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All Journal e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Ilmiah Manuntung JMM (Jurnal Masyarakat Mandiri) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Lamahu: Jurnal Pengabdian Masyarakat Terintegrasi Kartika : Jurnal Ilmiah Farmasi Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

Dwi Nurahmanto

Fakultas Farmasi Universitas Jember

Author-ID : 2973315

Agriculture, Biological Sciences & Forestry Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Optimasi Propilen Glikol dan Etanol sebagai Peningkat Penetrasi Ibuprofen dalam Sediaan Gel dengan Metode Simplex Lattice Design (Propylene Glycol and Ethanol Optimization as Ibuprofen Penetration Enhancer in Gel Dosage using Simplex Lattice Design Metho Baiq Wahyudyati Karnia Qisti; Dwi Nurahmanto; Viddy Agustian Rosyidi
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6611

Ibuprofen is a non-steroid anti inflammatory drug (NSAID) used for rheumatoid arthritis treatment. In this study, formulation, evaluation, and optimization of ibuprofen gel formula were conducted in order to determine the best ibuprofen penetration rate through the rats skin using propylene glycol and ethanol as penetration enhancers and to find out the optimum formula to get the best penetration rate with simplex lattice design method. Evaluations included organoleptic, pH, viscosity, gel dispersive, assay of gel formulations, and ibuprofen penetration rate assay. Penetration rate was determined by paddle type dissolution and the samples were analyzed by spectrophotometry UV-Vis. The results of ibuprofen penetration rate assay were analyzed and optimized using design expert trial version 10. The results of ibuprofen penetration rate were F1 1.524 ± 0.121 µg/cm2.minute; F2 1.945 ± 0.0104 µg/cm2.minute; and F3 1.173 ± 0.216 µg/cm2.minute. Penetration rate optimization resulted in one optimum solution formula which was 18.000% propylene glycol and 12.000% ethanol with a maximum flux of 1.957 ug/cm2.minute and desirability 1. It can be concluded that the best ibuprofen penetration rate was F2 with flux 1.945 ± 0.0104 µg/cm2.minute with 15% propylene glycol and 15% ethanol. Keywords: gel, ibuprofen, propylene glycol, ethanol, simplex lattice design

Optimasi Tween 80 dan Propilen Glikol dalam Self-Nanoemulsifying Drug Delivery System (SNEDDS) Minyak Atsiri Daun Kemangi (Ocimum basilicum) Nofia Elisa Putri; Dwi Nurahmanto; Viddy Agustian Rosyidi
Pustaka Kesehatan Vol 9 No 2 (2021): Volume 9 No.2, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i2.22628

Basil (Ocimum basilicum) is a plant from Lamiaceae family that has the potential for typhoid fever treatment. Basil essential oil is a hydrophobic compound being difficult to dissolve in the gastrointestinal tract. SNEDDS is one system that can solve this problem. The vital components of SNEDDS are surfactants and cosurfactants to increase the stability of the SNEDDS system by forming small droplets. This research determines the best composition of Tween 80 and Propylene glycol (PG), which can form nanoemulsion spontaneously in the gastrointestinal tract with a droplet size of nanometers. This research used a factorial design method to observed responses transmittance and emulsification time. Response transmittance and emulsification time then analyzed using Design Expert 11.0 to determine the optimum formula of SNEDDS basil essential oil. The optimum formula of SNEDDS basil essential oil obtained was a formula with a composition of 2.05 mL of Tween 80 and 1.35 mL of Propylene glycol. The optimum formula characterization test results showed a pH value of 7.01 ± 0.007; particle size 46.1 ± 0.61 nm; polydispersity index 0.46 ± 0.016. The antibacterial activity test optimum formula showed the ability to inhibit the growth of Salmonella typhi bacteria with an inhibition zone diameter of 20.50 ± 0.59 mm.

