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All Journal e-Journal Pustaka Kesehatan Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) UNEJ e-Proceeding Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Farmasi Indonesia Jurnal Sains dan Kesehatan Journal of Agropharmacy
Lusia Oktora Ruma Kumala Sari
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health

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Optimasi dan Formulasi Tablet Mengapung - Mucoadhesive Glimepirid dengan Kombinasi Polimer Karbopol dan HPMC K4M (Optimization and Formulation Floating - Mucoadhesive Glimepiride Tablet with Combination Carbopol and HPMC K4M) Hery Diar Febryanto; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Glimepiride is one of the preferred drug for the treatment of type II diabetes mellitus. Diabetes can affect gastric emptying time. Incomplete absorption of drugs often result in small bioavailability. Glimepiride was chosen as model drug because it has incomplete absorbtion due to less gastric residence time. Tablet make by direct compression using polymer carbopol, HPMC K4M and other additives. This study used factorial design. Factors that are optimazed are carbopol and HPMC K4M and responses used are floating lag time, floating duration time, mucoadhesive, dan DE 720. tablet were evaluated for invitro release characteristic for 12 hours. Area optimum obtained on the composition of the combination of Carbopol 69.20 to 70.60 mg and HPMC K4M 10.66 to 24.67 mg.   Keywords: glimepiride, floating mucoadhesive tablet, release kinetics, carbopol, HPMC K4M
Optimasi Sodium Starch Glycolate dan Crospovidone sebagai Superdisintegran dalam Sediaan Orally Disintegrating Tablet Meloksikam (Optimization of Sodium Starch Glycolate and Crospovidone as Superdisintegrant in Orally Disintegrating Meloxicam Tablet Dosag Eunike Aprilianio; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i3.5889

Abstract

Meloxicam is the second class of biopharmaceutical classification system that its solubility needs to be improved. Therefore, in this study solid dispersion of meloxicam were prepared using PEG 6000. Meloxicam is used to treat osteoarthritis that particularly experienced by geriatric patients. Geriatric patients have a difficulty to swallow conventional capsule or tablet, but orally disintegrating tablet (ODT) overcome this difficulty. The basic of ODT formulation is the use of superdisintegrant, like sodium starch glycolate (SSG) and crospovidone. The aim of this study was to find out the combination of superdisintegrant that shows optimum fomulation. The effect of superdisintegrant and their combination on hardness, friability, disintegration time and percentage of drugs released in 30 minutes (T30) also investigated. The design of formula used the simplex latice design with two component mixture: SSG and crospovidone. Results showed that the combination affected not significantly on disintegration time and friability of ODT, but they could improve hardness and T30. The optimum formula found at combination of 0 mg SSG and 8 mg crospovidone in 200 mg tablet. Keywords: meloxicam, sodium starch glycolate, crospovidone, ODT, simplex lattice design
An Optimasi Polivinil Pirolidon dan Kitosan dalam Sediaan Mucoadhesive Buccal Film Diltiazem HCl Viddy Agustian Rosyidi; Ulfia Dwi Novita; Lusia Lusia Oktora Ruma Kumala Sari
Pustaka Kesehatan Vol 7 No 3 (2019): Volume 7 No.3, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i3.11543

