ROS) and eicosanoids, which are involved in oxidative stress and inflammation.Objective. This study aimed to discover the effects of erdosteine administration in serum C - reactive protein (CRP) level in stable COPD patients.Methods. The research was a randomized controlled trial, which compared add-on therapy used erdosteine 300 mg bid versus placebo, for 10 days, combined with COPD standard treatments. The patients was recruited at RSKP Respira Yogyakarta outpatient clinics. Diagnoses were confirmed used spirometry based on GOLD criteria. Evaluation of CRP levels was hold before treatment and on the eleventh day, used highly sensitive quantitative immunometric assay.Result. Thirty-eight legible COPD patients recruited and randomly assigned to either erdosteine group or placebo group. One patient in erdosteine group was drop out because of exacerbation and one patient from each group were lost to follow up. There are 35 subjects (97.1% men, age range 40-77 years, median FEV1 0.83 (0.50-10.08) L, hs-CRP 0.84 (0.18-18) mg/L) who completed the study, 19 subjects in erdosteine and 16 subjects in placebo group. Baseline characteristics were similar between two groups. There were no significant decreases in median hs-CRP level in erdosteine vs. placebo group at day 11 (-0.10 (-16.16-+4.31) vs. 0.005 (-11.7-+11.03) mg/L; p 0.275). In COPD GOLD 3 sub-population, hs-CRP serum level decline was greater in erdosteine group compared to placebo (-0.56 (-16.16-+0.44) vs. 0.11 (-11.7- +11.03) mg/L; p 0.03) this might be related to greater oxidative stress in severe COPD that makes antioxidative effects of erdosteine reduce CRP more significantly in severe COPD.Conclusion. Effects of erdosteine supplements, 300 mg bid for 10 days, could decrease hs-CRP level in erdosteine insignificantly compared to placebo. Keywords: table COPD, C-reactive protein, erdosteine, FEV1, GOLD

Relationship between Interleukin-6 Expression with the Progressive and Severity of Ulcerative Arif Nur Widodo; Neneng Ratnasari; Siti Nurdjanah
Acta Interna The Journal of Internal Medicine Vol 9, No 1 (2019): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Background. Based on international statistics, the incidence of Inflammatory Bowel Disease (IBD) is about 2.2-14.3 cases per 100.000 people per year for Ulcerative Colitis (UC). In Indonesia, there is no epidemiological study of IBD. To assess the degree of severity associated with the ulcerative colitis disease can be used a varietyof tools, including the Truelove Witts score which has sensitivity and specificity that high enough for UC in the phase of active disease. Interleukin-6 (IL-6) is a pro-inflammatory cytokine that plays a very important role in the self-defense mechanism and acts as an acute-phase protein. Serum levels of IL-6 and increased expression in the colonic mucosa of active IBD patients indicate the level of IBD disease activity.Aims. The aim of the study was to determine the relationship between Interleukin-6 expression (IL-6) and the severity of UC disease using Truelove Witts classification.Methods. This study used a cross-sectional method that analyzed the relationship between IL-6 expression and UC weighing based on Truelove Witts classification using colon tissue biopsy results from UC patients who met inclusion and exclusion criteria.Results. Th ere were 26 subjects studied and performed an endoscopic analysis and anatomical pathology. Mean age of research subjects were 52.73 + 11.11 years with men's favored subjects (n = 15). Subjects were severe UC 16 (61.5%), moderate 7 (26.9%) and mild 3 (11.5%). More male subjects in mild UC, 12 vs. 3 and more female subjects in moderate-severe UC, 4 vs. 7 (p 0.032). Signifi cant diff erences in IL-6 expression in defecation were > 4 times/day, IL-6 300 (285-400) versus defecation < 4 times/day, IL-6 295 (212.1-340) p 0.039. Signifi cant diff erence in IL-6 expression between mild UC 295 (212.1-340) with moderate- severe UC 301.66 (235.57-400) with p value 0.032.Conclusion. IL-6 expression in moderate-severe UC subjects was higher than mild UC subjects based on Truelove Witts criteria.Keywords: Inflammatory Bowel Disease, Ulcerative Colitis, Truelove Witts classification, Interleukin-6.