Optimasi Suhu dan Lama Pemanasan dalam Pembentukan Kompleks Inklusi Glibenklamid-β-Siklodekstrin dengan Metode Sealed-Heating (Optimization Temperature and Heating Time Formation of Inclusion Complexes Glibenclamide-β-Cyclodextrin by Sealed-Heating Metho Aslyni Putri Suranina Barus; Lidya Ameliana; Dwi Nurahmanto
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Glibenclamide is a second-generation sulfonylurea that used for type II diabetes mellitus. Glibenclamide is included in the biopharmaceutical classification system (BCS) class II, which has a low solubility and high permeability. One effort that can be done to improve the solubility of drug is inclusion complexation. The aims of the study was to determine temperature and heating time on inclusion complexation of glibenclamide-β-cyclodextrin using sealed-heating method. Optimization done using a factorial design for two factors with 22 number of experiments. Inclusion complexes were determined its miosture content, solubility and in vitro dissolution. Moisture content study showed that F1> FB > FA > FAB. The results of solubility study were analyzed statistically using One-Way ANOVA and least significantly different (LSD). Statistical analysis showed that each formula had a significant difference solubility with FAB > FB > FA > F1>Control. Optimization on in vitro dissolution showed that FAB was an optimum formula with drug release of 87.24% within 180 min. This formula was characterized by DSC to observed for broadening, shifting and appearance of new peaks or disappearance of certain peaks. DSC analysis was indicated that inclusion complexation between glibenclamide and β-cyclodextrin was formed. Keywords: glibenclamide, β-cyclodextrin, inclusion complexe, sealed-heating

Optimasi Asam Glikolat dan Asam Sitrat dalam Krim Tabir Surya Kombinasi Titanium Dioksida, Avobenzone dan Octyl Methoxycinnamate desy diana sari; Lidya Ameliana; Dwi Nurahmanto
Pustaka Kesehatan Vol 8 No 3 (2020): Volume 8 No. 3, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i3.12266

Ultraviolet (UV) radiation is the main cause of sunburn and skin cancer. The adverse effects of UV radiation are solved by sunscreen as protection for longer outdoors. In this study, optimization of glycolic acid and citric acid in sunscreen cream combination of titanium dioxide, avobenzone, and octyl methoxycinnamate were investigated using simplex lattice design method. The sunscreen cream evaluation includes physicochemical testing (organoleptic, homogeneity, emulsion type, spreadability, viscosity, and pH) and sunscreen effectiveness (SPF, % erythema transmission, and % pigmentation transmission). The value of physicochemical testing are 5,96 cm - 6,3 cm of spreadability testing; 83,33 dPa.s – 108,33 dPa.s of viscosity testing; 4,06 – 4,67 of pH testing. The value of sunscreen effectiveness are 9,79 – 13,35 of SPF testing; 4,55x10-06 - 0,15x10-06% of % erythema transmission; 5,77 – 7,16 % of % pigmentation transmission. The optimum formula was obtained by combining glycolic acid 2% and citric acid 0% with a desirability value of 0,649.

Pengaruh Propilen Glikol dalam Patch Dispersi Padat Ketoprofen terhadap Karakteristik Fisika Kimia dan Laju Penetrasinya Lidya Ameliana; Haris Raudhatuzakinah Dwiputri; Dwi Nurahmanto
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7572

Ketoprofen is a non steroid anti-inflammatory drug (NSAID) used as analgesic and anti-inflammation. This research had been done by ketoprofen patch preparation and evaluations aiming to enhance its penetration through the skin using propylene glycol as penetration enhancer. Evaluations included homogenity testing and FTIR for ketoprofen solid dispersion and organoleptic, weight uniformity, thickness, folding endurance, surface pH, moisture content, and penetration rate assay of ketoprofen patch. Penetration rate was determined by paddle type dissolution and the sample was analyzed by spectrophotometry UV-Vis. The value of moisture content and penetration rate were analyzed by One Way ANOVA with confidence level of 95 %. The value of moisture contents were F0 1.17 ± 0.0551 %; F1 1.27 ± 0.0208 %; F2 1.33 ± 0.08 %; and F3 1.43 ± 0.0208 %. The penetration rates of ketoprofen were F0 0.5258 ± 0.0191 µg/cm2.minute; F1 0.6935 ± 0.0613 µg/cm2.minute; F1 0.6935 ± 0.0613 µg/cm2.minute; and F3 1.1260 ± 0.0850 µg/cm2.minute. It can be concluded that the formula with propylene glycol 150 mg/patch can deliver the best penetration rate and moisture content that were fullfill the requirements. Keywords: ketoprofen, patch, propilen glikol, penetratio enhancer, solid dispersion