Abstract

Diltiazem HCl adalah golongan benzoatiazepin penghambat kanal kalsium (calcium channel blocker) yang digunakan dalam pengobatan angina pektoris, aritmia, dan hipertensi. Diltiazem HCl mengalami first pass metabolism di hati, waktu paruh yang pendek yakni 3-5 jam dan bioavailabilitas diltiazem pada pemberian oral sekitar 40%. Sediaan mucoadhesive buccal film diltiazem HCl melepaskan obat ke mukosa buccal sehingga dapat menghindari first pass metabolism karena absorpsinya melalui sistem vena yang mengalir dari pipi. Tujuan penelitian ini adalah untuk mengetahui pengaruh polimer polivinil pirolidon (PVP) dan kitosan terhadap swelling index, waktu tinggal dan kekuatan mucoadhesive diltiazem HCl dalam sediaan mucoadhesive buccal film diltiazem HCl. Sediaan film dilakukan evaluasi swelling index, kekuatan mucoadhesive dan waktu tinggal mucoadhesive. Jumlah optimum untuk PVP adalah 1 mg dan kitosan sebesar 25 mg. Kombinasi polimer dengan jumlah tersebut dapat menghasilkan swelling index, kekuatan mucoadhesive, dan waktu tinggal mucoadhesive yaitu 3,641; 63,867 gF; dan 352,667 menit dan nilai desirability tertinggi yaitu 0,727. Kata kunci: mucoadhesive buccal film, diltiazem HCl, PVP, kitosan
Optimasi Hidroksipropil Metilselulosa dan Polivinil Pirolidon dalam Sediaan Mucoadhesive Buccal Film Diltiazem Hidroklorida Lusia Oktora Ruma Kumala Sari; Septi Sudianingsih; Yudi Wicaksono
Pustaka Kesehatan Vol 9 No 1 (2021): Volume 9 No.1, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i1.12228

Abstract

Diltiazem HCl is a class of benzodiazepine calcium channel blockers used to treat angina pectoris, arrhythmias, and hypertension. Diltiazem HCl improves first-pass metabolism, a short half time of 3-5 hours, and bioavailability of diltiazem for oral administration of about 40%. Mucoadhesive buccal film diltiazem HCl releases the drug to the buccal mucosa, so the first pass metabolism can be avoided because of its absorption through the venous system that flows from the cheek. This study aimed to study HPMC polymers and polyvinyl pyrrolidone (PVP) polymers on swelling index, residence time, mucoadhesive strength of mucoadhesive buccal film diltiazem HCl, FTIR, and drug release. The prepared film was evaluated for swelling index, mucoadhesive strength, and mucoadhesive residence time. The optimal amount for HPMC was 35 mg, and PVP was 15 mg. The combination of polymers with this amount can produce a swelling index was 3,00, mucoadhesive strength was 41,87 gF, and mucoadhesive residence time was 330,66. FTIR test indicated that there was no interaction between active function clusters of Diltiazem HCl and other excipients. The release of the optimum formula in the 360th minute was about 97.847%, following in the zero-order release model and Higuchi.
Optimasi Konsentrasi Span 80 dan Lama Pengadukan dalam Preparasi Microspheres Metformin Hidroklorida-kitosan (Optimization of Span 80 Concentration and Stiring Time on The Preparation of Metformin Hydrochloride-Chitosan Microspheres ) Christyn Novita S; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6614

Abstract

Metformin hydrochloride (MH) has been used as first line for type 2 diabetes mellitus treatment. However, it has relatively low bioavailability, short half-life and could cause gastrointestinal side effects, therefore it is appropriately prepared as microspheres. Microspheres is micro particle which is between 1-1,000 µm in size. Many factors affected the result of microspheres preparation, such as surfactant concentration and stirring time. This research was aimed to find the best composition of span 80 concentration and stirring time to produce MH-chitosan (CH) microspheres with the highest entrapment efficiency (EE) using factorial design optimization. MH was used as active substance, CH as polymer, span 80 as surfactant and non-aqueous solvent evaporation method was chosen for microspheres preparation technique. The optimized formula 2 % span 80 and 2 hours stirring time gained 86.803 ± 0.544 % EE, 24.571 ± 0.157 % drug loading, and 88.220 ± 0.137 % yield. The microspheres had a relatively smooth, bright surface, and spherical structure. The average particle’s size was 161.2 ± 1.743 μm. FTIR analysis indicated that there were no changes in the spesific functional clusters of MH as an active substance. Keywords: metfomin-hydrocloride-chitosan microspheres, non-aquoeous solvent evaporation, factorial design, span 80 concentration, stirring time.
Optimasi Konsentrasi Hidroksipropil Selulosa dan Polivinilpirolidon dalam Sediaan Buccal Film Simvastatin (Optimization Of Hydroxypropyl Cellulose and Polyvynylpyrolidone Concentration in Simvastatin Buccal Film) Nurul Qomariyah; Lidya Ameliana; Lusia Oktora Ruma Kumala Sari
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i1.3951