Transient Elastography Changes on Patient with Hepatic Cirhossis who were Treated by Simvastatin 20 Mg Compared to Simvastatin 10 mg Endro tanoyo; Neneng Ratnasari; Sutanto Maduseno
Acta Interna The Journal of Internal Medicine Vol 10, No 1 (2020): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.61292

Background. Liver cirrhosis is a pathological condition that describes the end stage of liver fibrosis. Fibrosis is currently a two-way process. The process of returning from fibrosis now is a clinical reality. According to Abraldes et al. (2009), administration of simvastatin for one month will increase liver cell regeneration and improve endothelial dysfunction. Liver biopsy is still the gold standard for assessing liver cirrhosis, but this procedure is invasive and has the potential to cause life-threatening complications. Liver biopsy is complicated by sampling errors (reaching 30%) and different abilities between observers. Transient elastography (Fibro scan) is a non-invasive modality for diagnosing liver fibrosis that has high sensitivity and specificity.Aim. The aim of the study was to discover the difference in effect, of simvastatin 20 mg compared to 10 mg for 3 months to improve liver stiffness in patients with liver cirrhosis.Method. The study design used a double blind, randomized clinical trial. The subjects of the study consisted of a group given simvastatin 10 mg / day and the group given simvastatin 20 mg / day for 3 months. Routine medications for cirrhosis were still made according to the original dose. During the study, an initial and final transient elastography examination was carried out and monthly supervision of medication compliance and side effects. Data analysis for statistical tests was carried out by t-test, Mann Whitney test, fisher’s-exact test, and ANOVA test.Result. A total of 21 subjects underwent thorough research and transient elastography. The simvastatin 10mg group (n = 12) experienced a decrease in liver stiffness, with a delta mean of liver stiffness of -4.97+7.09 (p <0.023) compared to the simvastatin 20 mg group (n = 9) with a heart stiffness of -4.09 + 10.06 (p= 0.982). Changed liver stiffness in the two groups were not statistically significant differences. Etiology and confounding drugs showed statistically no significant effect.Conclusion. Both simvastatin 10 mg and 20 mg can reduce liver stiffness. The effect of the two doses of the drug in reducing liver stiffness was not statistically significant different.

Correlation Between Tp-Te Interval With the Degree of Disfunction in Liver Cirrhosis Based on Child Pugh Turcotte Score in Dr. Sardjito General Hospital RA Aditya Adhi Puruhita; Hasanah Mumpuni; Neneng Ratnasari
Acta Interna The Journal of Internal Medicine Vol 10, No 2 (2020): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.62843

Background. Hyperdynamic syndrome due to portal hypertension in cirrhosis of the liver leads to failure ofcontractions and cardiac structures that result in complications of cardiomyopathy cirrhosis. The incidenceof arrhythmias was reported in various non- cardiac diseases including liver cirrhosis. We aim to evaluatethe T peak wave - T end (Tp-Te) as a parameter for suspected arrhythmias that occur in liver cirrhosis.Aims. To determine the correlation between the Tp-Te interval with dysfunction in the degree of livercirrhosis, which was assessed using the Child Pugh Turcotte score.Methods. This research is a cross-sectional study. Data taken from liver cirrhosis patients who has been metthe inclusion and exclusion criteria were admitted to the Inpatient and Outpatient Hospital Dr. Sardjito untilMay 2020, an assessment of the degree of dysfunction of liver cirrhosis with Child Pugh score Turcotte, andelectrocardiographic examination to assess Tp-Te wave. The independent variable was the Child Pugh Turcottescore, the dependent variable was the Tp-Te wavelength. Analysis of correlation data using the Spearman test.Results. Subjects included 51 patients with liver cirrhosis, correlation analysis found a strong correlation,the higher the Child Pugh Turcotte score was linearly correlated with the Tp-Te wavelength (r = 0.692; p<0.05). Wavelength Tp-Te at Child Pugh to any group showed a significant (p <0.001) , the wavelengthof Tp-Te Child Pugh A group 67.94 ± 7.80 ms, the Child Pugh B group 77.26 ± 8.38 ms, whereas inthe Child Pugh C group 92.31 ± 11.36 ms.Conclusion. There was a strong positive correlation between the Tp-Te interval with the degree of livercirrhosis dysfunction which was assessed using the Child Pugh Turcotte score.

