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All Journal e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Ilmiah Manuntung JMM (Jurnal Masyarakat Mandiri) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Lamahu: Jurnal Pengabdian Masyarakat Terintegrasi Kartika : Jurnal Ilmiah Farmasi Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Dwi Nurahmanto
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Optimasi Hidroksipropil Metilselulosa K-4M dan Carbopol® 940 pada Sediaan Patch Dispersi Padat Piroksikam Dwi Nurahmanto; Nurul Shalikha; Lidya Ameliana
Kartika : Jurnal Ilmiah Farmasi Vol 5 No 2 (2017)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v5i2.121

Abstract

Abstrak Piroksikam merupakan anti inflamasi non steroid (AINS) turunan oksikam yang berkhasiat sebagai analgesik dan antiinflamasi digunakan untuk pengobatan rheumatoid arthritis dan osteoarthritis. Piroksikam menyebabkan masalah pada saluran cerna dan first pass metabolism yang dapat dihindari dengan cara pemberian transdermal patch. Salah satu komponen patch yaitu polimer yang berfungsi untuk mengontrol kecepatan pelepasan obat dari sediaan. Penelitian ini dilakukan untuk menentukan komposisi terbaik dari kombinasi polimer hidroksipropil metilselulosa (HPMC) dan Carbopol terhadap % moisture content (MC) dan flux pelepasan sediaan transdermal patch dispersi padat piroksikam dengan rancangan formula Simplex Lattice Design. Piroksikam dibuat dalam bentuk dispersi padat dengan pembawa PEG 4000 untuk meningkatkan kelarutannya. Rancangan formula patch dispersi padat piroksikam dibuat dengan menggunakan tiga polimer Etil selulosa:HPMC:carbopol dimana yang divariasikan adalah perbandingan HPMC : Carbopol yaitu 1 : 0 ; 0,5 : 0,5 ; 0 : 1. Hasil uji menunjukkan ketiga formula memenuhi persyaratan keseragaman kadar dengan rentang keseragaman 3,735 – 97,349 %. Hasil juga menunjukkan formula 3 menghasilkan patch yang lebih tebal, pH permukaan patch lebih rendah, nilai % moisture content lebih besar dan nilai flux lebih tinggi dibandingkan formula 2 dan formula 3, Formula 3 mempunyai nilai % moisture content yang memenuhi persyaratan sebesar 6,613% dan nilai flux pelepasa yang paling bagus sebesar 32,562 µg/cm2.menit1/2. Hasil penelitian juga menunjukkan formula 1 memiliki keseragaman bobot lebih baik dibandingkan formula 2 dan formula 3. Dapat disimpulkan bahwa komposisi optimum dari kombinasi polimer HPMC dan Carbopol pada sediaan patch dispersi padat piroksikam yaitu formula dengan komposisi polimer HPMC sebanyak 0 mg dan Carbopol sebanyak 75 mg. Kata kunci:     Dispersi padat, patch piroksikam, HPMC, Carbopol Optimization of Hydroxypropyl Methylcellulose K-4M and  Carbopol® 940 in Solid Dispersion Piroxicam Patch Abstract Piroxicam is a non-steroidal anti-inflammatory (NSA) oxysmic derivative as an analgesic and anti-inflammatory agent used for the treatment of rheumatoid arthritis and osteoarthritis. Piroxicam causes problems in the gastrointestinal tract and first pass metabolism that can be avoided by giving transdermal patches. One of the patch components is a polymer that serves to control the speed of drug release from the preparation. The present study was conducted to determine the best composition of the combination of hydroxypropyl methylcellulose (HPMC) and Carbopol polymers against% moisture content (MC) and fluxes release of the pyroxicam dispersion transdermal patch dispersion with the design of the Simplex Lattice Design formula. Piroxicam is prepared in the form of a solid dispersion with a PEG 4000 carrier to increase its solubility. The design of a pyroxicam solid dispersion patch formulation was prepared using three ethyl cellulose polymers: HPMC: carbopol wherein the HPMC ratio is computed: Carbopol is 1: 0; 0.5: 0.5; 0: 1. The test results show the three formulas meet the requirements of uniformity of the content with a uniformity range of 3.735 - 97.349%. the results also show formula 3 resulting in thicker patches, lower patch pH surfaces, greater moisture content values and higher flux values than formula 2 and formula 3, Formula 3 has a moisture content value of 6.613% the finest fl ux flux of 32,562 μg / cm2.menit1 / 2. The results also show that formula 1 has better weight uniformity than formula 2 and formula 3. It can be concluded that the optimum composition of HPMC and Carbopol polymer combinations in the preparation of piroxicam solid dispersion patch is a formula with HPMC polymer composition as 0 mg and Carbopol as much as 75 mg.. Key words:      solid dispersion, piroxicam patch, HPMC, Carbopol
Optimasi Polyvinilpyrolidone K-30 dan Sodium Starch Glycolate pada Tablet Likuisolid Simvastatin dengan Desain Faktorial Nursatriya, Agne Yuliana; Sari, Lusia Oktora Ruma Kumala; Nurahmanto, Dwi
Pustaka Kesehatan Vol 11 No 3 (2023): Volume 11 No.3, 2023
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v11i3.18320