Abstract

Simvastatin, an antihyperlipidemia drug belongs to HMG-CoA reductase inhibitor, has extend first-pass metabolism and low bioavailability (5%) with 95-98% protein bond and short half-life (2 hours). The problem of low bioavailability can be solved by buccal delivery systems with producing simvastatin mucoadhesive buccal film. Concentration of HPC and PVP can affect the value of simvastatin release and mucoadhesive strength of film. Optimization using factorial design method determine the optimum concentration of HPC and PVP with highest simvastatin release and mucoadhesive strength. Solvent casting method used for preparation of 4 formula according to factorial design. The result was formula A (FA) with HPC and PVP concentration ratio (50: 10) gave the highest simvastatin release at 95.41% and the highest mucoadhesive strength at 73.37 grams. FTIR analysis results of FA indicated that there were no change in the functional groups on simvastatin as an active ingredient, and the mucoadhesive residence time showed that FA buccal films can be attached to the goat buccal tissues for 186 minutes. Keywords: Buccal film, mucoadhesive, simvastatin, HPC, PVP, factorial design. 
Optimasi Hydroxypropyl Methylcellulose dan Chitosan pada Tablet Floating-Mucoadhesive Diltiazem Hidroklorida Menggunakan Desain Faktorial Irsalina Triastutik; Lusia Oktora Ruma Kumala Sari; Lina Winarti
Pustaka Kesehatan Vol 8 No 3 (2020): Volume 8 No. 3, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i3.11419

Abstract

Diltiazem HCl is one of the drugs used for hypertension treatment. It requires frequent dosing, which is why diltiazem HCl needs to be formulated into preparations using a controlled release drug delivery system. The combination of floating and the mucoadhesive system is expected to increase the stomach's retention of the dosage form. This study aimed to determine the optimum composition of hydroxypropyl methylcellulose (HPMC K100M) and chitosan for floating mucoadhesive diltiazem HCl tablet. Tablets that have been prepared were evaluated for the tablet's physical characterization, powder flowability test, dissolution test, floating ability, and mucoadhesive test. Tablets were optimized using a factorial design, and the data were analyzed using design expert 11.0.0. The results showed that the optimum formula for polymer combination in diltiazem HCl tablet was 175 mg for HPMC K100M and 50 mg for chitosan. The combination of polymers with this amount can produce a floating lag time of 45,333 seconds, floating duration time >12 hours, and the strength of mucoadhesive is 81,633 grams.
Optimasi Kecepatan dan Lama Pengadukan dalam Preparasi Microspheres Metformin Hidroklorida Menggunakan Polimer Etil Selulosa (Optimization of Stirring Speed and Time on Preparation of Metformin Hydrochloride Microspheres Using Ethyl Cellulose Polymer) Amalia Fadila; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Metformin hydrochloride (MH) is a first line therapy in the treatment of noninsulin-dependent diabetes mellitus. However, MH has a very short half-life, relatively low bioavailability, and gastrointestinal adverse effects. Controlled released formulations can overcome this problem by increasing gastro retention time (GRT). Drug delivery systems aimed at improving GRT can be designed in a single units (eg, tablets) and multiple unit (eg, microspheres). Stirring speed and time affect several aspects such as shape, size, and particle size distribution, the release rate, and entrapment efficiency (EE) of the microspheres.. This research was aimed to find the stirring speed and time to produce MH microspheres having high EE. The result showed that the microspheres stirred at 1,000 rpm for 2 hours produced the highest EE, 84.792 ± 0.975 %; had the drug loading of 12.067 ± 0.0649 %; and yield of 99.44 ± 0.123 % with the particle size 157.5 ± 1.007 μm, has the spheres shape and a relatively smooth and bright surface morphology. FTIR analysis results indicated that there were no changes in the functional groups on MH as an active ingredient. Keywords: metformin hydrochloride-ethyl cellulose microspheres, non-aquoeous solvent evaporation, stirring speed, stirring time, factorial design
Optimasi Formula Tablet Effervescent Dispersi Padat Meloksikam Menggunakan Desain Faktorial Lusia Oktora Ruma Kumala Sari; Tiara Berlianti; Eka Deddy Irawan
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7571