EFEKTIVITAS EKSTRAKDAUN BENALU NANGKA (Macrosolencochinchinensis (Lour.) van Tiegh) DALAM MENCEGAH PERTUMBUHAN TUMOR PARU MENCIT BETINA Dwi Nurahmanto; Edy Meiyanto
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Cancer was ranked first as the cause of death in all over the world. Chemopreventive sought from traditional preparations for example, various types of plant parasites. This study aims to determine the chemopreventive activity of aqueous extract of leaves of parasites jackfruit ( Macrosolen cochinchinensis ( Lour. ) van Tiegh ) on the growth of lung tumors of mice ( Mus musculus ) female strain Balb / c induced benzo [a ] pyrene . This research was conducted using the method Newborn Mice. Test animals used female mice (Mus musculus) strain BALB / c and benzo [ a] pyrene as carcinogenic compounds. Female mice were divided into 5 groups. Cancer control group were injected with B [ a] P were dissolved in dimethylsulfoxide ( DMSO ) . Solvent control group was given the same volume of DMSO in the control of cancer. The treatment group was divided into three dose groups are a dose of 250, 500, and 750 mg / kg . Extract made after female mice induced B [a] P. Chemopreventive intensity expressed as percentage inhibition of tumors in each group by counting the number of tumor nodules on average per lung in each mouse organs within each group. Statistical analysis used is the analysis of Test homogenity of variances and continued with Mann- Whitney Test. Parasite jackfruit leaf aqueous extract (Macrosolencochincinensis (Lour.) van Tiegh) dose of I, II, and III were able to inhibit development into lung of female mice with the percentage inhibition respectively 50 %, 36.87 %, and 84.57 % .

DIVERSIFIKASI PRODUK OLAHAN TANAMAN BERKHASIAT OBAT GUNA MENDUKUNG TERWUJUDNYA DESA SENTRA HERBAL Iqbal Erdiansyah; Eliyatiningsih Eliyatiningsih; Dwi Nurahmanto; Vega Kartika Sari
JMM (Jurnal Masyarakat Mandiri) Vol 5, No 5 (2021): Oktober
Publisher : Universitas Muhammadiyah Mataram

Abstrak: Kecamatan Silo merupakan penghasil jahe terbesar di Kabupaten Jember. Pembuatan produk olahan herbal berpotensi dikembangkan sejalan dengan berkembangnya kesadaran hidup sehat. Animo masyarakat terhadap produk olahan herbal dapat ditingkatkan dengan adanya variasi produk dari berbagai komoditi herbal. Permasalahan dalam pengembangan produk herbal di Desa Pace, Silo, Jember antara lain pengetahuan yang terbatas dalam mengolah herbal sesuai standar dan perlunya menambah variasi produk. Kemampuan ibu-ibu anggota KWT Srikandi dalam melakukan manajemen pemasaran juga perlu ditingkatkan. Pelatihan pengolahan herbal bertujuan agar anggota KWT dapat memproduksi olahan herbal terstandar dan meningkatkan omzet penjualan. Kegiatan pelatihan dilakukan dengan cara sosialisasi dan praktek. Mitra yang terlibat pada kegiatan ini yaitu anggota KWT Srikandi sebanyak 25 orang. Evaluasi dilakukan dengan cara memantau secara berkala kualitas produk dan hasil penjualan secara offline maupun online. Hasil dari pelatihan menunjukkan peningkatan keterampilan dalam pembuatan produk olahan sebesar 28,6%, peningkatan keterampilan dalam menajemen pemasaran sebesar 37,6%, dan peningkatan omzet penjualan sirup herbal sebasar 875.000/ bulan. Abstract: Silo District is the largest producer of ginger in Jember Regency. Herbal products has the potential to be developed in line with the development of awareness of healthy living. The public's interest in herbal products can be increased by the variety of products from various herbal commodities. Problems in the development herbal products in Pace Village, Silo, Jember include limited knowledge in processing herbs according to standards and increasing product variety. The ability of the members of KWT Srikandi in marketing management also needs to be improved. This training aims to enable KWT members to produce standardized herbal and increase sales revenue. Training activities are carried out by means of socialization and practice. Partners involved were 25 members. Monitoring is carried out periodically on product quality and sales results both offline and online. The results showed an increase in product processing skills by 28.6%, marketing management by 37.6%, and sales revenue of herbal syrup by 875,000/month.

