Article Per Year (5 Year)
p-Index From 2021 - 2026
1.325
P-Index
This Author published in this journals
All Journal e-Journal Pustaka Kesehatan Jurnal Pengembangan Pendidikan Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi INDONESIAN JOURNAL OF PHARMACY Science and Technology Indonesia Jurnal Farmasi Indonesia Journal of Agropharmacy
Eka Deddy Irawan
Fakultas Farmasi Universitas Jember
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Education Environmental Science Health Professions Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Physics

Published : 25 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 25 Documents
Search

 1   2   3 
Optimasi Komposisi Hidroksipropil Metilselulosa dan Etil Selulosa dalam Preparasi Hollow Microspheres Kaptopril Irawan, Eka Deddy; Farkha, Fara Sukma; Ameliana, Lidya
Pustaka Kesehatan Vol 12 No 2 (2024): Volume 10 No.2, 2024
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v12i2.11911

Abstract

Hypertension is a condition while blood pressure is increasing. The normal value of blood pressure is <120/80 mmHg. One of the drugs used to reduce blood pressure is captopril. Captopril has a short half-time, so it requires repeated administration that allows fluctuations. To solve this shortcoming, an approach was carried out using a controlled delivery system, hollow microspheres. The purpose of this research is to optimize and determine the amount of Hydroxypropyl Methylcellulose (HPMC) and Ethyl Cellulose (EC) polymers that can produce the optimum formula. Optimization is done using the factorial design method. The response that will be observed in this research is the value of entrapment efficiency, buoyancy, and particle size. The optimum formula was obtained in the combination of HPMC and EC amounts in captopril hollow microspheres are 75 mg HPMC and 200 mg EC.
Optimasi Sodium Croscarmellose dan Pati Jagung Pregelatinasi dalam Orally Disintegrating Tablet Setirizin Dihidroklorida Irawan, Eka Deddy; Sari, Lusia Oktora Ruma Kumala; Cahyaningrum, Nitta
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (721.968 KB) | DOI: 10.35617/jfionline.v14i2.77

Abstract

Abstract: Cetirizine dihydrochloride (Cetirizine diHCL) is an effective antihistamine to treat allergies. Cetirizin diHCL tablets are a dosage form that is commonly on the market. However, people who experience allergies will have symptoms of difficulty swallowing which make it difficult to take cetirizine diHCl tablets. Therefore, it is necessary to make cetirizine diHCl in the form of orally disintegrating tablets (ODT) which can dissolve in saliva in a few seconds without chewing tablets or drink water. The proportion of binder and super disintegran was used in ODT preparations must be taken into calculation because it will greatly affect the physical characteristics of the tablets. This study aims to optimize the super disintegran Croscarmelose Sodium and pregelatinasi corn starch binders using factorial design methods. The responses studied were flow rate, hardness, brittleness, wetting time, and disintegration time. The increased Croscarmelose Sodium factor reduces the flow rate and hardness, increases brittleness, and decreases wetting and disintegration times. The increased factor of pregelatinasi corn starch will increase the flow rate and hardness, reduce friability and increase wetting time and disintegration time. The optimum formula was obtained from the concentration of Croscarmelose Sodium 6.613 mg and pregelatinasi corn starch 20 mg which resulted in a flow rate response of 13.438 g/second, hardness 4.646 kg, friability 0.815%, wetting time 63.667 seconds, and disintegration time 18.641seconds.
Pembentukan kokristal Ketoprofen-Urea-NaCl untuk Peningkatan Sifat Kelarutan Laily, Aisyah Prida; Irawan, Eka Deddy; Wisudyaningsih, Budipratiwi; Barikah, Kuni Zu’aimah; Wicaksono, Yudi
Journal of Agropharmacy Vol. 1 No. 1 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ketoprofen is a potent non-steroidal anti-inflammatory drug compound but is difficult to dissolve in water. This research aims to increase the solubility of ketoprofen through cocrystallization using a urea coformer with the addition of the inorganic salt NaCl. Cocrystallization was carried out using the solvent evaporation method using methanol. The characterization of the cocrystal results included PXRD, DSC, and FTIR. At the same time, the solubility evaluation was carried out using a solubility test in distilled water and a dissolution test in phosphate buffer media pH 7.4. The results showed that ketoprofen forms a cocrystal with the urea coformer, whereas adding NaCl produces a ketoprofen-urea-NaCl cocrystal with a lower crystallinity and melting point. The solubility of ketoprofen-urea-NaCl cocrystals in distilled water was 183.82 ± 2.84 mg/L, while ketoprofen-urea and ketoprofen cocrystals were 174.23 ± 6.83 and 171.12 ± 6.29 mg/L, respectively. The dissolution test in phosphate buffer medium pH 7.4 showed the dissolution rate of ketoprofen-urea-NaCl cocrystals > ketoprofen-urea cocrystals > ketoprofen.
Optimasi Moringa Gum dan Hidroksi Propil Metil Selulosa dalam Sediaan Mucoadhesive Buccal Film Diltiazem Hidroklorida Sari, Lusia Oktora Ruma Kumala; Hanif, Mohammad Ainul Fakhruddin; Irawan, Eka Deddy; Winarti, Lina; Barikah, Kuni Zu’aimah; Rosyidi, Viddy Agustian; Eryani, Mikhania Christiningtyas; Febryanto, Hery Diar
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Moringa gum is a natural polymer obtained from Moringa oleifera plant and has been used as a stabilizer, binder, disintegrant, and controlled release matrix. Moringa gum has a polyuronide group, which can potentially be a mucoadhesive agent. This study used moringa gum as a mucoadhesive agent in diltiazem HCl mucoadhesive buccal film. This research aimed to determine the effect of the combination of moringa gum and HPMC on surface pH, swelling index, and in-vitro mucoadhesive residence time. Mucoadhesive buccal films were evaluated for weight and thickness uniformity, folding resistance, drug content, surface pH, swelling index, in-vitro mucoadhesive residence time, and characterization in the form of FTIR and release studies. All formulations met the tests of uniformity of weight and thickness, folding resistance, and drug content. The results showed FB as the optimum formula with a surface pH of 5.803±0.101, a swelling index of 7.031±0.134, and a residence time of 505.67±4.51 minutes. FTIR showed no interaction, and the release study showed 82.197±1.178% release at 480 minutes. In conclusion, a combination of moringa gum and HPMC mucoadhesive buccal film has been successfully prepared with moringa gum as a mucoadhesive agent that increases the residence time.
Optimization of Hydrolyzed Pumpkin (Cucurbita Moschata) Starch as Natural Superdisintegrant in Promethazine HCl Sublingual Tablets Winarti, Lina; Asrofi, Muhammad; Lubis, Maralodia Almira; Lestari, Tirtawati Putri; Sari, Lusia Oktora Ruma Kumala; Irawan, Eka Deddy; Febryanto, Hery Diar; Afthoni, Muhammad Hilmi; Eryani, Mikhania Christiningtyas
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.502-514