Abstract

The liquisolid technique is one way to increase the drug dissolution rate, which has low solubility in water and can improve drug flow properties. This research aims to determine the optimum composition of a combination of polymer PVP K-30 and SSG on a liquisolid simvastatin tablet with a factorial design. The factorial design method is used to determine the effect of the concentration of two factors, namely PVP K-30 and SSG, on the response of hardness, friability, disintegration time, and dissolution. PVP K-30 acts as a binder, and SSG works as a disintegration, determines the optimum formula using expert design software version 1. The result showed that all formulas meet the requirements of hardness values (4-8 kg), friability (<1%), disintegration time of no more than 15 minutes, and dissolution in 30 minutes. The use of PVP K-30 concentration of 6 mg and SSG 24 mg indicated the optimum formula with a desirability value of 0,806.
Optimasi Tween 80 dan PEG 400 dalam Self Nanoemulsifying Drug Delivery System Antibakteri dari Minyak Daun Kemangi Andriyani, Novia; Nurahmanto, Dwi; Kumala Sari, Lusia Oktora Ruma
Pustaka Kesehatan Vol 12 No 2 (2024): Volume 10 No.2, 2024
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v12i2.22583

Abstract

Basil has antibacterial activity against Salmonella typhi with essential oils as active compounds. However, its volatile and hydrophobic nature makes it difficult to dissolve in the gastrointestinal tract so a self nanoemulsifying drug delivery system (SNEDDS) is needed. The study aimed to determine the effect of changes in the concentration and interaction of Tween 80 and PEG 400 on the percent transmittance response and emulsification time in SNEDDS of basil leaf oil. This research optimized of Tween 80 and PEG 400 using basil leaf oil as the oil phase with the percent transmittance response and emulsification time, then verified, characterized the organoleptic, pH, particle size, size distribution, and antibacterial activity. The concentration of Tween 80 and of PEG 400 would increase the percent transmittance and decrease the emulsification time. The interaction between two substances can decrease the percent transmittance and increase the emulsification time. The prediction software design expert 11 SNEDDS optimum formula namely Tween 80 2.05 ml and PEG 400 1.35 ml. The characteristics of the optimum formula produced were clear yellow with a distinctive basil aroma, pH 6.93±0.02, particle size 183.3±0.21 nm, and PI 0.341±0.02. SNEDDS of basil leaf oil inhibits S. typhi with an inhibition zone of 19.22 ± 0.01 mm.
PENGARUH PERBEDAAN CHEMICAL PENETRATION ENHANCER PADA PENETRASI TRANSDERMAL PATCH PROMETAZIN HCL Dwi Nurahmanto
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.68