PEMBIBITAN TANAMAN HERBAL DI DESA PACE KECAMATAN SILO KABUPATEN JEMBER GUNA MENUJU DESA SENTRA HERBAL Iqbal Erdiansyah; Eliyatiningsih Eliyatiningsih; Dwi Nurahmanto; Vega Kartika Sari
SELAPARANG Jurnal Pengabdian Masyarakat Berkemajuan Vol 4, No 1 (2020): November
Publisher : Universitas Muhammadiyah Mataram

ABSTRAKKecamatan Silo merupakan penghasil jahe terbesar di Kabupaten Jember pada Tahun 2017. Anggota Gapoktan di Desa Pace pernah sukses memproduksi kunyit hingga 10 ton. Cabe jawa telah dibudidayakan seluas 10 ha. Temulawak dan kencur juga dibudidayakan pada luasan yang lebih rendah. Hal tersebut menunjukkan Desa Pace berpotensi untuk dikembangkan sebagai sentra herbal di Kabupaten Jember. Di Desa Pace terdapat Gabungan Kelompok Tani (Gapoktan) Suka Maju yang beranggotan 9 kelompok tani dan satu kelompok wanita tani yang hingga kini aktif mendukung berkembangnya pertanian setempat melalui budidaya kopi dan berbagai komoditi herbal. Permasalahan dalam pengembangan dan produksi herbal di Desa Pace antara lain masih terbatasnya petani yang membudidayakan herbal sesuai GAP, sehingga tanaman herbal masih sebagai komoditi sampingan. Kegiatan diawali dari survei lahan dan pembangunan Rumah Pembibitan, dilanjutkan sosialisasi dan pendampingan budidaya aneka herbal sesuai GAP, yang bertujuan untuk meningkatkan kuantitas dan kualitas produksi agar produk yang dihasilkan terstandar. Peserta berjumlah 25 orang perwakilan dari tiap kelompok tani dan mendapatkan buku saku berisi SOP budidaya herbal, 2 paket polibag, dan bibit aneka tanaman herbal. Hasil kegiatan ini ialah anggota gapoktan memahami cara membudidayakan aneka tanaman herbal sesuai GAP dan dari hasil evaluasi 80% anggota gapoktan telah mempraktekkan di pekarangan rumah masing-masing. Kata kunci: pembibitan; tanaman herbal; desa pace; sentra herbal. ABSTRACTSilo District is the largest ginger producer in Jember Regency on 2017. The Gapoktan members in Pace had successfully produced up to 10 tons of turmeric. Chilies have been cultivated at 10 hectare. Temulawak and kencur are also cultivated at a lower area. This shows that Pace Village has the potential to be developed as an herbal center in Jember Regency. In Pace Village, there is the Association of Farmer Groups (Gapoktan) Suka Maju that has been actively supporting the development of local agriculture through the cultivation of coffee and various herbal commodities. Problems in the development and production of herbs in Pace Village include the limited number of farmers who cultivate herbs and comply with GAP, so that herbal plants are still a side commodity. The activity begins with a land survey and the construction of a nursery, continued with socialization and assistance for herbal cultivation according to GAP, which aims to increase the quantity and quality of production so that the products produced are standardized. Participants from each farmer group received a pocket book containing SOP for herbal cultivation, 2 polybag packages, and seeds of various herbal plants. The results of this activity is that Gapoktan members understand how to cultivate various herbal plants according to GAP and from the evaluation results of 80% Gapoktan members have practiced them in their respective yards. Keywords: nurseries; herbal plants; pace village; herbal center.

FORMULASI TABLET HISAP ANTIHIPERKOLESTEROL EKSTRAK DAUN Guazuma ulmifolia L. DAN EKSTRAK BUNGA Hibiscus sabdariffa L. Dwi Nurahmanto; Nuri Nuri; Ika Puspita Sari
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 13 No. 02 Desember 2016
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Daun Jati belanda (Guazuma ulmifolia L.) dan bunga rosella (Hibiscus sabdariffa L.) telah digunakan secara tradisional untuk menurunkan kadar kolesterol yang tinggi (hiperkolesterolemia). Kedua herbal ini mengandung senyawa yang dapat menurunkan kadar kolesterol, dengan mekanisme yang mungkin berbeda. Hasil penelitian sebelumnya menunjukkan bahwa kombinasi dari ekstrak daun Jati belanda dan bunga rosella mampu mengurangi konsentrasi plasma kolesterol, trigliserida, LDL, meningkatkan konsentrasi plasma HDL, dan menurunkan berat tubuh. Penelitian ini menggunakan kombinasi kedua ekstrak yang diformulasikan menjadi sediaan tablet hisap. Ekstrak dibuat granul dengan metode granulasi basah dalam tiga formula, yaitu F1, F2, dan F3 dengan komposisi bahan pengisi yang berbeda. Pengisi F1 hanya digunakan laktosa, F2 terdiri dari laktosa dan sukrosa sama banyak dan F3 hanya digunakan sukrosa. Hasil evaluasi granul menunjukkan bahwa semua formula memenuhi persyaratan sifat aliran dan kelembaban. Hasil evaluasi tablet menunjukkan bahwa semua formula memenuhi persyaratan kekerasan, hanya F2 yang memenuhi persyaratan kerapuhan, dan F2 yang paling disukai oleh para relawan. Jati belanda (Guazuma ulmifolia L.) leaves and rosella (Hibiscus sabdariffa L.) flowers have been used traditionally for lowering high levels of cholesterol (hypercholesterolemia). Both of these herbs contain compounds that can decrease high levels cholesterol, possibly by different mechanisms. The results of previous studies showed that combinations of Jati belanda leaves and rosella flowers extracts were able to reduce plasma concentrations of cholesterol, triglycerides, LDL, increased the plasma concentration of HDL, and lowering body weight. In this study, combination of both extract were formulated into antihypercholesterolemia lozenges. First, extracts were made granules by wet granulation method in three formulas, namely F1, F2, and F3 with different filler composition. The filler of F1 was lactose, F2 filler of consisted of lactose and sucrose in the same ratio, and F3 only used sucrose as filler. The result of granule evaluation showed that all formulas comply the requirements of flow properties and humidity. The result of tablets evaluation indicated that all formulas comply the requirements of hardness, but only the F2 comply the requirements of fragility, and F2 is most preferred by volunteers.