Abstract

An effervescent tablet of meloxicam solid dispersion has been developed for geriatric patients who have difficulty swallowing. The objective of this research was to know the optimum concentration of citric acid and sodium bicarbonate which produce the best effervescent tablet. A 2² factorial design was applied to investigate the effect of two factors: concentration of citric acid and sodium bicarbonate (effervescent materials) on hardness, dissolve time, and %drug released t30. Citric acid (6-18 mg) was used as acid source and sodium bicarbonate (18-105 mg) was used as base source. Software Design Expert trial version 10.0.5. was used to determine the optimum formula. The result showed that all formula satisfied the limit of hardness 2-4 kg/cm2 and friability <1%, but only formula (1), b, and ab that satisfied the limit of dissolve time <300 sec and %drug release t30 >70%. Formula A showed dissolve time 436 sec and %drug release t30 less than 70%. Desirability value of 0.917, which indicated the optimum formula, was obtained from the use of citric acid 6 mg and sodium bicarbonate 105 mg. Keywords: meloxicam, effervescent tablet, solid dispersion, factorial design
Optimasi Komposisi Pelarut Gliserin dan Propilen Glikol terhadap Disolusi Tablet Meloksikam Metode Likuisolid Menggunakan Simplex Lattice Design (Optimization Composition of Glycerin and Propylene Glycol Solvent on Dissolution of Meloxycam Tablet with Li Yudistirawati Khusna; Eka Deddy Irawan; Lusia Oktora Ruma Kumala Sari
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Meloxicam is Non Steroid Inflammation Drugs (NSAID) that inhibit cyclooxygenase-2 (COX-2). Meloxicam has poor solubility in water. The drug that has poor solubility, need to be modified to increase the solubility. The technique that can increase the solubility is liquisolid technique. The research aim was to develop tablet formulation of meloxicam by increasing the solubility using liquisolid method. This liquisolid tablet used combination of propylene glycol and glycerin as nonvolatile solvent to increase meloxicam release. The liquisolid tablets were evaluated for physical chemical characteristics e.g. homogeneity level, drug content uniformity, friability, hardness, disintegration time and in vitro drug release. Optimization composition of propylene glycol and glycerin used simplex lattice design method with nonvolatile solvent as a factor and dissolution efficiency (DE60) as response. The use of propylene glycol and glycerin will increase drug release. Optimum composition of propylene glycol and glycerin resulting optimum dissolution efficiency (DE60) between 78,88 – 88,48 % was propylene glycol with concentration of 0-15 mg and glycerin with concentration of 0-15 mg in 300 mg of tablet. Keyword: meloxicam, liquisolid, propylene glycol, glycerin, simplex lattice design
Co-Authors Amalia Fadila Ameliana, Lidya Andreas Henry Prasetyo Barikah, Kuni Zu’aimah Cahyaningrum, Nitta Christyn Novita S Dwi Nurahmanto Eka Deddy Irawan Eka Deddy Irawan Elok Rimadani Eryani, Mikhania Christiningtyas Eunike Aprilianio Eva Setyorini Hanif, Mohammad Ainul Fakhruddin Helmi Nur Laili Hery Diar Febryanto Irsalina Triastutik Kuni Zu’aimah Barikah Kuni Zu’aimah Barikah Liananta Fawzia Wulandari Lidya Ameliana Lina Winarti Nani Sukmawati Ninda Sukmaningrum Nursatriya, Agne Yuliana Nurul Qomariyah Putri Mustika Nandani Septi Sudianingsih Siti Munawaro Siti Munawaro, Siti Sukmaningrum, Ninda Tiara Berlianti Tintia Lintang Pratiwi Ulfia Dwi Novita Via Rahmatia Viddy Agustian Rosyidi Yudi Wicaksono Yudistirawati Khusna