Abstract

This research aims is to create a promethazine HCl patch transdermal drug delivery systems with the most excellent penetration. Transdermal drug delivery can be efficiently used for the active agents which undergo rapid first pass metabolism and oral absorption is often disrupted by nausea and vomiting, hence the transdermal patches of promethazine HCl were prepared by using different penetration enhancers,  propylene glycol, oleic acid and isopropyl alcohol. The prepared formulations were evaluated for thickness, weight variation, moisture content, drug content, morphology, and in vitro permeation studies. The patch morphology studies were performed by Scanning Electron Microscopy (SEM). The amount of promethazine HCl transfered by propylene glycol  25.77 ± 3.0396 ug, isopropil alcohol 25.758 ± 2.9022 ug and oleic acid 25.017 ± 8.1300 ug. The penetration of promethazine HCl patch with oleic acid enhancer, produce the highest penetration than isopropil alcohol and propylene glycol. there was no difference in penetration using propylene glycol and isopropyl alcohol. Oleic acid is the best enhancer for preparations patch containing promethazine HCl although the amount of promethazine HCl contained is the least. The whole formulations comply with the  patch dosage requirements
FORMULASI SEDIAAN GEL DISPERSI PADAT IBUPROFEN : STUDI GELLING AGENT DAN SENYAWA PENINGKAT PENETRASI Dwi Nurahmanto; Ifa Rosi Mahrifah; Rani Firda Nur Imaniah Azis; Viddy Agustian Rosyidi
Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v3i1.97

Abstract

ABSTRACT This study aims to determine the effect of using gelling agent and chemical penetration enhancer on the solid dispersion Ibuprofen gel in increasing the transdermal drug penetration. Inhibition of the COX-1 enzyme caused by ibuprofen in oral administration can cause side effects of gastrointestinal disorders, dyspepsia, diarrhea, upper gastrointestinal infections, nausea and bloating, resulting in a topical route to reduce side effects. The gel is prepared using hydroxy propyl methyl cellulose (HPMC) and carbopol® as gelling agents, and also propylene glycol and glycerin as chemical penetration enhancer compounds. The gel evaluation are viscosity, pH, spreadability and penetration flux rate. The value of the formula 3 penetration flux is 1.5383 ± 0.029 ug / cm2.minute, the formula 1 is 1.403 ± 0.055 ug / cm2. minute, the formula 2 is 0.756 ± 0.071 ug / cm2 minute, while the formula 4 is 0.5404 ± 0.106 ug / Cm2. minute. The amount of gelling agent concentration and chemical penetration enhancer compound effect on the value of the flux penetration
OPTIMASI POLIVINILPIROLIDON DAN CARBOPOL PADA SEDIAAN PATCH DISPERSI PADAT PIROKSIKAM Dwi Nurahmanto; Friska Wira Sabrina; Lidya Ameliana
Jurnal Ilmiah Manuntung Vol 3 No 2 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v3i2.129

Abstract

Piroxicam, a non steroidal anti inflammatory drugs (NSAID), is an oxicam derivative which can be used for treatment of various rheumatic diseases, such as rheumatoid arthritis and osteoarthritis. Piroxicam patch is an affective approach evading piroxicam’s side effect such as peptic ulcer and first pass metabolism. One of the patch components is polymer that the function is to control the speed of drug release from the patch. The aims of this study were to determine the optimum formula of a combination of polyvinylpyrolidone (PVP) and Carbopol to % moisture content (MC) and the flux release in solid dispersion piroxicam patch using Simplex Lattice Design. Piroxicam was prepared in the form of a solid dispersion in PEG 4000 to increase its solubility. The design formula of solid dispersion piroxicam patch made with the ratio PVP : Carbopol, that were 1 : 0; 0.5 : 0.5; 0 : 1. The optimum formula was chosen with the ratio PVP : Carbopol, 1: 0, which gave the best result of % MC and flux release. The result of % MC was 6.91% and the result of flux release was 35.543 µg/cm2.menit1/2.
Optimalisasi Kegiatan Promosi Desa Pace Sebagai Sentra Herbal Eliyatiningsih, Eliyatiningsih; Erdiansyah, Iqbal; Sari, Vega Kartika; Nurahmanto, Dwi
Lamahu: Jurnal Pengabdian Masyarakat Terintegrasi Vol 2, No 2: August 2023
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/ljpmt.v2i2.21165