Optimasi Jumlah Etil Selulosa dan Kecepatan Pengadukan dalam Preparasi Hollow Microspheres Kaptopril Eka Deddy Irawan; Taffana Windy Hananta; Dwi Nurahmanto
Pustaka Kesehatan Vol 10 No 1 (2022): Volume 10 No.1, 2022
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v10i1.11912

Captopril is an Angiotensin-Converting Enzyme inhibitor (ACE Inhibitor) used for the treatment of hypertension. It has been reported that the duration of antihypertensive action after a single oral dose of captopril is only 6–8 h, specific absorption in the stomach, stable at acidic pH and degraded at high pH. These indicate a promising potential of the captopril hollow microspheres system as an alternative to the conventional dosage form. The preparation method used in this study is non-aqueous solvent evaporation. This study aims to determine the amount of ethyl cellulose (EC) and stirring speed to produce hollow microspheres having entrapment efficiency (EE), buoyancy and particle size maximum. Determination of the optimum hollow formula microspheres captopril uses a design factorial of two factors at two levels. The factors used in this study were the amount of EC and stirring speed, while the observed response was EE, buoyancy and particle size. The chosen optimum formula will be verified and characterized (yield, SEM, FT-IR). Formula AB was the optimum formula with EE 90.68%, buoyancy 81.52% and particle size 267.10µm. The verification obtained results in accordance with the prediction of the Design-Expert software. The characterization results obtained a yield value of 98.33%, with a spherical shape, uneven surface morphology, and hollow core. The results of FT-IR analysis showed that there was no interaction between the drug and polymer used in the formulation.

Co-Authors A., Mohammad Zulfikhar Ali Djamhuri Ameliana, Lidya Andriyani, Novia Arafika, Whendy Waliya Aslyni Putri Suranina Barus Azis, Rani Firda Nur Imaniah Azis, Rani Firda Nur Imaniah Baiq Wahyudyati Karnia Qisti Budipratiwi Wisudiyaningsih Dessy Dwi Risky Ayuningtias desy diana sari Edy Meiyanto Edy Meiyanto Eka Deddy Irawan Eliyatiningsih, Eliyatiningsih Erdiansyah, Iqbal Evi Umayah Ulfa Feny Dhea Camelia Friska Wira Sabrina Gazzali, Amirah Mohd Haris Raudhatuzakinah Dwiputri Ifa Rosi Mahrifah Ika Puspitasari Iqbal Erdiansyah, Iqbal Kristine Dwi Puspitasari Kumala Sari, Lusia Oktora Ruma Lina Winarti Lusia Oktora Ruma Kumala Sari Maharani Dwi Pratiwi Mahrifah, Ifa Rosi Mahrifah, Ifa Rosi Nofia Elisa Putri Nuri Nuri Nursatriya, Agne Yuliana Nurul Shalikha Paramayuda, Farukh R.K.S., Lusia Oktora Rani Firda Nur Imaniah Azis Sabrina, Friska Wira Sabrina, Friska Wira Shalikha, Nurul Taffana Windy Hananta Vega Kartika Sari Viddy Agustian Rosyidi

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