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All Journal e-Journal Pustaka Kesehatan Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Pharmacon Pharmascience JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Abdimasku : Jurnal Pengabdian Masyarakat Jurnal farmasi UIN Alauddin Makassar Nusantara Science and Technology Proceedings
Bawon Triatmoko
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Journal : e-Journal Pustaka Kesehatan

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Uji Aktivitas Antibakteri Kombinasi Minyak Atsiri Biji Ketumbar (Coriandrum sativum L.) dan Gentamisin terhadap Staphylococcus epidermidis Bawon Triatmoko; Huda Almuttaqin; Dewi Dianasari
Pustaka Kesehatan Vol 6 No 3 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i3.9870

Abstract

Gentamicin is one of the antibiotics from the aminoglycoside group used for the treatment of infections. Gentamicin has side effect such as permanent ototoxicity and reversible nephrotoxicity. It was necessary to reduce these effects by combining antibiotic with natural ingredients, one of those is coriander seeds essential oil. Combination therapy is done to reduce the potential side effects, and increase antibacterial efficacy. Antibacterial activity test were conducted to measure the MIC values of gentamicin, essential oils of coriander seeds, and combination of both. Based on the antibacterial activity test, MIC value of gentamicin was 4 µg/mL, coriander seed essential oil was 50 µg/mL and MIC combination of gentamicin and essential oil of coriander seeds were 0.5 µg/mL and 50 µg/mL. The FIC Index value obtained was 1.125 meaning that the combination effect was indifferent. Indifferent combination effect means the use of a combination of coriander seeds essential oil and gentamicin as antibacterial was not better than the single use. Keywords: coriander, essential oil, antibacterial, FIC Index, S. epidermidis
Sitotoksisitas Minyak Mesoyi (Cryptocarya massoy) terhadap Sel Vero (Cytotoxicity of Mesoyi Oil (Cryptocarya massoy) on Vero Cell Lines) Bawon Triatmoko; Triana Hertiani; Agustinus Yuswanto
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Mesoyi oil distilled from the bark of Cryptocarya massoy have been used for traditional treatment of various ethnicities. However, its safety use has not been widely studied. This study aimed to investigate the cytotoxicity of mesoyi oil on vero cells in vitro. The Inhibitory concentration 50% (IC50) of mesoyi oil is evaluated using MTT assay. The results indicated that the mesoyi oil exhibited cytotoxic effects on vero cells with IC50 value of 97.4 μg//mL. This call for further studies to evaluate the cytotoxic activity in vivo. Keywords: cytotoxicity, essential oil, cryptocarya massoy, vero cell
Uji Aktivitas Antibakteri Ekstrak Metanol dan Fraksi Daun Kenikir (Cosmos caudatus Kunth) terhadap Salmonella typhi Achmad Syarifudin Noor; Bawon Triatmoko; Nuri Nuri
Pustaka Kesehatan Vol 8 No 3 (2020): Volume 8 No. 3, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i3.13008

Abstract

The leaves of kenikir are known to have many benefits, one of which can be used as medicine. Kenikir leaves are reported to have antibacterial activity against the bacteria Salmonella typhi (S.typhi). S. typhi is a bacterium that causes typhoid fever. Typhoid fever is still an endemic disease in Asian countries, especially Indonesia. Typhoid fever became the third largest disease in Indonesia in 2010. The study related to the antibacterial activity of kenikir leaf fraction to S. typhi has never been reported. Therefore, it is necessary to conduct research related to the antibacterial activity of extracts and leaf fractions of kenikir to compare their potential against S. typhi. The study was conducted using the disk diffusion method using 5 series of concentrations namely 5%, 10%, 15%, 20%, and 30%. Tests were carried out on methanol extract, hexane, ethyl acetate, and methanol-water fraction. The results showed that highest inhibition zone diameter is 7,75 mm which is reached by methanol extract. The order of the highest inhibiting zone diameter are extract, hexane, ethyl acetate, and methanol-water fraction.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Waru Gunung (Hibiscus macrophyllus) dan Fraksinya terhadap Staphylococcus aureus Afif Rifqie Maulana; Bawon Triatmoko; Mochammad Amrun Hidayat
Pustaka Kesehatan Vol 9 No 1 (2021): Volume 9 No.1, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i1.16432

Abstract

Infection is one of the main causes of world health problems, especially in developing countries like Indonesia, one of which is an acute respiratory infection caused by bacteria such as Staphylococcus aureus. Therapeutics are used for the treatment of infections today with antibiotics. However, there are many cases of bacterial resistance to antibiotics that need to develop alternatives derived from plants. One of the plants that have antibacterial activity is the leaves of Waru Gunung (Hibiscus macrophyllus). The purpose of this study was to determine whether the ethanolic extract of H. macrophyllus leaves and their fractions have antibacterial activity against S. aureus. The method used in this antibacterial activity test is the disk diffusion method with a test concentration of 5%, 10%, 15%, 20%, and 25%. The results of this study indicate that all test samples have antibacterial activity except in the water fraction. The highest antibacterial activity was obtained in the ethyl acetate fraction which attracted semipolar compounds in the ethanolic extract of H. macrophyllus leaves. The antibacterial activity of the test samples in sequence from high to low includes ethyl acetate fraction, ethanolic extract, n-hexane fraction, and water fraction.
Co-Authors Achmad Syarifudin Noor Adinda Kusuma Pertiwi Afif Rifqie Maulana Afrian Rosyadi Agustinus Yuswanto Amrina Rosyada Fajriyanti Ari Satia Nugraha Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Asia Asia Dewi Dianasari Dewi Dianasari Dianasari, Dewi Dinar Mutia Rani Dita Isnaini Prabawati Dwi Nurahmanto Dwi Nurahmanto Endah Puspitasari Fauzia Ken Nasititi Fawwas Batio Putra Pamungkas Gani Asri Muharam Huda Almuttaqin Ifan Arif Maulana Indah Yulia Ningsih Ita Husnul Chotimah Mariatul Kibthiyyah Marsalita Irine Prabandari Mochammad Amrun Hidayat Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Zainul Arifin Nafa Rosyida Zanuba Nasititi, Fauzia Ken Naura Bathari Winarto Nimas Ayu Amanda Putri Nuri Nuri Nuri Nuri Nuri Nuri Saeful Akhmad Tauladani Savitri, Ganevi Resta Triana Hertiani Wilda Nur Rohmatilah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Yoshinta Debby Ziyan Nihlatul Millah