Abstract

Pace Village, Silo District is a center for herbal plant production with several main herbal commodities such as Ginger, Curcuma, Citronella, and Javanese chili. The community still does not know the potential of the village as an herbal center because the promotional activities are not yet intensive. This community service activity aims to improve partners' skills in carrying out promotional activities. This community service activity method is Participatory Rural Appraisal (PRA) approach with several activities including the coordination with partners, the counseling and promotion skills training, the mentoring, and the evaluation. In this community service activity partners are assisted in making promotional media, assisting exhibition activities, launching herbal product outlets, and creating a website. The results of the activity show that partners' understanding of promotional activities has increased, and promotional activities have had a significant impact on increasing partners' income in selling various herbal products.
Optimization study on palm fat base (HAMIN®) and purified water proportion in diphenhydramine hydrochloride cream formulation Winarti, Lina; Gazzali, Amirah Mohd; Arafika, Whendy Waliya; Ameliana, Lidya; Ulfa, Evi Umayah; Nurahmanto, Dwi; Paramayuda, Farukh
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.30790

Abstract

HAMIN® is a self-emulsifying base composed of a mixture of hydrogenated palm kernel oil and hydrogenated palm kernel stearin. This formulation not only enhances the aesthetic quality of products but also simplifies the manufacturing process, as it eliminates the need for additional emulsifying agents to form a stable cream. Due to these properties, HAMIN® is considered highly suitable for the development of both pharmaceutical and cosmetic formulations. Despite its potential applications, no prior research has investigated the optimal ratio of HAMIN® palm fat base to distilled water distilled waterrequired to achieve desirable physical characteristics and drug release properties in cream formulations. Therefore, this study aims to determine the optimum composition of HAMIN® palm fat base and distilled water for the formulation of diphenhydramine hydrochloride cream. The optimization process was conducted using the simplex lattice design (SLD) method, a statistical approach commonly employed to evaluate and optimize multicomponent formulations. The experimental results demonstrated that increasing the concentration of HAMIN® palm fat base had a dominant effect on enhancing the pH, viscosity, adhesion, and stability of the cream. Conversely, a higher concentration of distilled water significantly improved spreadability, extrudability, and drug release flux. These findings indicate that the selection of base composition plays a crucial role in determining the overall performance of the cream formulation. The optimal formulation, as determined through SLD analysis, consisted of 41.667% HAMIN® palm fat base and 48.333% distilled water, achieving a desirability index of 0.649. This composition represents the most balanced formulation in terms of physical stability and drug release, making it a promising candidate for further pharmaceutical and cosmetic applications.
Co-Authors A., Mohammad Zulfikhar Ali Djamhuri Ameliana, Lidya Andriyani, Novia Arafika, Whendy Waliya Aslyni Putri Suranina Barus Azis, Rani Firda Nur Imaniah Azis, Rani Firda Nur Imaniah Baiq Wahyudyati Karnia Qisti Budipratiwi Wisudiyaningsih Dessy Dwi Risky Ayuningtias desy diana sari Edy Meiyanto Edy Meiyanto Eka Deddy Irawan Eliyatiningsih, Eliyatiningsih Erdiansyah, Iqbal Evi Umayah Ulfa Feny Dhea Camelia Friska Wira Sabrina Gazzali, Amirah Mohd Haris Raudhatuzakinah Dwiputri Ifa Rosi Mahrifah Ika Puspitasari Iqbal Erdiansyah, Iqbal Kristine Dwi Puspitasari Kumala Sari, Lusia Oktora Ruma Lina Winarti Lusia Oktora Ruma Kumala Sari Maharani Dwi Pratiwi Mahrifah, Ifa Rosi Mahrifah, Ifa Rosi Nofia Elisa Putri Nuri Nuri Nursatriya, Agne Yuliana Nurul Shalikha Paramayuda, Farukh R.K.S., Lusia Oktora Rani Firda Nur Imaniah Azis Sabrina, Friska Wira Sabrina, Friska Wira Shalikha, Nurul Taffana Windy Hananta Vega Kartika Sari Viddy Agustian Rosyidi