Abstract

Acid hydrolysis of pumpkin starch is a feasible strategy for developing novel pharmaceutical excipients, particularly natural superdisintegrants for sublingual and orally disintegrating tablet formulations. Given the requirement for extremely rapid tablet disintegration in sublingual dosage forms, selecting an efficient disintegrant is a critical formulation parameter. However, native pumpkin starch exhibits limited disintegration efficiency and generally requires high concentrations, which may adversely affect tablet hardness and friability. This study aimed to optimize the acid hydrolysis process of pumpkin starch and to evaluate the performance of the optimized hydrolyzed starch as a natural superdisintegrant in Promethazine HCl sublingual tablets. A factorial design was used to examine the impact of varying hydrolysis durations (3-9 days) and hydrochloric acid concentration (5-9%) on the physicochemical characteristics of the modified starch. The optimized hydrolyzed starch demonstrated a near-neutral pH (5.17 ± 0.03), acceptable moisture content (LOD 10.20 ± 0.44%), and excellent flow properties, as indicated by a low angle of repose (23.96°) and Carr’s index (9.99%). Scanning electron microscopy revealed increased surface irregularity and porosity, while FTIR analysis indicated enhanced exposure of hydroxyl groups, consistent with partial depolymerization of the starch polymer. The amylose content increased to 35.17%, accompanied by improved water uptake and swelling capacity. The effective pore radius (25.03 ± 0.35 µm) and swelling index (70.25 ± 0.57) were markedly higher than those of native pumpkin starch (12.27 µm and 44.30 ± 0.85, respectively), although slightly lower than crospovidone (27.65 µm and 99.97 ± 0.13). Incorporation of the hydrolyzed starch into Promethazine HCl sublingual tablets resulted in formulations with adequate mechanical strength (hardness 3.35 ± 0.05 kg), low friability (0.53 ± 0.04%), rapid disintegration (49.18 ± 0.75 s), and high drug release (96.79 ± 0.13%). These performances were comparable to those of crospovidone and superior to formulations containing native pumpkin starch. The improved tablet characteristics were primarily attributed to enhanced porosity and swelling capacity induced by acid hydrolysis. Overall, optimized hydrolyzed pumpkin starch demonstrates considerable potential as a sustainable, biodegradable, and cost-effective natural superdisintegrant for fast-disintegrating pharmaceutical tablet formulations.
Co-Authors ., Farhana Achmad Fudholi Amalia Fadila Ameliana, Lidya Barikah, Kuni Zu’aimah Cahyaningrum, Nitta Christyn Novita S Dwi Nurahmanto Eryani, Mikhania Christiningtyas Eunike Aprilianio Eva Setyorini Farkha, Fara Sukma Firdatus Sholehah Hanif, Mohammad Ainul Fakhruddin Hery Diar Febryanto Laily, Aisyah Prida Lestari, Tirtawati Putri Lina Winarti Lubis, Maralodia Almira Lusia Oktora Ruma K. S. Lusia Oktora Ruma Kumala Sari Muhammad Asrofi, Muhammad Ninda Sukmaningrum Siti Munawaro Siti Munawaro, Siti Sri Untari Sukmaningrum, Ninda Taffana Windy Hananta Tiara Berlianti Tintia Lintang Pratiwi Viddy Agustian Rosyidi Yudi Wicaksono Yudistirawati Khusna