Relationship of Geriatric Nutritional Risk Index (GNRI) with length of hospitalization and mortality rate in elderly patients Retno Ambarukminingsih; I Dewa Putu Pramantara; Neneng Ratnasari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 01 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The proportion of elderly population is growing faster than any other age group. Malnutrition isa widespread problem in elderly and has been recognized as the most common cause of mortalityand morbidity. Mini Nutritional Assessment (MNA) is recommended to detect malnutrition riskamong geriatrics. However, it is just appropriate for geriatric who stay at home. For hospitalizationpatients, Nutritional Risk Index (NRI) that using albumin and weight is recommended. However,the weight data is often not possible obtained in geriatrics. Therefore, Geriatric Nutritional RiskIndex (GNRI) using ideal body weight is recommended. The aim of this study was to evaluaterelationship of GNRI with length of hospitalization and mortality rate in geriatric patients. Thiswas an observational study with a prospective cohort design conducted in Dr. Sardjito GeneralHospital, Yogyakarta from January to February 2012. Patients who met the inclusion and exclusioncriteria were recruited. Laboratoty and clinical examinations as well as GNRI scoring were thenperformed. Patients were grouped into two groups i.e. patients with GNRI score < 82 and e”82. The patients were then monitored during hospitalization until they were discharged due todie or recovered. The length of stay and patients died were then recorded. The results showedthat the length of stay of patients with GNRI score < 82 (14.32 ± 8.20 days) was significantlylonger than those with GNRI score 82 (9.31 ± 6.15 days) (p = 0.006). Moreover, the mortalityrate of patients with GNRI score < 82 (42.1%) was significantly higher than those with GNRIscore 82 (2.8%) (p = 0.000). Kaplan-Meier survival analysis showed survival rate of patientswith GNRI score <82 rapidly decreased when compared with those with GNRI score 82. Inconclusion, there is negative correlation between GNRI with length of hospitalization and mortalityrate in elderly.

Symptoms of depression and quality of life in functional dyspepsia patients Muhammad Eko Cahyanto; Neneng Ratnasari; Agus Siswanto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 02 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Dyspepsia is a common disorder characterized by heartburn, nausea, vomiting, bloating, feelingof fullness or early satiety, and belching. Functional dyspepsia (FD) or non-ulcer dyspepsia is asyndrome without any physical or endoscopic abnormalities underlying these symptoms. Theimpacts of FD on psychological disturbances and quality of life in patients have been postulated.However, it has not much been a concern. This study was conducted to evaluate the relationshipbetween symptoms of depression and quality of life in patients with FD.This was an observationalstudy with cross-sectional design involving 30 patients. The symptoms of depression weremeasured by beck depression inventory (BDI) and the quality of life of patients were measuredby SF-36. The results showed that FD were more suffered consecutively by female patients(66.7%), age over 45 years (53.4%), housewives (56.6%), educated graduates (56.6%) andmarried (90.0%). Moreover, patients who experienced symptoms of clinical depression withlow, moderate and severe levels were 16.3%, 33.3% dan 10.0%, respectively. A significantcorrelation between depressive symptoms and the overall of patients quality of life was observed(r = 0.481; p<0.05). Furthermore analysis showed that among eight domains of health in SF-36analyzed, a negative significant correlation was observed between the depressive symptoms andthe three domains of health i.e. general physical function, limitation of motion caused byphysical problems, and vitality. In conclusion, there is a negative correlation between depressivesymptoms and quality of life in patients with FD

Co-Authors . Suharno Agus Siswanto Arif Nur Widodo Arif Rohman Hakim Aulia, Nisma Catharina Triwikatmani Deshinta Putri Mulya Didik Setyo Heriyanto Dite Ari Prapti Dwijayanti, Hervina Eko Budiono Endro tanoyo Fahmi Indrarti Farida, Yeni Firman Wahyudi Fita Rahmawati Fita Rahmawati Fujawati, Eli Hakim, Suharno Hasanah Mumpuni Hemi Senorita Hervina Dwijayanti I Dewa Putu Pramantara Jamhari Jamhari Juwita Raditya Lina Tjandra Marcellus, Marcellus Moch. Abdul Nasir Muhammad Arif Muhammad Eko Cahyanto Mulyani, Tuty Nanda Qoriansas Nugraha, Adityansyah Irendra Nur Signa Gumilas Nurdjanah S Nurdjanah S, Nurdjanah Probowati, Wiwiek Puji Lestari Putut Bayupurnama Putut Bayupurnama Putut Bayupurnama Putut Bayupurnama Putut Bayupurnama Putut Bayupurnama Putut Bayupurnama RA Aditya Adhi Puruhita Rachmad Aji Saksana Renovaldi, Dede Retno Ambarukminingsih Riska Humardewayani Adie SATRIYAS ILYAS Siti Maryani SITI MARYANI Siti Nurdjanah Siti Nurdjanah Siti Nurdjanah Siti Nurdjanah Siti Nurdjanah Siti Nurdjanah Siti Nurdjanah Sofia Mubarika Haryana Suhara, Ade Suhara Suharjo B Cahyono Suharjo B Cahyono Suharjo B Cahyono Suharjo Broto Cahyono Suharno Hakim Suryo Taroeno Susetyowati Susnita, Tia Aprilia Sutanto Maduseno Sutanto Maduseno Sutanto Maduseno Tri Murti Andayani Tuty Mulyani Wiwiek Probowati Yeni Farida Zagoto, Agnes Dina Irene Dorithy

Title

Found 47 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 47 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 47 Documents
Search